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ARVO Annual Meeting Abstract June 2022

SPVN06, a novel mutation-independent AAV-based gene therapy, dramatically reduces vision loss in the rd10 mouse model of rod-cone dystrophy

Florence Lorget; Melanie Marie; Hanen Khabou; Cardillia Simon; Didier Nuno; Phillip Vanlandingham; Alain Quiambao; Rafal Farjo; Deniz Dalkara; Jose Alain Sahel; Thierry D Leveillard

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):56 – A0029. doi:

ARVO Annual Meeting Abstract June 2022

VSX2 variants are responsible for bipolar cell dysfunction with distinct lens and chorioretinal alterations.

Vasily M. SMIRNOV; Matthieu Robert; Christel Condroyer; Aline Antonio; Jean-Michel Rozet; Jose Alain Sahel; Isabelle Perrault; Isabelle S Audo; Christina Zeitz

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):487 – A0064. doi:

ARVO Annual Meeting Abstract June 2022

Worldwide multicenter ocular imaging study (EyeConic) to identify patients eligible for cone-based optogenetics therapy

Lucas Janeschitz-Kriegl; Giacomo Calzetti; Michel Michaelides; Jose Alain Sahel; Zoltán Nagy; Katarina Stingl; Jin Zi-Bing; Jacque L Duncan; Eyal Banin; Byron L Lam; Michalis Georgiou; Boris Rosin; Viktória Szabo; Potyra Rosa; Bence György; Hendrik P Scholl

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):455. doi:

ARVO Annual Meeting Abstract June 2022

The phase III REFLECT trial: efficacy of bilateral gene therapy for Leber hereditary optic neuropathy (LHON) is maintained 2 years post administration

Patrick Yu-Wai-Man; Nancy Newman; Prem S Subramanian; Mark Moster; An-Guor Wang; Sean Donahue; Bart Leroy; Valerio Carelli; Valerie Biousse; Catherine Vignal-Clermont; Alfredo A Sadun; Gema Fernandez; Elizabeth Fortin; Rudrani Banik; Magali Taiel; Jose Alain Sahel

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):434. doi:

ARVO Annual Meeting Abstract June 2022

Genotype-phenotype correlation and disease modeling in RPGR -related cone and cone-rod dystrophies.

Marco Nassisi; Giuseppe De Bartolo; Saddek Mohand-Said; Christel Condroyer; Aline Antonio; Marie-Elise Lancelot; Kinga Maria Bujakowska; Vasily M. SMIRNOV; Thomas Pugliese; John Neidhardt; Jose Alain Sahel; Christina Zeitz; Isabelle S Audo

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):138 – A0318. doi:

ARVO Annual Meeting Abstract June 2022

Human corneal stromal stem cells express microRNA-29a in exosomes – a robust cell selection for stem cell therapy of corneal scarring

Gary Hin-Fai Yam; Mithun Santra; Jose Alain Sahel; James L Funderburgh; Vishal Jhanji

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):111 – A0209. doi:

ARVO Annual Meeting Abstract June 2022

Development and validation of a mobility test for Inherited Retinal Disease in real and virtual conditions - preliminary results.

Colas Nils Authié; Mylène Poujade; Alireza Talebi; Alexis Defer; Ariel Zenouda; Cecilia Coen; Yihan Zhang; Jose Alain Sahel; Saddek Mohand-Said; Philippe Chaumet-Riffaud; Isabelle S Audo

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):715 – F0443. doi:

ARVO Annual Meeting Abstract June 2022

Optogenetics in the clinic: safety and efficacy updates on the phase 1/2 clinical trial PIONEER

Jose Alain Sahel; Isabelle S Audo; Elise Boulanger-Scemama; Chloé Pagot; Angelo Arleo; Joseph N Martel; Simona Degli Esposti; Alexandre Delaux; Jean-Baptiste de Saint Aubert; Caroline de Montleau; Emmanuel Gutman; Jens Duebel; Serge Picaud; Deniz Dalkara; Magali Taiel; Botond Roska

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1106. doi:

ARVO Annual Meeting Abstract June 2022

Potent retinal protection by oral administration of a purine metabolite against age-related retinal degeneration and RHO-associated retinitis pigmentosa

Owen Clinger; Yibo Xi; Abhishek Vats; Amanda Wolf-Johnson; Lori Birder; Edwin Jackson; Jose Alain Sahel; Yuanyuan Chen

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1777 – F0326. doi:

ARVO Annual Meeting Abstract June 2022

Visual field loss and fitness to drive: preliminary results

julien Adrian; Caroline de Montleau; Jose Alain Sahel; Gérard Saillant; Philippe Chaumet-Riffaud

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2467 – F0044. doi:

ARVO Annual Meeting Abstract June 2022

Human iPSC-based retinal cell library for disease modeling and drug discovery

Sacha Reichman; Celine Nanteau; Marilou Clémençon; Marc Lechuga; Xavier Guillonneau; José-Alain Sahel; Olivier Goureau; Sandy Gozlan

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2440 – F0384. doi:

ARVO Annual Meeting Abstract June 2022

Association of patient characteristics with self-reported barriers to eye care at a free community vision screening event

Haniah A. Zaheer; Sarah Atta; Owen Clinger; Peggy J. Liu; Evan J. Waxman; Dana McGinnis-Thomas; Jose Alain Sahel; Andrew Williams

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2134 – A0162. doi:

ARVO Annual Meeting Abstract June 2022

Role of Metformin in the Development and Progression of Age-Related Macular Degeneration

