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ARVO Annual Meeting Abstract June 2025

Relative contributions of genetic and environmental factors to variance in photopic flash electroretinogram i-waves explored in a study of over 200 adult twins

Krishnika Vetrivel; Jit Kai Tan; Xiaofan Jiang; Shaun Leo; Taha Bhatti; Ambreen Tariq; Katie M Williams; Andrew Webster; Christopher J Hammond; Pirro G Hysi; Omar Abdul Rahman Mahroo

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):5602.

ARVO Annual Meeting Abstract June 2025

Long-flash electroretinograms recorded with a portable system for rapid diagnosis in patients with selective ON-bipolar cell impairment

Mahnoor Malik; Xiaofan Jiang; Zihe Xu; Isabelle Chow; Shaun Leo; Christopher J Hammond; Gordon T Plant; Andrew Webster; Omar Abdul Rahman Mahroo

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):5593.

ARVO Annual Meeting Abstract June 2025

Rod-isolated electroretinogram a-waves in KCNV2 -retinopathy compared with a large reference cohort: evidence for loss of an early negative transient

Sadat Yazdouni; Xiaofan Jiang; Shaun Leo; Pirro G Hysi; Anthony G Robson; Christopher J Hammond; Michel Michaelides; Andrew Webster; John Robson; Omar Abdul Rahman Mahroo

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):4671.

ARVO Annual Meeting Abstract June 2025

Insights into foveal development from a genome-wide association study of foveal pit depth

Callum Hunt; Ha-Jun Yoon; Nick Shrine; Kayesha Coley; Tu Zhanhan; Jonathan Zippin; Pirro G Hysi; Christopher J Hammond; Ala Moshiri; Rui Chen; Martin D. Tobin; Chiara Batini; Mervyn G. Thomas

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):2170.

ARVO Annual Meeting Abstract June 2025

Inclusion of serum metabolites in addition to polygenic risk score improves the prediction of AMD

Ajda Pristavec; Zakariya Jarrar; Omar Abdul Rahman Mahroo; Pirro G Hysi; Christopher J Hammond

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):2683.

ARVO Annual Meeting Abstract June 2025

Integrative genomics and metabolomics analysis reveals important metabolism-related mechanisms associated with Age-related Macular Degeneration

Lania Saleh; Zakariya Jarrar; Christopher J Hammond; Pirro G Hysi

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):3991.

Special Issue June 2025

Perspectives on Genetic and Environmental Factors in Myopia, Its Prediction, and the Future Direction of Research

PDF

Katie M. Williams; Christopher J. Hammond
TAGS: myopia, genetics
Invest. Ophthalmol. Vis. Sci.. 2025; 66(7):4. https://doi.org/10.1167/iovs.66.7.4

Genetics March 2025

An Ocular Gene-Set Expression Library for Heritability Partition and Cell Line Enrichment Analyses

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Pirro G. Hysi; Christopher J. Hammond
TAGS: cell lines, genes, genome-wide association study, libraries
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):11. https://doi.org/10.1167/iovs.66.3.11

Includes: Supplemental Content

Visual Neuroscience November 2024

The Electroretinogram I-Wave, a Component Originating in the Retinal OFF-Pathway, Associates With a Myopia Genetic Risk Polymorphism

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Zihe Xu; Jit Kai Tan; Krishnika Vetrivel; Xiaofan Jiang; Shaun M. Leo; Taha Bhatti; Ambreen Tariq; Andrew R. Webster; Anthony G. Robson; Christopher J. Hammond; Pirro G. Hysi; Omar A. Mahroo
TAGS: electroretinography, genetic risk, myopia, polymorphism
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):21. https://doi.org/10.1167/iovs.65.13.21

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

A metabolome-wide analysis of Intraocular pressure suggests neuroinflammatory mechanisms as possible mechanisms involved in glaucoma

Pirro G Hysi; Ajda Pristavec; Anthony P Khawaja; Jospeh Bastasic; David A Mackey; Janey L Wiggs; Jamie E Craig; Louis R Pasquale; Christopher J Hammond; Marie-Hélène Roy-Gagnon

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):997.

ARVO Annual Meeting Abstract June 2024

Are we amid a dry eye epidemic? - The increasing prevalence of dry eye disease in Europe

Morten S Magno; Leif Hynnekleiv; Christopher J Hammond; Tor Utheim; Jelle Vehof

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2855.

ARVO Annual Meeting Abstract June 2024

Exploring kinetics of the ganglion cell contribution to standard light-adapted flash electroretinograms by interocular comparison in patients with unilateral ganglion cell loss

Ahmed Ellabban; Harry Frederick Arbuthnott; Charlie Bosshard; Gordon Plant; Christopher J Hammond; Omar Abdul Rahman Mahroo

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1534.

ARVO Annual Meeting Abstract June 2024

Enhanced deep metagenomic sequencing of ocular microbes using saponification with the Nanopore platform

Jeremy Mirza; Michael Tsun Lau; Graham R Wallace; Philip Ian Murray; Christopher J Hammond; Russell N Van Gelder; Saaeha Rauz; Liying Low

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3183.

ARVO Annual Meeting Abstract June 2024

Epigenetic modifiers and their interactions with genetic polymorphisms in Intraocular Pressure and glaucoma

Xiaofan Jiang; Omar Abdul Rahman Mahroo; Dorota Skowronska-Krawczyk; Christopher J Hammond; Chris G Bell; Pirro G Hysi

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4626.

