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Glaucoma July 2024

Independent Effects of Blood Pressure on Intraocular Pressure and Retinal Ganglion Cell Degeneration: A Mendelian Randomization Study

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Skanda Rajasundaram; Ayellet V. Segrè; Dipender Gill; Benjamin Woolf; Seyedeh M. Zekavat; Stephen Burgess; Anthony P. Khawaja; Nazlee Zebardast; Janey L. Wiggs
TAGS: blood pressure, intraocular pressure, mendelian randomization analysis, open-angle glaucoma, retinal ganglion cells, tissue degeneration, sensitivity analysis, genetics, pleiotropism
Invest. Ophthalmol. Vis. Sci.. 2024; 65(8):35. https://doi.org/10.1167/iovs.65.8.35

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

Metabolomic Profiles of a High Genetic Risk Score for Exfoliation Syndrome/Glaucoma including LOXL1 Gene Polymorphisms

Namuunaa Juramt; Oana A. Zeleznik; Louis R Pasquale; Janey L Wiggs; Jae H Kang

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2171.

ARVO Annual Meeting Abstract June 2024

Connecting ocular and systemic health: Phenome- and genome- wide analyses of retinal layer thicknesses from optical coherence tomography imaging across >50k participants

Seyedeh Maryam Zekavat; Saman Doroodgar Jorshery; Franziska G Rauscher; Katrin Horn; Sayuri Sekimitsu; Yusrah Shweikh; Satoshi Koyama; Vineet Raghu; Tobias Elze; Ayellet Segre; Janey L Wiggs; Lucian V Del Priore; Jay C. Wang; Markus Scholz; Pradeep Natarajan; Nazlee Zebardast

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1014.

ARVO Annual Meeting Abstract June 2024

Primary open angle glaucoma polygenic risk score can identify individuals at low risk of disease onset in the Ocular Hypertension Treatment Study

Nazlee Zebardast; Sayuri Sekimitsu; Kanza Aziz; Yan Zhao; Rishabh Singh; John H Fingert; Mae O Gordon; Michael A Kass; Todd E Scheetz; Ayellet Segre; James D Brandt; Janey L Wiggs

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):996.

ARVO Annual Meeting Abstract June 2024

A metabolome-wide analysis of Intraocular pressure suggests neuroinflammatory mechanisms as possible mechanisms involved in glaucoma

Pirro G Hysi; Ajda Pristavec; Anthony P Khawaja; Jospeh Bastasic; David A Mackey; Janey L Wiggs; Jamie E Craig; Louis R Pasquale; Christopher J Hammond; Marie-Hélène Roy-Gagnon

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):997.

ARVO Annual Meeting Abstract June 2024

Machine learning based on prediagnostic metabolomic profiles identifies distinct subtypes of exfoliation glaucoma

Akiko Hanyuda; Oana A. Zeleznik; Yoshihiko Raita; Kazuno Negishi; Louis R Pasquale; Janey L Wiggs; Jae H Kang

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):998.

ARVO Annual Meeting Abstract June 2024

Gene-Environment Interaction Between Alcohol Intake and a CACNA1A SNP in Relation to Exfoliation Glaucoma/Glaucoma Suspect

Megan Yu; Hannah H Hwang; Namuunaa Juramt; Akiko Hanyuda; Louis R Pasquale; Janey L Wiggs; Jae H Kang

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):OD33.

ARVO Annual Meeting Abstract June 2024

Pre-diagnostic plasma endogenous steroids and the risk of exfoliation glaucoma

Hannah H Hwang; Megan Yu; Namuunaa Juramt; Oana A. Zeleznik; Louis R Pasquale; Janey L Wiggs; Jae H Kang

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):OD9.

ARVO Annual Meeting Abstract June 2024

Polygenic Risk Score for Primary Open Angle Glaucoma is Associated with Selective Laser Trabeculoplasty Outcomes

Prizka Avilia Puspa; Kanza Aziz; Sayuri Sekimitsu; Doaa Hegazy; Yan Zhao; Janey L Wiggs; Ayellet Segre; Nazlee Zebardast

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4242.

ARVO Annual Meeting Abstract June 2024

Genetic risk for open angle glaucoma subtypes is associated with specific visual field defect classes

Sayuri Sekimitsu; Sophie Smith; Yan Zhao; Mohammad Eslami; Mengyu Wang; Tobias Elze; Ayellet Segre; Jae H Kang; Joni Tururen; Aarno Palotie; Joel Raemoe; Janey L Wiggs; Nazlee Zebardast

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1015.

ARVO Annual Meeting Abstract June 2024

Genetically adjusted cup-to-disk ratio for detecting primary open angle glaucoma

Surya Pulukuri; Yan Zhao; Joyce Kang; Ayellet Segre; Sayuri Sekimitsu; Janey L Wiggs; Nazlee Zebardast

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4252.

