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ARVO Annual Meeting Abstract June 2024

OCT and OCTA comparative study of Macula and Optic Nerve in Attention Deficit Hyperactivity Disorder

Jose Javier Garcia-Medina; Carmen Miquel-Lopez; Antonio Eusebio Lopez-Hernandez; Diego Garcia-Ayuso; Maravillas de-Paco-Matallana; Jose Manuel Tamarit; Maria D Pinazo-Duran; Monica del-Rio-Vellosillo

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5509.

Retinal Cell Biology April 2024

Dose-Related Side Effects of Intravitreal Injections of Humanized Anti-Vascular Endothelial Growth Factor in Rats: Glial Cell Reactivity and Retinal Ganglion Cell Loss

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Ana Martínez-Vacas; Johnny Di Pierdomenico; Ana María Gómez-Ramirez; Manuel Vidal-Sanz; María P. Villegas-Pérez; Diego García-Ayuso
TAGS: adverse effects, aflibercept, antibodies, anti-vascular endothelial growth factor therapy, endothelial growth factors, eye, intravitreal injections, mass or substance concentration per volume, neuroglia, painful bladder syndrome
Invest. Ophthalmol. Vis. Sci.. 2024; 65(4):10. https://doi.org/10.1167/iovs.65.4.10

Includes: Supplemental Content

Retinal Cell Biology March 2020

Coordinated Intervention of Microglial and Müller Cells in Light-Induced Retinal Degeneration

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Johnny Di Pierdomenico; Ana Martínez-Vacas; Daniel Hernández-Muñoz; Ana M. Gómez-Ramírez; Francisco Javier Valiente-Soriano; Marta Agudo-Barriuso; Manuel Vidal-Sanz; María P. Villegas-Pérez; Diego García-Ayuso
TAGS: neuroglia, photoreceptors, phototoxicity, retina, retinal cone, retinal degeneration, tissue degeneration, microglia, light exposure
Invest. Ophthalmol. Vis. Sci.. 2020; 61(3):47. https://doi.org/10.1167/iovs.61.3.47

Articles December 2019

Topical Brimonidine or Intravitreal BDNF, CNTF, or bFGF Protect Cones Against Phototoxicity

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Francisco J. Valiente-Soriano; Arturo Ortín-Martínez; Johnny Di Pierdomenico; Diego García-Ayuso; Alejandro Gallego-Ortega; Juan A. Miralles de Imperial-Ollero; Manuel Jiménez-López; María Paz Villegas-Pérez; Larry A. Wheeler; Manuel Vidal-Sanz
TAGS: brain-derived neurotrophic factor, brimonidine, ciliary neurotrophic factor, fibroblast growth factor 2, lip, phototoxicity, retina, retinal cone, opsin, mice
Trans. Vis. Sci. Tech.. 2019; 8(6):36. https://doi.org/10.1167/tvst.8.6.36

Retina September 2018

Neuroprotective Effects of FGF2 and Minocycline in Two Animal Models of Inherited Retinal Degeneration

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Johnny Di Pierdomenico; Rebecca Scholz; F. Javier Valiente-Soriano; Maria C. Sánchez-Migallón; Manuel Vidal-Sanz; Thomas Langmann; Marta Agudo-Barriuso; Diego García-Ayuso; María Paz Villegas-Pérez
TAGS: animal model, fibroblast growth factor 2, minocycline, neuroprotective effect, photoreceptors, retinal degeneration, ciliary neurotrophic factor, rats
Invest. Ophthalmol. Vis. Sci.. 2018; 59(11):4392-4403. https://doi.org/10.1167/iovs.18-24621

Retina March 2018

Taurine Depletion Causes ipRGC Loss and Increases Light-Induced Photoreceptor Degeneration

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Diego García-Ayuso; Johnny Di Pierdomenico; Wahiba Hadj-Said; Mélanie Marie; Marta Agudo-Barriuso; Manuel Vidal-Sanz; Serge Picaud; María P. Villegas-Pérez
TAGS: retinal degeneration, taurine, tissue degeneration, retinal cone, photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2018; 59(3):1396-1409. https://doi.org/10.1167/iovs.17-23258

ARVO Annual Meeting Abstract June 2017

Differential and additive effects of bFGF and minocycline in two animal models of inherited retinal degeneration.

Johnny Di Pierdomenico; Diego Garcia-Ayuso; Marta Agudo-Barriuso; Manuel Vidal-Sanz; Maria Paz Villegas-Perez

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4549.

