%0 Journal Article %A Gutierrez-Bonet, Rosa %A Ruiz-Medrano, Jorge %A Peña-Garcia, Pablo %A Catanese, Muriel %A Sadeghi, Yalda %A Hashemi, Katayoon %A Gabison, Eric %A Ruiz-Moreno, José M. %T Macular Choroidal Thickening in Keratoconus Patients: Swept-Source Optical Coherence Tomography Study %B Translational Vision Science & Technology %D 2018 %R 10.1167/tvst.7.3.15 %J Translational Vision Science & Technology %V 7 %N 3 %P 15-15 %@ 2164-2591 %X To determine the choroidal thickness (CT) profile in keratoconus (KC) patients using swept-source optical coherence tomography (SS-OCT). This was a prospective, cross-sectional study. One hundred two eyes of 52 KC patients were studied using Pentacam and SS-OCT. The macular CT profile was created by manually measuring the distance between the retinal pigment epithelium and the choroid-sclera junction on horizontal b-scans at nine different macular locations. The results were compared to 93 eyes of 93 healthy controls. Mean age of the KC group was 34.9 ± 13.5 years and mean axial length (AL) was 24.1 ± 1.3 mm. Mean topographic KC classification (TKC) was 2.0; 39 eyes were classified as early KC (TKC <1–2), 34 eyes as moderate (TKC 2, 2–3), and 29 as advanced (TKC 3+). Mean subfoveal CT was 383.2 μm in KC patients and 280.5 μm in control group (P < 0.001). CT in KC patients was statistically thicker in all measure locations (P < 0.001). CT in KC eyes decreased with age, approaching control group at >45 years old, losing statistical significance (P = 0.37). CT in KC patients is statistically thicker than in healthy population. After age 45, CT decreases approaching control group values. This study describes changes in the CT profile of KC patients, a disease that was considered purely corneal. These choroidal changes argue that KC is a disease that likely involves several ocular structures other than the cornea, and could open new research lines related to the pathophysiology of KC. %[ 4/20/2021 %U https://doi.org/10.1167/tvst.7.3.15