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Meeting Abstract (7)
Journal Articles (3)

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Investigative Ophthalmology & Visual Science (9)
Translational Vision Science & Technology (1)

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ARVO Annual Meeting Abstract (7)
Retina (2)
Articles (1)

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Eye Anatomy and Disorders (3)
Genetics (3)
Imaging (3)
Retina (3)
Retinal Imaging (3)
Biochemistry and Molecular Biology (1)
Nanotechnology and Regenerative Medicine (1)
Surgery (1)
Translational Research (1)
Visual Neuroscience (1)
Visual Psychophysics and Physiological Optics (1)

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electroretinography (2)
mice (2)
mutation (2)
retinal cone (2)
achromatopsia (1)
cell survival (1)
dyes (1)
filters (1)
filtration (1)
gene therapy (1)

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ARVO Annual Meeting Abstract July 2019

Mirtron gene therapy for the treatment of rhodopsin-related dominant retinitis pigmentosa

Harry Otway Orlans; Michelle E McClements; Alun R Barnard; Cristina Martinez-Fernandez dela Camara; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5195.

Retina June 2019

Filtration of Short-Wavelength Light Provides Therapeutic Benefit in Retinitis Pigmentosa Caused by a Common Rhodopsin Mutation

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Harry O. Orlans; Jonathon Merrill; Alun R. Barnard; Peter Charbel Issa; Stuart N. Peirson; Robert E. MacLaren
TAGS: filters, filtration, housing, mice, mutation, retinitis pigmentosa, rhodopsin, retinal degeneration, electroretinography, retinal cone
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2733-2742. https://doi.org/10.1167/iovs.19-26964

Includes: Supplemental Content

Retina December 2018

A Novel Achromatopsia Mouse Model Resulting From a Naturally Occurring Missense Change in Cngb3

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Mark M. Hassall; Alun R. Barnard; Harry O. Orlans; Michelle E. McClements; Peter Charbel Issa; Sher A. Aslam; Robert E. MacLaren
TAGS: achromatopsia, mice, retinal cone, electroretinography, mutation
Invest. Ophthalmol. Vis. Sci.. 2018; 59(15):6102-6110. https://doi.org/10.1167/iovs.18-24328

ARVO Annual Meeting Abstract July 2018

The senescence marker P16 ink4a is expressed in ocular astrocytes

Tina storm; Harry Otway Orlans; Cristina Martinez-Fernandez Dela Camara; Arantxa Bolinches-Amorós; Angela J. Russell; Stephen G Davies; Alun R Barnard; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4613.

ARVO Annual Meeting Abstract July 2018

An optimized AAV vector for rod-specific gene expression

Harry Otway Orlans; Michelle McClements; Maria In?s Patrício; Alun R Barnard; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4534.

Articles July 2017

Impact of Vital Dyes on Cell Viability and Transduction Efficiency of AAV Vectors Used in Retinal Gene Therapy Surgery: An In Vitro and In Vivo Analysis

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Anna P. Salvetti; Maria I. Patrício; Alun R. Barnard; Harry O. Orlans; Doron G. Hickey; Robert E. MacLaren
TAGS: dyes, gene therapy, surgical procedures, operative, spatial vectors, cell survival, injections, toxic effect
Trans. Vis. Sci. Tech.. 2017; 6(4):4. https://doi.org/10.1167/tvst.6.4.4

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2017

Evaluation of the efficiency and specificity of short variants of the human PDE6b promoter in photoreceptor-like cells in vitro and ex vivo .

Caroline F Peddle; Harry O Orlans; Michelle E. McClements; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):629.

ARVO Annual Meeting Abstract June 2017

Quantitative assessment of photoreceptor degeneration by confocal scanning laser ophthalmoscopy in two mouse models of retinitis pigmentosa

Harry O Orlans; Alun R Barnard; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4874.

ARVO Annual Meeting Abstract September 2016

Transgene expression in the retina following AAV transduction: the WPRE effect

Maria Ines Patricio; Alun R Barnard; Harry Otway Orlans; Michelle McClements; Robert Maclaren

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):1152.

ARVO Annual Meeting Abstract September 2016

Quantification of Fluorescence in Retinal Sections by Confocal Microscopy

Harry Otway Orlans; Maria Ines Patricio; Alun R Barnard; Robert Maclaren

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):1706.

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