Data from a total of 243 eyes from 243 patients were used for the test set. The test set included 86 normal subjects, 87 patients with early glaucoma, and 70 patients with advanced (moderate-to-severe stage) glaucoma. The demographic characteristics are summarized in
Table 2. Age and gender were significantly different (
P = 0.011 and
P = 0.017, respectively) between the subject groups, whereas intraocular pressure, refractive error, central corneal thickness, and axial length were not. All VF parameters, such as the MD, PSD, and VF index, were significantly different (all
P values < 0.001) between the subject groups. The average MD was –1.23 dB/–3.16 dB/–13.35 dB (normal/early/advanced glaucoma, respectively).
Supplementary Fig. S2 shows the distribution of MD between subject group. All SD-OCT parameters were significantly different between the subject groups. In the SD-OCT macular ganglion cell analysis, the average GCIPL thickness was 80.2 µm (normal), 73.1 µm (early glaucoma), 63.6 µm (advanced glaucoma) and was significantly different between the subject groups (all
P values < 0.001). In SD-OCT ONH and RNFL analysis, the sectoral RNFL thicknesses were 109.5 µm, 69.4 µm, 65.3 µm, and 111.8 µm for normal subjects, 94.9 µm, 65.1 µm, 64.1 µm, and 87.7 µm for patients with early glaucoma, and 78.6 µm, 55.5 µm, 59.3 µm, and 67.1 µm for patients with advanced glaucoma (superior, temporal, nasal, and inferior sector, respectively), and these values were all significantly different between groups (all
P < 0.001). All sectoral RNFL thicknesses measured by SS-OCT were also significantly different between subject groups (all
P < 0.001) except for the image quality score (
P = 0.209).