@article{10.1167/tvst.9.5.22,
    author = {Moussa, Kareem and Feinstein, Max and Pekmezci, Melike and Lee, Jun Hui and Bloomer, Michele and Oldenburg, Catherine and Sun, Zhimin and Lee, Richard K. and Ying, Gui-shuang and Han, Ying},
    title = "{Histologic Changes Following Continuous Wave and Micropulse Transscleral Cyclophotocoagulation: A Randomized Comparative Study}",
    journal = {Translational Vision Science & Technology},
    volume = {9},
    number = {5},
    pages = {22-22},
    year = {2020},
    month = {04},
    abstract = "{   To compare the macroscopic and microscopic histologic changes in eyes treated with micropulse transscleral cyclophotocoagulation (MP-TCP) versus continuous wave transscleral cyclophotocoagulation (CW-TCP).    Twelve halves of globes from three pairs of adult cadaveric eyes were randomly assigned to nontreated control, CW-TCP, single MP-TCP treatment, or double MP-TCP treatments, and then sectioned for histologic analysis. Presence or absence of the following four unique histologic changes was recorded: splitting within the ciliary process epithelium (splitting), separation of the pigmented ciliary process epithelium from the stroma (separation), coagulation of collagen and destruction of ciliary process stroma (coagulation), and full-thickness destruction of ciliary process epithelium (destruction).    A total of 498 slides were analyzed, and laser scars in all treated specimens were located in the pars plana. Logistic regression analysis showed that compared with controls, CW-TCP-treated specimens were significantly more likely to experience separation (odds ratio [OR] = 11.1, P = 0.02), coagulation (OR = 24.3, P = 0.002), and destruction (OR = 11.1, P = 0.03). Destruction of the ciliary process epithelium was observed exclusively in CW-TCP-treated sections. No significant differences in histologic features were observed between controls and MP-TCP.    MP-TCP does not produce significant histologic changes in cadaveric eyes, whereas CW-TCP treatment does.    These findings improve understanding of the mechanism of MP-TCP, help explain the increased rates of adverse effects following CW-TCP treatment compared with MP-TCP, and describe effects of MP-TCP at various doses.  }",
    issn = {2164-2591},
    doi = {10.1167/tvst.9.5.22},
    url = {https://doi.org/10.1167/tvst.9.5.22},
    eprint = {https://arvojournals.org/arvo/content\_public/journal/tvst/938447/i2164-2591-386-1-1742.pdf},
}