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Retina June 2024

Perimacular Atrophy Following Voretigene Neparvovec-Rzyl Treatment in the Setting of Previous Contralateral Eye Treatment With a Different Viral Vector

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Cristy A. Ku; Austin D. Igelman; Samuel J. Huang; Steven T. Bailey; Andreas K. Lauer; Jacque L. Duncan; Richard G. Weleber; Paul Yang; Mark E. Pennesi
TAGS: atrophy, chorioretinal atrophy, eye, genes, viral vector, voretigene neparvovec, visual fields
Trans. Vis. Sci. Tech.. 2024; 13(6):11. https://doi.org/10.1167/tvst.13.6.11

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

Six-year results of a Phase I/IIa gene therapy trial in patients with Usher Syndrome Type-1B (USH1B)

Maria Parker; Paul Yang; Dongseok Choi; Saddek Mohand-Said; Shobana Aravind; Ambar Faridi; Elvira Chegarnov; Charles Butler; Pierre-Olivier Barale; Andreas K Lauer; Tim Stout; David Wilson; Richard Weleber; Mark E Pennesi; Jose Alain Sahel; Isabelle S Audo

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5327.

ARVO Annual Meeting Abstract June 2024

Subretinal gene therapy AGTC-501 for X-linked retinitis pigmentosa in the Phase 1/2 Horizon study: Post-hoc analysis of microperimetry results in the high dose groups

David G Birch; Andreas K Lauer; Paul Yang; Robert Sisk; Rajiv Anand; Darin Curtiss; Amy Christenson; Nadia K Waheed

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2133.

ARVO Annual Meeting Abstract June 2024

Photoreceptor structure following gene therapy in CNGA3 -mediated Achromatopsia: adaptive optics imaging results from a Phase 1/2 dose escalation clinical trial for AGTC-402 (rAAV2tYF-PR1.7-hCNGA3)

Yu You Jiang; Peiluo Xu; Christine Nichols Kay; Robert Sisk; Rachel M Huckfeldt; Jason Comander; Byron L Lam; Ninel Z. Gregori; Audina Berrocal; Mark E Pennesi; Andreas K Lauer; Amy Christenson; Nadia K Waheed; Jessica Ijams Wolfing Morgan

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3289.

ARVO Annual Meeting Abstract June 2024

Gene-edited monkey model of Usher 1B: Assessment of gene therapy

Martha Neuringer; Jonathan Stoddard; Rene Reynaga; Junghyun Ryu; Jon D Hennebold; Carol B Hanna; John V Brigande; Hannah Woolard; Andreas K Lauer; David Wilson; Mark E Pennesi; Sanford L Boye; Shannon Elizabeth Boye; Renee Christine Ryals; Trevor J Mcgill; Lauren Renner

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4269.

ARVO Annual Meeting Abstract June 2024

Using cytokine profiling to characterize the immune response associated with AAV subretinal administration

Rene Stephen Reynaga; Jonathan Stoddard; Lauren Renner; Hannah Woolard; Andreas K Lauer; Sanford L Boye; Shannon Elizabeth Boye; Steven Grey; Alison Weiss; Will Liguore; Trevor J Mcgill; Paul Yang; Renee Christine Ryals; Martha Neuringer

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6088.

ARVO Annual Meeting Abstract June 2023

Partial full-field electroretinogram rescue in patients with RPE65-related retinal dystrophy following gene replacement therapy

Alessia Amato; Wayne Tschetter; Samuel J Huang; Lesley Everett; Steve Bailey; Paul Yang; Andreas K Lauer; Mark E Pennesi

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):5207.

ARVO Annual Meeting Abstract June 2023

Nonhuman primate model of Usher Syndrome Type 1B: course of retinal degeneration and initial gene therapy results

Lauren Renner; Junghyun Ryu; Jon D Hennebold; Sanford L Boye; Carol Hanna; Fernanda Burch; Beth Kempton; Edward V Porsov; Rachel Spears; Benjamin Burwitz; Andreas K Lauer; David Wilson; Mark E Pennesi; Shannon Boye; John V Brigande; Martha Neuringer

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):475.

