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Ryan T. Yanagihara, Cecilia S. Lee, Daniel Shu Wei Ting, Aaron Y. Lee; Methodological Challenges of Deep Learning in Optical Coherence Tomography for Retinal Diseases: A Review. Trans. Vis. Sci. Tech. 2020;9(2):11. doi: https://doi.org/10.1167/tvst.9.2.11.
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© ARVO (1962-2015); The Authors (2016-present)
Artificial intelligence (AI)-based automated classification and segmentation of optical coherence tomography (OCT) features have become increasingly popular. However, its 3-dimensional volumetric nature has made developing an algorithm that generalizes across all patient populations and OCT devices challenging. Several recent studies have reported high diagnostic performances of AI models; however, significant methodological challenges still exist in applying these models in real-world clinical practice. Lack of large-image datasets from multiple OCT devices, nonstandardized imaging or post-processing protocols between devices, limited graphics processing unit capabilities for exploiting 3-dimensional features, and inconsistency in the reporting metrics are major hurdles in enabling AI for OCT analyses. We discuss these issues and present possible solutions.
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