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ARVO Annual Meeting Abstract June 2024

IL1 family signalling is not involved in retinal pigment epithelial (RPE) cell senescence in age-related macular degeneration (AMD)

Sarah Jean McFetridge; Heike Neubauer; Nina Zippel; Stefan Kreideweiss; Heping Xu; Mei Chen

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):771.

ARVO Annual Meeting Abstract June 2024

Developing novel therapies for macular fibrosis secondary to neovascular age-related macular degeneration

David Hughes; Jürgen Prestle; Nina Zippel; Leo Thomas; Heike Neubauer; Heping Xu; Mei Chen

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):706.

ARVO Annual Meeting Abstract June 2024

Single-cell RNA sequencing analysis revealed rod photoreceptors are most sensitive to age-induced degeneration

Mei Chen; Miao Tang; Bin Zou; Lia wei; Heping Xu

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):563.

ARVO Annual Meeting Abstract June 2024

SIGIRR dysfunction exasperates age-related inflammation and retinal degeneration

DIYA BHATTACHARYA; Thomas Friedel; Manon SZCZEPAN; Matthew Pilgrim; Yvonne Dombrowski; Heping Xu; Mei Chen

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):560.

ARVO Annual Meeting Abstract June 2024

Overcoming mitochondrial hyperfusion as a novel therapeutic target for retinal neuroprotection in diabetes

Jose R Hombrebueno; Aidan Anderson; Nada Alfahad; Dulani Wimalachandra; Kaouthar Bouzinab; Paula Rudzinska; Heather Wood; Heping Xu; Timothy Lyons; Nicholas Barnes; Parth Narendran; Janet Lord; Saaeha Rauz; Ian Ganley; Timothy Curtis; Graham R Wallace

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):326.

ARVO Annual Meeting Abstract June 2024

SOCS3 regulates retinal angiogenesis through modulating microglia SPP1 expression

Tianxi Wang; Emil Kriukov; Enton Lam; Andreas Stahl; Mei Chen; guoshuai cai; Petr Y Baranov; Heping Xu; Ye Sun

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1670.

ARVO Annual Meeting Abstract June 2024

Retinal Pigment Epithelial Cells Constitutively Express A Variety of Antimicrobial Peptides and the Expression Is Disrupted During Aging

Jian Liu; JinYan Qi; Caijiao Yi; Xuexue Cui; Xianglin Yuan; Wen Deng; Mei Chen; Heping Xu

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2181.

ARVO Annual Meeting Abstract June 2024

Clinical Characterization of Myopic Retinopathy in LRP2 Best-Cre-KO mice

JinYan Qi; Heping Xu

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3845.

ARVO Annual Meeting Abstract June 2024

The distribution and phenotype of Glioma-associated oncogene 1 (Gli1) expressing cells in ocular tissues

Matthew Pilgrim; Mei Chen; Heping Xu

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6689.

ARVO Annual Meeting Abstract June 2024

Altered Levels of Intraocular inflammatory factors Are Related to Retinal Vascular and Retinal Neurodegeneration in Myopic Retinopathy

Ling Zeng; Zhikuan Yang; Wei Pan; Ding Lin; Yao Tang; Baihua Chen; Heping Xu; xiaoning li

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6628.

ARVO Annual Meeting Abstract June 2024

Shared microbiota profile in the retina, choroid and the gut

Xuexue Cui; Jian Liu; Caijiao Yi; JinYan Qi; Wen Deng; Xiangling Yuan; Mei Chen; Heping Xu

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5622.

ARVO Annual Meeting Abstract June 2024

Higher Aqueous Level of Lipocalin-2 in Macular Fibrosis Secondary to Neovascular Age-related Macular Degeneration

Wen Deng; Caijiao Yi; Jian Liu; Jinyan Qi; Xuexue Cui; Xianglin Yuan; Changhua Ye; Zhongping Chen; Heping Xu

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4375.

ARVO Annual Meeting Abstract June 2024

Differential response to laser injury between young and aging retina

Caijiao Yi; Wen Deng; Jian Liu; JinYan Qi; Xuexue Cui; Xiangling Yuan; Mei Chen; Heping Xu

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):566.

ARVO Annual Meeting Abstract June 2023

RNA-seq analysis reveals the pro-fibrotic role of aged RPE/choroid in a mouse model of subretinal fibrosis

Caijiao Yi; Wen Deng; Jian Liu; Chang Luo; JinYan Qi; Xuexue Cui; Mei Chen; Heping Xu

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2060.

