Volume 14 Issue 2 | TVST

Editorial

Clinical and Scientific Considerations for Whole Eye Transplantation: An Ophthalmologist's Perspective Open Access

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Kimberly K. Gokoffski; Kia M. Washington; Roy S. Chuck

Tags: eye, transplantation, science

Translational Vision Science & Technology February 2025, Vol.14, 13. doi:https://doi.org/10.1167/tvst.14.2.13

Artificial Intelligence

RetOCTNet: Deep Learning–Based Segmentation of OCT Images Following Retinal Ganglion Cell Injury Open Access

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Gabriela Sanchez-Rodriguez; Linjiang Lou; Machelle T. Pardue; Andrew J. Feola

Tags: datasets, deep learning, retinal ganglion cells, wounds and injuries, retinal nerve fiber layer

Translational Vision Science & Technology February 2025, Vol.14, 4. doi:https://doi.org/10.1167/tvst.14.2.4

Deep Learning Approaches to Predict Geographic Atrophy Progression Using Three-Dimensional OCT Imaging Open Access

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Kenta Yoshida; Neha Anegondi; Adam Pely; Miao Zhang; Frederic Debraine; Karthik Ramesh; Verena Steffen; Simon S. Gao; Catherine Cukras; Christina Rabe; Daniela Ferrara; Richard F. Spaide; SriniVas R. Sadda; Frank G. Holz; Qi Yang

Tags: age-related macular degeneration, nonexudative, datasets, deep learning, diagnostic imaging, growth rate

Translational Vision Science & Technology February 2025, Vol.14, 11. doi:https://doi.org/10.1167/tvst.14.2.11

Automated Detection of Retinal Detachment Using Deep Learning-Based Segmentation on Ocular Ultrasonography Images Open Access

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Onur Caki; Umit Yasar Guleser; Dilek Ozkan; Mehmet Harmanli; Selahattin Cansiz; Cem Kesim; Rustu Emre Akcan; Ivan Merdzo; Murat Hasanreisoglu; Cigdem Gunduz-Demir

Tags: learning, retinal detachment, training, ultrasonography, retina

Translational Vision Science & Technology February 2025, Vol.14, 26. doi:https://doi.org/10.1167/tvst.14.2.26

Cornea & External Disease

Validation of the Ocular Pain Assessment Survey Instrument With Rasch Analysis Open Access

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Debbie Marie Ng; Xiu Wang; Chang Liu; MingYi Yu; Isabelle Xin Yu Lee; Jipson Hon Fai Wong; Regina Kay Ting Wong; Diana Xin Hui Chan; Yu-Chi Liu; Louis Hak Tien Tong

Tags: ocular pain, pain, rasch model, reliability, surveys

Translational Vision Science & Technology February 2025, Vol.14, 20. doi:https://doi.org/10.1167/tvst.14.2.20

Glaucoma

Detecting and Quantifying Glaucomatous Visual Function Loss With Continuous Visual Stimulus Tracking: A Case-Control Study Open Access

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Anne C. L. Vrijling; Minke J. de Boer; Remco J. Renken; Jan-Bernard C. Marsman; Joost Heutink; Frans W. Cornelissen; Nomdo M. Jansonius

Tags: glaucoma, vision, learning

Translational Vision Science & Technology February 2025, Vol.14, 3. doi:https://doi.org/10.1167/tvst.14.2.3

Objective Grading of Tonography Tracings for the Measurement of Outflow Facility Open Access

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Arthur J. Sit; Carol B. Toris; Vikas Gulati; Arash Kazemi; Jesse Gilbert; Shan Fan; David M. Reed; David O. Hodge; Sayoko E. Moroi

Tags: aqueous humor, intraocular pressure, eye, bland-altman plot

Translational Vision Science & Technology February 2025, Vol.14, 10. doi:https://doi.org/10.1167/tvst.14.2.10

Macular Oxygen Saturation in Glaucoma Using Retinal Oximetry of Visible Light Optical Coherence Tomography: A Pilot Study Open Access