ARVO Annual Meeting Abstract June 2023

Optimizing lipid nanoparticle-mediated photoreceptor transfection in the nonhuman primate.

Renee Christine Ryals; Milan Gautam; Rene Reynaga; Antony Jozic; Jeonghwan Kim; Elissa Bloom; Rachel Spears; Jonathan Stoddard; Andreas K Lauer; Martha Neuringer; Gaurav Sahay

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):785.

ARVO Annual Meeting Abstract June 2023

Six-month safety and efficacy of ATSN-101 in patients with Leber congenital amaurosis caused by biallelic mutations in GUCY2D (LCA1)

Christine Nichols Kay; Paul Yang; Artur V Cideciyan; Allen Ho; Andreas K Lauer; Shannon E Boye; Sanford L Boye; Alejandro J Roman; Vivian Wu; Alexandra V Garafalo; Alexander Sumaroka; Laura P Pardon; Dan Yoon; Kenji P Fujita; Samuel Jacobson

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1914.

ARVO Annual Meeting Abstract June 2023

Rhesus macaque model of Bardet-Biedl syndrome: Progression and response to gene therapy

Martha Neuringer; Junghyun Ryu; Jon D Hennebold; Carol Hanna; Fernanda Burch; Emily Mishler; Samuel Peterson; Betsy Ferguson; Rachel Spears; Hannah Woolard; Andreas K Lauer; David Wilson; Mark E Pennesi; Sanford L Boye; Shannon Boye; Lauren Renner

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3854.

Retina April 2023

Improved Rod Sensitivity as Assessed by Two-Color Dark-Adapted Perimetry in Patients With RPE65 -Related Retinopathy Treated With Voretigene Neparvovec-rzyl

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Cristy A. Ku; Austin D. Igelman; Samuel J. Huang; Huber Vasconcelos; Mariana Matioli da Palma; Steven T. Bailey; Andreas K. Lauer; Richard G. Weleber; Paul Yang; Mark E. Pennesi
TAGS: color, perimetry, retinal diseases, rod photoreceptors, rpe65 protein, voretigene neparvovec, vision
Trans. Vis. Sci. Tech.. 2023; 12(4):17. https://doi.org/10.1167/tvst.12.4.17

Includes: Multimedia, Supplemental Content

ARVO Annual Meeting Abstract June 2020

The age of patients with retinal degenerative diseases affects the injection pressure required for subretinal gene therapy delivery

Brittni A Scruggs; Huber Martins Vasconcelos Junior; Mark E Pennesi; Steven T Bailey; Andreas K Lauer

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4501.

ARVO Annual Meeting Abstract July 2019

An analysis of intraoperative optical coherence tomography findings in subretinal gene therapy surgery

Huber Vasconcelos Junior; Paul Yang; Mark E Pennesi; Brandon J Lujan; Andreas K Lauer

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6399.

ARVO Annual Meeting Abstract June 2017

Safety Profile of the Surgical Procedure for the Administration of Ocular Gene Therapies

Ronald BUGGAGE; Pierre-Olivier Barale; Sarah Ayello-Scheer; Andreas K Lauer; Tim Stout; Isabelle S Audo; Saddek Mohand-Said; Jose Alain Sahel; Paul Yang; Mark E Pennesi; Richard G Weleber; Laurence Titeux; Amel Lahmar; Preethi A Sundaram

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1491.

ARVO Annual Meeting Abstract June 2017

One Year Results of a Phase I/IIa Study of SAR422459 in Patients with Stargardt Macular Degeneration (SMD)

David J Wilson; Jose Alain Sahel; Richard G Weleber; Laura R Erker; Andreas K Lauer; Tim Stout; Isabelle S Audo; Saddek Mohand-Said; Pierre-Olivier Barale; Laurence Titeux; Ronald BUGGAGE

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3385.

