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ARVO Annual Meeting Abstract June 2024

OpRegen retinal pigment epithelial (RPE) cell therapy engrafts within the RPE of Gottingen mini-pigs by 4-weeks post-administration via subretinal delivery

Rachel Nicole Andrews; Henry E Wiley; Yuichiro Ogura; Amy Shelton; Tammy Tam; Ryan Boyd; Victoria Stevenson; Tracy Carlson; Colin Jennings; Kyle DePlancke; Vladimir Bantseev

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5416.

ARVO Annual Meeting Abstract June 2023

A Phase II Trial Evaluating Oral Minocycline in the Treatment of Geographic Atrophy in Age-Related Macular Degeneration

Tiarnan D L Keenan; Clare C Bailey; Sunil Bellur; Thilaka Arunachalam; Cathy Kangale-Whitney; Maria Abraham; Christine Orndahl; Supriya Menezes; Brett Jeffrey; Henry Wiley; Alisa Thavikulwat; Catherine Cukras; Emily Y. Chew; Wai T Wong

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):5058.

ARVO Annual Meeting Abstract June 2023

Early termination of a Phase 2 study of FHTR2163 in patients with geographic atrophy secondary to age-related macular degeneration

Nancy M Holekamp; Ling Ma; Flavia Brunstein; Jiameng Zhang; Henry Wiley; Hao Chen

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2263.

Retina December 2022

Investigations of Renal Function and Age-Related Macular Degeneration Phenotypes

PDF

Amisha D. Dave; Kristina Hess; Katherine G. Chen; Henry Wiley; Tiarnan D. L. Keenan; Elvira Agrón; Emily Y. Chew; Catherine A. Cukras
TAGS: age-related macular degeneration, phenotype, renal function
Trans. Vis. Sci. Tech.. 2022; 11(12):11. https://doi.org/10.1167/tvst.11.12.11

Artificial Intelligence October 2022

Deep Learning-Based Modeling of the Dark Adaptation Curve for Robust Parameter Estimation

PDF

Tharindu De Silva; Kristina Hess; Peyton Grisso; Alisa T. Thavikulwat; Henry Wiley; Tiarnan D. L. Keenan; Emily Y. Chew; Brett G. Jeffrey; Catherine A. Cukras
TAGS: dark adaptation, fitting curve to data, learning, neutrophil/lymphocyte ratio, retinal cone, rod photoreceptors
Trans. Vis. Sci. Tech.. 2022; 11(10):40. https://doi.org/10.1167/tvst.11.10.40

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2022

Quantification of the growth rate of prevalent and incident cRORA lesions in SD-OCT images

Michelle Amy Chen; Tharindu de silva; Alisa Thavikulwat; Henry Wiley; Tiarnan D L Keenan; Emily Y Chew; Catherine A Cukras

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1043 – F0290.

ARVO Annual Meeting Abstract June 2022

Automated detection of Drusenoid Pigment Epithelial Detachments (DPEDs) on OCT’s in patients with Age related Macular Degeneration (AMD)

Souvick Mukherjee; Tharindu de silva; Cameron Duic; Alisa T Thavikulwat; Kristina Hess; Henry Wiley; Tiarnan D L Keenan; Emily Y Chew; Catherine Cukras

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1035 – F0282.

ARVO Annual Meeting Abstract June 2022

Association of hyperreflective foci with disease severity and functional impairment in age-related macular degeneration

Cameron Duic; Kristina Hess; Alisa Thavikulwat; Henry Wiley; Tiarnan D L Keenan; Emily Y Chew; Catherine A Cukras

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1020 – F0267.

ARVO Annual Meeting Abstract June 2022

Long-term Visual Outcomes of juxta-papillary retinal hemangioblastoma in Von Hippel-Lindau Disease

Eleni Konstantinou; Sanjeeb Bhandari; Elvira Agron; Tiarnan D L Keenan; Catherine A Cukras; Alisa Thavikulwat; Henry Wiley; Emily Y Chew

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3140 – A0035.