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Jingyu Wang; Natalie Sadlak; Marissa G. Fiorello; Manishi Desai; Ji Yi

Tags: glaucoma, optical coherence tomography, oximetry, oxygen saturation measurement, pilot projects

Translational Vision Science & Technology February 2025, Vol.14, 12. doi:https://doi.org/10.1167/tvst.14.2.12

Evaluation of Serum and Aqueous Humor Neurofilament Light Chain as Markers of Neurodegeneration in Glaucoma Open Access

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Jonathan B. Lin; Hani El Helwe; Henisk Falah; Bruno L. Hammerschlag; Stephanie A. Schultz; George Baldwin; Yixi Xue; Ryan A. Vasan; Christian Song; Kristine Lo; Austin Meeker; Silas L. Wang; Pia Kivisäkk; David Solá-Del Valle; Milica A. Margeta

Tags: aqueous humor, glaucoma, nerve degeneration, neurofilament protein l, hypertension

Translational Vision Science & Technology February 2025, Vol.14, 24. doi:https://doi.org/10.1167/tvst.14.2.24

Lens

Advanced Artificial-Intelligence-Based Jiang Formula for Intraocular Lens Power in Congenital Ectopia Lentis Open Access

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Yan Liu; Xinyue Wang; Linghao Song; Yang Sun; Zexu Chen; Wannan Jia; Xin Shen; Yalei Wang; Xinyao Chen; Qiuyi Huo; Pranav Prakash Edavi; Tianhui Chen; Yongxiang Jiang

Tags: ectopia lentis, eye, intelligence, intraocular lens implant device, surgical procedures, operative

Translational Vision Science & Technology February 2025, Vol.14, 5. doi:https://doi.org/10.1167/tvst.14.2.5

Neuro-ophthalmology

Visual Tract Integrity Before and After Gene Therapy in Congenital Achromatopsia Open Access

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Hillel Abramovitch; Atira S. Bick; Nitzan Guy; Deena Elul; Ayelet Mckyton; Eyal Banin; Netta Levin

Tags: achromatopsia, gene therapy, personal integrity, visual pathways, optic tract

Translational Vision Science & Technology February 2025, Vol.14, 9. doi:https://doi.org/10.1167/tvst.14.2.9

New Method of Early RRMS Diagnosis Using OCT-Assessed Structural Retinal Data and Explainable Artificial Intelligence Open Access

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Miguel Ortiz; Ana Pueyo; Francisco J. Dongil; Luciano Boquete; Eva M. Sánchez-Morla; Rafael Barea; Juan M. Miguel-Jimenez; Almudena López-Dorado; Elisa Vilades; María J. Rodrigo; Beatriz Cordon; Elena Garcia-Martin

Tags: artificial intelligence, multiple sclerosis, relapsing-remitting

Translational Vision Science & Technology February 2025, Vol.14, 14. doi:https://doi.org/10.1167/tvst.14.2.14

Public Health

Associations Between Diabetic Retinopathy and Frailty: Insights From the National Health and Nutrition Examination Survey and Mendelian Randomization Open Access

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Jianqi Chen; Xuhao Chen; Xu Cao; Xiaohua Zhuo; Yuwen Wen; Guitong Ye; Yuan Zhang; Jinan Zhan; Hongmei Tan; Yingting Zhu; Yehong Zhuo

Tags: frailty, national health and nutrition examination survey, diabetic retinopathy, mendelian randomization analysis

Translational Vision Science & Technology February 2025, Vol.14, 2. doi:https://doi.org/10.1167/tvst.14.2.2

The Relationship Between Serum Biochemical Variables and Corneal Biomechanics Measured by Corvis ST Among Healthy Young Adults Open Access

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Dan-Lin Li; Min-Xin Liu; Ya-Jie Zheng; Yu Qin; Rong Ma; Gang Liang; Chen-Wei Pan

