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Artificial Intelligence February 2025

Deep Learning Approaches to Predict Geographic Atrophy Progression Using Three-Dimensional OCT Imaging

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Kenta Yoshida; Neha Anegondi; Adam Pely; Miao Zhang; Frederic Debraine; Karthik Ramesh; Verena Steffen; Simon S. Gao; Catherine Cukras; Christina Rabe; Daniela Ferrara; Richard F. Spaide; SriniVas R. Sadda; Frank G. Holz; Qi Yang
TAGS: age-related macular degeneration, nonexudative, datasets, deep learning, diagnostic imaging, growth rate
Trans. Vis. Sci. Tech.. 2025; 14(2):11. https://doi.org/10.1167/tvst.14.2.11

Includes: Supplemental Content

Retina January 2025

Characterization of the Disorganization of the Inner Retinal Layers in Diabetics Using Increased Axial Resolution Optical Coherence Tomography

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Katharina Wall; Lilith P. Arend; Leon von der Emde; Marlene Saßmannshausen; Frank G. Holz; Thomas Ach
TAGS: diabetes mellitus, diagnostic imaging, optical coherence tomography, spectral domain-optical coherence tomography
Trans. Vis. Sci. Tech.. 2025; 14(1):12. https://doi.org/10.1167/tvst.14.1.12

Retina January 2025

Deep Learning–Based SD-OCT Layer Segmentation Quantifies Outer Retina Changes in Patients With Biallelic RPE65 Mutations Undergoing Gene Therapy

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German Pinedo-Diaz; Birgit Lorenz; Sandrine H. Künzel; Sarah Thiele; Susana Ortega-Cisneros; Eduardo Bayro Corrochano; Frank G. Holz; Alexander Effland
TAGS: retina, rpe65 protein, spectral domain-optical coherence tomography, biological markers, deep learning, mutation, gene therapy, datasets
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):5. https://doi.org/10.1167/iovs.66.1.5

Includes: Supplemental Content

Retina December 2024

Prognostic Relevance of Relative Ellipsoid Zone Reflectivity for Ellipsoid Zone Loss in Macular Telangiectasia Type 2

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Lukas Goerdt; Jose Luis Rodriguez Garcia; Sandrine H. Künzel; Kristina Pfau; Kristin Raming; Simone Tzaridis; Matthias Schmid; Frank G. Holz; Ben Isselmann; Leonie Weinhold; Sarah Thiele
TAGS: patient prognosis, telangiectasis, spectral domain-optical coherence tomography
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):36. https://doi.org/10.1167/iovs.65.14.36

Artificial Intelligence September 2024

Generalizable Deep Learning for the Detection of Incomplete and Complete Retinal Pigment Epithelium and Outer Retinal Atrophy: A MACUSTAR Report

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Coen de Vente; Philippe Valmaggia; Carel B. Hoyng; Frank G. Holz; Mohammad M. Islam; Caroline C. W. Klaver; Camiel J. F. Boon; Steffen Schmitz-Valckenberg; Adnan Tufail; Marlene Saßmannshausen; Clara I. Sánchez; on behalf of the MACUSTAR Consortium
TAGS: datasets, deep learning, eye, retinal atrophy, retinal pigment epithelium, biological markers, cohort studies, training
Trans. Vis. Sci. Tech.. 2024; 13(9):11. https://doi.org/10.1167/tvst.13.9.11

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

Letter Acuity and Reading with a Subretinal Photovoltaic Implant in Geographic Atrophy

Mahi Muqit; Yannick Le Mer; Lisa Olmos de Koo; Frank G Holz; Jose Sahel; Daniel V Palanker

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6486.

ARVO Annual Meeting Abstract June 2024

Optic disc drusen in Pseudoxanthoma elasticum are associated with the extent of Bruch's membrane calcification

Kristin Raming; Sandrine H. Künzel; Maximilian Pfau; Doris Hendig; Frank G Holz; Kristina Pfau

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):404.

ARVO Annual Meeting Abstract June 2024

Deep-learning based quantification of RPE65- mutation inherited retinal degeneration from wide-angle images – novel biomarkers for natural history and interventional studies.

