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Lens April 2025

Macrophage-Hosted Porphyromonas gingivalis Is a Risk Factor for Cataract Development

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Dongzhe Zhang; Junwei Qu; Cuncun Ke; Xiumei Kong; Mengyun Liu; Iqbal Nawaz Khan; Shuxin Huang; Haijiao Tian; Tong Xie; Ke Qiu; Jing Li; Mingli Wang; Hui Li; Fengling Yuan; Weikai Guo; Mingya Cao; Jing Zhang; Keke Zhu; Jin Luo; Fengyan Zhang; Xiukun Cui; Hongmei Mu; Yanzhong Hu
TAGS: body tissue, cataract, epithelium, infections, lens (device), macrophages, risk factors, porphyromonas gingivalis, hypertension, lens, crystalline
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):68. https://doi.org/10.1167/iovs.66.4.68

Includes: Supplemental Content

Immunology and Microbiology January 2025

Piezo1 Enhances Macrophage Phagocytosis and Pyrin Activation to Ameliorate Fungal Keratitis

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Jiahui Yang; Jing Zhong; Zhenyuan Fu; Dalian He; Jing Zhang; Jin Yuan
TAGS: cornea, fungal keratitis, infections, macrophages, marenostrin, mice, phagocytosis, proteins, mycoses, mass or substance concentration per volume
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):33. https://doi.org/10.1167/iovs.66.1.33

Includes: Supplemental Content

Cornea January 2025

RSPO3 Promotes Proliferation and Self-Renewal of Limbal Epithelial Stem Cells Through a WNT/β-Catenin-Independent Signaling Pathway

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Yan Shen; Jiajia Wang; Yiqin Dai; Xichen Wan; Jing Zhang; Qihua Le
TAGS: corneal epithelium, epithelial stem cells, signal pathway, signal transduction pathways, wounds and injuries, proteins, mice, wound healing, mass or substance concentration per volume
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):8. https://doi.org/10.1167/iovs.66.1.8

Includes: Supplemental Content

Retina September 2024

Loss of ON-Pathway Function in Mice Lacking Lrit3 Decreases Recovery From Lens-Induced Myopia

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Baptiste Wilmet; Christelle Michiels; Jingyi Zhang; Jacques Callebert; José Alain Sahel; Serge Picaud; Isabelle Audo; Christina Zeitz
TAGS: lens (device), lens, crystalline, mice, myopia, recovery of function, 3,4-dihydroxyphenylacetic acid
Invest. Ophthalmol. Vis. Sci.. 2024; 65(11):18. https://doi.org/10.1167/iovs.65.11.18

Glaucoma July 2024

Pigment Dispersion Contributes to Ocular Immune Privilege in a DBA/2J Mouse Model of Pigmentary Glaucoma

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Qian Li; Liping Pu; Sijie Cheng; Shaoping Tang; Jingxue Zhang; Guoping Qing
TAGS: mice, pigment, immune privilege, glaucoma, pigmentary, particle, hypertension
Invest. Ophthalmol. Vis. Sci.. 2024; 65(8):51. https://doi.org/10.1167/iovs.65.8.51

ARVO Annual Meeting Abstract June 2024

Disruption of sphingolipid homeostasis promotes the progression of fungal keratitis

zhenyuan Fu; Jing Zhong; Jiahui Yang; Jing Zhang; Jin Yuan

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2907.

ARVO Annual Meeting Abstract June 2024

Inhibition of Microglial CSF1R signaling ameliorates neuroinflammation and photoreceptor degeneration in retinitis pigmentosa

Jiangmei Wu; Rong Li; Jing Zhang; Junqi Fan; Bin Lin

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1300.

ARVO Annual Meeting Abstract June 2024

A novel candidate gene, DUSP4 implicated in high myopia

Christina Zeitz; Wilmet Baptiste; Christelle Michiels; Jingyi ZHANG; Helen Frederiksen; Jacques Callebert; Marie-Laure Gimenez; Catherine W Morgans; Robert Duvoisin; Linda Horan; Robin Plevin; Jose Sahel; Serge A Picaud; Isabelle S Audo

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6152.

