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Articles May 2020

Intraocular Distribution and Kinetics of Intravitreally Injected Antibodies and Nanoparticles in Rabbit Eyes

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Hyeong Min Kim; Seungmin Ha; Hye Kyoung Hong; Yoonha Hwang; Pilhan Kim; Eunsol Yang; Jae Yong Chung; Sunyoung Park; Young Joo Park; Kyu Hyung Park; Hyuncheol Kim; Se Joon Woo
TAGS: antibodies, eye, kinetics, molecule, nanoparticles, oryctolagus cuniculus, vitreous body, fluorescence, immunoglobulin g, intravitreal injections
Trans. Vis. Sci. Tech.. 2020; 9(6):20. https://doi.org/10.1167/tvst.9.6.20

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2017

The role of Fc portion in the intravitreous half-life of anti-VEGF drugs

Kwangsic Joo; Sang Jun Park; Young Mi Na; Hye kyoung Hong; Yewon Choi; Jung Eun Lee; Hyuncheol Kim; Kyu Hyung Park; Ho Min Kim; Jae Yong Chung; Se Joon Woo

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1202.

ARVO Annual Meeting Abstract September 2016

Simulating Distribution of Drugs Depending on logP Values in a Rabbit Eye Model

Jihwang Lee; Hye kyoung Hong; Se Joon Woo; Hyuncheol Kim

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):6416.

Nantotechnology and Regenerative Medicine August 2015

Neuroprotective Effects of Human Serum Albumin Nanoparticles Loaded With Brimonidine on Retinal Ganglion Cells in Optic Nerve Crush Model

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Ko Eun Kim; Inseok Jang; Hyungwon Moon; Yu Jeong Kim; Jin Wook Jeoung; Ki Ho Park; Hyuncheol Kim
TAGS: albumins, brimonidine, nanoparticles, neuroprotective effect, optic nerve, retinal ganglion cells, serum albumin, wounds and injuries, cell survival, intravitreal injections
Invest. Ophthalmol. Vis. Sci.. 2015; 56(9):5641-5649. https://doi.org/10.1167/iovs.15-16538

ARVO Annual Meeting Abstract April 2014

Neuroprotective Effect of a Human Serum Albumin Nanoparticle on Retinal Ganglion Cells in the Glaucoma Animal Model

Inseok Jang; Hyungwon Moon; Kyung Nam Kim; Jin Wook Jeoung; Ki Ho Park; Hyuncheol Kim

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):2434.

ARVO Annual Meeting Abstract April 2014

Development and Evaluation of a polysiRNA delivery system to the retina

Changbum Sim; Ji Yeon Park; Ji Hyun Park; Hyekyoung Hong; Seong Joon Ahn; Se Joon Woo; Kyu Hyung Park; Hyuncheol Kim

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):4952.

Retina January 2014

Intraocular Pharmacokinetics of Ranibizumab in Vitrectomized Versus Nonvitrectomized Eyes

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Seong Joon Ahn; Jeeyun Ahn; Sunyoung Park; Hyuncheol Kim; Duck Jin Hwang; Ji Hyun Park; Ji Yeon Park; Jae Yong Chung; Kyu Hyung Park; Se Joon Woo
TAGS: eye, ranibizumab, pharmacokinetics, vitreous body
Invest. Ophthalmol. Vis. Sci.. 2014; 55(1):567-573. https://doi.org/10.1167/iovs.13-13054

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2013

Intraocular pharmacokinetics of bevacizumab and ranibizumab in vitrectomized versus non-vitrectomized rabbit eyes

Jeeyun Ahn; Sunyoung Park; Hyuncheol Kim; Ji Hyun Park; Ji Yeon Park; Duck Jin Hwang; Seong Joon Ahn; Yong-Kyu Kim; Kyu Hyung Park; Se Joon Woo

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):1080.

ARVO Annual Meeting Abstract June 2013

Neuroprotective effect on the retinal ganglion cells by brimonidine loaded HSA nanoparticles in the acute optic nerve crush model

Hyuncheol Kim; Hyungwon Moon; Kyoung Nam Kim; Yu Jeong Kim; Jin Wook Jeoung; Ki Ho Park

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):1094.

ARVO Annual Meeting Abstract March 2012

Pharmacokinetics of intravitreal bevacizumab (avastin) In vitrectomized eyes

Se Joon Woo; Jeeyun Ahn; Ji Hyun Park; Sunyoung Park; Kyu Hyung Park; Hyuncheol Kim

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):483.

ARVO Annual Meeting Abstract April 2011

Development Of An Optimized Nano-sized Sirna Delivery System To The Retina

Hyuncheol Kim; Hyunkoo Han; Heebeom Koo; Jin H. Na; Kwangmeyung Kim

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):428.

Physiology and Pharmacology October 2010

Evaluation of Clearance Mechanisms with Transscleral Drug Delivery

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Sung Jin Lee; Weiling He; Shaun B. Robinson; Michael R. Robinson; Karl G. Csaky; Hyuncheol Kim
TAGS: conjunctiva, drug clearance, drug delivery systems, excretory function, eye, implants, lymphatic vessels, body tissue, immunoglobulin g, retina
Invest. Ophthalmol. Vis. Sci.. 2010; 51(10):5205-5212. https://doi.org/10.1167/iovs.10-5337