ARVO Annual Meeting Abstract June 2017

Effect of age and signal strength index on retinal and choriocapillaris vessel density measured with optical coherence tomography angiography

Andrew Phillip Sill; Simon S. Gao; Yali Jia; Christina J Flaxel; Andreas K Lauer; Thomas S Hwang; Phoebe Lin; David Huang; Steven T Bailey

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4749.

ARVO Annual Meeting Abstract June 2017

Early detection of choriodal neovascularization with OCT Angiography

Steven T Bailey; Simon S. Gao; Christina J Flaxel; Thomas S Hwang; Andreas K Lauer; Phoebe Lin; David Huang; Yali Jia

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):820.

ARVO Annual Meeting Abstract September 2016

Phase I Safety and Tolerability results for RetinoStat ® , a Lentiviral Vector Expressing Endostatin and Angiostatin, in Patients with Advanced Neovascular Age-Related Macular Degeneration

Andreas K Lauer; Peter A Campochiaro; Elliott H Sohn; Michelle Kelleher; Richard Harrop; Julie Loader; Scott Ellis; Kyriacos Mitrophanous

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12)

ARVO Annual Meeting Abstract June 2015

Education for Retinopathy of Prematurity (ROP): Development and Assessment of a Novel Web-Based Educational Tool to Improve ROP Training

Robison Vernon Paul Chan; Michael Ryan; Samir Patel; Karyn Jonas; Susan Ostmo; Alexander David Port; Grace Sun; Andreas K Lauer; Michael F Chiang

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):964.

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Perimacular Atrophy Following Voretigene Neparvovec-Rzyl Treatment in the Setting of Previous Contralateral Eye Treatment With a Different Viral Vector

Six-year results of a Phase I/IIa gene therapy trial in patients with Usher Syndrome Type-1B (USH1B)

Subretinal gene therapy AGTC-501 for X-linked retinitis pigmentosa in the Phase 1/2 Horizon study: Post-hoc analysis of microperimetry results in the high dose groups

Photoreceptor structure following gene therapy in CNGA3 -mediated Achromatopsia: adaptive optics imaging results from a Phase 1/2 dose escalation clinical trial for AGTC-402 (rAAV2tYF-PR1.7-hCNGA3)

Gene-edited monkey model of Usher 1B: Assessment of gene therapy

Using cytokine profiling to characterize the immune response associated with AAV subretinal administration

Partial full-field electroretinogram rescue in patients with RPE65-related retinal dystrophy following gene replacement therapy

Nonhuman primate model of Usher Syndrome Type 1B: course of retinal degeneration and initial gene therapy results

Optimizing lipid nanoparticle-mediated photoreceptor transfection in the nonhuman primate.

Six-month safety and efficacy of ATSN-101 in patients with Leber congenital amaurosis caused by biallelic mutations in GUCY2D (LCA1)

Rhesus macaque model of Bardet-Biedl syndrome: Progression and response to gene therapy

Improved Rod Sensitivity as Assessed by Two-Color Dark-Adapted Perimetry in Patients With RPE65 -Related Retinopathy Treated With Voretigene Neparvovec-rzyl

The age of patients with retinal degenerative diseases affects the injection pressure required for subretinal gene therapy delivery

An analysis of intraoperative optical coherence tomography findings in subretinal gene therapy surgery

Safety Profile of the Surgical Procedure for the Administration of Ocular Gene Therapies

One Year Results of a Phase I/IIa Study of SAR422459 in Patients with Stargardt Macular Degeneration (SMD)

Effect of age and signal strength index on retinal and choriocapillaris vessel density measured with optical coherence tomography angiography

Early detection of choriodal neovascularization with OCT Angiography

Phase I Safety and Tolerability results for RetinoStat ® , a Lentiviral Vector Expressing Endostatin and Angiostatin, in Patients with Advanced Neovascular Age-Related Macular Degeneration

Education for Retinopathy of Prematurity (ROP): Development and Assessment of a Novel Web-Based Educational Tool to Improve ROP Training

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