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Articles May 2018

Thermal Stimulation of the Retina Reduces Bruch's Membrane Thickness in Age Related Macular Degeneration Mouse Models

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Jan Tode; Elisabeth Richert; Stefan Koinzer; Alexa Klettner; Claus von der Burchard; Ralf Brinkmann; Ralph Lucius; Johann Roider
TAGS: biological response modifiers, bruch's basal membrane, lasers, eye, age-related macular degeneration, mice, retina, laser therapy
Trans. Vis. Sci. Tech.. 2018; 7(3):2. doi: 10.1167/tvst.7.3.2

Retinal Cell Biology March 2018

Release of Different Cell Mediators During Retinal Pigment Epithelium Regeneration Following Selective Retina Therapy

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Elisabeth Richert; Stefan Koinzer; Jan Tode; Kerstin Schlott; Ralf Brinkmann; Jost Hillenkamp; Alexa Klettner; Johann Roider
TAGS: cytokine, vascular endothelial growth factor a, biological response modifiers, bodily secretions, cell size, culture media, fluorescent antibody technique, gelatinase a, ki-67 antigen, lasers, matrix metalloproteinases, choroid, retina, titration method, did not receive therapy or drug, retinal pigment epithelium, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2018; 59(3):1323-1331. doi: 10.1167/iovs.17-23163

ARVO Annual Meeting Abstract June 2017

Long term effects of repetitive administration of VEGF-antagonists on primary RPE cells – comparison between Ranibizumab, Bevacizumab and Aflibercept

Alexa Klettner; Johann Schottler; Niklas Randoll; Amke Caliebe; Ralph Lucius; Johann Roider

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):873. doi:

ARVO Annual Meeting Abstract June 2017

The barrier function, autophagy and inflammatory responses are similar under diabetic stimuli in retinal pigment epithelial cells derived from human induced pluripotent stem cells from the diabetic patients and the normal controls

Kati M Juuti-Uusitalo; Alexa Klettner; Elisabeth Richert; Mostafa Kiamehr; Arto Koistinen; Katriina Aalto-Setälä; Kai Kaarniranta; Heli Skottman

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2518. doi:

ARVO Annual Meeting Abstract June 2017

CRB-1 rd8 Mutation Influences the Extent of AMD-like Retinal Alterations in NRF2 Knock Out Mice and Favors CNV Formation

Jan Tode; Elisabeth Richert; Alexa Klettner; Claus Christian von der Burchard; Stefan Otto Johannes Koinzer; Johann Roider

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1989. doi:

ARVO Annual Meeting Abstract June 2017

Reduction of Bruchs Membrane (BrM) Thickness after Pulsed Laser Irradiation in Apolipoprotein (Apo) E Knock Out Mice

Elisabeth Richert; Jan Tode; Alexa Klettner; Stefan Otto Johannes Koinzer; Ralf Brinkmann; Jost Hillenkamp; Ralph Lucius; Johann Roider

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1938. doi:

ARVO Annual Meeting Abstract June 2017

Semaphorin 3F expression pattern in outer retina and RPE

Bertan Cakir; Johanna Walz; Anima D Buehler; Hansjuergen Agostini; Gunther R Schlunck; Alexa Klettner; Andreas Stahl

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):233. doi:

ARVO Annual Meeting Abstract September 2016

Laser Thermal Stimulation of the Retina (TS-R) reduces Thickness of Bruch’s Membrane (BrM) in Apolipoprotein (Apo) E knock out Mice

Jan Tode; Elisabeth Richert; Alexa Karina Klettner; Ralf Brinkmann; Stefan Koinzer; Johann Roider

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4424. doi:

ARVO Annual Meeting Abstract September 2016

Response of RPE-Choroid Explants to Thermal Stimulation Therapy of the Retinal Pigment Epithelium (TS-R)

Elisabeth Richert; Stefan Koinzer; Alexa Karina Klettner; Ralf Brinkmann; Jost Hillenkamp; Johann Roider

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4442. doi:

Biochemistry and Molecular Biology September 2016

The Antiproliferative Effect of Bevacizumab on Human Tenon Fibroblasts Is Not Mediated by Vascular Endothelial Growth Factor Inhibition

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Charlotte V. Fischer; Viktoria Mans; Maren Horn; Sabine Naxer; Alexa Klettner; Christian van Oterendorp
TAGS: vascular endothelial growth factor a, cell culture techniques, fibroblast, immunoglobulin g, antibodies, bevacizumab, mass or substance concentration per volume
Invest. Ophthalmol. Vis. Sci.. 2016; 57(11):4970-4977. doi: 10.1167/iovs.16-19938

Retinal Cell Biology October 2015

Effects of Cytokine Activation and Oxidative Stress on the Function of the Human Embryonic Stem Cell–Derived Retinal Pigment Epithelial Cells

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Kati Juuti-Uusitalo; Monica Nieminen; Felix Treumer; Minna Ampuja; Anne Kallioniemi; Alexa Klettner; Heli Skottman
TAGS: cytokine, oxidative stress, tumor necrosis factors, embryonic stem cells, bodily secretions, cell lines, gelatinase a, gelatinase b, genes, interstitial collagenase, stromelysin 1, proteins, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2015; 56(11):6265-6274. doi: 10.1167/iovs.15-17333

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2015

Pre-analytical parameters have significant impacts on VEGF levels measured from human plasma

