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Glaucoma November 2024

Proposing a Methodology for Axon-Centric Analysis of IOP-Induced Mechanical Insult

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Manik Bansal; Bingrui Wang; Susannah Waxman; Fuqiang Zhong; Yi Hua; Yuankai Lu; Juan Reynaud; Brad Fortune; Ian A. Sigal
TAGS: axon, body tissue, intraocular pressure, optic disk, volume, reconstructive surgical procedures
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):1. https://doi.org/10.1167/iovs.65.13.1

Includes: Supplemental Content

Glaucoma October 2024

Diagnostic Performance for Detection of Glaucomatous Structural Damage Using Pixelwise Analysis of Retinal Thickness Measurements

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Hongli Yang; Juan Reynaud; Glen P. Sharpe; Dawn Jennings; Cindy Albert; Trinity Holthausen; Xiue Jiang; Shaban Demirel; Steven L. Mansberger; Marcelo T. Nicolela; Stuart K. Gardiner; Balwantray C. Chauhan; Claude F. Burgoyne; Brad Fortune
TAGS: eye, glaucoma, pixel
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):17. https://doi.org/10.1167/iovs.65.12.17

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

Assessment of neurovascular coupling (NVC) in nonhuman primate (NHP) experimental glaucoma (EG) using laser speckle flowgraphy (LSFG) and optical coherence tomography angiography (OCTA) with flicker stimulation

Grant Cull; Juan Reynaud; Trinity Holthausen; Dawn Jennings; Michaela Dunn; Stuart Keith Gardiner; Kazuhiro Kurokawa; Brad Fortune

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1222.

ARVO Annual Meeting Abstract June 2024

Insulin protects against progression of experimental glaucoma (EG) in nonhuman primates (NHP)

Brad Fortune; Michaela Dunn; Grant Cull; Juan Reynaud; Dawn Jennings; Trinity Holthausen; Priya Chaudhary; Adriana Di Polo

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):941.

ARVO Annual Meeting Abstract June 2024

The Comb Artifact: Extravascular Motion Detected by OCT Angiography, a Novel Observation Related to Glaucoma

Arwa Arrashoud; Juan Reynaud; Michaela Dunn; Stuart Keith Gardiner; Grant Cull; Brad Fortune

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5924.

ARVO Annual Meeting Abstract June 2024

Method to assess ganglion cell layer somas in non-human primates using multifunctional AO-OCT/fSLO for translational research in glaucoma

Kana Orihara; Morgan Nemeth; Priya Chaudhary; Juan Reynaud; Grant Cull; Brad Fortune; Kazuhiro Kurokawa

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4330.

ARVO Annual Meeting Abstract June 2024

Topical insulin protects against retinal ganglion cell loss in nonhuman primate model of experimental glaucoma

Priya Chaudhary; Trinity Holthausen; Grant Cull; Michaela Dunn; Dawn Jennings; Juan Reynaud; Adriana Di Polo; Brad Fortune

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):667.

ARVO Annual Meeting Abstract June 2024

Optic Nerve Head (ONH) Spatial Transcriptomics in Non-Human Primate (NHP) Experimental Glaucoma (EG)

Galen Williams; Jinho Lee; Cheri Stowell; Juan Reynaud; Hongli Yang; Stuart Keith Gardiner; Nicholas Marsh-Armstrong; Claude F Burgoyne; Priya Chaudhary

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):635.

Glaucoma February 2024

Retrolaminar Demyelination of Structurally Intact Axons in Nonhuman Primate Experimental Glaucoma

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Priya Chaudhary; Howard Lockwood; Cheri Stowell; Eric Bushong; Juan Reynaud; Hongli Yang; Stuart K. Gardiner; Galen Wiliams; Imee Williams; Mark Ellisman; Nick Marsh-Armstrong; Claude Burgoyne
TAGS: axon, eye, glaucoma, myelin, demyelination
Invest. Ophthalmol. Vis. Sci.. 2024; 65(2):36. https://doi.org/10.1167/iovs.65.2.36

ARVO Annual Meeting Abstract October 2023

Relationship of optic nerve head blood flow and pulsatility to IOP and early-stage glaucomatous damage.