Birgit Lorenz; Eduardo Dávila-Meza; Sandrine H. Künzel; Frank G Holz; Eduardo Bayro-Corrochano; Alexander Effland

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1392.

ARVO Annual Meeting Abstract June 2024

Modeling reading speed and comfort in single and multiple subretinal implants

Clara Zabban; Seyda Ozcelik; Frank G Holz; Jose Alain Sahel; Ralf Hornig

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5422.

ARVO Annual Meeting Abstract June 2024

Improving the detection of progression in longitudinal microperimetry data in age-related macular degeneration by using pointwise analysis of data - a MACUSTAR study report

Jeremy TAN; Giovanni Montesano; Charlotte Behning; Hannah M P Dunbar; Robert Finger; Jan Henrik Terheyden; Stephen H Poor; Sergio Leal; Adnan Tufail; Frank G Holz; Ulrich F O Luhmann; David P. Crabb

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5686.

ARVO Annual Meeting Abstract June 2024

Geographic atrophy secondary to age-related macular degeneration: Significance of lesion location and functional determinants to vision-related quality of life

Eliza Eliza Broadbent; Sandrine H. Künzel; Philipp Möller; Moritz Linder; Lukas Goerdt; Joanna Czauderna; Steffen Schmitz-Valckenberg; Frank G Holz; Maximilian Pfau; Monika Fleckenstein

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5973.

ARVO Annual Meeting Abstract June 2024

Associations between structural phenotype and pathway-specific polygenic risk scores in intermediate age-related macular degeneration – a MACUSTAR report

Lukas Schloesser; Jan Henrik Terheyden; Charlotte Behning; Hannah Klinkhammer; Davide Garzone; Marlene Sassmannshausen; Steffen Schmitz-Valckenberg; Carel C B Hoyng; Clarisa Sanchez; Ulrich F O Luhmann; Klaus-Peter Moll; Sergio Leal; Matthias Schmid; Frank G Holz; Robert Finger

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):378.

ARVO Annual Meeting Abstract June 2024

The prognostic power of baseline visual function deficits in intermediate age-related macular degeneration (iAMD) for progression to late AMD - A MACUSTAR study report

Hannah M P Dunbar; Charlotte Behning; Alison M Binns; Jan Henrik Terheyden; Stephen H Poor; Robert Finger; David P. Crabb; Sergio Leal; Adnan Tufail; Frank G Holz; Matthias Schmid; Ulrich F O Luhmann

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1485.

ARVO Annual Meeting Abstract June 2024

Selective quantification of rod and cone photoreceptors using a high-resolution optical coherence tomography device.

Leon Alexander von der Emde; Julius Ameln; Aleksandr Gutnikov; Giulia Ritter; Frank G Holz; Wolf Harmening; Thomas Ach

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1420.

ARVO Annual Meeting Abstract June 2024

Patient-tailored fundus-controlled perimetry testing in intermediate and early atrophic age-related macular degeneration

Steffen Schmitz-Valckenberg; Petrus Chang; Monika Fleckenstein; Frank G Holz; Zhichao Wu; Robyn H Guymer; Liang Liu; Hao Chen; Maximilian Pfau

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2794.

ARVO Annual Meeting Abstract June 2024

Association of Ellipsoid Zone Reflectivity and Choriocapillaris Flow in Age-Related Macular Degeneration: a MACUSTAR study report

Yannick N. Liermann; Ben Isselmann; Marlene Sassmannshausen; Sandrine H. Künzel; Ulrich F O Luhmann; Sergio Leal; Matthias Schmid; Robert Finger; Steffen Schmitz-Valckenberg; Frank G Holz; Charlotte Behning; Sarah Thiele

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2315.

ARVO Annual Meeting Abstract June 2024

Remofuscin slows retinal thinning in Stargardt Disease (STGD1) – results from the Stargardt Remofuscin Treatment Trial (STARTT) a 2-year placebo-controlled study.