Johanna Madeleine Walz; Daniel Boehringer; Heidrun L Deissler; Peter Heiduschka; Alexa Klettner; Tim U. Krohne; Focke Ziemssen; Andreas Stahl

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):235. doi:

ARVO Annual Meeting Abstract June 2015

Intracellular uptake of therapeutic immunoglobulins and fusion proteins: Comparison between Aflibercept, Bevacizumab and Rituximab

Michaela Dithmer; Johann Roider; Alexa Karina Klettner

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):835. doi:

ARVO Annual Meeting Abstract June 2015

Influence of VEGF isoforms and VEGF inhibition on uveal melanoma cell lines - implications for therapeutic VEGF inhibition

Alexa Karina Klettner; Michaela Dithmer; Anna Maria Kirsch; Lidia Graefenstein; Sarah E Coupland; Johann Roider

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5315. doi:

ARVO Annual Meeting Abstract June 2015

Release of different cell mediators during retinal pigment epithelium (RPE) wound healing after Selective Retina Therapy (SRT) for prevention of early age-related macular degeneration (AMD)

Elisabeth Richert; Alexa Karina Klettner; Stefan Otto Johannes Koinzer; Johann Roider; Jost Hillenkamp

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):198. doi:

ARVO Annual Meeting Abstract April 2014

Effect of Selective Retina Therapy (SRT) on the inflammatory microenvironment of the subretinal space

Jost Hillenkamp; Sofya Bartsch; Alexa Karina Klettner; Ralf Brinkmann; Johann Roider

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):6348. doi:

ARVO Annual Meeting Abstract June 2013

Time-dependent intracellular pattern of Bevacizumab in RPE cells

Shereen Hassan M. Aboul Naga; Michaela Dithmer; Johann Roider; Alexa Klettner

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):4629. doi:

ARVO Annual Meeting Abstract June 2013

Fucoidan but not Mannan inhibits Bevacizumab uptake independently of phagocytosis and reduces VEGF expression in the RPE

Michaela Dithmer; Tim Meyer; Elisabeth Richert; Johann Roider; Alexa Klettner

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):5046. doi:

ARVO Annual Meeting Abstract June 2013

Differential effects of TLR-3 activated RPE on retinal microglia and blood-derived monocytes

Alexa Klettner; Timothy Hamann; Sebastian Wilker; Christin Berg; Karen Schlüter; Ralph Lucius; Mentlein Rolf; Johann Roider

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):4519. doi:

ARVO Annual Meeting Abstract March 2012

Regulation Of Constitutive Vascular Endothelial Growth Factor (VEGF) In RPE/Choroid Ocular Tissue And RPE Cell Culture

Alexa K. Klettner; Jens Lassen; Daniel Westhues; Johann Roider

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):3698. doi:

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Thermal Stimulation of the Retina Reduces Bruch's Membrane Thickness in Age Related Macular Degeneration Mouse Models

Release of Different Cell Mediators During Retinal Pigment Epithelium Regeneration Following Selective Retina Therapy

Long term effects of repetitive administration of VEGF-antagonists on primary RPE cells – comparison between Ranibizumab, Bevacizumab and Aflibercept

The barrier function, autophagy and inflammatory responses are similar under diabetic stimuli in retinal pigment epithelial cells derived from human induced pluripotent stem cells from the diabetic patients and the normal controls

CRB-1 rd8 Mutation Influences the Extent of AMD-like Retinal Alterations in NRF2 Knock Out Mice and Favors CNV Formation

Reduction of Bruchs Membrane (BrM) Thickness after Pulsed Laser Irradiation in Apolipoprotein (Apo) E Knock Out Mice

Semaphorin 3F expression pattern in outer retina and RPE

Laser Thermal Stimulation of the Retina (TS-R) reduces Thickness of Bruch’s Membrane (BrM) in Apolipoprotein (Apo) E knock out Mice

Response of RPE-Choroid Explants to Thermal Stimulation Therapy of the Retinal Pigment Epithelium (TS-R)

The Antiproliferative Effect of Bevacizumab on Human Tenon Fibroblasts Is Not Mediated by Vascular Endothelial Growth Factor Inhibition

Effects of Cytokine Activation and Oxidative Stress on the Function of the Human Embryonic Stem Cell–Derived Retinal Pigment Epithelial Cells

Pre-analytical parameters have significant impacts on VEGF levels measured from human plasma

Intracellular uptake of therapeutic immunoglobulins and fusion proteins: Comparison between Aflibercept, Bevacizumab and Rituximab

Influence of VEGF isoforms and VEGF inhibition on uveal melanoma cell lines - implications for therapeutic VEGF inhibition

Release of different cell mediators during retinal pigment epithelium (RPE) wound healing after Selective Retina Therapy (SRT) for prevention of early age-related macular degeneration (AMD)

Effect of Selective Retina Therapy (SRT) on the inflammatory microenvironment of the subretinal space

Time-dependent intracellular pattern of Bevacizumab in RPE cells

Fucoidan but not Mannan inhibits Bevacizumab uptake independently of phagocytosis and reduces VEGF expression in the RPE

Differential effects of TLR-3 activated RPE on retinal microglia and blood-derived monocytes

Regulation Of Constitutive Vascular Endothelial Growth Factor (VEGF) In RPE/Choroid Ocular Tissue And RPE Cell Culture

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