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Retina October 2024

Endpoints and Design for Clinical Trials in USH2A -Related Retinal Degeneration: Results and Recommendations From the RUSH2A Natural History Study

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Maureen G. Maguire; David G. Birch; Jacque L. Duncan; Allison R. Ayala; Lauren N. Ayton; Janet K. Cheetham; Peiyao Cheng; Todd A. Durham; Frederick L. Ferris, III; Carel B. Hoyng; Rachel M. Huckfeldt; Glenn J. Jaffe; Christine Kay; Eleonora M. Lad; Bart P. Leroy; Wendi Liang; Lee S. McDaniel; Michele Melia; Michel Michaelides; Mark E. Pennesi; José-Alain Sahel; Lassana Samarakoon; on behalf of the REDI Working Group and the Foundation Fighting Blindness Clinical Consortium Investigator Group
TAGS: cohort studies, eye, natural history, outcome measures, retinal degeneration, sample size, surrogate endpoints, vision, united states food and drug administration, perimetry
Trans. Vis. Sci. Tech.. 2024; 13(10):15. https://doi.org/10.1167/tvst.13.10.15

Includes: Supplemental Content

Artificial Intelligence August 2024

Topographic Clinical Insights From Deep Learning–Based Geographic Atrophy Progression Prediction

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Julia Cluceru; Neha Anegondi; Simon S. Gao; Aaron Y. Lee; Eleonora M. Lad; Usha Chakravarthy; Qi Yang; Verena Steffen; Michel Friesenhahn; Christina Rabe; Daniela Ferrara
TAGS: ablation, age-related macular degeneration, nonexudative, datasets, deep learning, masks, diagnostic imaging, growth rate, pixel, shape
Trans. Vis. Sci. Tech.. 2024; 13(8):6. https://doi.org/10.1167/tvst.13.8.6

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

Photobiomodulation Using the Valeda Multiwavelength Light Delivery System Demonstrates Significant Reduction in Risk for Vision Loss and Onset of Geographic Atrophy in Dry Age-Related Macular Degeneration

Todd Schneiderman; Victor H Gonzalez; David S Boyer; Richard B Rosen; Samantha Xavier; Allen Hu; David Warrow; Eleonora M Lad; Diana V Do; Allen Ho; Glenn J Jaffe; Marion Ronit Munk; Cindy Croissant; Stephanie Tedford; Rene Ruckert; Clark Tedford

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):379.

ARVO Annual Meeting Abstract June 2024

CD163-related biomarkers and association with functional impairment in intermediate age-related macular degeneration

Catherine Yao; Aden Swayze; Tajah Damm; Malina Sexton; Sandra S. Stinnett; Simone Degan; Eleonora M Lad

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3792.

Artificial Intelligence March 2024

RobOCTNet: Robotics and Deep Learning for Referable Posterior Segment Pathology Detection in an Emergency Department Population

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Ailin Song; Jay B. Lusk; Kyung-Min Roh; S. Tammy Hsu; Nita G. Valikodath; Eleonora M. Lad; Kelly W. Muir; Matthew M. Engelhard; Alexander T. Limkakeng; Joseph A. Izatt; Ryan P. McNabb; Anthony N. Kuo
TAGS: deep learning, emergency service, hospital, pathology, robotics, training, eye
Trans. Vis. Sci. Tech.. 2024; 13(3):12. https://doi.org/10.1167/tvst.13.3.12

Includes: Multimedia, Supplemental Content

ARVO Annual Meeting Abstract June 2023

Pooled safety analysis of a single intravitreal injection of JNJ-1887 (gene therapy, AAVCAGsCD59) in patients with age-related macular degeneration (AMD)

Eleonora M Lad; Daniel L Chao; Anthony Pepio; Wei Zhang; George Capuano; Adam Rogers; Brad J Baker; Michael Cohen; H. Nida Sen; Jeffrey S Heier

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):732.

ARVO Annual Meeting Abstract June 2023

Molecular Signature of Subretinal Microglia Signifies an Adaptive Response that is Protective in Retinal Degeneration (RD) Mice and is Conserved in Human AMD

Daniel Saban; Chen Yu; Sejiro Littleton; Catherine Bowes Rickman; Alan D. Proia; Eleonora M Lad

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2862.

ARVO Annual Meeting Abstract June 2023

Histopathological characterization of connective tissue growth factor (CTGF) expression in human eyes with age-related macular degeneration and diabetic retinopathy

Ella Arnon; Mathieu Brecheisen; Sabine Uhles; Peter D Westenskow; Eleonora M Lad; Alan D. Proia

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2749.

ARVO Annual Meeting Abstract June 2023

Association of National Eye Institute Visual Function Questionnaire 39 (NEI-VFQ39) Scores with Visual Function in Age-related Macular Degeneration over 24 months

Catherine Yao; Sandra Stinnett; Victoria Lue; Ulrich F O Luhmann; Eleonora M Lad

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2745.

ARVO Annual Meeting Abstract June 2022

Microperimetry and optical coherence tomography measures over 2 years in the RUSH2A study: annual rates of change from mixed effects modeling

Ajoy Vincent; Eleonora M Lad

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3339 – F0148.

ARVO Annual Meeting Abstract June 2022

Assessment of deep learning-based triage for robotically acquired retinal optical coherence tomography (OCT) images in an emergency department population

Ailin Song; Kyung-Min Roh; Jay Lusk; Nita Valikodath; Eleonora M Lad; Alexander T Limkakeng; Joseph A. Izatt; Ryan P McNabb; Anthony N Kuo

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3018 – F0288.

