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ARVO Annual Meeting Abstract June 2024

TTHX1114 Guards Against Ferroptosis in Primary Rabbit Corneal Endothelial Cells

Jessica Weant; Anna Stuhlfire; Lindsey Myers; Sarah Pizzuto; Tyler Todd; Grace Duffey; David Eveleth

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4147.

ARVO Annual Meeting Abstract June 2024

TTHX1114 Rescues Cells Against DNA damage and Cell Loss in Primary Rabbit Corneal Endothelial Cells

David Eveleth; Jessica Weant; Anna Stuhlfire; Lindsey Myers; Sarah Pizzuto

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4146.

ARVO Annual Meeting Abstract June 2023

Factors Affecting Recovery Following Descemet Stripping Only (DSO) with TTHX1114

Thomas Tremblay; David Eveleth

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):631.

ARVO Annual Meeting Abstract June 2023

TTHX1114 Protects Primary Rabbit Corneal Endothelial Cells from Oxidative Stress

Anna Stuhlfire; Lindsey Myers; Grace Duffey; Jessica Weant; David Eveleth

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):621.

ARVO Annual Meeting Abstract June 2023

The engineered fibroblast growth factor TTHX1114 mediates enrichment of proliferative and wound healing pathways in wounded human corneal endothelium

Grace Duffey; Lindsey Myers; Tyler Todd; Jessica Weant; David Eveleth

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):618.

ARVO Annual Meeting Abstract June 2023

Protection of endothelial cells by TTHX1114 in patients with Fuchs endothelial corneal dystrophy (FECD) undergoing Descemet’s Stripping Only (DSO) in combination with cataract surgery: evidence from the STORM study

David Eveleth; Thomas Tremblay

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1329.

ARVO Annual Meeting Abstract June 2023

Role of Fibroblast Growth Factor derivatives in corneal endothelial regeneration

David Eveleth

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2409.

ARVO Annual Meeting Abstract June 2022

A Phase 1/ Phase 2 Study Evaluating the Safety and Efficacy of TTHX1114 on the Regeneration of Corneal Endothelial Cells in Patients with Corneal Endothelial Dystrophy

David Eveleth; Thomas Tremblay

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2757 – A0246.

ARVO Annual Meeting Abstract June 2021

Accelerated regeneration of corneal endothelium after Descemet’s stripping mediated by the engineered fibroblast growth factor TTHX1114

Sarah Pizzuto; Jessica Weant; Natalie A Afshari; David Eveleth

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):797.

ARVO Annual Meeting Abstract June 2021

High endogenous Fibroblast Growth Factor 1 levels may explain regenerative response of rabbits to endothelial damage

David Eveleth; Grace Duffey; Lindsey Myers; Sarah Pizzuto; Jessica Weant

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):690.

Articles May 2021

Characterization of a Novel Caveolin Modulator That Reduces Vascular Permeability and Ocular Inflammation

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Pascal N. Bernatchez; Bo Tao; Ralph A. Bradshaw; David Eveleth; William C. Sessa
TAGS: caveolins, electroconvulsive therapy, eye inflammation, inflammation, peptides, uveitis, vascular permeability, vascular endothelial growth factor a, mice, epidural cortical stimulation
Trans. Vis. Sci. Tech.. 2021; 10(6):21. https://doi.org/10.1167/tvst.10.6.21

ARVO Annual Meeting Abstract June 2020

Accelerated healing of corneal endothelial lesions in organ culture by the engineered fibroblast growth factor TTHX1114

David Eveleth; Sarah Pizzuto; Jessica Weant; Jennifer Jenkins-Eveleth; Natalie A Afshari

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3255.

ARVO Annual Meeting Abstract June 2020

Proliferation of human corneal endothelia in organ culture stimulated by engineered human fibroblast growth factor 1 (FGF1) derivative TTHX1114

Sarah Pizzuto; David Eveleth; Jessica Weant; Jennifer Jenkins-Eveleth; Ralph A. Bradshaw

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3263.

ARVO Annual Meeting Abstract July 2019

Topical treatment with an engineered fibroblast growth factor 1 (TTHX1114) decreased inflammatory macrophages in the cornea associated with reduced corneal keratopathy in a mouse model of primary ocular herpes

David Eveleth; Nisha Dhanushkodi; Ruchi Srivastava; Pierre-Gregoire A Coulon; Soumyabrata Roy; Swayam Prakash; Lbachir BenMohamed

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4626.