ARVO Annual Meeting Abstract June 2024

Modelling the rod-driven electroretinogram a-wave elicited by strong flashes: insights from patients with selected post-phototransduction impairments

Omar Abdul Rahman Mahroo; Xiaofan Jiang; Shaun Leo; Pirro G Hysi; Thales A C De Guimarães; Anthony G Robson; Christopher J Hammond; Michel Michaelides; Andrew Webster; John Robson

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5854.

ARVO Annual Meeting Abstract June 2024

Metabolome-wide analysis identifies two plasma metabolites associated with age-related macular degeneration

Ajda Pristavec; Zakariya Jarrar; Pirro G Hysi; Christopher J Hammond

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6513.

Retina February 2024

Temporal-to-Nasal Macular Ganglion Cell and Inner Plexiform Layer Ratios in a Large Adult Twin Cohort: Correlations With Age and Heritability

PDF

Zakariya A. Jarrar; Khaldoon O. Al-Nosairy; Xiaofan Jiang; Ali Lamin; Dominic Wong; Abdus S. Ansari; Katie M. Williams; Sobha Sivaprasad; Michael B. Hoffmann; Pirro G. Hysi; Christopher J. Hammond; Omar A. Mahroo
TAGS: adult, cohort studies, ganglia, nose, twins
Invest. Ophthalmol. Vis. Sci.. 2024; 65(2):26. https://doi.org/10.1167/iovs.65.2.26

Clinical and Epidemiologic Research November 2023

Changes in Refractive Error During Young Adulthood: The Effects of Longitudinal Screen Time, Ocular Sun Exposure, and Genetic Predisposition

PDF

Samantha Sze-Yee Lee; Gareth Lingham; Carol A. Wang; Santiago Diaz Torres; Craig E. Pennell; Pirro G. Hysi; Christopher J. Hammond; Puya Gharahkhani; Rosie Clark; Jeremy A. Guggenheim; David A. Mackey
TAGS: adult, genetic predisposition to disease, myopia, refractive errors, screen time, sun exposure
Invest. Ophthalmol. Vis. Sci.. 2023; 64(14):28. https://doi.org/10.1167/iovs.64.14.28

Includes: Supplemental Content

Clinical and Epidemiologic Research July 2023

Prevalence, Concordance, and Heritability of Vitreomacular Interface Abnormalities in a Twin Study

PDF

Zakariya A. Jarrar; Abdus Samad Ansari; Katie M. Williams; Dominic S. Wong; Pirro G. Hysi; Omar A. Mahroo; Christopher J. Hammond
TAGS: prevalence, spectral domain-optical coherence tomography, twin studies
Invest. Ophthalmol. Vis. Sci.. 2023; 64(10):9. https://doi.org/10.1167/iovs.64.10.9

Includes: Supplemental Content

Retina June 2023

An Analysis of the Effect of ABCA4 p.Asn1868Ile Genotypes on Retinal Structure in 26,558 Participants in the UK Biobank

PDF

Mark J. Simcoe; Gavin Arno; Pirro G. Hysi; Tony Ko; Michel Michaelides; Christopher J. Hammond; Praveen J. Patel; Omar A. Mahroo; Andrew R. Webster; for the UK Biobank Eye and Vision Consortium*
TAGS: abca4 gene, biobanks, genotype, mutation, retina, retinal diseases, alleles, cohort studies, visual acuity
Invest. Ophthalmol. Vis. Sci.. 2023; 64(7):31. https://doi.org/10.1167/iovs.64.7.31

Includes: Supplemental Content

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Relative contributions of genetic and environmental factors to variance in photopic flash electroretinogram i-waves explored in a study of over 200 adult twins

Long-flash electroretinograms recorded with a portable system for rapid diagnosis in patients with selective ON-bipolar cell impairment

Rod-isolated electroretinogram a-waves in KCNV2 -retinopathy compared with a large reference cohort: evidence for loss of an early negative transient

Insights into foveal development from a genome-wide association study of foveal pit depth

Inclusion of serum metabolites in addition to polygenic risk score improves the prediction of AMD

Integrative genomics and metabolomics analysis reveals important metabolism-related mechanisms associated with Age-related Macular Degeneration

Perspectives on Genetic and Environmental Factors in Myopia, Its Prediction, and the Future Direction of Research

An Ocular Gene-Set Expression Library for Heritability Partition and Cell Line Enrichment Analyses

The Electroretinogram I-Wave, a Component Originating in the Retinal OFF-Pathway, Associates With a Myopia Genetic Risk Polymorphism

A metabolome-wide analysis of Intraocular pressure suggests neuroinflammatory mechanisms as possible mechanisms involved in glaucoma

Are we amid a dry eye epidemic? - The increasing prevalence of dry eye disease in Europe

Exploring kinetics of the ganglion cell contribution to standard light-adapted flash electroretinograms by interocular comparison in patients with unilateral ganglion cell loss

Enhanced deep metagenomic sequencing of ocular microbes using saponification with the Nanopore platform

Epigenetic modifiers and their interactions with genetic polymorphisms in Intraocular Pressure and glaucoma

Modelling the rod-driven electroretinogram a-wave elicited by strong flashes: insights from patients with selected post-phototransduction impairments

Metabolome-wide analysis identifies two plasma metabolites associated with age-related macular degeneration

Temporal-to-Nasal Macular Ganglion Cell and Inner Plexiform Layer Ratios in a Large Adult Twin Cohort: Correlations With Age and Heritability

Changes in Refractive Error During Young Adulthood: The Effects of Longitudinal Screen Time, Ocular Sun Exposure, and Genetic Predisposition

Prevalence, Concordance, and Heritability of Vitreomacular Interface Abnormalities in a Twin Study

An Analysis of the Effect of ABCA4 p.Asn1868Ile Genotypes on Retinal Structure in 26,558 Participants in the UK Biobank

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