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Wenjia Cai, Xiao Guo, Wei Wang, Kun Xiong, Xiaotong Han, Xia Gong, Meng Yuan, Yuting Li, Xiaoling Liang, Yizhi Liu, Wenyong Huang; Two-Year Choroidal Thickness Attenuation and Its Associations in Healthy Chinese Adults. Trans. Vis. Sci. Tech. 2022;11(6):21. doi: https://doi.org/10.1167/tvst.11.6.21.
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Identifying clinical associations causing attenuation in choroidal thickness (CT) among healthy Chinese adults.
A 2-year longitudinal study was conducted in volunteers aged over 30 years from China. All participants had no history of eye disease or surgery. All subjects underwent swept-source optical coherence tomography to measure the CT in the macular region at baseline and at 2-year follow-up. The regression models were based on the generalized estimating equation.
A total of 603 eyes of 336 healthy participants were included in the final analysis (mean [SD] age, 58.88 [8.82] years; 74.70% female). Mean (SD) choroidal thickness (MCT) was reduced significantly from 206.62 (72.42) to 194.02 (72.08) µm (difference, −12.60 µm; 95% confidence interval [CI], −13.62 to −11.57). Among the Early Treatment of Diabetic Retinopathy Study (ETDRS) grid, CT at the subfoveal sector showed the greatest 2-year reduction (difference, −14.55 µm; 95% CI, −15.87 to −13.22). The largest 2-year change was observed in the 50 to 59 years group (difference, −14.51 µm; 95% CI, −16.71 to −12.32). Multivariate regression showed female gender (β = −2.85; 95% CI, −5.65 to −0.56) and baseline MCT (β = −0.040; 95% CI, −0.056 to −0.024) were significantly and independently associated with greater 2-year CT decrease.
These results indicated that CT among Chinese healthy adults decreased during the 2-year follow-up, and the greater choroidal thinning rate was significantly associated with female gender and larger baseline MCT.
Longitudinal CT data of healthy adults provide a reference range when evaluating pathologic variations, especially for the age-related retinal-choroidal disorders.
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