Grant Cull; Michaela Dunn; Dawn Jennings; Juan Reynaud; Howard Lockwood; Trinity Holthausen; Stuart Keith Gardiner; Brad Fortune

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):4735.

Glaucoma August 2023

Utility of Light-Adapted Full-Field Electroretinogram ON and OFF Responses for Detecting Glaucomatous Functional Damage

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Michaela Dunn; Grant Cull; Juan Reynaud; Dawn Jennings; Trinity Holthausen; Adriana Di Polo; Brad Fortune
TAGS: electroretinography, glaucoma, photopsia, eye
Trans. Vis. Sci. Tech.. 2023; 12(8):16. https://doi.org/10.1167/tvst.12.8.16

Includes: Supplemental Content

ARVO Imaging in the Eye Conference Abstract June 2023

Localized orbital optic nerve axon loss estimates correlate with localized OCT measurements of retinal nerve fiber layer thickness (RNFLT) and minimum rim width (MRW) experimental glaucoma (EG).

Galen Williams; Priya Chaudhary; Juan Reynaud; Cheri Stowell; Grant Cull; Stuart Gardiner; Brad Fortune; Nick Marsh-Armstrong; Claude Burgoyne; Hongli Yang

Invest. Ophthalmol. Vis. Sci.. 2023; 64(9):PB0024.

ARVO Annual Meeting Abstract June 2023

Peri-Neural Canal Scleral Bowing and Choroidal Thickness in High Myopia

Hongli Yang; Ya Xing Wang; JInwook Jeoung; Seungwoo Hong; Stuart Keith Gardiner; Juan Reynaud; Brad Fortune; Michael J A Girard; Glen Sharpe; Marcelo Nicolela; Balwantray C Chauhan; Claude F Burgoyne

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):4159.

ARVO Annual Meeting Abstract June 2023

Variability in Posterior Laminar Surface segmentation and colocalization does not affect the detection of significant increases in retrolaminar Myelin Onset Distance in Non-Human Primate Early Experimental Glaucoma

Priya Chaudhary; Howard Lockwood; Cheri Stowell; Juan Reynaud; Hongli Yang; Stuart Keith Gardiner; Galen Williams; Eric Bushong; Mark Ellisman; Nicholas Marsh-Armstrong; Claude Burgoyne

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1023.

ARVO Annual Meeting Abstract June 2023

Longitudinal axon compression as a potential mechanism relating IOP-induced lamina cribrosa (LC) distortion and glaucomatous neural tissue loss

Bingrui Wang; Manik Bansal; Yi Hua; Fuqiang Zhong; Juan Reynaud; Brad Fortune; Ian A Sigal

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):4362.

ARVO Annual Meeting Abstract June 2023

Functional microvascular volume as a proportion of tissue volume is reduced in the RNFL but not the ONH rim at the onset of experimental glaucoma

Michaela Dunn; Juan Reynaud; Grant Cull; Dawn Jennings; Howard Lockwood; Trinity Holthausen; Stuart Keith Gardiner; Ian A Sigal; Claude F Burgoyne; Adriana Di Polo; Brad Fortune

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3779.

Artificial Intelligence March 2023

AxoNet 2.0: A Deep Learning-Based Tool for Morphometric Analysis of Retinal Ganglion Cell Axons

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Vidisha Goyal; A. Thomas Read; Matthew D. Ritch; Bailey G. Hannon; Gabriela Sanchez Rodriguez; Dillon M. Brown; Andrew J. Feola; Adam Hedberg-Buenz; Grant A. Cull; Juan Reynaud; Mona K. Garvin; Michael G. Anderson; Claude F. Burgoyne; C. Ross Ethier
TAGS: axon, datasets, learning
Trans. Vis. Sci. Tech.. 2023; 12(3):9. https://doi.org/10.1167/tvst.12.3.9

Includes: Supplemental Content

Glaucoma October 2022

Optic Nerve Head Myelin-Related Protein, GFAP, and Iba1 Alterations in Non-Human Primates With Early to Moderate Experimental Glaucoma

