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Special Issue October 2021

One-Year Follow-Up in a Phase 1/2a Clinical Trial of an Allogeneic RPE Cell Bioengineered Implant for Advanced Dry Age-Related Macular Degeneration

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Amir H. Kashani; Jane S. Lebkowski; Firas M. Rahhal; Robert L. Avery; Hani Salehi-Had; Sanford Chen; Clement Chan; Neal Palejwala; April Ingram; Wei Dang; Chih-Min Lin; Debbie Mitra; Britney O. Pennington; Cassidy Hinman; Mohamed A. Faynus; Jeffrey K. Bailey; Sukriti Mohan; Narsing Rao; Lincoln V. Johnson; Dennis O. Clegg; David R. Hinton; Mark S. Humayun
TAGS: age-related macular degeneration, follow-up, implants, retinal pigment cell, surgical procedures, operative, postoperative care, therapeutic immunosuppression
Trans. Vis. Sci. Tech.. 2021; 10(10):13. doi: https://doi.org/10.1167/tvst.10.10.13

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

Mutations in splicing factors that cause Retinitis Pigmentosa (RP) do not affect splicing in a global manner

Revital Bronstein; Sudeep Mehrotra; Elizabeth E. Capowski; Leah Foltz; Michael H Farkas; David M Gamm; Dennis O Clegg; Eric A Pierce

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):379. doi:

ARVO Annual Meeting Abstract July 2018

HLA-E-Expressing “Universal” Pluripotent Stem Cells as a Source of Retinal Pigment Epithelium to Treat Age-Related Macular Degeneration

mei jiang; Marta Stevanovic; Vanda Lopes; Biju Thomas; David Russell; Mark S. Humayun; Dennis O Clegg

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):539. doi:

Articles November 2016

ROCK Inhibition Promotes Attachment, Proliferation, and Wound Closure in Human Embryonic Stem Cell–Derived Retinal Pigmented Epithelium

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Roxanne H. Croze; William J. Thi; Dennis O. Clegg
TAGS: embryonic stem cells, epithelium, wound closure, wounds and injuries
Trans. Vis. Sci. Tech.. 2016; 5(6):7. doi: https://doi.org/10.1167/tvst.5.6.7

Includes: Supplemental Content

ARVO Annual Meeting Abstract September 2016

SD-OCT Assessment of Retinal Structure After Subretinal Implantation of a Substrate-Adherent Monolayer of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium

Ana Martynova; Amir H Kashani; Rodrigo A Brant; Michael Koss; Danhong Zhu; David R Hinton; Dennis O Clegg; Mark S Humayun

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4270. doi:

ARVO Annual Meeting Abstract September 2016

Using the Extracellular Matrix to Engineer Stem Cell Therapies for Ocular Disease

Dennis O Clegg

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

Retina May 2016

Survival and Functionality of hESC-Derived Retinal Pigment Epithelium Cells Cultured as a Monolayer on Polymer Substrates Transplanted in RCS Rats

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Biju B. Thomas; Danhong Zhu; Li Zhang; Padmaja B. Thomas; Yuntao Hu; Hossein Nazari; Francisco Stefanini; Paulo Falabella; Dennis O. Clegg; David R. Hinton; Mark S. Humayun
TAGS: implants, polymers, rats, retinal pigment epithelium, transplantation, surgical procedures, operative, implantation procedure, retinal cone, eye, rod photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2016; 57(6):2877-2887. doi: https://doi.org/10.1167/iovs.16-19238

Nantotechnology and Regenerative Medicine February 2015

Canonical/β-Catenin Wnt Pathway Activation Improves Retinal Pigmented Epithelium Derivation From Human Embryonic Stem Cells

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Lyndsay L. Leach; David E. Buchholz; Vignesh P. Nadar; Stefan E. Lowenstein; Dennis O. Clegg
TAGS: embryonic stem cells, epithelium, mitf protein, signal transduction, polymerase chain reaction, pmel17, genes, gene expression, wnt signaling pathway
Invest. Ophthalmol. Vis. Sci.. 2015; 56(2):1002-1013. doi: https://doi.org/10.1167/iovs.14-15835

