@article{10.1167/tvst.8.3.61, author = {Song, Ge and Chu, Kengyeh K. and Kim, Sanghoon and Crose, Michael and Cox, Brian and Jelly, Evan T. and Ulrich, J. Niklas and Wax, Adam}, title = "{First Clinical Application of Low-Cost OCT}", journal = {Translational Vision Science & Technology}, volume = {8}, number = {3}, pages = {61-61}, year = {2019}, month = {06}, abstract = "{ We present the design of a new low-cost optical coherence tomography (OCT) system and compare its retinal imaging capabilities to a standard commercial system through a clinical study. A spectral-domain OCT system was designed using various cost-reduction techniques to be low-cost, highly portable, and completely stand-alone. Clinical imaging was performed on 120 eyes of 60 patients (60 eyes of normal volunteers and 60 eyes with retinal disease) using both the low-cost OCT and a Heidelberg Engineering Spectralis OCT. Contrast-to-noise ratio (CNR) was measured from resulting images to determine system performance. The low-cost OCT system was successfully applied to clinical imaging of the retina. The system offers an axial resolution of 8.0 μm, a lateral resolution of 19.6 μm, and an imaging depth of 2.7 mm for a 6.6-mm field of view in the X and Y directions. Total cost is \\$5037, a significant size reduction compared to current commercial higher performance systems. Mean CNR value of low-cost OCT images is only 5.6\\% lower compared to the Heidelberg Spectralis. The images captured with the low-cost OCT were of adequate resolution and allowed for clinical diagnostics. It offers comparable performance as a retinal screening tool at a fraction of the cost of current commercial systems. Low-cost OCT has the potential to increase access to retinal imaging. }", issn = {2164-2591}, doi = {10.1167/tvst.8.3.61}, url = {https://doi.org/10.1167/tvst.8.3.61}, eprint = {https://arvojournals.org/arvo/content\_public/journal/tvst/937991/i2164-2591-8-3-61.pdf}, }