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ARVO Annual Meeting Abstract June 2024

Localization of Toll-like Receptors and Intracellular Lipid Droplets in an anaphylatoxin-induced AMD model in iPSC-derived retinal pigment epithelium

Katherine Patterson; Congxiao Zhang; Andrew Fausey; David McGaughey; Joys Annita David; Ruchi Sharma; Kapil Bharti

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):739.

ARVO Annual Meeting Abstract June 2024

USE OF METFORMIN AS A POTENTIAL TREATMENT FOR STARGARDT MACULOPATHY

Devika Abhijit Bose; Mitra Farnoodian; Ruchi Sharma; David McGaughey; Kapil Bharti

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2203.

ARVO Annual Meeting Abstract June 2024

An RPE subpopulation is resistant to oxidative-induced inflammation through SERPINE3-Caspase1 pathway

Huirong Li; Wei Yan; David McGaughey; Temesgen D Fufa; Lijin Dong; Tiansen Li; Suja Hiriyanna; Bin Guan; Koray Dogan Kaya; Ashley M Rasys; James Liu; Takerra Johnson; Jiwon Ryu; Brian P Brooks; Robert B Hufnagel

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2184.

ARVO Annual Meeting Abstract June 2024

Nested PCR as an economical and robust approach for detecting aberrant splicing events in clinically accessible tissues

Amelia Naik; Ehsan Ullah; Chelsea Bender; Ranya Al Rawi; Koray Dogan Kaya; David McGaughey; Aime Agather; Delphine Blain; Brian Patrick Brooks; Catherine A Cukras; Laryssa Huryn; Kerry E Goetz; Robert B Hufnagel; Bin Guan

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4696.

ARVO Annual Meeting Abstract June 2024

Identifying Novel Coloboma-Causing Gene Candidates Through a Cross-Species Meta Analysis

Daniel Sanchez-Mendoza; Uma Neelathi; David McGaughey; Elangovan Boobalan; Brian Patrick Brooks

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4674.

Retina September 2023

PLAE Web App Enables Powerful Searching and Multiple Visualizations Across One Million Unified Single-Cell Ocular Transcriptomes

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Vinay S. Swamy; Zachary A. Batz; David M. McGaughey
TAGS: cells, datasets, gene expression, genes, retinal cone, metadata, body tissue, macula lutea
Trans. Vis. Sci. Tech.. 2023; 12(9):18. https://doi.org/10.1167/tvst.12.9.18

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2023

Identifying novel candidate coloboma genes through cross-species gene expression profiling

Daniel Sanchez-Mendoza; Uma Neelathi; David McGaughey; Elangovan Boobalan; Tiziana Cogliati; Brian Patrick Brooks

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):4763.

ARVO Annual Meeting Abstract June 2023

Anaphylatoxins increase transposable element expression in human retinal pigment epithelium

Congxiao Zhang; Joys Annika David; David McGaughey; Andrew Fausey; Ruchi Sharma; Kapil Bharti

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2093.

ARVO Annual Meeting Abstract June 2023

SERPINE3 is an RPE-specific protease inhibitor critical for retinal function

Huirong Li; Jimmy Liu; Takerra Johnson; Lijin Dong; David McGaughey; Robert B. Hufnagel

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2998.

ARVO Annual Meeting Abstract June 2023

Piezo1 channels highly expressed in human RPE

Qin Wan; Joys Annika David; Congxiao Zhang; Tea Soon Park; Mitra Farnoodian; Eric Nguyen; Jair Montford; Colby Lewallen; Aman George; Kiyoharu Miyagishima; David McGaughey; Davide Ortolan; Devika Abhijit Bose; Arvydas Maminishkis; Ruchi Sharma; Kapil Bharti

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2982.

ARVO Annual Meeting Abstract June 2023

Eye in a Disk 2.0: Human Pan-Eye and Body Transcriptome Database

Prashit Parikh; Aaron denDekker; William Presley; Lev Prasov; Jason Matthew Lewis Miller; David McGaughey

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3266.

ARVO Annual Meeting Abstract June 2023

Multi-omics approach reveals metabolic switch in developing iPSC-derived RPE

Ruchi Sharma; Zander Esh; Davide Ortolan; Jair Montford; Jiwon Ryu; David McGaughey; Alan Jarmusch; Kapil Bharti

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3514.

Genetics November 2022

Zfp503/Nlz2 Is Required for RPE Differentiation and Optic Fissure Closure

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Elangovan Boobalan; Amy H. Thompson; Ramakrishna P. Alur; David M. McGaughey; Lijin Dong; Grace Shih; Emile R. Vieta-Ferrer; Ighovie F. Onojafe; Vijay K. Kalaskar; Gavin Arno; Andrew J. Lotery; Bin Guan; Chelsea Bender; Omar Memon; Lauren Brinster; Clement Soleilhavoup; Lia Panman; Tudor C. Badea; Andrea Minella; Antonio Jacobo Lopez; Sara M. Thomasy; Ala Moshiri; Delphine Blain; Robert B. Hufnagel; Tiziana Cogliati; Kapil Bharti; Brian P. Brooks
TAGS: embryo, fissure, mice, optics, eye, transcription factor
Invest. Ophthalmol. Vis. Sci.. 2022; 63(12):5. https://doi.org/10.1167/iovs.63.12.5

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2021

Million Cell Retina Transcriptome Meta-Atlas for All

David McGaughey; Vinay Swamy; Zachary Batz; Temesgen Fufa; Robert B Hufnagel

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2609.

