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Retina December 2024

Retinal Degeneration Associated With Biallelic RDH12 Variants: Longitudinal Evaluation of Retinal Structure and Visual Function in Pediatric Patients

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Tomas S. Aleman; Alejandro J. Roman; Katherine E. Uyhazi; Yu You Jiang; Emma C. Bedoukian; Alexander Sumaroka; Vivian Wu; Malgorzata Swider; Iryna Viarbitskaya; Robert C. Russell; Elizabeth O. Shagena; Arlene J. Santos; Leona W. Serrano; Kelsey M. Parchinski; Rebecca J. Kim; Mariejel L. Weber; Alexandra V. Garafalo; Dorothy A. Thompson; Albert M. Maguire; Jean Bennett; Drew H. Scoles; Erin C. O'Neil; Jessica I. W. Morgan; Artur V. Cideciyan
TAGS: pediatrics, retina, retinal cone, retinal degeneration, vision, photoreceptors, diagnostic imaging, rod photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):30. https://doi.org/10.1167/iovs.65.14.30

Includes: Supplemental Content

New Developments in Vision Research August 2024

Report From the Second Global Scientific Conference on Clinical Trial Design and Outcome Measures for RDH12 -Associated Inherited Retinal Degeneration

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Silvia Cerolini; Jean Bennett; Bart P. Leroy; Todd Durham; Courtney Coates; Mathew T. Pletcher; Sue Lacey; Tomas S. Aleman
TAGS: gene therapy, outcome measures, retinal degeneration, science, vision
Trans. Vis. Sci. Tech.. 2024; 13(8):17. https://doi.org/10.1167/tvst.13.8.17

ARVO Annual Meeting Abstract June 2024

Treatment Potential of RPGRIP1 -associated Inherited Retinal Degenerations

Emma Bedoukian; Jean Bennett; Katherine E. Uyhazi; Albert Maguire; Erin O'Neil; Emily Krauss; Alejandro J Roman; Alexander Sumaroka; Malgorzata Swider; Drew Scoles; Alexandra V Garafalo; Artur V Cideciyan; Tomas S Aleman

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2209.

ARVO Annual Meeting Abstract June 2024

AAV8- hLCA5 Subretinal Delivery to the Macula in LCA5 -associated Leber Congenital Amaurosis ( LCA5 -LCA): Preliminary Safety and Efficacy Results of an Ongoing Phase I/II Gene Therapy Trial

Tomas S Aleman; Artur V Cideciyan; Mariejel L Weber; Arlene Santos; Katherine E. Uyhazi; Kelsey Parchinski; William Chung; Paris Margaritis; junwei sun; Drew Scoles; Alexandra V Garafalo; Ashwath Jayagopal; Benjamin R Yerxa; Sarah Tuller; Albert Maguire; Jean Bennett

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3288.

ARVO Annual Meeting Abstract June 2023

A patient-driven, multi-stakeholder, collaborative approach to address IRD endpoint challenges: the RDH12 example

Silvia Cerolini; Jean Bennett; Bart Peter Leroy; Tomas S Aleman; Avril Daly; Todd Durham; Courtney Coates; Mathew Pletcher; Sue Lacey

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):795.

ARVO Annual Meeting Abstract June 2023

Structural and Functional Relationships in RDH12 -Associated Early-Onset Severe Inherited Retinal Degeneration

Erin O'Neil; Vivian Qin; Mariejel Weber; Katherine E. Uyhazi; Drew Scoles; Yu You Jiang; Albert Maguire; Jean Bennett; Jessica Ijams Wolfing Morgan; Tomas S Aleman

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1541.

Retina January 2023

Optimization and Validation of a Virtual Reality Orientation and Mobility Test for Inherited Retinal Degenerations

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Jean Bennett; Elena M. Aleman; Katherine H. Maguire; Jennifer Nadelmann; Mariejel L. Weber; William M. Maguire; Ayodele Maja; Erin C. O'Neil; Albert M. Maguire; Alexander J. Miller; Tomas S. Aleman
TAGS: luminance, mobility, mobility testing, retinal degeneration, virtual reality, vision, visual fields, questionnaires, eye
Trans. Vis. Sci. Tech.. 2023; 12(1):28. https://doi.org/10.1167/tvst.12.1.28

Includes: Multimedia, Supplemental Content

ARVO Annual Meeting Abstract June 2022

A novel virtual reality orientation and mobility test to assess functional vision in patients with inherited retinal dystrophies

Jean Bennett; Elena M Aleman; Katherine Maguire; Alexander J Miller; Mariejel Weber; Ayodele Kobina Maja; Albert M Maguire; Tomas S Aleman

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4496 – F0283.

