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ARVO Annual Meeting Abstract June 2024

VIAN-c4551 delivered in eye drops reaches high therapeutic concentrations in the back of the eye of rabbits.

Magdalena Zamora; Juan Pablo Robles; Elva Adán-Castro; Lourdes Siqueiros-Márquez; Jose Fernando García-Rodrigo; Daniela Granados-Carrasco; Thomas Bertsch; Jakob Triebel; Gonzalo Martinez de la Escalera; Carmen Clapp

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3146.

ARVO Annual Meeting Abstract June 2024

VIAN-c4551 is a potent topical inhibitor of VEGF and Ang-2 that reduces macular edema and angiogenesis in vascular retinopathies.

Juan Pablo Robles; Magdalena Zamora; Lourdes Siqueiros-Márquez; Elva Adán-Castro; Jose Fernando García-Rodrigo; Daniela Granados-Carrasco; Thomas Bertsch; Jakob Triebel; Gonzalo Martinez de la Escalera; Carmen Clapp

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4933.

ARVO Annual Meeting Abstract June 2024

VIAN-c4551 inhibits oxygen-induced retinopathy in mice

Lourdes Montserrat SIQUEIROS; Jose Fernando García-Rodrigo; Elva Adán Castro; Daniela Granados-Carrasco; Juan Pablo Robles; Magdalena Zamora; Xarubet Ruiz Herrera; Thomas Bertsch; Jakob Triebel; Gonzalo Martinez de la Escalera; Carmen Clapp

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6287.

ARVO Annual Meeting Abstract June 2024

VIAN-c4551 in eye drops inhibits the excessive retinal vasopermeability induced by VEGF and diabetes in rodents

Elva Adán Castro; Juan Pablo Robles; Magdalena Zamora; Lourdes Siqueiros-Márquez; Daniela Granados-Carrasco; Jose Fernando García-Rodrigo; Marlon García-Roa; Ellery López-Star; Thomas Bertsch; Jakob Triebel; Gonzalo Martinez de la Escalera; Carmen Clapp

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6236.

ARVO Annual Meeting Abstract June 2023

Levosulpiride for the treatment of diabetic macular edema: A phase 2, randomized, pilot clinical trial

Mariana Edith López Hernánez; Maria Del Carmen Clapp; Carlos Nuñez; Elva Adán- Castro; Renata García; Marlon García Roa; Juan Fernando Rubio Mijangos; Jorge Sánchez; Gabriela Ramírez Hernández; Nundehui Diaz Lezama; Ellery López Star; Thomas Bertsch; Gonzálo Martínez de la Escalera; Jakob Triebel; Nayeli Piñeiro; Monserrat Siqueiros

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2657.

Articles August 2020

Levosulpiride Increases the Levels of Prolactin and Antiangiogenic Vasoinhibin in the Vitreous of Patients with Proliferative Diabetic Retinopathy

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Carlos D. Nuñez-Amaro; Aura Ileana Moreno-Vega; Elva Adan-Castro; Magdalena Zamora; Renata Garcia-Franco; Paulina Ramirez-Neria; Marlon Garcia-Roa; Yolanda Villalpando; Juan Pablo Robles; Gabriela Ramirez-Hernandez; Mariana Lopez; Jorge Sanchez; Ellery Lopez-Star; Thomas Bertsch; Gonzalo Martinez de la Escalera; Ma. Ludivina Robles-Osorio; Jakob Triebel; Carmen Clapp
TAGS: angiogenesis inhibitors, diabetes mellitus, prolactin, vitreous body, proliferative diabetic retinopathy, hyperprolactinemia, placebos
Trans. Vis. Sci. Tech.. 2020; 9(9):27. https://doi.org/10.1167/tvst.9.9.27

ARVO Annual Meeting Abstract June 2020

Prolactin improves retinal function in streptozotocin-induced diabetes

Lourdes Montserrat SIQUEIROS; Elva Hortencia Adan Castro; Francisco Freinet Núñez; Gabriela Ramirez-Hernandez; Daniela Granados-Carrasco; Xarubeth Ruiz-Herrera; Gonzálo Martínez de la Escalera; Carmen Clapp

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):280.

ARVO Annual Meeting Abstract June 2020

Sulpiride increases intraocular vasoinhibin and protects against diabetic retinopathy in rats

Elva Hortencia Adan Castro; Gabriela Ramirez-Hernandez; Nundehui Diaz-Lezama; Lourdes Montserrat SIQUEIROS; Daniela Granados-Carrasco; Xarubeth Ruiz-Herrera; Fernando Lopez-Barrera; Ludivina Robles-Osorio; Gonzálo Martínez de la Escalera; Carmen Clapp

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1881.

ARVO Annual Meeting Abstract June 2020

The prolactin/vasoinhibin axis regulates early postnatal retinal vascularization

Francisco Freinet Núñez; Lourdes Montserrat SIQUEIROS; Miguel Vázquez-Membrillo; Elva Hortencia Adan Castro; Gabriela Ramirez-Hernandez; Gonzálo Martínez de la Escalera; Carmen Clapp

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4958.

ARVO Annual Meeting Abstract September 2016

An AAV2 vector encoding prolactin reverses blood retinal barrier pathology when administered intravitreally to diabetic rats

Nundehui Diaz-Lezama; Zhijian Wu; Elva Adan-Castro; Bibiana Moreno-Carranza; Gonzalo Martinez de la Escalera; Carmen Clapp

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):758.

ARVO Annual Meeting Abstract April 2014

Analysis of retinal vasoinhibins and their ocular generation in diabetic and non-diabetic rats

Elva Hortencia Adan-Castro; Nundehui Diaz-Lezama; Gonzalo Martínez de la Escalera; Stephanie Thebault; Yazmín Macotela; Carmen Clapp

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1053.