Retina June 2021

North Carolina Macular Dystrophy: Phenotypic Variability and Computational Analysis of Disease-Associated Noncoding Variants

PDF

David J. Green; Eva Lenassi; Cerys S. Manning; David McGaughey; Vinod Sharma; Graeme C. Black; Jamie M. Ellingford; Panagiotis I. Sergouniotis
TAGS: body tissue, datasets, macular dystrophy, phenotype, retina, gene expression, genetic screening, genes, enhancer elements, genetic
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):16. https://doi.org/10.1167/iovs.62.7.16

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

Regional transcriptome map of the adult rhesus macaque retina and RPE-choroid

Ameera Mungale; Temesgen D Fufa; David McGaughey; Congxiao Zhang; Arvydas Maminishkis; Sheldon S Miller; Brian Patrick Brooks; Robert Hufnagel

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):998.

ARVO Annual Meeting Abstract July 2019

Anaphylatoxin Complement Proteins C3a and C5a Induce AMD Cellular Endophenotypes in iPSC-RPE Through Apically Localized C3aR and C5aR Receptors

Malika Nimmagadda; Fnu Ruchi; Aman George; Zoya Quershy; Qin Wan; Justin Chang; Balendu Shekhar Jha; Davide Ortolan; Madhu Lal; Marc Ferrer; Juan Amaral; David McGaughey; Kapil Bharti

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1243.

ARVO Annual Meeting Abstract July 2019

Differential transcriptome profile associated with pigmentation defects in induced pluripotent stem cell-derived retinal pigment epithelium from Albinism patients

Aman George; Fnu Ruchi; Tyler Pfister; David McGaughey; Nathan Hotaling; Mones S Abu-Asab; Qin Wan; Congxiao Zhang; Kapil Bharti; Brian Patrick Brooks

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2877.

ARVO Annual Meeting Abstract July 2019

Multimodal genomic analysis of hydroxychloroquine toxicity in a large cohort

Ehsan Ullah; David McGaughey; Amy Turriff; Paul A Sieving; Robert B Hufnagel; Catherine A Cukras

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6054.

ARVO Annual Meeting Abstract July 2019

De novo transcriptomes built from hundreds of human cornea, retina, and RPE RNA-seq samples identifies thousands of differentially expressed ocular specific gene transcripts and novel eye disease relevant exons

Vinay Swamy; Brian Patrick Brooks; Robert B Hufnagel; David McGaughey

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1000.

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Localization of Toll-like Receptors and Intracellular Lipid Droplets in an anaphylatoxin-induced AMD model in iPSC-derived retinal pigment epithelium

USE OF METFORMIN AS A POTENTIAL TREATMENT FOR STARGARDT MACULOPATHY

An RPE subpopulation is resistant to oxidative-induced inflammation through SERPINE3-Caspase1 pathway

Nested PCR as an economical and robust approach for detecting aberrant splicing events in clinically accessible tissues

Identifying Novel Coloboma-Causing Gene Candidates Through a Cross-Species Meta Analysis

PLAE Web App Enables Powerful Searching and Multiple Visualizations Across One Million Unified Single-Cell Ocular Transcriptomes

Identifying novel candidate coloboma genes through cross-species gene expression profiling

Anaphylatoxins increase transposable element expression in human retinal pigment epithelium

SERPINE3 is an RPE-specific protease inhibitor critical for retinal function

Piezo1 channels highly expressed in human RPE

Eye in a Disk 2.0: Human Pan-Eye and Body Transcriptome Database

Multi-omics approach reveals metabolic switch in developing iPSC-derived RPE

Zfp503/Nlz2 Is Required for RPE Differentiation and Optic Fissure Closure

Million Cell Retina Transcriptome Meta-Atlas for All

North Carolina Macular Dystrophy: Phenotypic Variability and Computational Analysis of Disease-Associated Noncoding Variants

Regional transcriptome map of the adult rhesus macaque retina and RPE-choroid

Anaphylatoxin Complement Proteins C3a and C5a Induce AMD Cellular Endophenotypes in iPSC-RPE Through Apically Localized C3aR and C5aR Receptors

Differential transcriptome profile associated with pigmentation defects in induced pluripotent stem cell-derived retinal pigment epithelium from Albinism patients

Multimodal genomic analysis of hydroxychloroquine toxicity in a large cohort

De novo transcriptomes built from hundreds of human cornea, retina, and RPE RNA-seq samples identifies thousands of differentially expressed ocular specific gene transcripts and novel eye disease relevant exons

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