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Glaucoma August 2024

GSK3β Inhibitors Inhibit TGFβ Signaling in the Human Trabecular Meshwork

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Chenna Kesavulu Sugali; Naga Pradeep Rayana; Jiannong Dai; Devon H. Harvey; Kamesh Dhamodaran; Weiming Mao
TAGS: proteins, signal transduction, trabecular meshwork, perfusion, luciferases
Invest. Ophthalmol. Vis. Sci.. 2024; 65(10):3. https://doi.org/10.1167/iovs.65.10.3

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

Standardize clinical trials monitoring with Large Language Model (LLM)-enhanced FAQ management

Jason K Lai; Nicolas Delporte; Brian Tung; Youshi Zhang; Chisom Madu; Daniyar Douletbekov; Carlos Quezada Ruiz; Jian Dai

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):361.

ARVO Annual Meeting Abstract June 2024

The role of ATP-binding cassette transporter A1 (ABCA1) in glucocorticoid-induced lipid and extracellular matrix accumulation in the trabecular meshwork

Jiannong Dai; Devon Harvey; Chenna Kesavulu Sugali; Weiming Mao

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3582.

ARVO Annual Meeting Abstract June 2024

The effect of cross-linked actin networks (CLANs) on primary human trabecular meshwork cell proliferation and senescence

Devon Harvey; Jiannong Dai; Chenna Kesavulu Sugali; Weiming Mao

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3554.

ARVO Annual Meeting Abstract June 2024

Exploring the role of the distal outflow tissue in glucocorticoid-induced ocular hypertension

Weiming Mao; Devon H. Harvey; Naga Pradeep Rayana; Chenna Kesavulu Sugali; Jiannong Dai

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5142.

ARVO Annual Meeting Abstract June 2023

A pilot study of machine learning models for prediction of treatment response in patients with diabetic macular edema in a phase II clinical trial

Zhuoyu Wen; Yusuke Kikuchi; Oluwatobi Idowu; Jian Dai; Qi Yang; Carlos Quezada-Ruiz

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):241.

ARVO Annual Meeting Abstract June 2023

Inhibition of pterygium cell fibrosis by the Rho kinase inhibitor

Jiannong Dai; naga rayana; Michael Peng; Chenna Kesavulu Sugali; Shaohui Liu; Weiming Mao

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1395.

ARVO Annual Meeting Abstract June 2023

Inhibition of the Wnt signaling pathway induces ER stress and proapoptotic markers in the trabecular meshwork

Chenna Kesavulu Sugali; Jiannong Dai; Weiming Mao

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2429.

ARVO Annual Meeting Abstract June 2023

Development of a novel mouse anterior segment perfusion culture model

Weiming Mao; Michael Peng; Naga Pradeep Rayana; Jiannong Dai; Chenna Kesavulu Sugali

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3467.

ARVO Annual Meeting Abstract June 2022

Detecting patients with ocular comorbidities when screening for diabetic retinopathy (DR): an out-of-distribution (OOD) perspective

Jelena Novosel; Jian Dai; Daniela Ferrara; Fethallah Benmansour

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2987 – F0257.

ARVO Annual Meeting Abstract June 2022

Predicting optimal treatment regimen for patients with neovascular age-related macular degeneration (nAMD) using machine learning

Yusuke Kikuchi; Ales Neubert; Jian Dai; Carlos Quezada Ruiz

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2986 – F0256.

ARVO Annual Meeting Abstract June 2022

Machine learning approach to identify future treatment requirement in pretreated nAMD patients based on OCT images

Ales Neubert; Andreas Maunz; Siqing Yu; Thu Le von Strauss; Andreas Wenzel; Jian Dai

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2991 – F0261.

ARVO Annual Meeting Abstract June 2022

The role of actin binding protein in the formation of cross-linked actin networks (CLANs) in trabecular meshwork cells

Jiannong Dai; Naga pradeep Rayana; Chenna Kesavulu Sugali; Weiming Mao

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2722 – A0086.

ARVO Annual Meeting Abstract June 2022

SMAD4-β-catenin nuclear complex inhibits TGFβ2-induced pathological changes in the trabecular meshwork.

Chenna Kesavulu Sugali; Naga pradeep Rayana; Jiannong Dai; Weiming Mao

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2644.

ARVO Annual Meeting Abstract June 2022

The role of age and sex in the TGFβ2-induced ocular hypertension mouse model

Naga pradeep Rayana; Weiming Mao; Chenna Kesavulu Sugali; Jiannong Dai; Michael Peng

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3289 – A0389.

