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Andreas Ebneter, Despina Kokona, Joël Jovanovic, Martin S. Zinkernagel; Dramatic Effect of Oral CSF-1R Kinase Inhibitor on Retinal Microglia Revealed by In Vivo Scanning Laser Ophthalmoscopy. Trans. Vis. Sci. Tech. 2017;6(2):10. doi: 10.1167/tvst.6.2.10.
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This report provides sound evidence that the small molecule pharmaceutical PLX5622, a highly selective CSF-1R kinase inhibitor, crosses the blood–retina barrier and suppresses microglia activity. Members of this class of drug are in advanced clinical development stages and may represent a novel approach to modulate ocular inflammatory processes.
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