Physiology and Pharmacology May 2008

Mapping of the Neonatal Fc Receptor in the Rodent Eye

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Hyuncheol Kim; Robert N. Fariss; Connie Zhang; Shaun B. Robinson; Michelle Thill; Karl G. Csaky
TAGS: body tissue, eye, fc receptors, immunohistochemistry, newborn, reverse transcriptase polymerase chain reaction, rodentia, monoclonal antibodies, rna, messenger, immunoglobulin g
Invest. Ophthalmol. Vis. Sci.. 2008; 49(5):2025-2029. https://doi.org/10.1167/iovs.07-0871

Cornea May 2007

A Pharmacokinetic and Safety Evaluation of an Episcleral Cyclosporine Implant for Potential Use in High-Risk Keratoplasty Rejection

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Susan S. Lee; Hyuncheol Kim; Nam Sun Wang; Peter M. Bungay; Brian C. Gilger; Peng Yuan; Jonghyeon Kim; Karl G. Csaky; Michael R. Robinson
TAGS: cyclosporine, implants, keratoplasty, rejection (psychology), pharmacokinetics, safety, cornea
Invest. Ophthalmol. Vis. Sci.. 2007; 48(5):2023-2029. https://doi.org/10.1167/iovs.06-0985

Physiology and Pharmacology June 2006

A Novel Bioerodible Deep Scleral Lamellar Cyclosporine Implant for Uveitis

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Brian C. Gilger; Jacklyn H. Salmon; David A. Wilkie; Lars P. J. Cruysberg; Jonghyeon Kim; Matt Hayat; Hyuncheol Kim; Stephanie Kim; Peng Yuan; Susan S. Lee; Susan M. Harrington; Patrick R. Murray; Henry F. Edelhauser; Karl G. Csaky; Michael R. Robinson
TAGS: cyclosporine, implants, sclera, uveitis
Invest. Ophthalmol. Vis. Sci.. 2006; 47(6):2596-2605. https://doi.org/10.1167/iovs.05-1540

Biochemistry and Molecular Biology December 2005

Transscleral-RPE Permeability of PEDF and Ovalbumin Proteins: Implications for Subconjunctival Protein Delivery

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Juan Amaral; Robert N. Fariss; Maria M. Campos; W. Gerald Robison, Jr; Hyuncheol Kim; Robert Lutz; S. Patricia Becerra
TAGS: ovalbumin, permeability, proteins, ovum, sclera
Invest. Ophthalmol. Vis. Sci.. 2005; 46(12):4383-4392. https://doi.org/10.1167/iovs.05-0492

Includes: Supplemental Content

Physiology and Pharmacology February 2005

Preclinical Evaluation of a Novel Episcleral Cyclosporine Implant for Ocular Graft-Versus-Host Disease

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Hyuncheol Kim; Karl G. Csaky; Brian C. Gilger; James P. Dunn; Susan S. Lee; Marcus Tremblay; Francisco de Monasterio; Ginger Tansey; Peng Yuan; Peter M. Bungay; Robert J. Lutz; Michael R. Robinson
TAGS: cyclosporine, graft-versus-host disease, implants, oryctolagus cuniculus
Invest. Ophthalmol. Vis. Sci.. 2005; 46(2):655-662. https://doi.org/10.1167/iovs.04-1076

Physiology and Pharmacology August 2004

Controlled Drug Release from an Ocular Implant: An Evaluation Using Dynamic Three-Dimensional Magnetic Resonance Imaging

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Hyuncheol Kim; Michael R. Robinson; Martin J. Lizak; Ginger Tansey; Robert J. Lutz; Peng Yuan; Nam S. Wang; Karl G. Csaky
TAGS: gadolinium dtpa, implants, eye, 3d mri, controlled substances
Invest. Ophthalmol. Vis. Sci.. 2004; 45(8):2722-2731. https://doi.org/10.1167/iovs.04-0091

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Intraocular Distribution and Kinetics of Intravitreally Injected Antibodies and Nanoparticles in Rabbit Eyes

The role of Fc portion in the intravitreous half-life of anti-VEGF drugs

Simulating Distribution of Drugs Depending on logP Values in a Rabbit Eye Model

Neuroprotective Effects of Human Serum Albumin Nanoparticles Loaded With Brimonidine on Retinal Ganglion Cells in Optic Nerve Crush Model

Neuroprotective Effect of a Human Serum Albumin Nanoparticle on Retinal Ganglion Cells in the Glaucoma Animal Model

Development and Evaluation of a polysiRNA delivery system to the retina

Intraocular Pharmacokinetics of Ranibizumab in Vitrectomized Versus Nonvitrectomized Eyes

Intraocular pharmacokinetics of bevacizumab and ranibizumab in vitrectomized versus non-vitrectomized rabbit eyes

Neuroprotective effect on the retinal ganglion cells by brimonidine loaded HSA nanoparticles in the acute optic nerve crush model

Pharmacokinetics of intravitreal bevacizumab (avastin) In vitrectomized eyes

Development Of An Optimized Nano-sized Sirna Delivery System To The Retina

Evaluation of Clearance Mechanisms with Transscleral Drug Delivery

Mapping of the Neonatal Fc Receptor in the Rodent Eye

A Pharmacokinetic and Safety Evaluation of an Episcleral Cyclosporine Implant for Potential Use in High-Risk Keratoplasty Rejection

A Novel Bioerodible Deep Scleral Lamellar Cyclosporine Implant for Uveitis

Transscleral-RPE Permeability of PEDF and Ovalbumin Proteins: Implications for Subconjunctival Protein Delivery

Preclinical Evaluation of a Novel Episcleral Cyclosporine Implant for Ocular Graft-Versus-Host Disease

Controlled Drug Release from an Ocular Implant: An Evaluation Using Dynamic Three-Dimensional Magnetic Resonance Imaging

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