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Retina June 2024

Influencing Factors on Pupillary Light Responses as a Biomarker for Local Retinal Function in a Large Normative Cohort

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Ricarda Jendritza; Krunoslav Stingl; Torsten Strasser; Ronja Jung; Felix Tonagel; Paul Richter; Anton Sonntag; Tobias Peters; Helmut Wilhelm; Barbara Wilhelm; Carina Kelbsch
TAGS: biological markers, cardiac progenitor cells, cohort studies, pupil, pupil light reflex, retinal cone, rod photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2024; 65(6):3. https://doi.org/10.1167/iovs.65.6.3

Retina August 2023

Rod and Cone Function Measured Objectively by Chromatic Pupil Campimetry Show a Different Preservation Between Distinct Genotypes in Retinitis Pigmentosa

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Carina Kelbsch; Melanie Kempf; Ronja Jung; Friederike Kortüm; Milda Reith; Laura Kuehlewein; Susanne Kohl; Torsten Strasser; Tobias Peters; Helmut Wilhelm; Barbara Wilhelm; Krunoslav Stingl; Katarina Stingl
TAGS: genotype, pupil, pupil reaction, retinal cone, retinitis pigmentosa, rod photoreceptors, rpe65 protein, cardiac progenitor cells
Invest. Ophthalmol. Vis. Sci.. 2023; 64(11):18. https://doi.org/10.1167/iovs.64.11.18

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2022

Central Visual Function and Genotype-Phenotype Correlations in PDE6A -Associated Retinitis Pigmentosa in Preparation for a Gene Supplemental Trial

Ditta Zobor; Torsten Strasser; Gunnar Blumenstock; Katarina Stingl; M. Dominik Fischer; Barbara Wilhelm; Eberhart Zrenner; Bernd Wissinger; Susanne Kohl; Nicole Weisschuh; Laura Kuehlewein

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4499 – F0286.

Genetics May 2022

Central Visual Function and Genotype–Phenotype Correlations in PDE6A -Associated Retinitis Pigmentosa

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Laura Kuehlewein; Torsten Straßer; Gunnar Blumenstock; Katarina Stingl; M. Dominik Fischer; Barbara Wilhelm; Eberhart Zrenner; Bernd Wissinger; Susanne Kohl; Nicole Weisschuh; Ditta Zobor; for the RD-CURE Consortium
TAGS: genotype, genotype-phenotype associations, pde6a gene, phenotype, retinitis pigmentosa, vision, color vision, genetics, eye
Invest. Ophthalmol. Vis. Sci.. 2022; 63(5):9. https://doi.org/10.1167/iovs.63.5.9

Retina March 2022

Evaluation of Local Rod and Cone Function in Stargardt Disease

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Krunoslav Stingl; Carel Hoyng; Melanie Kempf; Susanne Kohl; Ronja Jung; Giulia Righetti; Laura Kühlewein; Lisa Pohl; Friederike Kortüm; Carina Kelbsch; Barbara Wilhelm; Tobias Peters; Katarina Stingl; on behalf of the SORAPRAZAN consortium
TAGS: cardiac progenitor cells, pupil reaction, retinal cone, rod photoreceptors, stargardt's disease, constriction procedure
Invest. Ophthalmol. Vis. Sci.. 2022; 63(3):6. https://doi.org/10.1167/iovs.63.3.6

Articles May 2021

Longitudinal Evaluation of Hyper-Reflective Foci in the Retina Following Subretinal Delivery of Adeno-Associated Virus in Non-Human Primates

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Eduardo Rodríguez-Bocanegra; Fabian Wozar; Immanuel P. Seitz; Felix F. L. Reichel; Alex Ochakovski; Kirsten Bucher; Barbara Wilhelm; K. Ulrich Bartz-Schmidt; Tobias Peters; M. Dominik Fischer; for the RD-CURE Consortium
TAGS: adeno-associated virus, eye, gene therapy, injections, primates, retina, spectral domain-optical coherence tomography, surgical procedures, operative, microglia
Trans. Vis. Sci. Tech.. 2021; 10(6):15. https://doi.org/10.1167/tvst.10.6.15

Includes: Supplemental Content

Articles May 2020

Chromatic Pupil Campimetry Reveals Functional Defects in Exudative Age-Related Macular Degeneration with Differences Related to Disease Activity

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Carina Kelbsch; Jakob Lange; Helmut Wilhelm; Barbara Wilhelm; Tobias Peters; Melanie Kempf; Laura Kuehlewein; Krunoslav Stingl
TAGS: constriction procedure, exudative age-related macular degeneration, pupil, pupil constriction, pupil reaction
Trans. Vis. Sci. Tech.. 2020; 9(6):5. https://doi.org/10.1167/tvst.9.6.5

