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Clinical Trials December 2021

Conversion of Central Subfield Thickness Measurements of Diabetic Macular Edema Across Cirrus and Spectralis Optical Coherence Tomography Instruments

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Jennifer K. Sun; Kristin Josic; Michele Melia; Adam R. Glassman; Clare Bailey; Kakarla V. Chalam; Emily Y. Chew; Catherine Cukras; Sandeep Grover; Glenn J. Jaffe; Richard Lee; Jared S. Nielsen; Darby J. S. Thompson; Henry E. Wiley; Frederick L. Ferris, 3rd; for the DRCR Retina Network
TAGS: diabetic macular edema, eye, optical coherence tomography, sensitivity analysis
Trans. Vis. Sci. Tech.. 2021; 10(14):34. doi: https://doi.org/10.1167/tvst.10.14.34

Includes: Supplemental Content

Clinical Trials December 2021

Phase 1 Dose-Escalation Study of Plasma Kallikrein Inhibitor THR-149 for the Treatment of Diabetic Macular Edema

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Pravin U. Dugel; Arshad M. Khanani; Brian B. Berger; Sunil Patel; Mitchell Fineman; Glenn J. Jaffe; Petra Kozma-Wiebe; Jeffrey Heier
TAGS: diabetic macular edema, injections, plasma kallikrein, safety, inflammation, surrogate endpoints, eye
Trans. Vis. Sci. Tech.. 2021; 10(14):28. doi: https://doi.org/10.1167/tvst.10.14.28

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2021

A multimodal deep learning (DL) model to predict visual acuity response in the CATT study

Jelena Novosel; Neha Anegondi; Jian Dai; Ebenezer Daniel; Glenn J Jaffe; Maureen G Maguire; Jeffrey R Willis

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):81. doi:

ARVO Annual Meeting Abstract June 2021

Risuteganib Modulates Multiple Transcription Factors regulated by Hydroquinone in Human RPE Cells

Ping Yang; Nicholas Anthony Besley; Scott W Lallier; Zixuan Shao; John Y Park; Hampar Karageozian; Vicken Karageozian; Glenn J Jaffe

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2697. doi:

ARVO Annual Meeting Abstract June 2021

Reduction in Cystoid Macular Edema and Ellipsoid Zone Reconstitution in Non-paraneoplastic Autoimmune Retinopathy Treated with Anti-Interleukin-6 Monoclonal Antibodies

Jordan Deaner; Glenn J Jaffe; Robert T Keenan; Lisa Carnago; Dilraj Grewal

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1406. doi:

ARVO Annual Meeting Abstract June 2021

Robotically aligned OCT enables physically distanced imaging and relevant measurements in a retina clinic population

Ryan P McNabb; Pablo Ortiz; Kyung-Min Roh; Mark Draelos; Stefanie G Schuman; Glenn J Jaffe; Eleonora M Lad; Joseph Izatt; Anthony N Kuo

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2457. doi:

ARVO Annual Meeting Abstract June 2021

Optical Coherence Tomography Signs of Early Atrophy in Age-related Macular Degeneration: Inter-Reader Agreement

Steffen Schmitz-Valckenberg; Zhichao Wu; Maximilian Pfau; Barbara Blodi; Frank G Holz; Petrus Chang; Glenn J Jaffe; Sandra Liakopoulos; Srinivas R Sadda; Giovanni Staurenghi; Robyn H Guymer

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1936. doi:

ARVO Annual Meeting Abstract June 2021

Resveratrol Attenuates Priming of the NLRP3 Inflammasome by Hydrogen Peroxide

Scott Lallier; Nicholas Anthony Besley; Ping Yang; Glenn J Jaffe

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2704. doi:

ARVO Annual Meeting Abstract June 2021

ST266 Improves Survival and Mitochondrial Function in Human RPE Cells Under Oxidative Stress

Nicholas Anthony Besley; Ping Yang; Scott W Lallier; Howard Wessel; Larry Brown; Glenn J Jaffe

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2701. doi:

ARVO Annual Meeting Abstract June 2021

HAWK and HARRIER 48-week data: potential for treatment interval extension in patients with nAMD disease activity at Week 16

Ramin Tadayoni; Glenn J Jaffe; Frank G Holz; Ursula Schmidt-Erfurth; Kanji Takahashi; Gemmy Chui Ming Cheung; Seenu Hariprasad; Kinfemichael Gedif; Rasmus Olsen; Catherine Best; Peter K Kaiser

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):426. doi:

ARVO Annual Meeting Abstract June 2021

The RUSH2A study: Baseline microperimetry and SD-OCT measures

Eleonora M Lad; Wendi Liang; Glenn J Jaffe; Zengtian Deng; Jessica Loo; Dibyendu Mukherjee; Sina Farsiu

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2435. doi:

ARVO Annual Meeting Abstract June 2021

Combining artificial intelligence and robotics: a semi-automated optical coherence tomography-based approach for posterior eye disease screening

Ailin Song; Pablo Ortiz; Mark Draelos; Stefanie G Schuman; Glenn J Jaffe; Sina Farsiu; Joseph Izatt; Ryan P McNabb; Anthony N Kuo

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):120. doi:

Retinal Cell Biology August 2020

Risuteganib Protects against Hydroquinone–induced Injury in Human RPE Cells

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Ping Yang; Zixuan Shao; Nicholas A. Besley; Samantha E. Neal; Kristen L. Buehne; John Park; Hampar Karageozian; Vicken Karageozian; Ian T. Ryde; Joel N. Meyer; Glenn J. Jaffe
TAGS: combined modality therapy, retinal pigment cell, wounds and injuries, actins, rna-seq
Invest. Ophthalmol. Vis. Sci.. 2020; 61(10):35. doi: https://doi.org/10.1167/iovs.61.10.35

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2020

Risuteganib Modifies Hydroquinone-regulated Gene Expression and Protects against Hydroquinone-induced Cytotoxic Effects in Human RPE Cells

Ping Yang; Zixuan Shao; Nicholas Besley; John Y Park; Hampar Karageozian; Vicken Karageozian; Glenn J Jaffe

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3117. doi:

ARVO Annual Meeting Abstract June 2020

Baseline visual fields in the RUSH2A study: Associated factors and correlation with measures of disease severity

Jacque L Duncan; Wendi Liang; Isabelle S Audo; David G Birch; Joseph Carroll; Janet K. Cheetham; Laura R Erker; Frederick L Ferris; Elise Heon; Robert Hufnagel; Alessandro Iannaccone; Glenn J Jaffe; Christine N Kay; Maureen Maguire; Michel Michaelides; Mark E Pennesi

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3364. doi:

ARVO Annual Meeting Abstract June 2020

Deep learning-based automatic segmentation of retinal cavitations on OCT images of MacTel2

Jessica Loo; Cindy Xinji Cai; Emily Chew; Martin Friedlander; Glenn J Jaffe; Sina Farsiu

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1616. doi:

ARVO Annual Meeting Abstract June 2020

Meta-learning approach to automatically register multivendor retinal images

Ali Hasan; Zengtian Deng; Jessica Loo; Dibyendu Mukherjee; Jacque L Duncan; David G Birch; Glenn J Jaffe; Sina Farsiu

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1634. doi:

ARVO Annual Meeting Abstract June 2020

In-vivo quantitative analysis of pterygium volume using anterior segment optical coherence tomography imaging

Sumru Onal; Jessica Loo; Victor L Perez Quinones; Tan Nguyen; Madhu Cherukury; Sina Farsiu; Glenn J Jaffe

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):488. doi:

ARVO Annual Meeting Abstract June 2020

Deep learning-based automatic segmentation of intact ellipsoid zone area on optical coherence tomography images of USH2A-related retinal degeneration

Sina Farsiu; Jessica Loo; Jacque L Duncan; David G Birch; Glenn J Jaffe

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):485. doi:

ARVO Annual Meeting Abstract June 2020

Registry and Natural History Study to Evaluate Clinical Non-Central Geographic Atrophy (GA) Who are CarRIers of High-Risk GeneTic Variants Associated with Age-Related Macular Degeneration (CLARITY): Study Outline and Available Baseline Data

William Bridges; Nancy Holekamp; Stephen Couvillion; Raj Maturi; Jared S Nielsen; Dante Joseph Pieramici; Glenn J Jaffe; KD Nguyen; Renta Hutabarat; Stephen Eckert; Richard MacKenna; Kiran Patki; Alia Rashid; Johanna M Seddon; Sandra Rojas-Caro

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1043. doi:

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Conversion of Central Subfield Thickness Measurements of Diabetic Macular Edema Across Cirrus and Spectralis Optical Coherence Tomography Instruments

Phase 1 Dose-Escalation Study of Plasma Kallikrein Inhibitor THR-149 for the Treatment of Diabetic Macular Edema

A multimodal deep learning (DL) model to predict visual acuity response in the CATT study

Risuteganib Modulates Multiple Transcription Factors regulated by Hydroquinone in Human RPE Cells

Reduction in Cystoid Macular Edema and Ellipsoid Zone Reconstitution in Non-paraneoplastic Autoimmune Retinopathy Treated with Anti-Interleukin-6 Monoclonal Antibodies

Robotically aligned OCT enables physically distanced imaging and relevant measurements in a retina clinic population

Optical Coherence Tomography Signs of Early Atrophy in Age-related Macular Degeneration: Inter-Reader Agreement

Resveratrol Attenuates Priming of the NLRP3 Inflammasome by Hydrogen Peroxide

ST266 Improves Survival and Mitochondrial Function in Human RPE Cells Under Oxidative Stress

HAWK and HARRIER 48-week data: potential for treatment interval extension in patients with nAMD disease activity at Week 16

The RUSH2A study: Baseline microperimetry and SD-OCT measures

Combining artificial intelligence and robotics: a semi-automated optical coherence tomography-based approach for posterior eye disease screening

Risuteganib Protects against Hydroquinone–induced Injury in Human RPE Cells

Risuteganib Modifies Hydroquinone-regulated Gene Expression and Protects against Hydroquinone-induced Cytotoxic Effects in Human RPE Cells

Baseline visual fields in the RUSH2A study: Associated factors and correlation with measures of disease severity

Deep learning-based automatic segmentation of retinal cavitations on OCT images of MacTel2

Meta-learning approach to automatically register multivendor retinal images

In-vivo quantitative analysis of pterygium volume using anterior segment optical coherence tomography imaging

Deep learning-based automatic segmentation of intact ellipsoid zone area on optical coherence tomography images of USH2A-related retinal degeneration

Registry and Natural History Study to Evaluate Clinical Non-Central Geographic Atrophy (GA) Who are CarRIers of High-Risk GeneTic Variants Associated with Age-Related Macular Degeneration (CLARITY): Study Outline and Available Baseline Data

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