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Meeting Abstract (7)
Journal Articles (2)

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Investigative Ophthalmology & Visual Science (8)
Translational Vision Science & Technology (1)

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ARVO Annual Meeting Abstract (7)
Articles (1)
Retina (1)

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Genetics (2)
Eye Anatomy and Disorders (1)
Retina (1)
Translational Research (1)

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aflibercept (1)
bland-altman plot (1)
capsid (1)
choroidal neovascularization (1)
choroideremia (1)
disease vectors (1)
eye (1)
gene therapy (1)
genetics (1)
injections (1)

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Retina December 2024

Design and Characterization of a Novel Intravitreal Dual-Transgene Genetic Medicine for Neovascular Retinopathies

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Melissa A. Calton; Roxanne H. Croze; Christian Burns; Ghezal Beliakoff; Tandis Vazin; Paul Szymanski; Christopher Schmitt; Austin Klein; Meredith Leong; Melissa Quezada; Jenny Holt; Gabe Bolender; Katherine Barglow; Devi Khoday; Thomas Mason; Katherine Delaria; Mohammad Hassanipour; Melissa Kotterman; Arshad M. Khanani; David Schaffer; Peter Francis; David Kirn
TAGS: eye, gene therapy, genetics, retinal diseases, transgenes, spatial vectors, choroidal neovascularization, capsid, primates, disease vectors
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):1. https://doi.org/10.1167/iovs.65.14.1

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

Preclinical characterization of 4D-175, a novel AAV-based investigational intravitreal gene therapy for geographic atrophy

Melissa Calton; Roxanne Croze; Laura Kovacs; Maria Osuna; Domokos Lauko; Ted Sullivan; Caralee Schaefer; Devi Khoday; Joseph Vacca; An Song; David Kirn

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6164.

ARVO Annual Meeting Abstract June 2023

Interim results for the Phase 1/2 PRISM Trial evaluating 4D-150, a dual-transgene intravitreal genetic medicine in individuals with neovascular (wet) age-related macular degeneration

Arshad M. Khanani; Vrinda S Hershberger; Christine Nichols Kay; Allen Hu; David Aaron Eichenbaum; Glenn J Jaffe; Carol Chung; Somayeh Honarmand; Chyong Nien; Schonmei Lee; Harsha Kabra; David Kirn; Robert Kim

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):5055.

ARVO Annual Meeting Abstract June 2022

Natural history of the progression of choroideremia; 24-month follow-up

David G Birch; Paul S Bernstein; Ian M MacDonald; Timothy Stout; David Liao; Kirsten Locke; Yi Zhai; Manlong Xu; Mark Lomax; Shobana Aravind; Jennifer Verriotto; David Kirn; Peter Francis

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4291.

Articles June 2020

Quantification of RPE Changes in Choroideremia Using a Photoshop-Based Method

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Yi Zhai; Manlong Xu; Ioannis S. Dimopoulos; David G. Birch; Paul S. Bernstein; Jenny Holt; David Kirn; Peter Francis; Ian M. MacDonald
TAGS: choroideremia, bland-altman plot
Trans. Vis. Sci. Tech.. 2020; 9(7):21. https://doi.org/10.1167/tvst.9.7.21

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2020

The natural history of choroideremia; progressive loss of visual function and retinal structure

David G Birch; Paul S Bernstein; Ian M MacDonald; Timothy Stout; David S Liao; Kirsten G Locke; Yi Zhai; Audra K Miller; Jenny Holt; Adia Jackson Leung; Somayeh Honarmand; Paul Jordan; Ulrich F O Luhmann; David H Kirn; Peter J Francis

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1908.

ARVO Annual Meeting Abstract July 2019

Quantification of RPE changes in choroideremia using a Photoshop-based protocol

Yi Zhai; Manlong Xu; Ioannis Dimopoulos; David G Birch; Paul S Bernstein; Peter Francis; Jenny Holt; David Kirn; Ian M MacDonald

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6131.

ARVO Annual Meeting Abstract June 2017

Novel AAV Variants Show Superior Gene Delivery in Human Retinal Cell Models

Melissa Ann Kotterman; Tandis Vazin; Ghezal Beliakoff; Roxanne Croze; Mohammad Hassanipour; Christopher Schmitt; Marco Wallroth; Melissa Quezada; David V. Schaffer; David Kirn

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4089.

ARVO Annual Meeting Abstract June 2017

Towards A DNA-Directed RNA Interference (ddRNAi) Therapy Delivered Intravitreally Using a Novel AAV Capsid to Treat Choroidal Neovascularization (CNV)

David Suhy; Shih-chu Kao; Melissa Ann Kotterman; Albert Doan; Vanessa Ufombah-Strings; Claudia Kloth; Natalie Suhy; Peter Roelvink; David Kirn; David Schaffer

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4121.

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Online ISSN: 2164-2591

Investigative Ophthalmology & Visual Science
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