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Artificial Intelligence

Robust Uncertainty-Informed Glaucoma Classification Under Data Shift Open Access
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Homa Rashidisabet; R. V. Paul Chan; Yannek I. Leiderman; Thasarat Sutabutr Vajaranant; Darvin Yi
Tags: datasets, glaucoma
Translational Vision Science & Technology June 2025, Vol.14, 3. doi:https://doi.org/10.1167/tvst.14.6.3
AI Quantification of Vascular Lesions in Mouse Fundus Fluorescein Angiography Open Access
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Vinodhini Jayananthan; Tyler Heisler Taylor; David Henry Greentree; Bryce Collison; Nagaraj Kerur
Tags: choroidal neovascularization, fluorescein angiography, lasers, mice, precision
Translational Vision Science & Technology June 2025, Vol.14, 4. doi:https://doi.org/10.1167/tvst.14.6.4
Comparison of AI-Automated and Manual Subfoveal Choroidal Thickness Measurements in an Elderly Population Using Optical Coherence Tomography Open Access
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Wen-Da Zhou; Han-Qing Zhao; Jia-Qi Geng; Yu-Hang Yang; Li Dong; Rui-heng Zhang; Wen-Bin Wei; Lei Shao
Tags: older adult, optical coherence tomography, diagnostic imaging
Translational Vision Science & Technology June 2025, Vol.14, 9. doi:https://doi.org/10.1167/tvst.14.6.9
Machine Learning Applied to Visual Fields of Dominant Optic Atrophy Patients Open Access
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Catarina P. Coutinho; Ferdinando Zanchetta; Michele Carbonelli; Marco Battista; Alice Galzignato; Chiara La Morgia; Giulia Amore; Martina Romagnoli; Giacomo Savini; Luigi Brotto; Paolo Nucci; Leonardo Caporali; Francesco Bandello; Valerio Carelli; Maria Lucia Cascavilla; Rita Fioresi; Piero Barboni
Tags: antithymoglobulin, arterial tortuosity syndrome, dead on arrival, optic atrophy, autosomal dominant, periodic paralysis, potassium-sensitive cardiodysrhythmic type
Translational Vision Science & Technology June 2025, Vol.14, 20. doi:https://doi.org/10.1167/tvst.14.6.20
Development of Deep Learning Models to Screen Posterior Staphylomas in Highly Myopic Eyes Using UWF-OCT Images Open Access
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Yining Wang; Changyu Chen; Ziye Wang; Yijin Wu; Hongshuang Lu; Jianping Xiong; Keigo Sugisawa; Koju Kamoi; Kyoko Ohno-Matsui
Tags: datasets, deep learning, eye, staphyloma, retina
Translational Vision Science & Technology June 2025, Vol.14, 25. doi:https://doi.org/10.1167/tvst.14.6.25
Challenges for Opticians in Evaluating Small Pigmented Choroidal Lesions: Potential Support From the MelAInoma Deep Learning Algorithm Open Access
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Shiva Sabazade; Marco A. Lumia Michalski; Sara Wittskog; Mats Holmström; Maria Nilsson; Gustav Stålhammar
Tags: deep learning, noma, opticians, optometrists, melanoma
Translational Vision Science & Technology June 2025, Vol.14, 29. doi:https://doi.org/10.1167/tvst.14.6.29
Optic Cup and Disc Segmentation of Fundus Images Using Artificial Intelligence Externally Validated With Optical Coherence Tomography Measurements Open Access
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Scott Kinder; Steve McNamara; Christopher Clark; Benjamin Bearce; Upasana Thakuria; Yoga Advaith Veturi; Galia Deitz; Talisa E. de Carlo Forest; Naresh Mandava; Malik Y. Kahook; Praveer Singh; Jayashree Kalpathy-Cramer
Tags: artificial intelligence, datasets, glaucoma, optic cup, optic disk
Translational Vision Science & Technology June 2025, Vol.14, 30. doi:https://doi.org/10.1167/tvst.14.6.30

