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Hongting Liu, Millena G. Bittencourt, Jiangxia Wang, Raafay Sophie, Rachel Annam, Mohamed A. Ibrahim, Yasir J. Sepah, Ahmadreza Moradi, Hendrik P. N. Scholl, Quan Dong Nguyen; Assessment of Central Retinal Sensitivity Employing Two Types of Microperimetry Devices. Trans. Vis. Sci. Tech. 2014;3(5):3. doi: https://doi.org/10.1167/tvst.3.5.3.
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To compare the retinal sensitivity measurements obtained with two microperimeters, the Micro-Perimeter 1 (MP-1) and the Optos optical coherence tomography (OCT)/scanning laser ophthalmoscope (SLO) in subjects with and without maculopathies.
Forty-five eyes with no known ocular disease and 47 eyes with maculopathies were examined using both microperimeters. A contrast-adjusted scale was applied to resolve the different stimuli and background luminance existing between the two devices.
There was a strong ceiling effect with the MP-1 in the healthy group, with 90.1% (1136 of 1260) test points clustered at 20 dB. The mean sensitivity for the corresponding points in the OCT/SLO was 25.8 ± 1.9 dB. A floor effect was also observed with the OCT/SLO in the maculopathy group with 9.7% (128 of 1316) points clustered at 9-dB values. The corresponding mean sensitivity in the MP-1 was 1.7 ± 3.9 dB. A regression equation between the two microperimeters was established in the common 10 to19 dB intervals as: OCT/SLO = 15.6 + 0.564 × MP-1 − 0.009 × MP-12 + k (k is an individual point constant; MP-1 coefficient P < 0.001; MP-12 coefficient P = 0.006).
The OCT/SLO and the MP-1 provide two different ranges of contrasts for microperimetry examination. Broadening the dynamic range may minimize the constraint of the ceiling and floor effect. There is a significant mathematical relationship in the common interval of the contrast scale.
Translational Relevance: :
Applying a unified and broadened dynamic range in different types of microperimeters will help to generate consistent clinical reference for measurements.
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