Articles December 2019

Chromatic Full-Field Stimulus Threshold and Pupillography as Functional Markers for Late-Stage, Early-Onset Retinitis Pigmentosa Caused by CRB1 Mutations

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Krunoslav T. Stingl; Laura Kuehlewein; Nicole Weisschuh; Saskia Biskup; Frans P. M. Cremers; M. Imran Khan; Carina Kelbsch; Tobias Peters; Marius Ueffing; Barbara Wilhelm; Eberhart Zrenner; Katarina Stingl
TAGS: eye, illness length, mutation, pupil reaction, retinitis pigmentosa
Trans. Vis. Sci. Tech.. 2019; 8(6):45. https://doi.org/10.1167/tvst.8.6.45

Articles November 2019

Objective Measurement of Local Rod and Cone Function Using Gaze-Controlled Chromatic Pupil Campimetry in Healthy Subjects

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Carina Kelbsch; Katarina Stingl; Melanie Kempf; Torsten Strasser; Ronja Jung; Laura Kuehlewein; Helmut Wilhelm; Tobias Peters; Barbara Wilhelm; Krunoslav Stingl
TAGS: constriction procedure, gaze, pupil, pupil reaction, retinal cone, rod photoreceptors
Trans. Vis. Sci. Tech.. 2019; 8(6):19. https://doi.org/10.1167/tvst.8.6.19

ARVO Annual Meeting Abstract July 2019

Effects of Subretinal AAV8 Gene Therapy on Microperimetry in CNGA3 Achromatopsia Patients

G. Alex Ochakovski; Ahmad Zhour; Laura Kuehlewein; Susanne Kohl; Andrea Rindtorff; Karl Ulrich Bartz-Schmidt; Marius Ueffing; Eberhart Zrenner; Stylianos Michalakis; Martin Biel; Bernd Wissinger; Tobias Peters; Barbara Wilhelm; M. Dominik Fischer

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2921.

ARVO Annual Meeting Abstract July 2019

Evaluation of pupil responses to local stimuli in Patients with retinitis pigmentosa caused by USH2A mutations

Tobias Peters; Krunoslav Stingl; Karl Ulrich Bartz-Schmidt; Laura Kuehlewein; Carina Kelbsch; Melanie Kempf; Eberhart Zrenner; Barbara Wilhelm; Katarina Stingl

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1829.

ARVO Annual Meeting Abstract July 2019

Objective Measurement of Functional Defects in Age-related Macular Degeneration by Pupil Campimetry

Carina Kelbsch; Jakob Lange; Helmut Wilhelm; Barbara Wilhelm; Tobias Peters; Melanie Kempf; Laura Kuehlewein; Krunoslav Stingl

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2295.

ARVO Annual Meeting Abstract July 2019

Pupil campimetry: An objective measurement of local rod and/or cone function by pupillary response

Krunoslav Stingl; Tobias Peters; Torsten Strasser; Helmut Wilhelm; Barbara Wilhelm; Melanie Kempf; Katarina Stingl; Carina Kelbsch

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6461.

ARVO Annual Meeting Abstract July 2018

Safety study in cynomolgus monkeys after subretinal injection of rAAV.hPDE6A

Tobias Peters; Barbara Wilhelm; Birgit Korbmacher; Sven Korte; Karl Ulrich Bartz-Schmidt; Stylianos Michalakis; Guy Alex Ochakovski; M Dominik Fischer

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2658.

ARVO Annual Meeting Abstract July 2018

First Gene Supplementation Therapy for CNGA3-linked Achromatopsia

M Dominik Fischer; Stylianos Michalakis; Barbara Wilhelm; Nadine Kahle; Tobias Peters; Karl Ulrich Bartz-Schmidt; Susanne Kohl; Mathias W Seeliger; Nicole Weisschuh; Ditta Zobor; Eberhart Zrenner; Marius Ueffing; Martin Biel; Bernd Wissinger

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2982.

ARVO Annual Meeting Abstract July 2018

Changes in Microchip Position after Implantation of a Subretinal Vision Prosthesis in Humans

Laura Kuehlewein; Nicole Troelenberg; Krunoslav Stingl; Sebastian Schleehauf; Akos Kusnyerik; Helmut Sachs; Johann Roider; Timothy L Jackson; Robert E MacLaren; Caroline Chee; Barbara Wilhelm; Florian Gekeler; Karl Ulrich Bartz-Schmidt; Eberhart Zrenner; Katarina Stingl

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4561.

