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Artificial Intelligence August 2024

Automatic Determination of Endothelial Cell Density From Donor Cornea Endothelial Cell Images

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Beth Ann M. Benetz; Ved S. Shivade; Naomi M. Joseph; Nathan J. Romig; John C. McCormick; Jiawei Chen; Michael S. Titus; Onkar B. Sawant; Jameson M. Clover; Nathan Yoganathan; Harry J. Menegay; Robert C. O'Brien; David L. Wilson; Jonathan H. Lass
TAGS: cornea, deep learning, donors, endothelial cells, scleroderma, coup de sabre, eye banks, training
Trans. Vis. Sci. Tech.. 2024; 13(8):40. https://doi.org/10.1167/tvst.13.8.40

Includes: Supplemental Content

Artificial Intelligence February 2023

Machine Learning Analysis of Postkeratoplasty Endothelial Cell Images for the Prediction of Future Graft Rejection

PDF

Naomi Joseph; Beth Ann Benetz; Prathyush Chirra; Harry Menegay; Silke Oellerich; Lamis Baydoun; Gerrit R. J. Melles; Jonathan H. Lass; David L. Wilson
TAGS: diagnostic imaging, endothelial cells, machine learning, rejection (psychology), transplant rejection, eye, descemet membrane endothelial keratoplasty, datasets
Trans. Vis. Sci. Tech.. 2023; 12(2):22. https://doi.org/10.1167/tvst.12.2.22

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2021

Effect of S-Nitrosylation on post-mortem donor cornea endothelial health during hypothermic storage period

Ahmed Omar; Onkar Sawant; James Reynolds; Kayla Jones; Stephanie How; Lin Zhu; Daniel Daroszewski; Jonathan H Lass

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):927.

ARVO Imaging in the Eye Conference Abstract July 2020

Automatic segmentation with guided correction of post-keratoplasty corneal endothelial cell images and predictive feature extraction.

Naomi Joseph; Elizabeth Fitzpatrick; Chaitanya Kolluru; Harry Menegay; Stephanie Burke; Jonathan H Lass; Beth Ann Benetz; David L Wilson

Invest. Ophthalmol. Vis. Sci.. 2020; 61(9):PB0048.

ARVO Annual Meeting Abstract July 2019

The Association of Eye Bank Observations, Donor and Recipient Factors with Operative Complications in the Cornea Preservation Time Study

Kevin Ross; Christopher Stoeger; Robert O'Brien; Loretta Szczotka-Flynn; Allison Ayala; Maureen G Maguire; Beth Ann Benetz; Jonathan H Lass

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6301.

ARVO Annual Meeting Abstract July 2019

Comparison of Deep Learning and Manual Endothelial Cell Analysis in Donor Corneas post Descemet Stripping Automated Endothelial Keratoplasty (DSAEK)

Naomi Joseph; Chaitanya Kolluru; Harry Menegay; Steph Burke; Jonathan H Lass; Beth Ann Benetz; David Wilson

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1483.

ARVO Annual Meeting Abstract July 2018

Comparison of endothelial cell density determined by eye banks and by a centralized reading center in the Cornea Preservation Time Study (CPTS)

Beth Ann Benetz; Harry Menegay; Allison Ayala; Loretta Szczotka-Flynn; Robert O'Brien; Maureen G. Maguire; Kevin Ross; Jonathan H Lass

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2892.

ARVO Annual Meeting Abstract September 2016

Manual adjustment of specular images: Correcting what the computer can't see after DMEK

Zachary Mayko; Beth Ann Benetz; Christopher Stoeger; Harry Menegay; Chris Donovan; Mark A Terry; Jonathan H Lass

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):1934.

ARVO Annual Meeting Abstract September 2016

Do specular images of endothelial cell density post DMEK preparation tell you anything new?

Christopher Stoeger; Beth Ann Benetz; Zachary Mayko; Harry Menegay; Chris Donovan; Mark A Terry; Jonathan H Lass

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):1935.