Cornea & External Disease

Artificial Intelligence Aided Analysis of Anterior Segment Optical Coherence Tomography Imaging to Monitor the Device-Cornea Joint After Synthetic Cornea Implantation Open Access
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Esen Karamursel Akpek; Gavin Li; Anthony J. Aldave; Guillermo Amescua; Kathryn A. Colby; Maria S. Cortina; Jose de la Cruz; Jean-Marie A. Parel; Thomas Schmiedel
Tags: artificial intelligence, cornea, diagnostic imaging, implantation procedure, optical coherence tomography
Translational Vision Science & Technology June 2025, Vol.14, 1. doi:https://doi.org/10.1167/tvst.14.6.1
Analysis of In Vivo Sclera Impact on the Biomechanics of Myopic Eyes Open Access
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Ruisi Xie; Yan Huo; Yutong Li; Zhengyuan Qu; Haohan Zou; Yan Wang
Tags: biomechanics, cornea, eye, myopia, sclera
Translational Vision Science & Technology June 2025, Vol.14, 8. doi:https://doi.org/10.1167/tvst.14.6.8
Far-Red, High-Resolution, Reflection-Free Images of the Anterior Segment in Retro-Illumination Open Access
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Anthony Ain; Sylvain Poinard; Thierry Lepine; Oliver Dorado-Cortez; Sébastien Urbaniak; Jean-Marie Papillon; Philippe Gain; Gilles Thuret
Tags: diagnostic imaging, lighting, slit lamps, light
Translational Vision Science & Technology June 2025, Vol.14, 11. doi:https://doi.org/10.1167/tvst.14.6.11
A Method for Visualizing Corneal Dynamics Through Pixel Intensity Tracking Open Access
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Ana R. Arizcuren; Alejandra Consejo
Tags: cornea, pixel
Translational Vision Science & Technology June 2025, Vol.14, 24. doi:https://doi.org/10.1167/tvst.14.6.24
In Vivo Stability of Electronic Intraocular Lens Implant for Corneal Blindness Open Access
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Ibraim V. Vieira; Victoria H. Fan; Michael W. Wiemer; Brian E. Lemoff; Kishan S. Sood; Maria Julia Mussa; Charles Q. Yu
Tags: blindness, cornea, implants, intraocular lens implant device, eye
Translational Vision Science & Technology June 2025, Vol.14, 33. doi:https://doi.org/10.1167/tvst.14.6.33

Glaucoma

Anatomy of the Macular Ganglion Cell Layer Plexus on Projection-Resolved Optical Coherence Tomographic Angiography Open Access
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Jie Wang; Karine D. Bojikian; Aiyin Chen; Ping Wei; Liang Liu; Yali Jia; David Huang
Tags: angiogram, ganglia, optical coherence tomography, nerve fibers
Translational Vision Science & Technology June 2025, Vol.14, 5. doi:https://doi.org/10.1167/tvst.14.6.5
Valproic Acid Application to Modify Post Surgical Fibrosis in a Model of Minimally Invasive Bleb Surgery Open Access
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Phey Feng Lo; Merry Gunawan; Zhu Li Yap; Carol Leong; Fuxuan Kwek; Jayasudha Varadarajan; Xiaomeng Wang; Masaaki Kageyama; Tina T. Wong
Tags: blister, surgical procedures, operative, valproic acid, fibrosis, surgical procedures, minimally invasive
Translational Vision Science & Technology June 2025, Vol.14, 6. doi:https://doi.org/10.1167/tvst.14.6.6
Interocular Asymmetry of OCT Retinal Nerve Fiber Layer Values in a Normative Population: The Framingham Heart Study Open Access
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Louay Almidani; Jasdeep Sabharwal; Anoush Shahidzadeh; Ana Collazo Martinez; Shu Jie Ting; Brinda Vaidya; Xuejuan Jiang; Tim Kowalczyk; Alexa Beiser; Lucia Sobrin; Sudha Seshadri; Pradeep Ramulu; Amir H. Kashani
Tags: eye, framingham heart study, glaucoma, retinal nerve fiber layer, spectral domain-optical coherence tomography
Translational Vision Science & Technology June 2025, Vol.14, 7. doi:https://doi.org/10.1167/tvst.14.6.7
Factors Affecting Bleb Morphology and Postoperative Intraocular Pressure in Inferotemporal PreserFlo MicroShunt Implantation Open Access
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Shunsuke Nakakura; Ryo Asaoka; Etsuko Terao; Yasuko Fujisawa; Satomi Oogi; Kanae Ueda
Tags: blister, implantation procedure, intraocular pressure, postoperative care, language morphology
Translational Vision Science & Technology June 2025, Vol.14, 32. doi:https://doi.org/10.1167/tvst.14.6.32
Multi-Omic Insight Into the Molecular Networks of Mitochondrial Dysfunction in the Pathogenesis of Primary Open-Angle Glaucoma Open Access
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Li-Hua Chen; Hai-Jiang Zhang; Qing-Ao Xiao
Tags: methylation, mitochondria, mitochondrial diseases, open-angle glaucoma, pathogenesis
Translational Vision Science & Technology June 2025, Vol.14, 37. doi:https://doi.org/10.1167/tvst.14.6.37