ARVO Annual Meeting Abstract April 2014

Diabetes enhances the efficacy of adeno-associated virus vectors in rat retina

Nundehui Diaz-Lezama; Zhijian Wu; Elva Hortencia Adan-Castro; David Arredondo; Gonzalo Martínez de la Escalera; Stephanie Thebault; Peter Colosi; Carmen Clapp

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3323.

ARVO Annual Meeting Abstract June 2013

Enhancement of AAV2-mediated retinal transduction in diabetic rats

Nundehui Díaz-Lezama; Zhijian Wu; Mayda Ramírez; Bibiana Moreno-Carranza; Gonzalo Martinez de la Escalera; Peter Colosi; Carmen Clapp

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):2716.

ARVO Annual Meeting Abstract June 2013

The hormone prolactin: a novel endogenous trophic factor able to limit retinal degeneration

Stephanie Thebault; Edith Arnold; Andrés Quintanar-Stéphano; Gerardo Rojas-Piloni; Miguel Condés-Lara; Nadine Binart; Gonzalo Martinez de la Escalera; Carmen Clapp

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):1271.

ARVO Annual Meeting Abstract March 2012

Prolactin In Milk Promotes The Regression Of Hyaloid Vasculature By Increasing Intraocular Vasoinhibins

Zulma Duenas; Gonzalo Martinez de la Escalera; Carmen Clapp

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):2527.

Retina November 2011

Vasoinhibin Gene Transfer by Adenoassociated Virus Type 2 Protects against VEGF- and Diabetes-Induced Retinal Vasopermeability

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Mayda Ramírez; Zhijian Wu; Bibiana Moreno-Carranza; Michael C. Jeziorski; Edith Arnold; Nundehui Díaz-Lezama; Gonzalo Martínez de la Escalera; Peter Colosi; Carmen Clapp
TAGS: diabetes mellitus, gene transfer techniques, spatial vectors, vascular endothelial growth factor a, viruses, evans blue stain, diabetes mellitus, type 2, transgenes, verification
Invest. Ophthalmol. Vis. Sci.. 2011; 52(12):8944-8950. https://doi.org/10.1167/iovs.11-8190

ARVO Annual Meeting Abstract April 2011

Vasoinhibins Reduce The Bradykinin-induced Increase Of Endothelial Permeability In Vitro And In Vivo

David Arredondo; Edith Arnold; Celina Garcia; Gonzalo Martinez de la Escalera; Carmen Clapp; Stephanie Thebault

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):4889.

ARVO Annual Meeting Abstract April 2011

Matrix Metalloproteinases in the Vitreous Cleave Prolactin to Vasoinhibins

Mayda Ramirez; Jorge Aranda; Edith Arnold; Nundehui Diaz-Lezama; Carlos Alvarez-Guzman; Yazmin Macotela; Gonzalo Martinez de la Escalera; Carmen Clapp

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):4890.

ARVO Annual Meeting Abstract April 2011

Effect of the Hormone Prolactin on Photoreceptor Survival

Edith Arnold; Miguel Condés-Lara; Andrés Quintanar-Stephano; Gerardo Rojas-Piloni; German Baeza; Gonzalo Martinez de la Escalera; Stephanie Thebault; Carmen Clapp

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):5455.

ARVO Annual Meeting Abstract April 2011

Prolactin Prevents The High-glucose-induced Reduction Of Paracellular Permeability In Polarized Arpe-19 Cultures

Stephanie Thebault; Edith Arnold; German Baeza Cruz; Gonzalo Martinez de la Escalera; Carmen Clapp

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):881.

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VIAN-c4551 delivered in eye drops reaches high therapeutic concentrations in the back of the eye of rabbits.

VIAN-c4551 is a potent topical inhibitor of VEGF and Ang-2 that reduces macular edema and angiogenesis in vascular retinopathies.

VIAN-c4551 inhibits oxygen-induced retinopathy in mice

VIAN-c4551 in eye drops inhibits the excessive retinal vasopermeability induced by VEGF and diabetes in rodents

Levosulpiride for the treatment of diabetic macular edema: A phase 2, randomized, pilot clinical trial

Levosulpiride Increases the Levels of Prolactin and Antiangiogenic Vasoinhibin in the Vitreous of Patients with Proliferative Diabetic Retinopathy

Prolactin improves retinal function in streptozotocin-induced diabetes

Sulpiride increases intraocular vasoinhibin and protects against diabetic retinopathy in rats

The prolactin/vasoinhibin axis regulates early postnatal retinal vascularization

An AAV2 vector encoding prolactin reverses blood retinal barrier pathology when administered intravitreally to diabetic rats

Analysis of retinal vasoinhibins and their ocular generation in diabetic and non-diabetic rats

Diabetes enhances the efficacy of adeno-associated virus vectors in rat retina

Enhancement of AAV2-mediated retinal transduction in diabetic rats

The hormone prolactin: a novel endogenous trophic factor able to limit retinal degeneration

Prolactin In Milk Promotes The Regression Of Hyaloid Vasculature By Increasing Intraocular Vasoinhibins

Vasoinhibin Gene Transfer by Adenoassociated Virus Type 2 Protects against VEGF- and Diabetes-Induced Retinal Vasopermeability

Vasoinhibins Reduce The Bradykinin-induced Increase Of Endothelial Permeability In Vitro And In Vivo

Matrix Metalloproteinases in the Vitreous Cleave Prolactin to Vasoinhibins

Effect of the Hormone Prolactin on Photoreceptor Survival

Prolactin Prevents The High-glucose-induced Reduction Of Paracellular Permeability In Polarized Arpe-19 Cultures

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