Cornea September 2018

An Engineered Human Fibroblast Growth Factor-1 Derivative, TTHX1114, Ameliorates Short-term Corneal Nitrogen Mustard Injury in Rabbit Organ Cultures

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David D. Eveleth; Jennifer J. Eveleth; Amuthakannan Subramaniam; Rita Hahn; Peihong Zhou; Marion K. Gordon; Ralph A. Bradshaw
TAGS: cornea, fibroblast growth factor 1, organ culture techniques, oryctolagus cuniculus, vesicants, wounds and injuries, mechlorethamine, corneal epithelium, nitrogen mustard compounds, wound healing
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4720-4730. https://doi.org/10.1167/iovs.18-24568

ARVO Annual Meeting Abstract June 2017

Engineered FGF-1 derivatives as protective agents in nitrogen mustard induced corneal injury

David Eveleth; Jennifer Eveleth; Marion K Gordon; Amuthakannan Subramaniam; Rita A Hahn; Kenneth Thomas; Michael blaber; Ralph Bradshaw

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1176.

ARVO Annual Meeting Abstract September 2016

Accelerated healing of corneal endothelial lesions induced by engineered FGF-1 derivatives

Ralph Bradshaw; Michael Blaber; Amuthakannan Subramanian; David Ornitz; David Eveleth

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):1269.

ARVO Annual Meeting Abstract September 2016

Caveolin modulators suppress inflammation in the B10.RIII mouse model of uveitis

David Eveleth; William Sessa; Ralph Bradshaw; Amuthakannan Subramanian; James T Rosenbaum; Phoebe Lin

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):1881.

ARVO Annual Meeting Abstract June 2015

Engineered FGF-1 derivatives stimulate proliferation of corneal endothelial cells

David Eveleth; Xue Xia; Ken Thomas; Michael Blaber

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):1169.

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TTHX1114 Guards Against Ferroptosis in Primary Rabbit Corneal Endothelial Cells

TTHX1114 Rescues Cells Against DNA damage and Cell Loss in Primary Rabbit Corneal Endothelial Cells

Factors Affecting Recovery Following Descemet Stripping Only (DSO) with TTHX1114

TTHX1114 Protects Primary Rabbit Corneal Endothelial Cells from Oxidative Stress

The engineered fibroblast growth factor TTHX1114 mediates enrichment of proliferative and wound healing pathways in wounded human corneal endothelium

Protection of endothelial cells by TTHX1114 in patients with Fuchs endothelial corneal dystrophy (FECD) undergoing Descemet’s Stripping Only (DSO) in combination with cataract surgery: evidence from the STORM study

Role of Fibroblast Growth Factor derivatives in corneal endothelial regeneration

A Phase 1/ Phase 2 Study Evaluating the Safety and Efficacy of TTHX1114 on the Regeneration of Corneal Endothelial Cells in Patients with Corneal Endothelial Dystrophy

Accelerated regeneration of corneal endothelium after Descemet’s stripping mediated by the engineered fibroblast growth factor TTHX1114

High endogenous Fibroblast Growth Factor 1 levels may explain regenerative response of rabbits to endothelial damage

Characterization of a Novel Caveolin Modulator That Reduces Vascular Permeability and Ocular Inflammation

Accelerated healing of corneal endothelial lesions in organ culture by the engineered fibroblast growth factor TTHX1114

Proliferation of human corneal endothelia in organ culture stimulated by engineered human fibroblast growth factor 1 (FGF1) derivative TTHX1114

Topical treatment with an engineered fibroblast growth factor 1 (TTHX1114) decreased inflammatory macrophages in the cornea associated with reduced corneal keratopathy in a mouse model of primary ocular herpes

An Engineered Human Fibroblast Growth Factor-1 Derivative, TTHX1114, Ameliorates Short-term Corneal Nitrogen Mustard Injury in Rabbit Organ Cultures

Engineered FGF-1 derivatives as protective agents in nitrogen mustard induced corneal injury

Accelerated healing of corneal endothelial lesions induced by engineered FGF-1 derivatives

Caveolin modulators suppress inflammation in the B10.RIII mouse model of uveitis

Engineered FGF-1 derivatives stimulate proliferation of corneal endothelial cells

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