ARVO Annual Meeting Abstract June 2017

The effect of light exposure in the population of different retinal neurons under taurine depletion

Diego Garcia-Ayuso; Johnny Di Pierdomenico; Wahiba Hadj Said; Melanie MARIE; Marta Agudo-Barriuso; Manuel Vidal-Sanz; Serge A Picaud; Maria Paz Villegas-Perez

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):290.

ARVO Annual Meeting Abstract June 2017

Taurine deficiency induces retinal inflammation

Wahiba Hadj Said; Élisabeth Dubus; Stéphane Fouquet; Sauleine Sanglier; Diego Garcia-Ayuso; Maria Paz Villegas-Perez; Jose Alain Sahel; Serge A Picaud

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5870.

ARVO Annual Meeting Abstract September 2016

Study of the neuroprotective effects of BDNF, bFGF, CNTF or several doses of PEDF in a focal Light-emission-diode (LED) - induced phototoxicity model in adult albino mice

F Javier Valiente-Soriano; Diego García-Ayuso; Arturo Ortin-Martinez; Manuel Jimenez-Lopez; Yolanda Caja-Matas; Antonio Cánovas-León; Jose Manuel Bernal-Garro; S Patricia Becerra; María Paz Villegas-Pérez; Manuel Vidal-Sanz

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):186.

ARVO Annual Meeting Abstract September 2016

Glial cell activation and migration during photoreceptor death in two rat models of inherited retinal degeneration.

Johnny Di Pierdomenico; Diego García-Ayuso; Marta Agudo-Barriuso; Manuel Vidal-Sanz; María Paz Villegas-Pérez

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2241.

ARVO Annual Meeting Abstract September 2016

Repeated intravitreal injections cause stronger microglial and macroglial reactions than single injections

María Paz Villegas-Pérez; Johnny Di Pierdomenico; Diego Garcia-Ayuso; Manuel Jimenez-Lopez; Ana María Gómez-Ramírez; Marta Agudo-Barriuso; Manuel Vidal-Sanz

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2676.

ARVO Annual Meeting Abstract September 2016

Phototoxicity causes a transient downregulation of melanopsin in the rat retina.

Diego García-Ayuso; Caridad Galindo-Romero; Johnny Di Pierdomenico; Jose Manuel Bernal-Garro; Marcelino Avilés-Trigueros; Manuel Vidal-Sanz; Marta Agudo-Barriuso; María Paz Villegas-Pérez

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2747.

Retina September 2016

Quantitative and Topographical Analysis of the Losses of Cone Photoreceptors and Retinal Ganglion Cells Under Taurine Depletion

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Wahiba Hadj-Saïd; Nicolas Froger; Ivana Ivkovic; Manuel Jiménez-López; Élisabeth Dubus; Julie Dégardin-Chicaud; Manuel Simonutti; César Quénol; Nathalie Neveux; María Paz Villegas-Pérez; Marta Agudo-Barriuso; Manuel Vidal-Sanz; Jose-Alain Sahel; Serge Picaud; Diego García-Ayuso
TAGS: retina, retinal cone, taurine, retinal degeneration, retinal ganglion cells, mice, opsin
Invest. Ophthalmol. Vis. Sci.. 2016; 57(11):4692-4703. https://doi.org/10.1167/iovs.16-19535

Retinal Cell Biology July 2016

Different Ipsi- and Contralateral Glial Responses to Anti-VEGF and Triamcinolone Intravitreal Injections in Rats

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Johnny Di Pierdomenico; Diego García-Ayuso; Manuel Jiménez-López; Marta Agudo-Barriuso; Manuel Vidal-Sanz; María Paz Villegas-Pérez
TAGS: antibodies, anti-vascular endothelial growth factor therapy, injections, intravitreal injections, microglia, rats, retina, triamcinolone, eye, glial fibrillary acidic protein
Invest. Ophthalmol. Vis. Sci.. 2016; 57(8):3533-3544. https://doi.org/10.1167/iovs.16-19618

Retina July 2015

Inherited Photoreceptor Degeneration Causes the Death of Melanopsin-Positive Retinal Ganglion Cells and Increases Their Coexpression of Brn3a

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Diego García-Ayuso; Johnny Di Pierdomenico; Gema Esquiva; Francisco Manuel Nadal-Nicolás; Isabel Pinilla; Nicolás Cuenca; Manuel Vidal-Sanz; Marta Agudo-Barriuso; María P. Villegas-Pérez
TAGS: melanopsin, photoreceptors, rats, tissue degeneration, retina, retinal ganglion cells, antibodies
Invest. Ophthalmol. Vis. Sci.. 2015; 56(8):4592-4604. https://doi.org/10.1167/iovs.15-16808

ARVO Annual Meeting Abstract June 2015

Focal Light-emitting-diode (LED)-induced cone photoreceptor degeneration in mice can be prevented with Brimonidine or trophic factors.

