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ARVO Annual Meeting Abstract June 2020

Cross-species transcriptomic and epigenomic analysis reveals key regulators of injury response and neuronal regeneration in vertebrate retinas

Thanh Hoang; Jie Wang; Patrick Boyd; Fang Wang; Clayton Santiago; John D Ash; Andy J Fischer; David R Hyde; Jiang Qian; Seth Blackshaw

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3220. doi:

ARVO Annual Meeting Abstract June 2020

Universal Responses to Stress in Inherited Retinal Degeneration

John D Ash; Jerome E Roger; Elodie-Kim Grellier; Anand Swaroop; Katya Lobanova; Casey Keuthan

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3221. doi:

ARVO Annual Meeting Abstract July 2019

STAT3 is a potential genetic modifier of photoreceptor gene expression during stress

Casey Keuthan; Clayton Santiago; John D Ash

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):466. doi:

ARVO Annual Meeting Abstract July 2019

The metabolic sensor AMPK is essential for the high metabolic program of Photoreceptors, but is surprisingly not required in RPE cells.

John D Ash; Lei Xu; Emily Brown

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1719. doi:

Clinical and Epidemiologic Research April 2019

The Common Antidiabetic Drug Metformin Reduces Odds of Developing Age-Related Macular Degeneration

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Emily E. Brown; Jacob D. Ball; Zhaoyi Chen; Gibran S. Khurshid; Mattia Prosperi; John D. Ash
TAGS: age-related macular degeneration, antidiabetics, metformin
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1470-1477. doi: https://doi.org/10.1167/iovs.18-26422

Perspective July 2018

Inherited Retinal Degenerations: Current Landscape and Knowledge Gaps

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Jacque L. Duncan; Eric A. Pierce; Amy M. Laster; Stephen P. Daiger; David G. Birch; John D. Ash; Alessandro Iannaccone; John G. Flannery; José A. Sahel; Donald J. Zack; Marco A. Zarbin; and the Foundation Fighting Blindness Scientific Advisory Board
TAGS: genes, genetics, retinal degeneration, comprehension, animal model, mutation
Trans. Vis. Sci. Tech.. 2018; 7(4):6. doi: https://doi.org/10.1167/tvst.7.4.6

ARVO Annual Meeting Abstract July 2018

Evidence that the AMPK activator, Metformin, induced protection of the retina and RPE through metabolic reprogramming

Lei Xu; Jianhai Du; John D Ash

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1186. doi:

ARVO Annual Meeting Abstract July 2018

Comparative transcriptomic and epigenomic analysis identifes regulators of neurogenic competence in retinal Müller glia.

Seth Blackshaw; Thanh Hoang; Jie Wang; Manuela Lahne; Levi Todd; Clayton Santiago; Nathalie Squires; Patrick Boyd; John D Ash; Andrew J Fischer; Jiang Qian; David R Hyde

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):991. doi:

ARVO Annual Meeting Abstract July 2018

Transcriptomics analysis of Muller glia in response to different damage paradigms in the adult zebrafish retina

David R Hyde; Patrick Boyd; Manuela Lahne; Thanh Hoang; Jie Wang; Clayton Santiago; Seth Blackshaw; Jiang Qian; John D Ash; Andy Fischer

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):992. doi:

ARVO Annual Meeting Abstract July 2018

Superoxide Dismutase 2 Deletion in Retinal Pigment Epithelium (RPE) Results in Age and Light-Dependent Mitochondrial Oxidative Stress and RPE-damage

Emily Brown; Alfred S Lewin; John D Ash

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2453. doi:

ARVO Annual Meeting Abstract July 2018

STAT3 directly regulates stress-induced expression of Edn2, to promote protection of photoreceptors through the activation of EdnrA

Marcus Hooper; Clayton Santiago; John D Ash

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2508. doi:

ARVO Annual Meeting Abstract July 2018

Müller cell transcriptional unit to regulate stress induced LIF expression

Clayton Santiago; Marcus Hooper; Thanh Hoang; Jie Wang; Jiang Qian; Seth Blackshaw; John D Ash

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2511. doi:

ARVO Annual Meeting Abstract July 2018

Development of a drug-regulated, broad-spectrum neuroprotective gene therapy for retinal degeneration

John D Ash; Casey Keuthan; Aisha Imam; Sanford L Boye; Shannon Elizabeth Boye; Clayton Santiago

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3961. doi:

ARVO Annual Meeting Abstract July 2018

Evidence that Stat3 protects photoreceptors by increasing expression of protein editing genes and decreasing outer segment genes

Casey Keuthan; Clayton Santiago; Marcus Hooper; Linda Qian; John D Ash

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4449. doi:

ARVO Annual Meeting Abstract June 2017

Deletion of Mitochondrial Antioxidant Enzyme Sod2 Induces Light-Dependent Retinal Degeneration with Aging

Emily Brown; John D Ash; Alfred S Lewin

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2294. doi:

ARVO Annual Meeting Abstract June 2017

A non-redundant role for PGC-1β in retinal homeostasis and photoreceptor resistance to oxidative stress induced by light exposure

Casey J Keuthan; Cassidy M Chason; John D Ash

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3016. doi:

ARVO Annual Meeting Abstract June 2017

Genetic loss of the metabolic sensor AMPK results in an accelerated aging of the retina

Lei Xu; Lena T Phu; Abraham M Bell; John D Ash

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3017. doi:

ARVO Annual Meeting Abstract June 2017

Toll-like receptor 2 promotes photoreceptor survival in acute retinal injury

Marcus Hooper; Clayton P Santiago; Raghav Ramchander; John D Ash

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5894. doi:

ARVO Annual Meeting Abstract June 2017

Using RiboTag and Sun1-sfGFP technologies to map Müller cell-specific epigenetic regulation of stress-induced LIF expression in vivo.

Clayton P Santiago; Casey J Keuthan; Aisha A Imam; John D Ash

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5902. doi:

ARVO Annual Meeting Abstract June 2017

Thioredoxin plays a key role in retinal neuropathy prior to endothelial damage in diabetic mice

Xiang Ren; John D Ash; Li Kong

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):88. doi:

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Cross-species transcriptomic and epigenomic analysis reveals key regulators of injury response and neuronal regeneration in vertebrate retinas

Universal Responses to Stress in Inherited Retinal Degeneration

STAT3 is a potential genetic modifier of photoreceptor gene expression during stress

The metabolic sensor AMPK is essential for the high metabolic program of Photoreceptors, but is surprisingly not required in RPE cells.

The Common Antidiabetic Drug Metformin Reduces Odds of Developing Age-Related Macular Degeneration

Inherited Retinal Degenerations: Current Landscape and Knowledge Gaps

Evidence that the AMPK activator, Metformin, induced protection of the retina and RPE through metabolic reprogramming

Comparative transcriptomic and epigenomic analysis identifes regulators of neurogenic competence in retinal Müller glia.

Transcriptomics analysis of Muller glia in response to different damage paradigms in the adult zebrafish retina

Superoxide Dismutase 2 Deletion in Retinal Pigment Epithelium (RPE) Results in Age and Light-Dependent Mitochondrial Oxidative Stress and RPE-damage

STAT3 directly regulates stress-induced expression of Edn2, to promote protection of photoreceptors through the activation of EdnrA

Müller cell transcriptional unit to regulate stress induced LIF expression

Development of a drug-regulated, broad-spectrum neuroprotective gene therapy for retinal degeneration

Evidence that Stat3 protects photoreceptors by increasing expression of protein editing genes and decreasing outer segment genes

Deletion of Mitochondrial Antioxidant Enzyme Sod2 Induces Light-Dependent Retinal Degeneration with Aging

A non-redundant role for PGC-1β in retinal homeostasis and photoreceptor resistance to oxidative stress induced by light exposure

Genetic loss of the metabolic sensor AMPK results in an accelerated aging of the retina

Toll-like receptor 2 promotes photoreceptor survival in acute retinal injury

Using RiboTag and Sun1-sfGFP technologies to map Müller cell-specific epigenetic regulation of stress-induced LIF expression in vivo.

Thioredoxin plays a key role in retinal neuropathy prior to endothelial damage in diabetic mice

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