Tags: biomechanics, cornea, young adult

Translational Vision Science & Technology February 2025, Vol.14, 19. doi:https://doi.org/10.1167/tvst.14.2.19

Refractive Intervention

Refractive Development and Choroidal Vascularity in the Form-Deprivation Pigmented Rabbit Model Open Access

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Zhihao Jiang; Wenjia Yan; Haili Fang; Chang Liu; Zhaotian Zhang; Zhiquan Li; Yantao Wei; Yao Ni

Tags: choroid, dopamine, eye, myopia, oryctolagus cuniculus

Translational Vision Science & Technology February 2025, Vol.14, 18. doi:https://doi.org/10.1167/tvst.14.2.18

Retina

Effect of the Sugar Present in the Culture Medium on the Preservation of Human RPE Cell Suspensions Open Access

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Shohei Kitahata; Hinako Ichikawa; Yuji Tanaka; Shin Tanaka; Tatsuya Inoue; Maiko Maruyama-Inoue; Kazuaki Kadonosono

Tags: culture media, retinal pigment cell, sugars, fructose

Translational Vision Science & Technology February 2025, Vol.14, 1. doi:https://doi.org/10.1167/tvst.14.2.1

Structure–Function Relationships in Geographic Atrophy Based on Mesopic Microperimetry, Fundus Autofluorescence, and Optical Coherence Tomography Open Access

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Souvick Mukherjee; Thilaka Arunachalam; Cameron Duic; Maria Abraham; Christine Orndahl; Supriya Menezes; Elvira Agrón; Maximilian Pfau; Tharindu de Silva; Clare Bailey; Alisa T. Thavikulwat; Sunil Bellur; SriniVas R. Sadda; Emily Y. Chew; Brett G. Jeffrey; Wai T. Wong; Tiarnan D. L. Keenan

Tags: age-related macular degeneration, nonexudative, fundus autofluorescence imaging, optical coherence tomography, scotoma, vision

Translational Vision Science & Technology February 2025, Vol.14, 7. doi:https://doi.org/10.1167/tvst.14.2.7

Design, Fabrication, and Surgical Testing of the 3D-Printed Large-Array Port-System for the Implantation of Large Epiretinal Stimulators Open Access

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Frederic Kuba Balcewicz; Sabine Baumgarten; Kim Schaffrath; Jiayun Wang; Sandra Johnen; Peter Walter; Tibor Lohmann

Tags: implantation procedure, printing, three-dimensional, surgical procedures, operative, eye

Translational Vision Science & Technology February 2025, Vol.14, 8. doi:https://doi.org/10.1167/tvst.14.2.8

Phenotypic Distinctions Between EYS- and USH2A-Associated Retinitis Pigmentosa in an Asian Population Open Access

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Ellis Y. H. Yeo; Taro Kominami; Tien-En Tan; Lathiksha Babu; Kevin G. S. Ong; Weilun Tan; Yasmin M. Bylstra; Kanika Jain; Rachael W. C. Tang; Saadia Z. Farooqui; Sylvia P. R. Kam; Choi-Mun Chan; Ranjana S. Mathur; Saumya S. Jamuar; Weng Khong Lim; Koji Nishiguchi; Beau J. Fenner

Tags: asian, cohort studies, phenotype, retinitis pigmentosa, symptom onset

Translational Vision Science & Technology February 2025, Vol.14, 16. doi:https://doi.org/10.1167/tvst.14.2.16

Association Between Hormone Levels and Retinopathy in Patients With Type 2 Diabetes: A Cross-Sectional Study Open Access

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Yu Meng; Xueli Yang; Yuxin Fan; Ming Liu; Fengqi Zhou; Qihua Wang; Yuezhu Lu; Yun Zhu; Hua Yan

Tags: diabetes mellitus, type 2, gonadal hormones, hormones, retinal diseases, testosterone

Translational Vision Science & Technology February 2025, Vol.14, 17. doi:https://doi.org/10.1167/tvst.14.2.17