ARVO Annual Meeting Abstract June 2022

Correlations between Renal Function and Age-Related Macular Degeneration (AMD) Phenotypes

Amisha Dave; Kristina Hess; Katherine Chen; Henry Wiley; Tiarnan D L Keenan; Elvira Agron; Emily Y Chew; Catherine A Cukras

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3525.

Clinical Trials December 2021

Conversion of Central Subfield Thickness Measurements of Diabetic Macular Edema Across Cirrus and Spectralis Optical Coherence Tomography Instruments

PDF

Jennifer K. Sun; Kristin Josic; Michele Melia; Adam R. Glassman; Clare Bailey; Kakarla V. Chalam; Emily Y. Chew; Catherine Cukras; Sandeep Grover; Glenn J. Jaffe; Richard Lee; Jared S. Nielsen; Darby J. S. Thompson; Henry E. Wiley; Frederick L. Ferris, 3rd; for the DRCR Retina Network
TAGS: diabetic macular edema, eye, optical coherence tomography, sensitivity analysis
Trans. Vis. Sci. Tech.. 2021; 10(14):34. https://doi.org/10.1167/tvst.10.14.34

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2021

Oral HIF-2α inhibitor belzutifan for ocular von Hippel-Lindau (VHL) disease

Henry Wiley; Hanna R. Coleman; Eric Jonasch; Ramaprasad Srinivasan; Frede Donskov; Anders Kruse; Jodi K. Maranchie; Jay Chhablani; Tobias Else; Hakan Demirci; Benjamin L. Maughan; Mary Elizabeth Hartnett; Rodolfo F. Perini; Eric K. Park; Emily Y Chew

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):32.

ARVO Annual Meeting Abstract June 2021

Deep-learning based sequence modelling of the dark adaptation curve for noise reduction and parameter prediction in patients with AMD

Tharindu de silva; Peyton Grisso; Souvick Mukherjee; Brett G Jeffrey; Henry Wiley; Tiarnan D L Keenan; Emily Y Chew; Catherine A. Cukras

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2824.

ARVO Annual Meeting Abstract June 2021

Correlations Between AMD Severity and OCT Thickness

Peyton Grisso; Jeong W Pak; Tharindu De Silva; Henry Wiley; Tiarnan D L Keenan; Elvira Agron; Emily Y Chew; Catherine A Cukras

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):313.

Articles June 2020

Repeatability of Scotopic Sensitivity and Dark Adaptation Using a Medmont Dark-Adapted Chromatic Perimeter in Age-related Macular Degeneration

PDF

Durin Uddin; Brett G. Jeffrey; Oliver Flynn; Wai Wong; Henry Wiley; Tiarnan Keenan; Emily Chew; Catherine Cukras
TAGS: age-related macular degeneration, dark adaptation, rod photoreceptors, retinal cone
Trans. Vis. Sci. Tech.. 2020; 9(7):31. https://doi.org/10.1167/tvst.9.7.31

Includes: Supplemental Content

Articles June 2020

Trans-Ocular Electric Current In Vivo Enhances AAV-Mediated Retinal Transduction in Large Animal Eye After Intravitreal Vector Administration

PDF

Hongman Song; Yong Zeng; Sheik Pran Babu Sardar Pasha; Ronald A. Bush; Camasamudram Vijayasarathy; Haohua Qian; Lisa Wei; Henry E. Wiley; Zhijian Wu; Paul A. Sieving
TAGS: eye, retina, spatial vectors, transfer technique, oryctolagus cuniculus, mice, fibroblast growth factor 2, intravitreal injections
Trans. Vis. Sci. Tech.. 2020; 9(7):28. https://doi.org/10.1167/tvst.9.7.28

ARVO Annual Meeting Abstract June 2020

Characteristic assessment of longitudinal multi-modal imaging preceding geographic atrophy

Tharindu de silva; Emily Chew; Tiarnan D L Keenan; Henry Wiley; Wai T. Wong; Dominique Noriega; Catherine A Cukras

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2355.