ARVO Annual Meeting Abstract June 2022

Preparation for a Gene Therapy Trial for LCA5 -Associated Retinal Degenerations: Treatment Potential in Patients and Dose-ranging Studies in Non-human Primates

Paris Margaritis; Jean Bennett; Steven Chomistek; Vidyullatha Vasireddy; Ivan Shpylchak; Zhangyong Wei; Angela Luo; Junwei Sun; Shangzhen Zhou; Jennifer Pham; Albert M Maguire; Katherine E. Uyhazi; Tomas S Aleman

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4141 – F0378.

ARVO Annual Meeting Abstract June 2022

Central Structural and Functional Abnormalities in Choroideremia: Longitudinal and Cross-sectional Observations from a Large Cohort of Patients

Erin O'Neil; Katherine E. Uyhazi; Kurt Scavelli; Keli O'Connor; Elizabeth Shagena; Yu You Jiang; Albert M Maguire; Jessica Ijams Wolfing Morgan; Jean Bennett; Tomas S Aleman

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4529 – F0316.

ARVO Annual Meeting Abstract June 2022

Preparation for a Gene Augmentation Trial for RDH12 -Associated Retinal Degenerations

Tomas S Aleman; Brent A Bell; Steven Chomistek; Junwei Sun; Mariejel Weber; Jay V Pendyala; Albert M Maguire; Jennifer Pham; Ivan Shpylchak; Shangzhen Zhou; Angela Luo; Paris Margaritis; Zhangyong Wei; Jean Bennett

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4512 – F0299.

Articles May 2022

Restoration of Vision and Retinal Responses After Adeno-Associated Virus–Mediated Optogenetic Therapy in Blind Dogs

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Sergei Nikonov; Puya Aravand; Arkady Lyubarsky; Roman Nikonov; Angela J. Luo; Zhangyong Wei; Albert M. Maguire; Nicholas T. Phelps; Ivan Shpylchak; Keirnan Willett; Tomas S. Aleman; Rachel M. Huckfeldt; Pavitra S. Ramachandran; Jean Bennett
TAGS: adeno-associated virus, dog, domestic, gene therapy, optogenetics, retina, retinal cone, vision, mice, animal model
Trans. Vis. Sci. Tech.. 2022; 11(5):24. https://doi.org/10.1167/tvst.11.5.24

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2021

Bardet-Biedl Syndrome-7 (BBS7) Shows Treatment Potential and a Cone-Rod Dystrophy Phenotype that Recapitulates the Non-Human Primate Model

Erin O'Neil; Tomas S Aleman; Keli O'Connor; Yu You Jiang; Isabella Aleman; Jessica Ijams Wolfing Morgan; Brian Toussaint; Jean Bennett

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1525.

ARVO Annual Meeting Abstract June 2021

Five-Year Post-Injection Results of the Phase 3 Trial of Voretigene Neparvovec-rzyl in Biallelic RPE65 Mutation-Associated Inherited Retinal Disease

Jean Bennett; Stephen R Russell; Katherine A High; Arlene V Drack; Zi-Fan Yu; Daniel C Chung; Kathy Reape; Albert M Maguire

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3540.

ARVO Annual Meeting Abstract June 2021

Dissecting the disease mechanism of Leber congenital amaurosis type 5 (LCA5) using retinal affinity proteomics

Siebren Faber; Stef Letteboer; Alejandro Garanto; Katrin Junger; Tina Beyer; Jean Bennett; Marius Ueffing; Rob W.J. Collin; Karsten Boldt; Ronald Roepman

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3077.

ARVO Annual Meeting Abstract June 2021

Cone mosaic integrity in choroideremia following gene augmentation via subretinal injection of AAV2- hCHM

Jessica Ijams Wolfing Morgan; Yu You Jiang; Leona W Serrano; Denise J Pearson; Jean Bennett; Albert M Maguire; Tomas S Aleman

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):47.