Retina April 2018

Humoral Immune Response After Intravitreal But Not After Subretinal AAV8 in Primates and Patients

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Felix F. Reichel; Tobias Peters; Barbara Wilhelm; Martin Biel; Marius Ueffing; Bernd Wissinger; Karl U. Bartz-Schmidt; Reinhild Klein; Stylianos Michalakis; M. Dominik Fischer; for the RD-CURE Consortium

Invest. Ophthalmol. Vis. Sci.. 2018; 59(5):1910-1915. https://doi.org/10.1167/iovs.17-22494

Includes: Supplemental Content

Retina November 2017

Superior Retinal Gene Transfer and Biodistribution Profile of Subretinal Versus Intravitreal Delivery of AAV8 in Nonhuman Primates

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Immanuel P. Seitz; Stylianos Michalakis; Barbara Wilhelm; Felix F. Reichel; G. Alex Ochakovski; Eberhart Zrenner; Marius Ueffing; Martin Biel; Bernd Wissinger; Karl U. Bartz-Schmidt; Tobias Peters; M. Dominik Fischer; for the RD-CURE Consortium
TAGS: cohort studies, disease vectors, dna, gene transfer techniques, genome, injections, primates, spatial vectors, body tissue, surgical procedures, operative
Invest. Ophthalmol. Vis. Sci.. 2017; 58(13):5792-5801. https://doi.org/10.1167/iovs.17-22473

Includes: Supplemental Content

Retina August 2017

Subretinal Injection for Gene Therapy Does Not Cause Clinically Significant Outer Nuclear Layer Thinning in Normal Primate Foveae

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G. Alex Ochakovski; Tobias Peters; Stylianos Michalakis; Barbara Wilhelm; Bernd Wissinger; Martin Biel; K. Ulrich Bartz-Schmidt; M. Dominik Fischer; for the RD-CURE Consortium
TAGS: gene therapy, injections, primates, safety, serotonin uptake inhibitors, retina, eye, surgical procedures, operative
Invest. Ophthalmol. Vis. Sci.. 2017; 58(10):4155-4160. https://doi.org/10.1167/iovs.17-22402

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2017

Optical coherence tomography in patients with Alpha IMS subretinal implant

Laura Kuehlewein; Veronique Kitiratschky; Mariya Gosheva; Thomas Edwards; Robert E MacLaren; Akos Kusnyerik; Cristina Angelescu; Timothy L Jackson; Chen-Hsin Sun; Caroline Chee; Helmut G Sachs; Barbara Wilhelm; Florian Gekeler; Karl Ulrich Bartz-Schmidt; Eberhart Zrenner; Katarina Stingl

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4189.

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Influencing Factors on Pupillary Light Responses as a Biomarker for Local Retinal Function in a Large Normative Cohort

Rod and Cone Function Measured Objectively by Chromatic Pupil Campimetry Show a Different Preservation Between Distinct Genotypes in Retinitis Pigmentosa

Central Visual Function and Genotype-Phenotype Correlations in PDE6A -Associated Retinitis Pigmentosa in Preparation for a Gene Supplemental Trial

Central Visual Function and Genotype–Phenotype Correlations in PDE6A -Associated Retinitis Pigmentosa

Evaluation of Local Rod and Cone Function in Stargardt Disease

Longitudinal Evaluation of Hyper-Reflective Foci in the Retina Following Subretinal Delivery of Adeno-Associated Virus in Non-Human Primates

Chromatic Pupil Campimetry Reveals Functional Defects in Exudative Age-Related Macular Degeneration with Differences Related to Disease Activity

Chromatic Full-Field Stimulus Threshold and Pupillography as Functional Markers for Late-Stage, Early-Onset Retinitis Pigmentosa Caused by CRB1 Mutations

Objective Measurement of Local Rod and Cone Function Using Gaze-Controlled Chromatic Pupil Campimetry in Healthy Subjects

Effects of Subretinal AAV8 Gene Therapy on Microperimetry in CNGA3 Achromatopsia Patients

Evaluation of pupil responses to local stimuli in Patients with retinitis pigmentosa caused by USH2A mutations

Objective Measurement of Functional Defects in Age-related Macular Degeneration by Pupil Campimetry

Pupil campimetry: An objective measurement of local rod and/or cone function by pupillary response

Safety study in cynomolgus monkeys after subretinal injection of rAAV.hPDE6A

First Gene Supplementation Therapy for CNGA3-linked Achromatopsia

Changes in Microchip Position after Implantation of a Subretinal Vision Prosthesis in Humans

Humoral Immune Response After Intravitreal But Not After Subretinal AAV8 in Primates and Patients

Superior Retinal Gene Transfer and Biodistribution Profile of Subretinal Versus Intravitreal Delivery of AAV8 in Nonhuman Primates

Subretinal Injection for Gene Therapy Does Not Cause Clinically Significant Outer Nuclear Layer Thinning in Normal Primate Foveae

Optical coherence tomography in patients with Alpha IMS subretinal implant

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