RT Journal Article
A1 Moussa, Kareem
A1 Feinstein, Max
A1 Pekmezci, Melike
A1 Lee, Jun Hui
A1 Bloomer, Michele
A1 Oldenburg, Catherine
A1 Sun, Zhimin
A1 Lee, Richard K.
A1 Ying, Gui-shuang
A1 Han, Ying
T1 Histologic Changes Following Continuous Wave and Micropulse Transscleral Cyclophotocoagulation: A Randomized Comparative Study
JF Translational Vision Science & Technology
JO Trans. Vis. Sci. Tech.
YR 2020
DO 10.1167/tvst.9.5.22
VO 9
IS 5
SP 22
OP 22
SN 2164-2591
AB    To compare the macroscopic and microscopic histologic changes in eyes treated with micropulse transscleral cyclophotocoagulation (MP-TCP) versus continuous wave transscleral cyclophotocoagulation (CW-TCP).    Twelve halves of globes from three pairs of adult cadaveric eyes were randomly assigned to nontreated control, CW-TCP, single MP-TCP treatment, or double MP-TCP treatments, and then sectioned for histologic analysis. Presence or absence of the following four unique histologic changes was recorded: splitting within the ciliary process epithelium (splitting), separation of the pigmented ciliary process epithelium from the stroma (separation), coagulation of collagen and destruction of ciliary process stroma (coagulation), and full-thickness destruction of ciliary process epithelium (destruction).    A total of 498 slides were analyzed, and laser scars in all treated specimens were located in the pars plana. Logistic regression analysis showed that compared with controls, CW-TCP-treated specimens were significantly more likely to experience separation (odds ratio [OR] = 11.1, P = 0.02), coagulation (OR = 24.3, P = 0.002), and destruction (OR = 11.1, P = 0.03). Destruction of the ciliary process epithelium was observed exclusively in CW-TCP-treated sections. No significant differences in histologic features were observed between controls and MP-TCP.    MP-TCP does not produce significant histologic changes in cadaveric eyes, whereas CW-TCP treatment does.    These findings improve understanding of the mechanism of MP-TCP, help explain the increased rates of adverse effects following CW-TCP treatment compared with MP-TCP, and describe effects of MP-TCP at various doses.  
RD 4/13/2021
UL https://doi.org/10.1167/tvst.9.5.22