Cornea December 2014

A Mathematical Model to Predict Endothelial Cell Density Following Penetrating Keratoplasty With Selective Dropout From Graft Failure

PDF

Tonya D. Riddlesworth; Craig Kollman; Jonathan H. Lass; Sanjay V. Patel; R. Doyle Stulting; Beth Ann Benetz; Robin L. Gal; Roy W. Beck
TAGS: endothelial cells, keratoplasty, penetrating, mathematical model, tissue transplants
Invest. Ophthalmol. Vis. Sci.. 2014; 55(12):8409-8415. https://doi.org/10.1167/iovs.14-15683

Cornea July 2014

Mitochondrial Polymorphism A10398G and Haplogroup I Are Associated With Fuchs' Endothelial Corneal Dystrophy

PDF

Yi-Ju Li; Mollie A. Minear; Xuejun Qin; Jacqueline Rimmler; Michael A. Hauser; R. Rand Allingham; Robert P. Igo; Jonathan H. Lass; Sudha K. Iyengar; Gordon K. Klintworth; Natalie A. Afshari; Simon G. Gregory
TAGS: dna, mitochondrial, endothelium, hereditary corneal dystrophy, mitochondria, polymorphism, alleles, genetics, smoking, single nucleotide polymorphism, genome-wide association study
Invest. Ophthalmol. Vis. Sci.. 2014; 55(7):4577-4584. https://doi.org/10.1167/iovs.13-13517

ARVO Annual Meeting Abstract April 2014

Visual and cognitive improvement following cataract surgery in dementia patients

Jonathan H Lass; Julie Belkin; Thomas Steinemann; Tatiana Majer; Alan Lerner; Sara Debanne; Grover Gilmore

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):2795.

ARVO Annual Meeting Abstract April 2014

Common variants in TCF4 and three novel genes increase susceptibility to Fuchs Dystrophy

Sudha K Iyengar; Yi-Ju Li; Robert P Igo; Kathryn P Burdon; John H Fingert; John Gottsch; Gordon K Klintworth; Jonathan H Lass; Natalie A Afshari; FECD Genetics Consortium

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):4070.

Cornea August 2013

Association of Smoking and Other Risk Factors With Fuchs' Endothelial Corneal Dystrophy Severity and Corneal Thickness

PDF

Xiaolin Zhang; Robert P. Igo, Jr; Jeremy Fondran; V. Vinod Mootha; Matt Oliva; Kristin Hammersmith; Alan Sugar; Jonathan H. Lass; Sudha K. Iyengar
TAGS: cornea, diabetes mellitus, diabetes mellitus, type 2, endothelium, eye, hereditary corneal dystrophy, risk factors, smoking, universities, consultants
Invest. Ophthalmol. Vis. Sci.. 2013; 54(8):5829-5835. https://doi.org/10.1167/iovs.13-11918

ARVO Annual Meeting Abstract March 2012

The relationship of smoking and other risk factors to severity of Fuchs’ Endothelial Corneal Dystrophy

Xiaolin Zhang; Jeremy Fondran; Robert P. Igo, Jr.; Matt Oliva; Jonathan H. Lass; Sudha K. Iyengar

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):78.

ARVO Annual Meeting Abstract April 2011

The Role of Corneal Thickness in Fuchs' Endothelial Corneal Dystrophy

Laura J. Kopplin; Katie Przepyszny; Brian Schmotzer; Lovleen Sharma; Karen Rudo; Denise Babineau; Sudha K. Iyengar; Jonathan H. Lass; FECD Genetics Multi-Center Study Group

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):1463.

Clinical Trials November 2010

Risk Factors for Corneal Infiltrative Events during Continuous Wear of Silicone Hydrogel Contact Lenses

PDF

Loretta Szczotka-Flynn; Jonathan H. Lass; Ajay Sethi; Sara Debanne; Beth Ann Benetz; Matthew Albright; Beth Gillespie; Jana Kuo; Michael R. Jacobs; Alfred Rimm
TAGS: contact lenses, cornea, hydrogel, lens (device), lens, crystalline, risk factors, silicones
Invest. Ophthalmol. Vis. Sci.. 2010; 51(11):5421-5430. https://doi.org/10.1167/iovs.10-5456