ARVO Annual Meeting Abstract June 2023

Higher Aqueous Levels of Vascular Cell Adhesion Molecule-1 (VCAM-1) Is Related to Macular Fibrosis in Neovascular Age-related Macular Degeneration

Wen Deng; Juan Chen; Wei Pan; Jian Liu; Caijiao Yi; Zengchao Zhou; Yiqin Duan; Xiangyan Ning; Jun Li; Jianbo Wan; Dan Zhou; Changhua Ye; Zhongping Chen; Heping Xu

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2204.

ARVO Annual Meeting Abstract June 2023

The LRP2 is involved in the inflammatory and autophagy pathways in photoreceptors

JinYan Qi; Jian Liu; Caijiao Yi; Wen Deng; Xuexue Cui; Heping Xu

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):4429.

ARVO Annual Meeting Abstract June 2022

CCR2+ monocytes critically contribute to subretinal fibrosis at the chronic stage of the disease.

Manon SZCZEPAN; Maria Llorian-Salvador; Matthias Mack; Mei Chen; Heping Xu

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):25.

Immunology and Microbiology June 2021

Retinal Pigment Epithelial Cells Express Antimicrobial Peptide Lysozyme – A Novel Mechanism of Innate Immune Defense of the Blood-Retina Barrier

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Jian Liu; Caijiao Yi; Wei Ming; Miao Tang; Xiao Tang; Chang Luo; Bo Lei; Mei Chen; Heping Xu
TAGS: muramidase, retinal pigment cell, antimicrobials, peptides
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):21. https://doi.org/10.1167/iovs.62.7.21

Retinal Cell Biology February 2021

K ATP Opener Attenuates Diabetic-Induced Müller Gliosis and Inflammation by Modulating Kir6.1 in Microglia

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Hong Li; Donglong Chen; Wei Sun; Jiansu Chen; Chang Luo; Heping Xu; Jacey Hongjie Ma; Shibo Tang
TAGS: diabetes mellitus, gliosis, inflammation, microglia, pinacidil
Invest. Ophthalmol. Vis. Sci.. 2021; 62(2):3. https://doi.org/10.1167/iovs.62.2.3

Includes: Supplemental Content

Biochemistry and Molecular Biology September 2020

VEGF-B Is an Autocrine Gliotrophic Factor for Müller Cells under Pathologic Conditions

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María Llorián-Salvador; Peter Barabas; Eimear M. Byrne; Judith Lechner; Josy Augustine; Timothy M. Curtis; Mei Chen; Heping Xu
TAGS: vascular endothelial growth factor b, vascular endothelial growth factor a, hypoxia
Invest. Ophthalmol. Vis. Sci.. 2020; 61(11):35. https://doi.org/10.1167/iovs.61.11.35

Includes: Supplemental Content

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IL1 family signalling is not involved in retinal pigment epithelial (RPE) cell senescence in age-related macular degeneration (AMD)

Developing novel therapies for macular fibrosis secondary to neovascular age-related macular degeneration

Single-cell RNA sequencing analysis revealed rod photoreceptors are most sensitive to age-induced degeneration

SIGIRR dysfunction exasperates age-related inflammation and retinal degeneration

Overcoming mitochondrial hyperfusion as a novel therapeutic target for retinal neuroprotection in diabetes

SOCS3 regulates retinal angiogenesis through modulating microglia SPP1 expression

Retinal Pigment Epithelial Cells Constitutively Express A Variety of Antimicrobial Peptides and the Expression Is Disrupted During Aging

Clinical Characterization of Myopic Retinopathy in LRP2 Best-Cre-KO mice

The distribution and phenotype of Glioma-associated oncogene 1 (Gli1) expressing cells in ocular tissues

Altered Levels of Intraocular inflammatory factors Are Related to Retinal Vascular and Retinal Neurodegeneration in Myopic Retinopathy

Shared microbiota profile in the retina, choroid and the gut

Higher Aqueous Level of Lipocalin-2 in Macular Fibrosis Secondary to Neovascular Age-related Macular Degeneration

Differential response to laser injury between young and aging retina

RNA-seq analysis reveals the pro-fibrotic role of aged RPE/choroid in a mouse model of subretinal fibrosis

Higher Aqueous Levels of Vascular Cell Adhesion Molecule-1 (VCAM-1) Is Related to Macular Fibrosis in Neovascular Age-related Macular Degeneration

The LRP2 is involved in the inflammatory and autophagy pathways in photoreceptors

CCR2+ monocytes critically contribute to subretinal fibrosis at the chronic stage of the disease.

Retinal Pigment Epithelial Cells Express Antimicrobial Peptide Lysozyme – A Novel Mechanism of Innate Immune Defense of the Blood-Retina Barrier

K ATP Opener Attenuates Diabetic-Induced Müller Gliosis and Inflammation by Modulating Kir6.1 in Microglia

VEGF-B Is an Autocrine Gliotrophic Factor for Müller Cells under Pathologic Conditions

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