%0 Journal Article
%A Gutierrez-Bonet, Rosa
%A Ruiz-Medrano, Jorge
%A Peña-Garcia, Pablo
%A Catanese, Muriel
%A Sadeghi, Yalda
%A Hashemi, Katayoon
%A Gabison, Eric
%A Ruiz-Moreno, José M.
%T Macular Choroidal Thickening in Keratoconus Patients: Swept-Source Optical Coherence Tomography Study
%B Translational Vision Science & Technology
%D 2018
%R 10.1167/tvst.7.3.15
%J Translational Vision Science & Technology
%V 7
%N 3
%P 15-15
%@ 2164-2591
%X    To determine the choroidal thickness (CT) profile in keratoconus (KC) patients using swept-source optical coherence tomography (SS-OCT).    This was a prospective, cross-sectional study. One hundred two eyes of 52 KC patients were studied using Pentacam and SS-OCT. The macular CT profile was created by manually measuring the distance between the retinal pigment epithelium and the choroid-sclera junction on horizontal b-scans at nine different macular locations. The results were compared to 93 eyes of 93 healthy controls.    Mean age of the KC group was 34.9 ± 13.5 years and mean axial length (AL) was 24.1 ± 1.3 mm. Mean topographic KC classification (TKC) was 2.0; 39 eyes were classified as early KC (TKC <1–2), 34 eyes as moderate (TKC 2, 2–3), and 29 as advanced (TKC 3+). Mean subfoveal CT was 383.2 μm in KC patients and 280.5 μm in control group (P < 0.001). CT in KC patients was statistically thicker in all measure locations (P < 0.001). CT in KC eyes decreased with age, approaching control group at >45 years old, losing statistical significance (P = 0.37).    CT in KC patients is statistically thicker than in healthy population. After age 45, CT decreases approaching control group values.    This study describes changes in the CT profile of KC patients, a disease that was considered purely corneal. These choroidal changes argue that KC is a disease that likely involves several ocular structures other than the cornea, and could open new research lines related to the pathophysiology of KC.  
%[ 10/1/2020
%U https://doi.org/10.1167/tvst.7.3.15