Effect of Combination Use of Aqueous Humor Secretion Inhibitor Eye Drops on Aflibercept Level: A Preliminary Analysis Open Access

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Satoru Inoda; Hidenori Takahashi; Ryota Takahashi; Yuto Hashimoto; Hana Yoshida; Hironori Takahashi; Yujiro Fujino; Kenichi Aizawa; Hidetoshi Kawashima; Yasuo Yanagi

Tags: aflibercept, aqueous humor, bodily secretions, eyedrops, hypertension

Translational Vision Science & Technology February 2025, Vol.14, 21. doi:https://doi.org/10.1167/tvst.14.2.21

Idiopathic Macular Hole Area to Foveal Avascular Zone Ratio and Its Effects on Visual Acuity Before and After Surgery Open Access

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Junji Kanno; Takuhei Shoji; Hirokazu Ishii; Hisashi Ibuki; Yuji Yoshikawa; Takanori Sasaki; Kei Shinoda

Tags: macular holes, preoperative care, surgical procedures, operative, visual acuity, regression analysis

Translational Vision Science & Technology February 2025, Vol.14, 22. doi:https://doi.org/10.1167/tvst.14.2.22

OCT Angiography of Type 1 Macular Neovascularization in AMD: A Morphometric Evaluation Open Access

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Maria Cristina Savastano; Claudia Fossataro; Matteo Mario Carlà; Valentina Cestrone; Ilaria Biagini; Clara Rizzo; Raphael Kilian; Sandrine A. Zweifel; Daniel R. Muth; Francesco Faraldi; Stanislao Rizzo; David Sarraf

Tags: macular neovascularization, angiogram, biological markers

Translational Vision Science & Technology February 2025, Vol.14, 23. doi:https://doi.org/10.1167/tvst.14.2.23

Evaluating Blood Flow Speed in Retinal Microaneurysms Secondary to Diabetic Retinopathy Using Variable Interscan Time Analysis OCTA Open Access

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Hiroyuki Takahashi; Yunchan Hwang; Jungeun Won; Muhammad Usman Jamil; Antonio Yaghy; Michelle C. Liang; Caroline R. Baumal; Andre J. Witkin; Kyoko Ohno-Matsui; Jay S. Duker; James G. Fujimoto; Nadia K. Waheed

Tags: diabetic retinal microaneurysm, diabetic retinopathy, fluid flow, macrophage activation syndrome, meconium aspiration syndrome

Translational Vision Science & Technology February 2025, Vol.14, 27. doi:https://doi.org/10.1167/tvst.14.2.27

Uveitis

Genetics of Circulating Inflammatory Proteins and Iridocyclitis: An Exploratory Mendelian Randomization Study Open Access

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Huan Liu; Fuzhen Li; Feiyan Wang; Ziqing Hu; Liping Du; Jing Wei

Tags: cytokine, iridocyclitis, genetics, proteins, mendelian randomization analysis

Translational Vision Science & Technology February 2025, Vol.14, 6. doi:https://doi.org/10.1167/tvst.14.2.6

Clinical Trials

A Single-Center Sham and Active-Controlled Double-Blind Randomized Crossover Trial of the Magnetic Levator Prosthesis for Severe Blepharoptosis Open Access

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Kevin E. Houston; Shrinivas Pundlik; Prerana Shivshanker; Alex R. Bowers; Sarah LaRosa; Mara Robinson; James Chodosh; Lynn Brandes; Patrick Lee; Eleftherios I. Paschalis

Tags: eyelid ptosis, prostheses, safety, adverse event

Translational Vision Science & Technology February 2025, Vol.14, 15. doi:https://doi.org/10.1167/tvst.14.2.15

Methods

MEDTEG (Minimum Entropy Dynamic Test Grids): A Novel Algorithm for Adding New Test Locations to a Perimetric Test Grid Open Access

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Pete R. Jones

Tags: entropy, perimetry, scotoma

Translational Vision Science & Technology February 2025, Vol.14, 25. doi:https://doi.org/10.1167/tvst.14.2.25

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