PDF

Priya Chaudhary; Cheri Stowell; Juan Reynaud; Stuart K. Gardiner; Hongli Yang; Galen Williams; Imee Williams; Nicholas Marsh-Armstrong; Claude F. Burgoyne
TAGS: eye, glaucoma, glial fibrillary acidic protein, myelin, optic disk, pixel, proteins, optic nerve, primates, paraffin
Invest. Ophthalmol. Vis. Sci.. 2022; 63(11):9. https://doi.org/10.1167/iovs.63.11.9

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2022

Decreased retrolaminar Myelin protein expression in Non-Human Primate (NHP) Early Experimental Glaucoma (EG) is accompanied by increased Iba1(+) cell counts and decreased GFAP signal intensity

Priya Chaudhary; Cheri Stowell; Juan Reynaud; Stuart Keith Gardiner; Galen Williams; Imee Williams; Nicholas Marsh-Armstrong; Claude F Burgoyne

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):933 – A0402.

ARVO Annual Meeting Abstract June 2022

Correlating longitudinal Optical Coherence Tomography (OCT) structural change to retrolaminar myelin-related protein alteration in non-human primate (NHP) early experimental glaucoma (EG)

Hongli Yang; Priya Chaudhary; Cheri Stowell; Juan Reynaud; Stuart Keith Gardiner; Galen Williams; Imee Williams; Nicholas Marsh-Armstrong; Claude F Burgoyne

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3095.

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Proposing a Methodology for Axon-Centric Analysis of IOP-Induced Mechanical Insult

Diagnostic Performance for Detection of Glaucomatous Structural Damage Using Pixelwise Analysis of Retinal Thickness Measurements

Assessment of neurovascular coupling (NVC) in nonhuman primate (NHP) experimental glaucoma (EG) using laser speckle flowgraphy (LSFG) and optical coherence tomography angiography (OCTA) with flicker stimulation

Insulin protects against progression of experimental glaucoma (EG) in nonhuman primates (NHP)

The Comb Artifact: Extravascular Motion Detected by OCT Angiography, a Novel Observation Related to Glaucoma

Method to assess ganglion cell layer somas in non-human primates using multifunctional AO-OCT/fSLO for translational research in glaucoma

Topical insulin protects against retinal ganglion cell loss in nonhuman primate model of experimental glaucoma

Optic Nerve Head (ONH) Spatial Transcriptomics in Non-Human Primate (NHP) Experimental Glaucoma (EG)

Retrolaminar Demyelination of Structurally Intact Axons in Nonhuman Primate Experimental Glaucoma

Relationship of optic nerve head blood flow and pulsatility to IOP and early-stage glaucomatous damage.

Utility of Light-Adapted Full-Field Electroretinogram ON and OFF Responses for Detecting Glaucomatous Functional Damage

Localized orbital optic nerve axon loss estimates correlate with localized OCT measurements of retinal nerve fiber layer thickness (RNFLT) and minimum rim width (MRW) experimental glaucoma (EG).

Peri-Neural Canal Scleral Bowing and Choroidal Thickness in High Myopia

Variability in Posterior Laminar Surface segmentation and colocalization does not affect the detection of significant increases in retrolaminar Myelin Onset Distance in Non-Human Primate Early Experimental Glaucoma

Longitudinal axon compression as a potential mechanism relating IOP-induced lamina cribrosa (LC) distortion and glaucomatous neural tissue loss

Functional microvascular volume as a proportion of tissue volume is reduced in the RNFL but not the ONH rim at the onset of experimental glaucoma

AxoNet 2.0: A Deep Learning-Based Tool for Morphometric Analysis of Retinal Ganglion Cell Axons

Optic Nerve Head Myelin-Related Protein, GFAP, and Iba1 Alterations in Non-Human Primates With Early to Moderate Experimental Glaucoma

Decreased retrolaminar Myelin protein expression in Non-Human Primate (NHP) Early Experimental Glaucoma (EG) is accompanied by increased Iba1(+) cell counts and decreased GFAP signal intensity

Correlating longitudinal Optical Coherence Tomography (OCT) structural change to retrolaminar myelin-related protein alteration in non-human primate (NHP) early experimental glaucoma (EG)

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