Lacrimal Apparatus, Eyelids, Orbit

WNT Mimetic-Induced Lacrimal Gland Regeneration Reverses Aqueous Tear Deficiency Open Access
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Huy Nguyen; Russell B. Fletcher; Tom Lopez; Elizabeth Whisler; Kelsey R. Logas; Navrose Dhaliwal; Timothy Suen; Mengrui Zhang; Archana Dilip; Tom Z. Yuan; Hayoung Go; Jay Ye; Parthasarathy Sampathkumar; Nick Suen; Hui Chen; Wen-Chen Yeh; Yang Li; Yorick Post
Tags: lacrimal gland, ligation, acinar cells, mice, body tissue
Translational Vision Science & Technology June 2025, Vol.14, 19. doi:https://doi.org/10.1167/tvst.14.6.19

Lens

Novel Subclassification of Presbyopia Based on Lens Functional and Structural Features Open Access
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Xiangjia Zhu; Xin Liu; Wenwen He; Kaiwen Cheng; Jiaqi Meng; Jiao Qi; Jing Zhao; Yi Lu; Xingtao Zhou
Tags: lens (device), lens, crystalline, presbyopia, surgical procedures, operative
Translational Vision Science & Technology June 2025, Vol.14, 26. doi:https://doi.org/10.1167/tvst.14.6.26
Comparing Myopia Control Effects of Three Different Orthokeratology Lenses and Spectacle Lenses With Highly Aspherical Lenslets in Low Myopia Children Open Access
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Na Li; Luodian Luobu; Bei Du; Weiping Lin; Ruihua Wei
Tags: child, lens (device), lens, crystalline, myopia, orthokeratology contact lenses
Translational Vision Science & Technology June 2025, Vol.14, 27. doi:https://doi.org/10.1167/tvst.14.6.27
Assessment of Diffractive Intraocular Lenses Using Near-Infrared Light: A Critical Evaluation Open Access
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Ricardo Elsner; Mario Gerlach; Sebastian Bohn; Jan Sievers; Heinrich Stolz; Rudolf F. Guthoff; Oliver Stachs; Karsten Sperlich
Tags: eye, immunoglobulins, thyroid-stimulating, intraocular lens implant device, intraocular lens implantation procedure, lens (device)
Translational Vision Science & Technology June 2025, Vol.14, 36. doi:https://doi.org/10.1167/tvst.14.6.36