Immunology and Microbiology February 2005

Activation of Toll-Like Receptor (TLR)2, TLR4, and TLR9 in the Mammalian Cornea Induces MyD88-Dependent Corneal Inflammation

PDF

Angela C. Johnson; Fred P. Heinzel; Eugenia Diaconu; Yan Sun; Amy G. Hise; Douglas Golenbock; Jonathan H. Lass; Eric Pearlman
TAGS: cornea, corneal stroma, keratitis, mice, myd88 gene, toll-like receptor, toll-like receptor 2, toll-like receptor 4, toll-like receptor 9, mammals
Invest. Ophthalmol. Vis. Sci.. 2005; 46(2):589-595. https://doi.org/10.1167/iovs.04-1077

Immunology and Microbiology September 2002

IL-4 and IL-13 Regulation of ICAM-1 Expression and Eosinophil Recruitment in Onchocerca volvulus Keratitis

PDF

Ravi B. Berger; Nathan M. Blackwell; Jonathan H. Lass; Eugenia Diaconu; Eric Pearlman
TAGS: eosinophils, intercellular adhesion molecule 1, interleukin-13, interleukin-4, keratitis, cornea, intestinal volvulus, antigens, regulation
Invest. Ophthalmol. Vis. Sci.. 2002; 43(9):2992-2997.

Immunology and Microbiology July 2002

Regulation of Endotoxin-Induced Keratitis by PECAM-1, MIP-2, and Toll-like Receptor 4

PDF

Saloni Khatri; Jonathan H. Lass; Fred P. Heinzel; W. Matthew Petroll; John Gomez; Eugenia Diaconu; Carolyn M. Kalsow; Eric Pearlman
TAGS: cd31 antigens, endotoxins, keratitis, toll-like receptor 4, cornea
Invest. Ophthalmol. Vis. Sci.. 2002; 43(7):2278-2284.

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Automatic Determination of Endothelial Cell Density From Donor Cornea Endothelial Cell Images

Machine Learning Analysis of Postkeratoplasty Endothelial Cell Images for the Prediction of Future Graft Rejection

Effect of S-Nitrosylation on post-mortem donor cornea endothelial health during hypothermic storage period

Automatic segmentation with guided correction of post-keratoplasty corneal endothelial cell images and predictive feature extraction.

The Association of Eye Bank Observations, Donor and Recipient Factors with Operative Complications in the Cornea Preservation Time Study

Comparison of Deep Learning and Manual Endothelial Cell Analysis in Donor Corneas post Descemet Stripping Automated Endothelial Keratoplasty (DSAEK)

Comparison of endothelial cell density determined by eye banks and by a centralized reading center in the Cornea Preservation Time Study (CPTS)

Manual adjustment of specular images: Correcting what the computer can't see after DMEK

Do specular images of endothelial cell density post DMEK preparation tell you anything new?

A Mathematical Model to Predict Endothelial Cell Density Following Penetrating Keratoplasty With Selective Dropout From Graft Failure

Mitochondrial Polymorphism A10398G and Haplogroup I Are Associated With Fuchs' Endothelial Corneal Dystrophy

Visual and cognitive improvement following cataract surgery in dementia patients

Common variants in TCF4 and three novel genes increase susceptibility to Fuchs Dystrophy

Association of Smoking and Other Risk Factors With Fuchs' Endothelial Corneal Dystrophy Severity and Corneal Thickness

The relationship of smoking and other risk factors to severity of Fuchs’ Endothelial Corneal Dystrophy

The Role of Corneal Thickness in Fuchs' Endothelial Corneal Dystrophy

Risk Factors for Corneal Infiltrative Events during Continuous Wear of Silicone Hydrogel Contact Lenses

Activation of Toll-Like Receptor (TLR)2, TLR4, and TLR9 in the Mammalian Cornea Induces MyD88-Dependent Corneal Inflammation

IL-4 and IL-13 Regulation of ICAM-1 Expression and Eosinophil Recruitment in Onchocerca volvulus Keratitis

Regulation of Endotoxin-Induced Keratitis by PECAM-1, MIP-2, and Toll-like Receptor 4

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