Jennifer Adeghate; Rikki Enzor; Bushra Usmani; Peter Jones; Jamie Odden; Asad Farooq Durrani; Benjamin Botsford; Steve Koscumb; Oscar Marroquin; Jose Alain Sahel

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3529. doi:

ARVO Annual Meeting Abstract June 2022

Retrospective natural history of retinitis pigmentosa due to RHO , PDE6A, or PDE6B mutations: the PHENOROD1 study

Alice Le Meur; Daniel C Chung; Léa Thiebault; Pierre-Axel Vinot; Berthe Pom; Thierry D Leveillard; Saddek Mohand-Said; Jose Alain Sahel; Isabelle S Audo

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4497 – F0284. doi:

ARVO Annual Meeting Abstract June 2022

OCT inner to outer retina reflectivity ratio-independent predictor of retinal function in retinitis pigmentosa

Manuel Paez; MIchelle Alabek; Jose Alain Sahel; Boris Rosin

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4483 – F0270. doi:

ARVO Annual Meeting Abstract June 2022

Prospective natural history of retinitis pigmentosa due to RHO , PDE6A , or PDE6B mutations: interim analysis of the PHENOROD2 study

Anne Celle; Alice Le Meur; Daniel C Chung; Saddek Mohand-Said; Jose Alain Sahel; Isabelle S Audo

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4294. doi:

ARVO Annual Meeting Abstract June 2022

Visual acuity and full-field stimulus thresholds (FST) over 2 years in the RUSH2A study: annual rates of change from mixed effects modeling

Peiyao Cheng; David G Birch; Jacque L Duncan; Frederick L Ferris; Maureen G Maguire; Allison R. Ayala; Janet K Cheetham; Todd Durham; Abigail T Fahim; Rachel M Huckfeldt; Michel Michaelides; Mark E Pennesi; Jose Alain Sahel; Katarina Stingl; Ajoy Vincent; Christina Y Weng

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4480 – F0267. doi:

ARVO Annual Meeting Abstract June 2022

Three dimensional analysis of Haller vessels in healthy eyes

Anindya Samanta; Mohammed Nasar Ibrahim; Sumit Singh; Amrish Selvam; Mohammed Abdul Rasheed; Jose Alain Sahel; Kiran Kumar Vupparaboina; Jay Chhablani

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2094 – F0083. doi:

ARVO Annual Meeting Abstract June 2022

Pigment Epithelial Detachment Vascularity Index (PEDVI) in Neovascular Age-Related Macular Degeneration: An Image Processing Approach

Amrish Selvam; Manan Patel; Arnim Kuchhal; Joshua Ong; Mohammed Abdul Rasheed; Shanmukh Reddy Manne; Mohammed Nasar Ibrahim; Jose Alain Sahel; Kiran Kumar Vupparaboina; Jay Chhablani

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1024 – F0271. doi:

ARVO Annual Meeting Abstract June 2022

Three-dimensional (3-D) analysis of the Haller's vessels in diseased eyes: comparison with healthy eyes

Jay Chhablani; Sumit Singh; Mohammed Nasar Ibrahim; Anindya Samanta; Amrish Selvam; Vinisha Sant; Mohammed Abdul Rasheed; Jose Alain Sahel; Kiran Kumar Vupparaboina

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):484 – A0021. doi:

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SPVN06, a novel mutation-independent AAV-based gene therapy, dramatically reduces vision loss in the rd10 mouse model of rod-cone dystrophy

VSX2 variants are responsible for bipolar cell dysfunction with distinct lens and chorioretinal alterations.

Worldwide multicenter ocular imaging study (EyeConic) to identify patients eligible for cone-based optogenetics therapy

The phase III REFLECT trial: efficacy of bilateral gene therapy for Leber hereditary optic neuropathy (LHON) is maintained 2 years post administration

Genotype-phenotype correlation and disease modeling in RPGR -related cone and cone-rod dystrophies.

Human corneal stromal stem cells express microRNA-29a in exosomes – a robust cell selection for stem cell therapy of corneal scarring

Development and validation of a mobility test for Inherited Retinal Disease in real and virtual conditions - preliminary results.

Optogenetics in the clinic: safety and efficacy updates on the phase 1/2 clinical trial PIONEER

Potent retinal protection by oral administration of a purine metabolite against age-related retinal degeneration and RHO-associated retinitis pigmentosa

Visual field loss and fitness to drive: preliminary results

Human iPSC-based retinal cell library for disease modeling and drug discovery

Association of patient characteristics with self-reported barriers to eye care at a free community vision screening event

Role of Metformin in the Development and Progression of Age-Related Macular Degeneration

Retrospective natural history of retinitis pigmentosa due to RHO , PDE6A, or PDE6B mutations: the PHENOROD1 study

OCT inner to outer retina reflectivity ratio-independent predictor of retinal function in retinitis pigmentosa

Prospective natural history of retinitis pigmentosa due to RHO , PDE6A , or PDE6B mutations: interim analysis of the PHENOROD2 study

Visual acuity and full-field stimulus thresholds (FST) over 2 years in the RUSH2A study: annual rates of change from mixed effects modeling

Three dimensional analysis of Haller vessels in healthy eyes

Pigment Epithelial Detachment Vascularity Index (PEDVI) in Neovascular Age-Related Macular Degeneration: An Image Processing Approach

Three-dimensional (3-D) analysis of the Haller's vessels in diseased eyes: comparison with healthy eyes

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