ARVO Annual Meeting Abstract June 2024

Inhibition of BAX/BAK-mediated apoptosis promotes retinal ganglion cell maintenance in human retinal organoids

Jingliang Simon Zhang; Robert Johnston

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):951.

Retina May 2024

Prediction of Visual Outcome After Rhegmatogenous Retinal Detachment Surgery Using Artificial Intelligence Techniques

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Hui Guo; Chubin Ou; Guangyi Wang; Bingxing Lu; Xinyu Li; Tinghua Yang; Jinglin Zhang
TAGS: artificial intelligence, rhegmatogenous retinal detachment, surgical outcome, surgical procedures, operative, deep learning, retinal detachment
Trans. Vis. Sci. Tech.. 2024; 13(5):17. https://doi.org/10.1167/tvst.13.5.17

Immunology and Microbiology January 2024

Comparative Analysis of Molecular Landscape in Mouse Models and Patients Reveals Conserved Inflammation Pathways in Age-Related Macular Degeneration

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Yan-Shan Liu; Jia-Qi Pan; Xu-Bin Pan; Fan-Sheng Kong; Jing-Qian Zhang; Zhi-Yuan Wei; Zhou-Heng Xu; Jun-Hua Rao; Ji-Hong Wang; Jian-Huan Chen
TAGS: age-related macular degeneration, choroidal neovascularization, genes, inflammation, mice, retinitis, multiomics, lasers, rna-seq, proteins
Invest. Ophthalmol. Vis. Sci.. 2024; 65(1):13. https://doi.org/10.1167/iovs.65.1.13

Includes: Supplemental Content

Biochemistry and Molecular Biology September 2023

Kallistatin Deficiency Induces the Oxidative Stress-Related Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells: A Novel Protagonist in Age-Related Macular Degeneration

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Gang Shen; Yanmei Li; Yongcheng Zeng; Fuyan Hong; Jing Zhang; Yan Wang; Chengwei Zhang; Wei Xiang; Jinhong Wang; Zhenzhen Fang; Weiwei Qi; Xia Yang; Guoquan Gao; Ti Zhou
TAGS: age-related macular degeneration, epithelial to mesenchymal transition, retinal pigment cell, stress, oxidative stress
Invest. Ophthalmol. Vis. Sci.. 2023; 64(12):15. https://doi.org/10.1167/iovs.64.12.15

Includes: Supplemental Content

Lacrimal Apparatus, Eyelids, Orbit June 2023

Establishment and Comparison of Two Different Animal Models of Graves’ Orbitopathy

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Wei Wang; Jing-Wen Zhang; Yu-Jie Qin; Hong-Yan Li; Yu-Xiang Dai; Hong Li
TAGS: animal model, immunization, thyrotropin receptor, adenoviruses, mice, body tissue, genes
Trans. Vis. Sci. Tech.. 2023; 12(6):12. https://doi.org/10.1167/tvst.12.6.12

Biochemistry and Molecular Biology June 2023

HSF4 Transcriptionally Activates Autophagy by Regulating ATG9a During Lens Terminal Differentiation

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Jing Zhang; Ning Jiang; Chunxiao Du; Hongzan Guo; Ranqi Meng; Xinyu Hou; Mugen Liu; Yanzhong Hu; Xiukun Cui
TAGS: autophagy, lens (device), lens, crystalline, mice, rapamycin, catabolism, organelles
Invest. Ophthalmol. Vis. Sci.. 2023; 64(7):5. https://doi.org/10.1167/iovs.64.7.5

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2023

CD33 regulates the inflammatory response and mitochondrial activity of microglial cells in the rd10 mouse model of retinitis pigmentosa

Jing Zhang; Jiang-Mei Wu; Bin Lin

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2421.

