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Articles May 2022

Restoration of Vision and Retinal Responses After Adeno-Associated Virus–Mediated Optogenetic Therapy in Blind Dogs

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Sergei Nikonov; Puya Aravand; Arkady Lyubarsky; Roman Nikonov; Angela J. Luo; Zhangyong Wei; Albert M. Maguire; Nicholas T. Phelps; Ivan Shpylchak; Keirnan Willett; Tomas S. Aleman; Rachel M. Huckfeldt; Pavitra S. Ramachandran; Jean Bennett
TAGS: adeno-associated virus, dog, domestic, gene therapy, optogenetics, retina, retinal cone, vision, mice, animal model
Trans. Vis. Sci. Tech.. 2022; 11(5):24. doi: https://doi.org/10.1167/tvst.11.5.24

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

Safety of the Subretinal Delivery of RGX-314 AAV8-anti-VEGF Fab Gene Therapy in NHP: Retinal Structure Over One Year

Michael J. Ammar; Elaine J Zhou; Jessica Ijams Wolfing Morgan; Katherine E Uyhazi; Arkady Lyubarsky; Erik Wielechowski; Gui-Shuang Ying; Erin Bote; Leah Makaron; Stephen Yoo; James Wilson; Jean Bennett; Albert M Maguire; Anna Tretiakova; Tomas S Aleman

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1422. doi:

ARVO Annual Meeting Abstract July 2018

Safety of subretinal delivery of RGX-314 (AAV8-anti-VEGF Fab) in the non-human primate as assessed by full-field ERG

Arkady Lyubarsky; Erik Wielechowski; Tomas S Aleman; Albert M Maguire; Gui-Shuang Ying; Erin Bote; Leah Makaron; Jessica Ijams Wolfing Morgan; Anna Tretiakova; James Wilson; Jean Bennett

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4546. doi:

ARVO Annual Meeting Abstract June 2017

Subretinal delivery of RGX-314 AAV8-anti-VEGF Fab gene therapy in NHP

Anna Tretiakova; Tomas S Aleman; Arkady Lyubarsky; Elaine J Zhou; Erik Wielechowski; Gui-Shuang Ying; Erin Bote; Leah Makaron; Stephen Yoo; Jean Bennett; Albert M Maguire; James Wilson

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4509. doi:

ARVO Annual Meeting Abstract June 2017

Intravitreal injection of AAV7m8.hLCA5 restores photoreceptor function in Lca5-/- mice to nearly WT levels.

Puya Aravand; Ji Yun Song; Shangzhen Zhou; Jieyan Pan; Arkady Lyubarsky; Jean Bennett; Sergei S Nikonov

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4551. doi:

ARVO Annual Meeting Abstract June 2017

Normal parameters of the full field ERG recorded with bipolar electrodes in Cynomolgus Macaque ( Macaque fascicularis )

Arkady Lyubarsky; Erik Wielechowski; Tomas S Aleman; Albert M Maguire; Gui-Shuang Ying; Erin Bote; Leah Makaron; James Wilson; Jean Bennett; Anna P. Tretiakova

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5344. doi:

ARVO Annual Meeting Abstract September 2016

Light Avoidance in Mice May Be not Related to Photoreceptor-Driven Input.

Arkady Lyubarsky; Jean Bennett

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2768. doi:

ARVO Annual Meeting Abstract September 2016

rAAV-mediated gene augmentation improves retinal and visual function and retinal structure in a mouse model for LCA5

Ji Yun Song; Puya Aravand; Ilan McNamara; Junwei Sun; Arkady Lyubarsky; Jean Bennett

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5151. doi:

ARVO Annual Meeting Abstract April 2014

Differential Function of Gγ13 in Rod Bipolar and ON Cone Bipolar Cells

Hari Ramakrishnan; Anuradha Dhingra; Marie E Fina; Arkady Lyubarsky; Sergei Nikonov; Noga Vardi

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):4169. doi:

ARVO Annual Meeting Abstract June 2013

AAV Mediated Gene Transfer Restores Retinal and Visual Function in Lebercilin-/- (LCA5) Mice

Daniel Chung; Jeannette Bennicelli; Adam Wojno; Nicoletta Commins; Robert Bloom; Daniel Bennett; Thu Duong; Meera Sivalingam; Arkady Lyubarsky; Jean Bennett

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):2710. doi:

ARVO Annual Meeting Abstract June 2013

High Throughput Behavioral Estimates of Visual Thresholds in Mice in a Watermaze with Cued Escape Platform

Arkady Lyubarsky; Muhammad Sheheryar Khan; Meera Sivalingam; Jean Bennett

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):3030. doi:

ARVO Annual Meeting Abstract March 2012

Gß3 is Required for Normal Light ON Responses and for the Assembly of the mGluR6-associated Signaling Complex