Tobias Peters; Katarina Stingl; Wolfgang Klein; Mario G Fsadni; Nils Meland; Patty P.A. Dhooge; Camiel Boon; Andrew Lotery; Maurizio Battaglia Parodi; Philipp Herrmann; Frank G Holz; Steffen Schmitz-Valckenberg; Philipp Möller; Carel C B Hoyng

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2205.

ARVO Annual Meeting Abstract June 2024

Real-world safety and effectiveness of voretigene neparvovec: Year 3 interim results from the PERCEIVE study

M Dominik Fischer; Francesca Simonelli; Isabelle S Audo; Bart Peter Leroy; Line Kessel; Joao Pedro Marques; Mirjana Bjelos; James Bainbridge; Manar Aoun; Rainer Maier; Rehna Khan; Andreas Clemens; Frank G Holz

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3290.

ARVO Annual Meeting Abstract June 2024

Characterizing the disorganization of the retinal inner layers in diabetic retinopathy: using a new high-resolution optical coherence tomography device

Katharina Wall; Lilith P. Arend; Leon Alexander von der Emde; Marlene Sassmannshausen; Frank G Holz; Thomas Ach

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3199.

ARVO Annual Meeting Abstract June 2024

Reduced relative Ellipsoid Zone Reflectivity is associated with Ellipsoid Zone loss development and progression in Macular Telangiectasia Type 2

Lukas Goerdt; Leonie Weinhold; Ben Isselmann; Jose Luis Rodriguez; Sandrine H. Künzel; Kristina Pfau; Kristin Raming; Simone Tzaridis; Frank G Holz; Sarah Thiele

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3130.

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Deep Learning Approaches to Predict Geographic Atrophy Progression Using Three-Dimensional OCT Imaging

Characterization of the Disorganization of the Inner Retinal Layers in Diabetics Using Increased Axial Resolution Optical Coherence Tomography

Deep Learning–Based SD-OCT Layer Segmentation Quantifies Outer Retina Changes in Patients With Biallelic RPE65 Mutations Undergoing Gene Therapy

Prognostic Relevance of Relative Ellipsoid Zone Reflectivity for Ellipsoid Zone Loss in Macular Telangiectasia Type 2

Generalizable Deep Learning for the Detection of Incomplete and Complete Retinal Pigment Epithelium and Outer Retinal Atrophy: A MACUSTAR Report

Letter Acuity and Reading with a Subretinal Photovoltaic Implant in Geographic Atrophy

Optic disc drusen in Pseudoxanthoma elasticum are associated with the extent of Bruch's membrane calcification

Deep-learning based quantification of RPE65- mutation inherited retinal degeneration from wide-angle images – novel biomarkers for natural history and interventional studies.

Modeling reading speed and comfort in single and multiple subretinal implants

Improving the detection of progression in longitudinal microperimetry data in age-related macular degeneration by using pointwise analysis of data - a MACUSTAR study report

Geographic atrophy secondary to age-related macular degeneration: Significance of lesion location and functional determinants to vision-related quality of life

Associations between structural phenotype and pathway-specific polygenic risk scores in intermediate age-related macular degeneration – a MACUSTAR report

The prognostic power of baseline visual function deficits in intermediate age-related macular degeneration (iAMD) for progression to late AMD - A MACUSTAR study report

Selective quantification of rod and cone photoreceptors using a high-resolution optical coherence tomography device.

Patient-tailored fundus-controlled perimetry testing in intermediate and early atrophic age-related macular degeneration

Association of Ellipsoid Zone Reflectivity and Choriocapillaris Flow in Age-Related Macular Degeneration: a MACUSTAR study report

Remofuscin slows retinal thinning in Stargardt Disease (STGD1) – results from the Stargardt Remofuscin Treatment Trial (STARTT) a 2-year placebo-controlled study.

Real-world safety and effectiveness of voretigene neparvovec: Year 3 interim results from the PERCEIVE study

Characterizing the disorganization of the retinal inner layers in diabetic retinopathy: using a new high-resolution optical coherence tomography device

Reduced relative Ellipsoid Zone Reflectivity is associated with Ellipsoid Zone loss development and progression in Macular Telangiectasia Type 2

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