The association of individual AMD characteristics (large drusen, SDD, pigment, HRF, choroidal neovascularization (CNV), GA, AMDSC) with renal function is shown in
Table 2. In these univariate analyses, statistical significance was found for the association between eGFR–CrCys and both the presence of SDD (
P = 0.017) (
Fig. 2) and HRF (
P = 0.037).
Figure 2 demonstrates that SDD participants are overall older than the general group of participants, but do not show a markedly decreased eGFR–CrCys compared with age-similar participants without SDD. The association between AMDSC and eGFR–CrCys as a continuous variable demonstrated borderline statistical significance toward worse renal function in significant effect of AMDSC stages (parameter estimate, −0.77;
P = 0.054). Similarly, univariate analyses assessing RIT and OCT measurements (choroidal thickness, mean central RPEDC volume, total RPEDC volume, mean central NSR volume, and total NSR volume) as continuous variables, found RIT (estimate, −0.54 units/minute; 95% CI, −0.81 to −0.27;
P < 0.001) and total NSR volume (estimate, 9.58 units/minute; 95% CI, 2.85–16.30;
P = 0.006) to be significantly correlated with decreased renal function (
Table 2). However, after adjustment for age, no association was found with decreased renal function for any of the AMD features (
Table 3). This was also the case when eGFR–CrCys was assessed as a categorical variable with four groups (>90, 60–90, 30–60, and <30). This finding implies a colinearity of AMD features with age, rather than a true effect of AMD parameters.