ARVO Imaging in the Eye Conference Abstract July 2020

Downstream effects of retinal gene therapy on the volume of the lateral geniculate nucleus (LGN): A functional and structural assessment

Mikhail Lipin; Philip Cook; Theresa Mowad; Jean Bennett; Albert Maguire; Manzar Ashtari

Invest. Ophthalmol. Vis. Sci.. 2020; 61(9):PB0042.

ARVO Annual Meeting Abstract June 2020

Multi-modal adaptive optics imaging in GUCA1A -associated autosomal dominant cone-rod dystrophy

Yu You Jiang; Erin O'Neil; Leona Serrano; Denise J. Pearson; Jean Bennett; Tomas Aleman; Jessica Ijams Wolfing Morgan

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):214.

ARVO Annual Meeting Abstract June 2020

Short-term assessment of subfoveal injection of AAV2- hCHM gene augmentation in Choroideremia using adaptive optics ophthalmoscopy

Jessica Ijams Wolfing Morgan; Yu You Jiang; Leona Serrano; Denise J. Pearson; Jean Bennett; Albert Maguire; Tomas Aleman

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1130.

ARVO Annual Meeting Abstract June 2020

Psychometric evaluation of a modified version of the Visual Function Questionnaire using data from a Phase III trial in biallelic RPE65 mutation-associated inherited retinal dystrophy

Judit Banhazi; Daniel Viriato; Claudio Spera; Nicola Williamson; Helena Bradley; Elizabeth Exall; Jean Bennett

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1578.

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Retinal Degeneration Associated With Biallelic RDH12 Variants: Longitudinal Evaluation of Retinal Structure and Visual Function in Pediatric Patients

Report From the Second Global Scientific Conference on Clinical Trial Design and Outcome Measures for RDH12 -Associated Inherited Retinal Degeneration

Treatment Potential of RPGRIP1 -associated Inherited Retinal Degenerations

AAV8- hLCA5 Subretinal Delivery to the Macula in LCA5 -associated Leber Congenital Amaurosis ( LCA5 -LCA): Preliminary Safety and Efficacy Results of an Ongoing Phase I/II Gene Therapy Trial

A patient-driven, multi-stakeholder, collaborative approach to address IRD endpoint challenges: the RDH12 example

Structural and Functional Relationships in RDH12 -Associated Early-Onset Severe Inherited Retinal Degeneration

Optimization and Validation of a Virtual Reality Orientation and Mobility Test for Inherited Retinal Degenerations

A novel virtual reality orientation and mobility test to assess functional vision in patients with inherited retinal dystrophies

Preparation for a Gene Therapy Trial for LCA5 -Associated Retinal Degenerations: Treatment Potential in Patients and Dose-ranging Studies in Non-human Primates

Central Structural and Functional Abnormalities in Choroideremia: Longitudinal and Cross-sectional Observations from a Large Cohort of Patients

Preparation for a Gene Augmentation Trial for RDH12 -Associated Retinal Degenerations

Restoration of Vision and Retinal Responses After Adeno-Associated Virus–Mediated Optogenetic Therapy in Blind Dogs

Bardet-Biedl Syndrome-7 (BBS7) Shows Treatment Potential and a Cone-Rod Dystrophy Phenotype that Recapitulates the Non-Human Primate Model

Five-Year Post-Injection Results of the Phase 3 Trial of Voretigene Neparvovec-rzyl in Biallelic RPE65 Mutation-Associated Inherited Retinal Disease

Dissecting the disease mechanism of Leber congenital amaurosis type 5 (LCA5) using retinal affinity proteomics

Cone mosaic integrity in choroideremia following gene augmentation via subretinal injection of AAV2- hCHM

Downstream effects of retinal gene therapy on the volume of the lateral geniculate nucleus (LGN): A functional and structural assessment

Multi-modal adaptive optics imaging in GUCA1A -associated autosomal dominant cone-rod dystrophy

Short-term assessment of subfoveal injection of AAV2- hCHM gene augmentation in Choroideremia using adaptive optics ophthalmoscopy

Psychometric evaluation of a modified version of the Visual Function Questionnaire using data from a Phase III trial in biallelic RPE65 mutation-associated inherited retinal dystrophy

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