ARVO Annual Meeting Abstract June 2022

Monocyte Biomarkers of Early-Intermediate Age-Related Macular Degeneration

Aden Swayze; Leonie Kurzlechner; Malina Sexton; Alan D Proia; Simone Degan; Eleonora M Lad

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):362 – F0193.

ARVO Annual Meeting Abstract June 2022

Change in Low Luminance Questionnaire (LLQ) scores in early and intermediate AMD over 24 months

Richmond Woodward; Pali Singh; Sandra Stinnett; Ulrich F O Luhmann; Eleonora M Lad

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):318 – F0149.

ARVO Annual Meeting Abstract June 2022

Cone contrast testing as an early functional biomarker of age-related macular degeneration

Vaishali H Oza; Leonie Kurzlechner; Cheryl Nordstrom; Ulrich F O Luhmann; Sandra Stinnett; Eleonora M Lad

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):317 – F0148.

ARVO Annual Meeting Abstract June 2022

Augmentation of Protective Microglia Restricts Outer Retinal Degeneration and Preserves Vision

Chen Yu; Eleonora M Lad; Alan Proia; Daniel R Saban

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):23.

ARVO Annual Meeting Abstract June 2022

A Deep Learning Algorithm to Predict Short-term Progression to Geographic Atrophy on Spectral Domain-OCT

Eleonora M Lad; Cynthia A Toth; Dong Wang; Ricardo Henao; Lawrence Carin

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3016 – F0286.

ARVO Annual Meeting Abstract June 2021

A Phase 1b Multi-Center, Open Label, Single-Arm Safety Study of Intravitreal Pegcetacoplan Supporting the Phase 3 DERBY and OAKS Studies for Geographic Atrophy: A Solution to “Tarmac Delay"

Nathan Steinle; jeffrey heier; Rishi P Singh; David S Boyer; Eleonora M Lad; Ravi Metlapally; Ramiro Ribiero; Charles Clifton Wykoff; Chris Holmes

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):278.

ARVO Annual Meeting Abstract June 2021

The RUSH2A study: Baseline microperimetry and SD-OCT measures

Eleonora M Lad; Wendi Liang; Glenn J Jaffe; Zengtian Deng; Jessica Loo; Dibyendu Mukherjee; Sina Farsiu

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2435.

ARVO Annual Meeting Abstract June 2021

Analyzing the Retinal and Choroidal Vasculature and Structure in Cognitively Healthy Individuals at Higher Genetic Risk for Alzheimer’s Disease using a Convolutional Neural Network

Cason Robbins; Dilraj Singh Grewal; Dong Wang; Clayton Wisely; Ricardo Henao; Jia Min Lee; Rupesh V Agrawal; Srinath Soundararajan; Atalie C. Thompson; Brenda Plassman; Eleonora M Lad; Heather Whitson; Lawrence Carin; Sharon Fekrat

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2489.

ARVO Annual Meeting Abstract June 2021

Robotically aligned OCT enables physically distanced imaging and relevant measurements in a retina clinic population

Ryan P McNabb; Pablo Ortiz; Kyung-Min Roh; Mark Draelos; Stefanie G Schuman; Glenn J Jaffe; Eleonora M Lad; Joseph Izatt; Anthony N Kuo

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2457.

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Endpoints and Design for Clinical Trials in USH2A -Related Retinal Degeneration: Results and Recommendations From the RUSH2A Natural History Study

Topographic Clinical Insights From Deep Learning–Based Geographic Atrophy Progression Prediction

Photobiomodulation Using the Valeda Multiwavelength Light Delivery System Demonstrates Significant Reduction in Risk for Vision Loss and Onset of Geographic Atrophy in Dry Age-Related Macular Degeneration

CD163-related biomarkers and association with functional impairment in intermediate age-related macular degeneration

RobOCTNet: Robotics and Deep Learning for Referable Posterior Segment Pathology Detection in an Emergency Department Population

Pooled safety analysis of a single intravitreal injection of JNJ-1887 (gene therapy, AAVCAGsCD59) in patients with age-related macular degeneration (AMD)

Molecular Signature of Subretinal Microglia Signifies an Adaptive Response that is Protective in Retinal Degeneration (RD) Mice and is Conserved in Human AMD

Histopathological characterization of connective tissue growth factor (CTGF) expression in human eyes with age-related macular degeneration and diabetic retinopathy

Association of National Eye Institute Visual Function Questionnaire 39 (NEI-VFQ39) Scores with Visual Function in Age-related Macular Degeneration over 24 months

Microperimetry and optical coherence tomography measures over 2 years in the RUSH2A study: annual rates of change from mixed effects modeling

Assessment of deep learning-based triage for robotically acquired retinal optical coherence tomography (OCT) images in an emergency department population

Monocyte Biomarkers of Early-Intermediate Age-Related Macular Degeneration

Change in Low Luminance Questionnaire (LLQ) scores in early and intermediate AMD over 24 months

Cone contrast testing as an early functional biomarker of age-related macular degeneration

Augmentation of Protective Microglia Restricts Outer Retinal Degeneration and Preserves Vision

A Deep Learning Algorithm to Predict Short-term Progression to Geographic Atrophy on Spectral Domain-OCT

A Phase 1b Multi-Center, Open Label, Single-Arm Safety Study of Intravitreal Pegcetacoplan Supporting the Phase 3 DERBY and OAKS Studies for Geographic Atrophy: A Solution to “Tarmac Delay"

The RUSH2A study: Baseline microperimetry and SD-OCT measures

Analyzing the Retinal and Choroidal Vasculature and Structure in Cognitively Healthy Individuals at Higher Genetic Risk for Alzheimer’s Disease using a Convolutional Neural Network

Robotically aligned OCT enables physically distanced imaging and relevant measurements in a retina clinic population

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