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ARVO Annual Meeting Abstract June 2022

Ex vivo analysis of mast cell degranulation in human donor choroids

Imran Ahmed Bhutto; Tomohiro Niizawa; Alexandra Pado; Erin McDonnell; Gerard A Lutty; Malia Michelle Edwards

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3029 – F0400. doi:

ARVO Annual Meeting Abstract June 2022

Improved generation and long-term engraftment of retinal organoids from Tankyrase/PARP-Inhibitor-Regulated Naïve human pluripotent stem cells (TIRN-hPSC)

Ludovic Zimmerlin; Imran Ahmed Bhutto; Riya Kanherkar; Tea Soon Park; Michael Barbato; Michael Koldobskiy; Ying Liu; Mandeep Singh; Gerard A Lutty; Elias T Zambidis

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3725 – F0331. doi:

Articles December 2021

Topical Ketotifen Fumarate Inhibits Choroidal Mast Cell Degranulation and Loss of Retinal Pigment Epithelial Cells in Rat Model for Geographic Atrophy

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Tomohiro Nizawa; Imran A. Bhutto; Anupama Tiwari; Rhonda R. Grebe; Jesse Alt; Rana Rais; Malia M. Edwards; Gerard A. Lutty
TAGS: atrophy, choroid, electroretinography, eyedrops, gel, hydrogel, ketotifen, mast cell degranulation, mast-cell sarcoma, minimally conscious state
Trans. Vis. Sci. Tech.. 2021; 10(14):37. doi: https://doi.org/10.1167/tvst.10.14.37

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2021

Topical Ketotifen fumarate inhibits mast cell degranulation and loss of retinal pigment epithelial cells in rat model for geographic atrophy

Tomohiro Niizawa; Imran Ahmed Bhutto; Anupama Tiwari; Rhonda R. Grebe; Jesse Alt; Rana Rais; Malia Michelle Edwards; Gerard A Lutty

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):252. doi:

Retinal Cell Biology July 2020

Retinal Glial and Choroidal Vascular Pathology in Donors Clinically Diagnosed With Stargardt Disease

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Malia M. Edwards; Vera L. Bonilha; Imran A. Bhutto; Brent A. Bell; D. Scott McLeod; Joe G. Hollyfield; Gerard A. Lutty
TAGS: donors, retina, stargardt's disease, chief complaint, atrophy, diagnostic imaging, pathology, tissue membrane, eye, neuroglia
Invest. Ophthalmol. Vis. Sci.. 2020; 61(8):27. doi: https://doi.org/10.1167/iovs.61.8.27

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2020

Visualization of choroidal vasculature in pigmented mouse eyes

Imran Ahmed Bhutto; Anupama Tiwari; Benjamin R Thomson; Malia Michelle Edwards; Gerard A Lutty

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2235. doi:

ARVO Annual Meeting Abstract June 2020

Increased expression of epithelial-to-mesenchymal transition markers in geographic atrophy

Anupama Tiwari; Imran Ahmed Bhutto; Malia Michelle Edwards; Rhonda Grebe; Gerard A Lutty

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2273. doi:

ARVO Annual Meeting Abstract June 2020

Long-term engraftment of mature human photoreceptors following subretinal transplantation of naïve hPSC-derived retinal organoids

Elias Zambidis; Imran Ahmed Bhutto; Riya T Kanherkar; Tea Soon Park; Rebecca T Moses; Ludovic T Zimmerlin; Ying T Liu; Mandeep S Singh; Gerard A Lutty

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):5203. doi:

ARVO Annual Meeting Abstract June 2020

Targeted intravenous dendrimer-drug therapies for AMD

Kannan Rangaramanujam; Siva Pramodh Pramodh Kambhampati; Imran Ahmed Bhutto; Tony Wu; Scott McLeod; Gerard A Lutty

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4929. doi:

ARVO Annual Meeting Abstract July 2019

The efficacy of mast cell stabilizer in the experiment rat model of geographic atrophy

Shuntaro Ogura; Rajkumar Baldeosingh; Siva Pramodh Kambhampati; Gerard A Lutty

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5380. doi:

ARVO Annual Meeting Abstract July 2019

Tryptase release after degranulation of Mast Cells in a Model for Geographic Atrophy

Rajkumar Baldeosingh; Shuntaro Ogura; Siva Pramodh Kambhampati; Malia Michelle Edwards; Gerard A Lutty

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1231. doi:

ARVO Annual Meeting Abstract July 2019

Targeting TFEB (transcription factor EB) as a novel approach for AMD therapy

Stacey L Hose; Sayan Ghosh; Nadezda A. Stepicheva; Sara Jabalameli; Imran Ahmed Bhutto; Peng Shang; Meysam Yazdankhah; Joseph Weiss; Gerard A Lutty; J Samuel Zigler, Jr; Leah Byrne; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1238. doi:

ARVO Annual Meeting Abstract July 2019

Role of Lipocalin-2 in iron homeostasis and inflammasome activation in pathogenesis of age-related macular degeneration (AMD)