Includes: Supplemental Content

ARVO Annual Meeting Abstract April 2014

Induced Pluripotent Stem Cell-derived Tissues Elicit Selective Immunogenicity

Daniel Feitelberg; Peter D Westenskow; Stephen Bravo; Tongbiao Zhao; Zhili Rong; Carli M Wittgrove; Liliana P Paris; Dennis O Clegg; Yang Xu; Martin Friedlander

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):2673. doi:

ARVO Annual Meeting Abstract April 2014

Safety outcome of subretinal human embryonic stem cell-derived pigment epithelium (hESC-RPE) transplantation in Yucatan mini-pigs with oral or intravenous immunosupression.

Paulo Falabella; Michael J Koss; Francisco Rosa Stefanini; Marcel Pfister; Gerald J Chader; Biju B Thomas; Padmaja Thomas; Dennis O Clegg; David R Hinton; Mark S Humayun

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):2674. doi:

ARVO Annual Meeting Abstract April 2014

Functional consequences of the suppression of MHC-II expression on human stem cell derived retinal pigment epithelium (hES-RPE)

Hossein Nazari Khanamiri; Keijiro Ishikawa; Danhong Zhu; Sherry T Hikita; Dennis O Clegg; David R Hinton; Mark S Humayun

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3979. doi:

ARVO Annual Meeting Abstract April 2014

Comparative analysis of retinal layers after subretinal stem cell implantation in Yucatan mini-pigs

Francisco Rosa Stefanini; Michael J Koss; Paulo Falabella; Marcel Pfister; David R Hinton; Biju B Thomas; Padmaja Thomas; Dennis O Clegg; Mark S Humayun

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3999. doi:

ARVO Annual Meeting Abstract March 2012

Morphological and Functional Evaluation of hESC-RPE Cell Suspension Injection in RCS Rats

Laura Liu; Yuntao Hu; Alejandra Gonzalez-Calle; Danhong Zhu; Padmaja B. Thomas; Biju B. Thomas; Gerald J. Chader; Dennis O. Clegg; David R. Hinton; Mark S. Humayun

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):311. doi:

ARVO Annual Meeting Abstract March 2012

Behavioral and Electrophysiological Evaluation of Long-term Functionality of hESC Derived RPE Monolayer Implanted in RCS Rats

Biju B. Thomas; Alejandra Gonzalez-Calle; Yuntao Hu; Laura Liu; Danhong Zhu; Padmaja B. Thomas; Ann L. Philip; Dennis O. Clegg; David R. Hinton; Mark S. Humayun

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):313. doi:

ARVO Annual Meeting Abstract March 2012

Evaluation of hESC-Derived Retinal Pigment Epithelial Cells Cultured as a Monolayer on Polymer Substrate Transplanted in RCS Rats

Padmaja B. Thomas; Biju B. Thomas; Laura Liu; Yuntao Hu; Danhong Zhu; Ernesto Barron; Dennis O. Clegg; David R. Hinton; Mark S. Humayun

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):5920. doi:

ARVO Annual Meeting Abstract March 2012

Polarized Human Embryonic Stem Cell-Derived RPE Maintains its Monolayer Integrity and Function after Long-term in vitro Culture

Danhong Zhu; Dennis O. Clegg; David R. Hinton

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):5924. doi:

ARVO Annual Meeting Abstract April 2011

Quantitative Analysis of Possible Surgical Shear Force Stress on Polymer Substrates Seeded With Human Embryonic Stem Cell (hESC) Derived Retinal Pigment Epithelium (RPE) Monolayers Implanted into the Rat Subretinal Space

Biju B. Thomas; Laura Liu; Yuntao Hu; DaHong Zhu; Padmaja B. Thomas; Louis K. Hirsch; Ashish Ahuja; Dennis O. Clegg; David R. Hinton; Mark S. Humayun

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):3187. doi:

ARVO Annual Meeting Abstract April 2011

Human Embryonic Stem Cell Derived Retinal Pigment Epithelial Cells Cultured on Polymer Substrates Maintain a Confluent Monolayer Structure in the Subretinal Space of Implanted rats

Laura Liu; Yuntao Hu; Danhong Zhu; Padmaja B. Thomas; Kelsey Ford; Ashish K. Ahuja; Biju B. Thomas; Dennis O. Clegg; David R. Hinton; Mark S. Humayun

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):3190. doi:

ARVO Annual Meeting Abstract April 2011

Culture of Polarized Embryonic Stem Cell-Derived RPE on Synthetic Substrates

Danhong Zhu; Sherry T. Hikita; Xuemei Deng; Bo Lu; Lincoln V. Johnson; Dennis O. Clegg; Yuchong Tai; Ashish Ahuja; Mark Humayun; David R. Hinton

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):3191. doi:

OSA Fall Vision Meeting Abstract December 2008

Stem cell derived retinal pigment Epithelium for the treatment of age-related Macular degeneration

David E. Buchholz; Sherry T. Hikita; Monte J. Radeke; Kathryn E. Blashke; Lincoln V. Johnson; Dennis O. Clegg

Journal of Vision. 2008; 8(17):47. doi: https://doi.org/10.1167/8.17.47

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One-Year Follow-Up in a Phase 1/2a Clinical Trial of an Allogeneic RPE Cell Bioengineered Implant for Advanced Dry Age-Related Macular Degeneration

Mutations in splicing factors that cause Retinitis Pigmentosa (RP) do not affect splicing in a global manner

HLA-E-Expressing “Universal” Pluripotent Stem Cells as a Source of Retinal Pigment Epithelium to Treat Age-Related Macular Degeneration

ROCK Inhibition Promotes Attachment, Proliferation, and Wound Closure in Human Embryonic Stem Cell–Derived Retinal Pigmented Epithelium

SD-OCT Assessment of Retinal Structure After Subretinal Implantation of a Substrate-Adherent Monolayer of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium

Using the Extracellular Matrix to Engineer Stem Cell Therapies for Ocular Disease

Survival and Functionality of hESC-Derived Retinal Pigment Epithelium Cells Cultured as a Monolayer on Polymer Substrates Transplanted in RCS Rats

Canonical/β-Catenin Wnt Pathway Activation Improves Retinal Pigmented Epithelium Derivation From Human Embryonic Stem Cells

Induced Pluripotent Stem Cell-derived Tissues Elicit Selective Immunogenicity

Safety outcome of subretinal human embryonic stem cell-derived pigment epithelium (hESC-RPE) transplantation in Yucatan mini-pigs with oral or intravenous immunosupression.

Functional consequences of the suppression of MHC-II expression on human stem cell derived retinal pigment epithelium (hES-RPE)

Comparative analysis of retinal layers after subretinal stem cell implantation in Yucatan mini-pigs

Morphological and Functional Evaluation of hESC-RPE Cell Suspension Injection in RCS Rats

Behavioral and Electrophysiological Evaluation of Long-term Functionality of hESC Derived RPE Monolayer Implanted in RCS Rats

Evaluation of hESC-Derived Retinal Pigment Epithelial Cells Cultured as a Monolayer on Polymer Substrate Transplanted in RCS Rats

Polarized Human Embryonic Stem Cell-Derived RPE Maintains its Monolayer Integrity and Function after Long-term in vitro Culture

Quantitative Analysis of Possible Surgical Shear Force Stress on Polymer Substrates Seeded With Human Embryonic Stem Cell (hESC) Derived Retinal Pigment Epithelium (RPE) Monolayers Implanted into the Rat Subretinal Space

Human Embryonic Stem Cell Derived Retinal Pigment Epithelial Cells Cultured on Polymer Substrates Maintain a Confluent Monolayer Structure in the Subretinal Space of Implanted rats

Culture of Polarized Embryonic Stem Cell-Derived RPE on Synthetic Substrates

Stem cell derived retinal pigment Epithelium for the treatment of age-related Macular degeneration

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