ARVO Annual Meeting Abstract June 2022

A novel ex vivo human anterior segment perfusion culture model using dornor corneal rims

Weiming Mao; Michael Peng; Tyler J Margetts; Chenna Kesavulu Sugali; Naga pradeep Rayana; Jiannong Dai; Tasneem Putliwala Sharma; Vijaykrishna Raghunathan

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3287 – A0387.

Glaucoma September 2021

Using CRISPR Interference as a Therapeutic Approach to Treat TGFβ2-Induced Ocular Hypertension and Glaucoma

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Naga Pradeep Rayana; Chenna Kesavulu Sugali; Jiannong Dai; Michael Peng; Shaohui Liu; Yucheng Zhang; Jun Wan; Weiming Mao
TAGS: crispr, eye, glaucoma, mice, ocular hypertension, cytomegalovirus, lentiviral vector, adenoviruses, genes
Invest. Ophthalmol. Vis. Sci.. 2021; 62(12):7. https://doi.org/10.1167/iovs.62.12.7

Includes: Supplemental Content

ARVO Imaging in the Eye Conference Abstract August 2021

Development and validation of a machine learning (ML) model for predicting 3-month (M) best-corrected visual acuity (BCVA) after monthly ranibizumab (RBZ) treatment in patients with neovascular age-related macular degeneration (nAMD)

Andreas Maunz; Ian Lloyd Jones; Jian Dai

Invest. Ophthalmol. Vis. Sci.. 2021; 62(11):24.

ARVO Annual Meeting Abstract June 2021

A pilot study using machine learning (ML) to predict treatment outcomes in patients with neovascular age-related macular degeneration (nAMD) using phase 2 trial data

Yusuke Kikuchi; Michael Kawczynski; Neha Anegondi; Jian Dai; Carlos Quezada Ruiz

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):82.

ARVO Annual Meeting Abstract June 2021

A multimodal deep learning (DL) model to predict visual acuity response in the CATT study

Jelena Novosel; Neha Anegondi; Jian Dai; Ebenezer Daniel; Glenn J Jaffe; Maureen G Maguire; Jeffrey R Willis

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):81.

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GSK3β Inhibitors Inhibit TGFβ Signaling in the Human Trabecular Meshwork

Standardize clinical trials monitoring with Large Language Model (LLM)-enhanced FAQ management

The role of ATP-binding cassette transporter A1 (ABCA1) in glucocorticoid-induced lipid and extracellular matrix accumulation in the trabecular meshwork

The effect of cross-linked actin networks (CLANs) on primary human trabecular meshwork cell proliferation and senescence

Exploring the role of the distal outflow tissue in glucocorticoid-induced ocular hypertension

A pilot study of machine learning models for prediction of treatment response in patients with diabetic macular edema in a phase II clinical trial

Inhibition of pterygium cell fibrosis by the Rho kinase inhibitor

Inhibition of the Wnt signaling pathway induces ER stress and proapoptotic markers in the trabecular meshwork

Development of a novel mouse anterior segment perfusion culture model

Detecting patients with ocular comorbidities when screening for diabetic retinopathy (DR): an out-of-distribution (OOD) perspective

Predicting optimal treatment regimen for patients with neovascular age-related macular degeneration (nAMD) using machine learning

Machine learning approach to identify future treatment requirement in pretreated nAMD patients based on OCT images

The role of actin binding protein in the formation of cross-linked actin networks (CLANs) in trabecular meshwork cells

SMAD4-β-catenin nuclear complex inhibits TGFβ2-induced pathological changes in the trabecular meshwork.

The role of age and sex in the TGFβ2-induced ocular hypertension mouse model

A novel ex vivo human anterior segment perfusion culture model using dornor corneal rims

Using CRISPR Interference as a Therapeutic Approach to Treat TGFβ2-Induced Ocular Hypertension and Glaucoma

Development and validation of a machine learning (ML) model for predicting 3-month (M) best-corrected visual acuity (BCVA) after monthly ranibizumab (RBZ) treatment in patients with neovascular age-related macular degeneration (nAMD)

A pilot study using machine learning (ML) to predict treatment outcomes in patients with neovascular age-related macular degeneration (nAMD) using phase 2 trial data

A multimodal deep learning (DL) model to predict visual acuity response in the CATT study

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