Manuel Vidal-Sanz; F Javier Valiente-Soriano; Arturo Ortin-Martinez; Diego García-Ayuso; Manuel Jiménez-López; Jose M Bernal-Garro; Luis Alarcón-Martínez; Larry A Wheeler; Maria Paz Villegas-Perez

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5667.

ARVO Annual Meeting Abstract June 2015

Retinal distribution of cone and retinal ganglion cell degenerations in taurine-depleted mice

Wahiba Hadj Said; Diego García-Ayuso; Nicolas G Froger; Ivana Ivkovic; Manuel Jiménez-López; Julie Degardin; Manuel SIMONUTTI; Manuel Vidal-Sanz; Jose Alain Sahel; Serge A Picaud

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4646.

ARVO Annual Meeting Abstract April 2014

Characterization of a new model of focal cone degeneration induced by a Light-emitting-diode (LED).

F Javier Valiente-Soriano; Arturo Ortin-Martinez; Diego García-Ayuso; Manuel Jimenez-Lopez; Luis Alarcon-Martinez; Jose Manuel Bernal-Garro; Francisco Manuel Nadal-Nicolas; Marta Agudo; Maria Paz Villegas-Perez; Manuel Vidal-Sanz

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):4368.

ARVO Annual Meeting Abstract April 2014

Cone neuroprotection afforded by Brimonidine and BDNF in a new model of focal Light-Emitting-Diode (LED)-induced phototoxicity

Arturo Ortin-Martinez; F Javier Valiente-Soriano; Diego García-Ayuso; Manuel Jimenez-Lopez; Luis Alarcon-Martinez; Jose Manuel Bernal-Garro; Leticia Nieto-Lopez; Marta Agudo; Maria Paz Villegas-Perez; Manuel Vidal-Sanz

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):4369.

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OCT and OCTA comparative study of Macula and Optic Nerve in Attention Deficit Hyperactivity Disorder

Dose-Related Side Effects of Intravitreal Injections of Humanized Anti-Vascular Endothelial Growth Factor in Rats: Glial Cell Reactivity and Retinal Ganglion Cell Loss

Coordinated Intervention of Microglial and Müller Cells in Light-Induced Retinal Degeneration

Topical Brimonidine or Intravitreal BDNF, CNTF, or bFGF Protect Cones Against Phototoxicity

Neuroprotective Effects of FGF2 and Minocycline in Two Animal Models of Inherited Retinal Degeneration

Taurine Depletion Causes ipRGC Loss and Increases Light-Induced Photoreceptor Degeneration

Differential and additive effects of bFGF and minocycline in two animal models of inherited retinal degeneration.

The effect of light exposure in the population of different retinal neurons under taurine depletion

Taurine deficiency induces retinal inflammation

Study of the neuroprotective effects of BDNF, bFGF, CNTF or several doses of PEDF in a focal Light-emission-diode (LED) - induced phototoxicity model in adult albino mice

Glial cell activation and migration during photoreceptor death in two rat models of inherited retinal degeneration.

Repeated intravitreal injections cause stronger microglial and macroglial reactions than single injections

Phototoxicity causes a transient downregulation of melanopsin in the rat retina.

Quantitative and Topographical Analysis of the Losses of Cone Photoreceptors and Retinal Ganglion Cells Under Taurine Depletion

Different Ipsi- and Contralateral Glial Responses to Anti-VEGF and Triamcinolone Intravitreal Injections in Rats

Inherited Photoreceptor Degeneration Causes the Death of Melanopsin-Positive Retinal Ganglion Cells and Increases Their Coexpression of Brn3a

Focal Light-emitting-diode (LED)-induced cone photoreceptor degeneration in mice can be prevented with Brimonidine or trophic factors.

Retinal distribution of cone and retinal ganglion cell degenerations in taurine-depleted mice

Characterization of a new model of focal cone degeneration induced by a Light-emitting-diode (LED).

Cone neuroprotection afforded by Brimonidine and BDNF in a new model of focal Light-Emitting-Diode (LED)-induced phototoxicity

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