ARVO Annual Meeting Abstract June 2023

CX3CR1 deficiency induces glial cell reactivity and cone photoreceptor loss in the retina via the Stat3 signal pathway

LI RONG; Jiang-Mei Wu; Jing Zhang; Bin Lin

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2942.

ARVO Annual Meeting Abstract June 2023

Development of an RNA Targeting Based Gene Therapy Product for Neovascular Age-Related Macular Degeneration (nAMD)

Linyu Shi; Shaoran Wang; Weiwei Wu; Xing Wang; Qi Yang; Jingyu Zhang; Sheng He; Hongting Du; Jipeng Song; Chenhua Yang; Mengke Zhu; Xuan Yao; Hui Yang

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):934.

ARVO Annual Meeting Abstract June 2023

Restoration of retinal function and structure in an Rpe65 -deficient murine model via AAV9-mediated gene replacement therapy

Weiwei Wu; Sheng He; Qi Yang; Chenhua Yang; Jingyu Zhang; Jipeng Song; Mengke Zhu; Linyu Shi; Xuan Yao; Hui Yang

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2418.

ARVO Annual Meeting Abstract June 2023

Retinal ganglion cell generation and loss in human retinal organoids

Jingliang Simon Zhang; Robert Johnston

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3179.

Retina April 2023

Retinal Vascular Oxygen Saturation in Adults With Anisometropia

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Shanshan Ge; Liang Yang; Yuehua Zhou; Chen Li; Jing Zhang
TAGS: adult, anisometropia, myopia, oxygen saturation measurement, eye
Trans. Vis. Sci. Tech.. 2023; 12(4):14. https://doi.org/10.1167/tvst.12.4.14

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Macrophage-Hosted Porphyromonas gingivalis Is a Risk Factor for Cataract Development

Piezo1 Enhances Macrophage Phagocytosis and Pyrin Activation to Ameliorate Fungal Keratitis

RSPO3 Promotes Proliferation and Self-Renewal of Limbal Epithelial Stem Cells Through a WNT/β-Catenin-Independent Signaling Pathway

Loss of ON-Pathway Function in Mice Lacking Lrit3 Decreases Recovery From Lens-Induced Myopia

Pigment Dispersion Contributes to Ocular Immune Privilege in a DBA/2J Mouse Model of Pigmentary Glaucoma

Disruption of sphingolipid homeostasis promotes the progression of fungal keratitis

Inhibition of Microglial CSF1R signaling ameliorates neuroinflammation and photoreceptor degeneration in retinitis pigmentosa

A novel candidate gene, DUSP4 implicated in high myopia

Inhibition of BAX/BAK-mediated apoptosis promotes retinal ganglion cell maintenance in human retinal organoids

Prediction of Visual Outcome After Rhegmatogenous Retinal Detachment Surgery Using Artificial Intelligence Techniques

Comparative Analysis of Molecular Landscape in Mouse Models and Patients Reveals Conserved Inflammation Pathways in Age-Related Macular Degeneration

Kallistatin Deficiency Induces the Oxidative Stress-Related Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells: A Novel Protagonist in Age-Related Macular Degeneration

Establishment and Comparison of Two Different Animal Models of Graves’ Orbitopathy

HSF4 Transcriptionally Activates Autophagy by Regulating ATG9a During Lens Terminal Differentiation

CD33 regulates the inflammatory response and mitochondrial activity of microglial cells in the rd10 mouse model of retinitis pigmentosa

CX3CR1 deficiency induces glial cell reactivity and cone photoreceptor loss in the retina via the Stat3 signal pathway

Development of an RNA Targeting Based Gene Therapy Product for Neovascular Age-Related Macular Degeneration (nAMD)

Restoration of retinal function and structure in an Rpe65 -deficient murine model via AAV9-mediated gene replacement therapy

Retinal ganglion cell generation and loss in human retinal organoids

Retinal Vascular Oxygen Saturation in Adults With Anisometropia

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