Anuradha Dhingra; Ying Xu; Arkady Lyubarsky; Marie Fina; Adam Neinstein; Noga Vardi

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):3155. doi:

ARVO Annual Meeting Abstract April 2011

Flash Pupillometry as a Tool for High Sensitivity Non-invasive Testing of the Retinal Function in Mice

Arkady Lyubarsky; Therese Cronin; Jean Bennett

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):5644. doi:

Retina February 2011

The Oral Iron Chelator Deferiprone Protects against Iron Overload–Induced Retinal Degeneration

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Majda Hadziahmetovic; Ying Song; Natalie Wolkow; Jared Iacovelli; Steven Grieco; Jennifer Lee; Arkady Lyubarsky; Domenico Pratico; John Connelly; Michael Spino; Z. Leah Harris; Joshua L. Dunaief
TAGS: deferiprone, iron, iron chelating agents, iron overload, mice, retinal degeneration, retina, oxidative stress, did not receive therapy or drug, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2011; 52(2):959-968. doi: https://doi.org/10.1167/iovs.10-6207

Retina March 2008

Nrl -Knockout Mice Deficient in Rpe65 Fail to Synthesize 11- cis Retinal and Cone Outer Segments

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Kecia L. Feathers; Arkady L. Lyubarsky; Naheed W. Khan; Karen Teofilo; Anand Swaroop; David S. Williams; Edward N. Pugh, Jr; Debra A. Thompson
TAGS: mice, retinal cone, retinoids, eye
Invest. Ophthalmol. Vis. Sci.. 2008; 49(3):1126-1135. doi: https://doi.org/10.1167/iovs.07-1234

Retina June 2005

Cone-like Morphological, Molecular, and Electrophysiological Features of the Photoreceptors of the Nrl Knockout Mouse

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Lauren L. Daniele; Concepcion Lillo; Arkady L. Lyubarsky; Sergei S. Nikonov; Nancy Philp; Alan J. Mears; Anand Swaroop; David S. Williams; Edward N. Pugh, Jr
TAGS: photoreceptors, retinal cone, mice, retina
Invest. Ophthalmol. Vis. Sci.. 2005; 46(6):2156-2167. doi: https://doi.org/10.1167/iovs.04-1427

Biochemistry and Molecular Biology October 2003

RP1 Is Required for the Correct Stacking of Outer Segment Discs

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Qin Liu; Arkady Lyubarsky; Jason H. Skalet; Edward N. Pugh, Jr; Eric A. Pierce
TAGS: mice, proteins, rna, messenger, photoreceptors, retinal degeneration, mutation, homozygote
Invest. Ophthalmol. Vis. Sci.. 2003; 44(10):4171-4183. doi: https://doi.org/10.1167/iovs.03-0410

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Restoration of Vision and Retinal Responses After Adeno-Associated Virus–Mediated Optogenetic Therapy in Blind Dogs

Safety of the Subretinal Delivery of RGX-314 AAV8-anti-VEGF Fab Gene Therapy in NHP: Retinal Structure Over One Year

Safety of subretinal delivery of RGX-314 (AAV8-anti-VEGF Fab) in the non-human primate as assessed by full-field ERG

Subretinal delivery of RGX-314 AAV8-anti-VEGF Fab gene therapy in NHP

Intravitreal injection of AAV7m8.hLCA5 restores photoreceptor function in Lca5-/- mice to nearly WT levels.

Normal parameters of the full field ERG recorded with bipolar electrodes in Cynomolgus Macaque ( Macaque fascicularis )

Light Avoidance in Mice May Be not Related to Photoreceptor-Driven Input.

rAAV-mediated gene augmentation improves retinal and visual function and retinal structure in a mouse model for LCA5

Differential Function of Gγ13 in Rod Bipolar and ON Cone Bipolar Cells

AAV Mediated Gene Transfer Restores Retinal and Visual Function in Lebercilin-/- (LCA5) Mice

High Throughput Behavioral Estimates of Visual Thresholds in Mice in a Watermaze with Cued Escape Platform

Gß3 is Required for Normal Light ON Responses and for the Assembly of the mGluR6-associated Signaling Complex

Flash Pupillometry as a Tool for High Sensitivity Non-invasive Testing of the Retinal Function in Mice

The Oral Iron Chelator Deferiprone Protects against Iron Overload–Induced Retinal Degeneration

Nrl -Knockout Mice Deficient in Rpe65 Fail to Synthesize 11- cis Retinal and Cone Outer Segments

Cone-like Morphological, Molecular, and Electrophysiological Features of the Photoreceptors of the Nrl Knockout Mouse

RP1 Is Required for the Correct Stacking of Outer Segment Discs

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