Neuro-ophthalmology

Evolution of Visual Field Defects After Occipital Stroke: A Quantitative Analysis Open Access
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Elizabeth L. Saionz; Matthew R. Cavanaugh; Brent A. Johnson; Donald Harrington; Geoffrey K. Aguirre; Krystel R. Huxlin
Tags: cerebrovascular accident, ischemic stroke, visual field defects, visual fields
Translational Vision Science & Technology June 2025, Vol.14, 14. doi:https://doi.org/10.1167/tvst.14.6.14
Aquaporin-4 Peptide Injection in Mice Induces Retinal and Optic Nerve Alterations That Simulate Those of Neuromyelitis Optica Spectrum Disorder Open Access
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Mina Okuda-Arai; Sotaro Mori; Yoshichika Katsura; Shota Miyake; Kenichi Serizawa; Makoto Nakamura
Tags: immunization, mice, neuromyelitis optica, optic nerve, optic neuritis
Translational Vision Science & Technology June 2025, Vol.14, 21. doi:https://doi.org/10.1167/tvst.14.6.21
Inflammatory Proteins Mediate the Effect of Gut Microbiota on Graves’ Ophthalmopathy: A Mendelian Randomization Study Open Access
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Yipao Li; Lu Chen; Shaokai Lin; Wei An; Linfeng Miao; Minghui Wan; Binjun Zhang
Tags: gastrointestinal microbiome, graves' ophthalmopathy, idiopathic pneumonia syndrome, mendelian randomization analysis, proteins
Translational Vision Science & Technology June 2025, Vol.14, 34. doi:https://doi.org/10.1167/tvst.14.6.34

Retina

Characterizing Inner Retinal Changes in End-Stage Inherited Retinal Diseases That Might be Suitable for Optogenetic Therapies Open Access
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Benjamin W. J. Ng; Tien-En Tan; Vasil Kostin; Robert E. MacLaren; Jasmina Cehajic-Kapetanovic
Tags: optogenetics, retinal diseases, spectral domain-optical coherence tomography, macular dystrophy, retina
Translational Vision Science & Technology June 2025, Vol.14, 2. doi:https://doi.org/10.1167/tvst.14.6.2
Electroretinography With the RM Electrode: Normative Reference Ranges, Variation With Age, and Comparison With the Burian–Allen Electrode Open Access
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Brett G. Jeffrey; Xueyang Yin; Christina Appleman; Sobany Suy; Anna Papadogiannis; Daniel Claus; Brian P. Brooks; Marisa Boyle; Laryssa A. Huryn; Wadih M. Zein
Tags: electroretinography, erg protein, human, reference values
Translational Vision Science & Technology June 2025, Vol.14, 13. doi:https://doi.org/10.1167/tvst.14.6.13
High-Resolution, Motion-Corrected, Volume-Fused OCT for Investigating Longitudinal Changes in Subretinal Drusenoid Deposits in Intermediate AMD Open Access
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Jungeun Won; Antonio Yaghy; Stefan B. Ploner; Stephanie Kaiser; Jessica M. Girgis; Yunchan Hwang; Muhammad Usman Jamil; Andreas Maier; Nadia K. Waheed; James G. Fujimoto
Tags: face, motion, volume, eye, diagnostic imaging
Translational Vision Science & Technology June 2025, Vol.14, 15. doi:https://doi.org/10.1167/tvst.14.6.15
Three-Dimensional Choroidal Contour Mapping in Healthy and Diseased Eyes Open Access
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Supriya Arora; Sumit Randhir Singh; Sharat Chandra Vupparaboina; Brian Rosario; Mohammed Nasar Ibrahim; Amrish Selvam; Arman Zarnegar; Sanjana Harihar; Vinisha Sant; Jose Alain Sahel; Kiran Kumar Vupparaboina; Jay Chhablani
Tags: cob protocol, eye
Translational Vision Science & Technology June 2025, Vol.14, 16. doi:https://doi.org/10.1167/tvst.14.6.16
Retinal Vessel Geometry and Retinal Abnormalities in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy Open Access
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Wenbo Zhang; Xuecong Zhou; Jiacheng Liu; Tian Tian; Yu Guo; Chen Ling; Jingjing Xu; Qijie Wei; Yang Liu; Yuan Wu
Tags: arterial disease, brain, cadasil, infarction, leukoencephalopathies
Translational Vision Science & Technology June 2025, Vol.14, 17. doi:https://doi.org/10.1167/tvst.14.6.17
An Analysis of Scotopic Microperimetry in Healthy Adults Open Access
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Daniel A. O. Adeyoju; Amandeep S. Josan; Laura J. Taylor; Robert E. MacLaren
Tags: adult, eye, reliability, rod photoreceptors, eye diseases
Translational Vision Science & Technology June 2025, Vol.14, 18. doi:https://doi.org/10.1167/tvst.14.6.18
Ocular Characteristics and Genotype-Oriented Disease Spectrum of Alström Syndrome in Taiwan Open Access
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Chien-Chien Cheng; Chien-Yu Lin; Ting-Chieh Ko; Yu-Shu Huang; Chu-Hsuan Huang; Chang-Hao Yang; Tzyy-Chang Ho; Pei-Lung Chen; Ta-Ching Chen
Tags: alstrom syndrome, genotype, taiwan, obesity, electroretinography
Translational Vision Science & Technology June 2025, Vol.14, 22. doi:https://doi.org/10.1167/tvst.14.6.22
Minimizing Pupil Size Dependence in Flicker ERG Using Stiles–Crawford Compensation Open Access
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Kumiko Kato; C. Quentin Davis; Nooshin Zeinali; Asako Sugawara; Hisashi Matsubara; Masahiko Sugimoto; Yuzen Kashima; Keitaro Mizumoto; Hidetaka Kudo; Eiichiro Nagasaka; Daphne L. McCulloch; Mineo Kondo
Tags: electroretinography, photopsia, pupil size, pupil, luminance
Translational Vision Science & Technology June 2025, Vol.14, 23. doi:https://doi.org/10.1167/tvst.14.6.23
Treatment Efficacy of a Dual Release of Aflibercept and Dexamethasone From a Single Hydrogel Drug Delivery System in a Rodent Model Open Access
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Kayla M. Rudeen; Chryssa M. Maloney; Katherine L. Lydon; Leandro B. C. Teixeria; William F. Mieler; Jennifer J. Kang-Mieler
Tags: aflibercept, choroidal neovascularization, dexamethasone, drug delivery systems, hydrogel
Translational Vision Science & Technology June 2025, Vol.14, 31. doi:https://doi.org/10.1167/tvst.14.6.31
Significant Correlation Between Retinal Blood Flow and Oxygen Saturation During Intravitreal Aflibercept Treatment for Central Retinal Vein Occlusion Open Access
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Yukiko Miyoshi; Yuki Nakano; Yuta Koyama; Rie Osaka; Junichiro Akimitsu; Aki Booka; Kiyoshi Suzuma
Tags: aflibercept, central retinal vein occlusion, oxygen saturation measurement, vascular flow
Translational Vision Science & Technology June 2025, Vol.14, 35. doi:https://doi.org/10.1167/tvst.14.6.35