ARVO Annual Meeting Abstract June 2024

Lipoprotein metabolism pathway genetic risk score is associated with distinct glaucoma phenotypes in a clinical biobank

Kanza Aziz; Yan Zhao; Sayuri Sekimitsu; Mohammad Eslami; Ayellet Segre; Tobias Elze; Janey L Wiggs; Nazlee Zebardast

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):661.

ARVO Annual Meeting Abstract June 2024

Characterization of glaucoma-relevant phenotypes in an Angiopoietin-like 7 zebrafish knockout line

McKenzie Gillison; Anna Larson; Shi Song Rong; Janey L Wiggs; Inas F Aboobakar

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):626.

ARVO Annual Meeting Abstract June 2024

ClinGen Ocular Domain Working Group standards for disease nomenclature and variant classification

Robert B Hufnagel; Kristy Lee; Emily Place; Janey L Wiggs

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):451.

ARVO Annual Meeting Abstract June 2024

Screening by Glaucoma Polygenic Risk Score to Identify Primary Open-Angle Glaucoma in Two Biobanks: an Interim Report

Hetince Zhao; Louis R. Pasquale; Nazlee Zebardast; Rachel H. Lee; Kanza Aziz; David S Friedman; Thi Ha Vy; Ron Do; Ayellet Segre; Janey L Wiggs

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1010.

ARVO Annual Meeting Abstract June 2024

A novel 13q32.1 deletion in a Filipino Congenital Microcoria (MCOR) family

Ma. Carmela Guevarra; Edward Ryan Collantes; Michael Sibulo; Divine Joe Grace Marcelino; Nilo Vincent II Florcruz; Janey L Wiggs

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4669.

ARVO Annual Meeting Abstract June 2024

Functional Roles of SOX21 and GPR180 in Congenital Microcoria: Insights from Zebrafish Knockdown Models

Angel Tevar; Anna Larson; Divine Joe Grace Marcelino; Ma. Carmela Guevarra; Edward Ryan Collantes; Shi Song Rong; Janey L Wiggs

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4666.

ARVO Annual Meeting Abstract June 2024

Evaluating the clinical validity of gene-disease relationships in inherited ocular conditions

Emily Place; Emmanuelle Souzeau; Janey L Wiggs

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4654.

ARVO Annual Meeting Abstract June 2024

Female Reproductive Factors and Risk of Exfoliation Glaucoma/Glaucoma Suspect

Jae H Kang; Megan Yu; Hannah H Hwang; Namuunaa Juramt; Louis R Pasquale; Janey L Wiggs

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4615.

ARVO Annual Meeting Abstract June 2024

Using GWAS and Polygenic risk scores for Glaucoma Risk Stratification

Janey L Wiggs

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4338.

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Independent Effects of Blood Pressure on Intraocular Pressure and Retinal Ganglion Cell Degeneration: A Mendelian Randomization Study

Metabolomic Profiles of a High Genetic Risk Score for Exfoliation Syndrome/Glaucoma including LOXL1 Gene Polymorphisms

Connecting ocular and systemic health: Phenome- and genome- wide analyses of retinal layer thicknesses from optical coherence tomography imaging across >50k participants

Primary open angle glaucoma polygenic risk score can identify individuals at low risk of disease onset in the Ocular Hypertension Treatment Study

A metabolome-wide analysis of Intraocular pressure suggests neuroinflammatory mechanisms as possible mechanisms involved in glaucoma

Machine learning based on prediagnostic metabolomic profiles identifies distinct subtypes of exfoliation glaucoma

Gene-Environment Interaction Between Alcohol Intake and a CACNA1A SNP in Relation to Exfoliation Glaucoma/Glaucoma Suspect

Pre-diagnostic plasma endogenous steroids and the risk of exfoliation glaucoma

Polygenic Risk Score for Primary Open Angle Glaucoma is Associated with Selective Laser Trabeculoplasty Outcomes

Genetic risk for open angle glaucoma subtypes is associated with specific visual field defect classes

Genetically adjusted cup-to-disk ratio for detecting primary open angle glaucoma

Lipoprotein metabolism pathway genetic risk score is associated with distinct glaucoma phenotypes in a clinical biobank

Characterization of glaucoma-relevant phenotypes in an Angiopoietin-like 7 zebrafish knockout line

ClinGen Ocular Domain Working Group standards for disease nomenclature and variant classification

Screening by Glaucoma Polygenic Risk Score to Identify Primary Open-Angle Glaucoma in Two Biobanks: an Interim Report

A novel 13q32.1 deletion in a Filipino Congenital Microcoria (MCOR) family

Functional Roles of SOX21 and GPR180 in Congenital Microcoria: Insights from Zebrafish Knockdown Models

Evaluating the clinical validity of gene-disease relationships in inherited ocular conditions

Female Reproductive Factors and Risk of Exfoliation Glaucoma/Glaucoma Suspect

Using GWAS and Polygenic risk scores for Glaucoma Risk Stratification

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