ARVO Annual Meeting Abstract June 2020

Quantitative Analysis of Optical Coherence Tomography Scans in Patients with Hydroxychloroquine Toxicity

Raul Fernando Membreno; Tharindu de silva; Tiarnan D L Keenan; Henry Wiley; Wai T. Wong; Emily Chew; Catherine A Cukras

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4287.

ARVO Annual Meeting Abstract July 2019

Ocular findings in a phase 2 trial testing the first-in-class oral HIF-2α inhibitor, PT2385, for renal cell carcinoma in von Hippel-Lindau disease

Henry Wiley; Ramaprasad Srinivasan; Marston Linehan; Catherine A Cukras; Tiarnan D L Keenan; Wai T Wong; Emily Y Chew

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2782.

ARVO Annual Meeting Abstract July 2019

Immuno-phenotyping of X-linked retinoschisis (XLRS) subjects in a Phase I/IIa AAV8-RS1 gene therapy clinical trial reveals baseline differences in systemic immune cell proportions but minimal further changes after vector administration.

Alaknanda Mishra; Camasamudram Vijaysarathy; Rafael Villasmil; Henry Wiley; Yong Zeng; Julie Laux; Benjamin Chaigne-Delalande; Lisa Wei; H Nida Sen; Catherine A Cukras; Paul A Sieving

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5196.

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OpRegen retinal pigment epithelial (RPE) cell therapy engrafts within the RPE of Gottingen mini-pigs by 4-weeks post-administration via subretinal delivery

A Phase II Trial Evaluating Oral Minocycline in the Treatment of Geographic Atrophy in Age-Related Macular Degeneration

Early termination of a Phase 2 study of FHTR2163 in patients with geographic atrophy secondary to age-related macular degeneration

Investigations of Renal Function and Age-Related Macular Degeneration Phenotypes

Deep Learning-Based Modeling of the Dark Adaptation Curve for Robust Parameter Estimation

Quantification of the growth rate of prevalent and incident cRORA lesions in SD-OCT images

Automated detection of Drusenoid Pigment Epithelial Detachments (DPEDs) on OCT’s in patients with Age related Macular Degeneration (AMD)

Association of hyperreflective foci with disease severity and functional impairment in age-related macular degeneration

Long-term Visual Outcomes of juxta-papillary retinal hemangioblastoma in Von Hippel-Lindau Disease

Correlations between Renal Function and Age-Related Macular Degeneration (AMD) Phenotypes

Conversion of Central Subfield Thickness Measurements of Diabetic Macular Edema Across Cirrus and Spectralis Optical Coherence Tomography Instruments

Oral HIF-2α inhibitor belzutifan for ocular von Hippel-Lindau (VHL) disease

Deep-learning based sequence modelling of the dark adaptation curve for noise reduction and parameter prediction in patients with AMD

Correlations Between AMD Severity and OCT Thickness

Repeatability of Scotopic Sensitivity and Dark Adaptation Using a Medmont Dark-Adapted Chromatic Perimeter in Age-related Macular Degeneration

Trans-Ocular Electric Current In Vivo Enhances AAV-Mediated Retinal Transduction in Large Animal Eye After Intravitreal Vector Administration

Characteristic assessment of longitudinal multi-modal imaging preceding geographic atrophy

Quantitative Analysis of Optical Coherence Tomography Scans in Patients with Hydroxychloroquine Toxicity

Ocular findings in a phase 2 trial testing the first-in-class oral HIF-2α inhibitor, PT2385, for renal cell carcinoma in von Hippel-Lindau disease

Immuno-phenotyping of X-linked retinoschisis (XLRS) subjects in a Phase I/IIa AAV8-RS1 gene therapy clinical trial reveals baseline differences in systemic immune cell proportions but minimal further changes after vector administration.

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