Review

Current Applications of Artificial Intelligence for Fuchs Endothelial Corneal Dystrophy: A Systematic Review Open Access
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Siyin Liu; Lynn Kandakji; Aleksander Stupnicki; Dayyanah Sumodhee; Marcello T. Leucci; Scott Hau; Shafi Balal; Arthur Okonkwo; Ismail Moghul; Sandor P. Kanda; Bruce D. Allan; Dan M. Gore; Kirithika Muthusamy; Alison J. Hardcastle; Alice E. Davidson; Petra Liskova; Nikolas Pontikos
Tags: artificial intelligence, cornea, corneal edema, corneal endothelium, datasets
Translational Vision Science & Technology June 2025, Vol.14, 12. doi:https://doi.org/10.1167/tvst.14.6.12

Letters to the Editor

Advancing Retinal Imaging Interpretation: The Role of Optical Properties and Wavelength Selection Open Access
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Jessica Galvan; Mariana Gouveia Bastos Meirelles; Ricardo Luz Leitão Guerra
Tags: optics, retinal imaging
Translational Vision Science & Technology June 2025, Vol.14, 28. doi:https://doi.org/10.1167/tvst.14.6.28

Author Response to Letter

Author Response: The Future of Retinitis Pigmentosa Research: Unlocking the Potential of Branched-Chain Amino Acid Therapy Open Access
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Hanako O. Ikeda; Tomoko Hasegawa; Hiroyasu Abe; Yoko Amino; Takayuki Nakagawa; Harue Tada; Manabu Miyata; Akio Oishi; Satoshi Morita; Akitaka Tsujikawa
Translational Vision Science & Technology June 2025, Vol.14, 10. doi:https://doi.org/10.1167/tvst.14.6.10
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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