Sayan Ghosh; Peng Shang; Meysam Yazdankhah; Imran Ahmed Bhutto; Nadezda A. Stepicheva; Joseph Weiss; Stacey L Hose; Gerard A Lutty; J Samuel Zigler, Jr; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1345. doi:

ARVO Annual Meeting Abstract July 2019

Infiltrating immune cells and pathophysiology in Diabetic Retinopathy (DR)

Imran Ahmed Bhutto; Tanuja Vaidya; Sayan Ghosh; Archana Padmanabhan; Meysam Yazdankhah; Peng Shang; Nadezda A. Stepicheva; Stacey L Hose; J Samuel Zigler, Jr; Santosh GopiKrishna; Thirumalesh MB; Gerard A Lutty; Arkasubhra Ghosh; Swaminathan Sethu; Debasish Sinha

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2683. doi:

ARVO Annual Meeting Abstract July 2019

Naïve pluripotency improves human diabetic iPSC derived-vascular progenitor cell engraftment and migration in an ischemic retinopathy mouse model

Tea Soon Park; Ludovic Zimmerlin; Imran Ahmed Bhutto; Riya Kanherkar; Rebecca Evans-Moses; Gerard A Lutty; Elias T Zambidis

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2792. doi:

ARVO Annual Meeting Abstract July 2019

Müller cell remodeling and phagocytosis in Choroidoremia

Malia Michelle Edwards; Rhonda Grebe; Rajkumar Baldeosingh; Gerard A Lutty

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4388. doi:

ARVO Annual Meeting Abstract July 2019

Indian hedgehog (Ihh) secreted by adult choroid endothelial cells` regulates choroidal homeostasis and immune response

Christin Hanke-Gogokhia; Guillermo Lehmann; Yang Hu; Rohan Bareja; Micheal Ginsberg; Daniel Nolan; Alexandre Wojcinski; Robert F Mullins; Gerard A Lutty; Olivier Elemento; Alexandra Joyner; Shahin Rafii; Ignacio Benedicto; Enrique J Rodriguez-Boulan

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5238. doi:

Special Issue September 2018

An Acute Injury Model for the Phenotypic Characteristics of Geographic Atrophy

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Imran A. Bhutto; Shuntaro Ogura; Rajkumar Baldeosingh; D. Scott McLeod; Gerard A. Lutty; Malia M. Edwards
TAGS: atrophy, injections, phenotype, wounds and injuries, eye, chief complaint, photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2018; 59(4):AMD143-AMD151. doi: https://doi.org/10.1167/iovs.18-24245

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

Interleukin 33 stimulates Müller cell migration and proliferation.

Malia Michelle Edwards; Rajkumar Baldeosingh; Manasee Gedam; Gerard A Lutty

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1481. doi:

ARVO Annual Meeting Abstract July 2018

Tumor Necrosis Factor alpha stimulates Müller cell migration and proliferation.

Rajkumar Baldeosingh; Manasee Gedam; Gerard A Lutty; Malia Michelle Edwards

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1483. doi:

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Ex vivo analysis of mast cell degranulation in human donor choroids

Improved generation and long-term engraftment of retinal organoids from Tankyrase/PARP-Inhibitor-Regulated Naïve human pluripotent stem cells (TIRN-hPSC)

Topical Ketotifen Fumarate Inhibits Choroidal Mast Cell Degranulation and Loss of Retinal Pigment Epithelial Cells in Rat Model for Geographic Atrophy

Topical Ketotifen fumarate inhibits mast cell degranulation and loss of retinal pigment epithelial cells in rat model for geographic atrophy

Retinal Glial and Choroidal Vascular Pathology in Donors Clinically Diagnosed With Stargardt Disease

Visualization of choroidal vasculature in pigmented mouse eyes

Increased expression of epithelial-to-mesenchymal transition markers in geographic atrophy

Long-term engraftment of mature human photoreceptors following subretinal transplantation of naïve hPSC-derived retinal organoids

Targeted intravenous dendrimer-drug therapies for AMD

The efficacy of mast cell stabilizer in the experiment rat model of geographic atrophy

Tryptase release after degranulation of Mast Cells in a Model for Geographic Atrophy

Targeting TFEB (transcription factor EB) as a novel approach for AMD therapy

Role of Lipocalin-2 in iron homeostasis and inflammasome activation in pathogenesis of age-related macular degeneration (AMD)

Infiltrating immune cells and pathophysiology in Diabetic Retinopathy (DR)

Naïve pluripotency improves human diabetic iPSC derived-vascular progenitor cell engraftment and migration in an ischemic retinopathy mouse model

Müller cell remodeling and phagocytosis in Choroidoremia

Indian hedgehog (Ihh) secreted by adult choroid endothelial cells` regulates choroidal homeostasis and immune response

An Acute Injury Model for the Phenotypic Characteristics of Geographic Atrophy

Interleukin 33 stimulates Müller cell migration and proliferation.

Tumor Necrosis Factor alpha stimulates Müller cell migration and proliferation.

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