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ARVO Annual Meeting Abstract June 2024

Chronic post-infectious uveitis in the PMU mouse model is associated with a Th17 adaptive immune response

Xudong Peng; Leslie Wilson; Katherine Costello; Kathryn Pepple

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5054.

ARVO Annual Meeting Abstract June 2023

Intraocular Innate Lymphoid Cell (ILC) Populations in Three Murine Models of Uveitis

Xudong Peng; Katherine Costello; Leslie Wilson; Kathryn Pepple

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1925.

Uveitis March 2023

Systemic Administration of Acazicolcept, a Dual CD28 and Inducible T cell Costimulator Inhibitor, Ameliorates Experimental Autoimmune Uveitis

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Leslie Wilson; Katherine E. Lewis; Lawrence S. Evans; Stacey R. Dillon; Kathryn L. Pepple
TAGS: adrenal corticosteroids, autoimmunity, cd28 antigens, glucocorticoids, mineralocorticoids, systemic therapy, t-lymphocytes, uveitis, cytokine, eye
Trans. Vis. Sci. Tech.. 2023; 12(3):27. https://doi.org/10.1167/tvst.12.3.27

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2022

Systemic Administration of Acazicolcept (ALPN-101), a Dual ICOS/CD28 Antagonist, Suppresses Ocular Inflammation in Rat Experimental Autoimmune Uveitis

Kathryn L Pepple; Katherine Lewis; Leslie Wilson; Lawrence Evans; Stacey Dillon

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1097.

ARVO Annual Meeting Abstract June 2021

Developing a deep learning classifier for uveitis scoring on mouse OCT images

Sarah John; Jessica Jeni Na; Shreya Swaminathan; Leslie Wilson; Yue Wu; Kathryn Pepple

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2115.

ARVO Annual Meeting Abstract June 2021

Peptidyl Arginine Deiminase 4 (PAD4) inhibition does not prevent neutrophil extracellular traps (NETs) formation or significantly decrease ocular inflammation in two mouse models of uveitis

Leslie Wilson; Victoria Wang; Runa Kuley; Richard Moore; Christian Lood; Kathryn Pepple

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3457.

ARVO Annual Meeting Abstract June 2020

Intravitreal Injection of ALPN-101, a Dual ICOS/CD28 Antagonist, Suppresses Ocular Inflammation in Rat Experimental Autoimmune Uveitis

Kathryn L Pepple; Leslie Wilson; Katherine E Lewis; Lawrence S Evans; Stacey R Dillon

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3674.

Articles September 2019

Uveitis Therapy With Shark Variable Novel Antigen Receptor Domains Targeting Tumor Necrosis Factor Alpha or Inducible T-Cell Costimulatory Ligand

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Kathryn L. Pepple; Leslie Wilson; Russell N. Van Gelder; Marina Kovaleva; Obinna C. Ubah; John Steven; Caroline J. Barelle; Andrew Porter
TAGS: cytokine, inflammation, ligands, receptors, antigen, sharks, t-lymphocytes, tumor necrosis factor-alpha, uveitis, dexamethasone, eye
Trans. Vis. Sci. Tech.. 2019; 8(5):11. https://doi.org/10.1167/tvst.8.5.11

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

Inflammatory cell type-specific bioluminescence for quantitative scoring of uveitis in vivo

Kathryn L Pepple; Leslie Wilson; Russell N Van Gelder; Kevin Rolnick

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1724.

ARVO Annual Meeting Abstract July 2018

Fully automated quantification of retinal cones and anterior chamber cells using deep learning

yue wu; Sa Xiao; Ariel Rokem; Cecilia S Lee; Leslie Wilson; Kathryn Pepple; Ramkumar Sabesan; Aaron Y. Lee

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1222.

ARVO Annual Meeting Abstract July 2018

Systemic antigen exposure increases intraocular inflammation in primed mycobacterial uveitis (PMU)

Leslie Wilson; Russell Van Gelder; Kathryn Pepple

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2546.

Immunology and Microbiology May 2018

Comparison of Aqueous and Vitreous Lymphocyte Populations From Two Rat Models of Experimental Uveitis

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Kathryn L. Pepple; Leslie Wilson; Russell N. Van Gelder
TAGS: fluid flow, lymphocytes, uveitis, vitreous body, eye, b-lymphocytes, t-lymphocytes
Invest. Ophthalmol. Vis. Sci.. 2018; 59(6):2504-2511. https://doi.org/10.1167/iovs.18-24192

Includes: Supplemental Content

Immunology and Microbiology March 2017

In Vivo Bioluminescence Imaging for Longitudinal Monitoring of Inflammation in Animal Models of Uveitis

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Michal B. Gutowski; Leslie Wilson; Russell N. Van Gelder; Kathryn L. Pepple
TAGS: animal model, bioluminescence, diagnostic imaging, inflammation, uveitis, eye, luminol
Invest. Ophthalmol. Vis. Sci.. 2017; 58(3):1521-1528. https://doi.org/10.1167/iovs.16-20824

ARVO Annual Meeting Abstract September 2016

Comparison of Spectral Domain and Swept Source Optical Coherence Tomography in a Rat Model of Anterior Uveitis

Leslie Wilson; Woo June Choi; Ruikang K Wang; Russell N Van Gelder; Kathryn L Pepple

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2189.

ARVO Annual Meeting Abstract September 2016

A pilot feasibility study for using in vivo bioluminescence imaging for longitudinal monitoring of inflammation in a rodent model of uveitis

Michal Gutowski; Leslie Wilson; Russell N Van Gelder; Kathryn L. Pepple

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2221.

Immunology and Microbiology July 2016

Quantitative Assessment of Anterior Segment Inflammation in a Rat Model of Uveitis Using Spectral-Domain Optical Coherence Tomography

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Kathryn L. Pepple; Woo June Choi; Leslie Wilson; Russell N. Van Gelder; Ruikang K. Wang
TAGS: inflammation, spectral domain-optical coherence tomography, uveitis, ciliary body, cell count, cornea
Invest. Ophthalmol. Vis. Sci.. 2016; 57(8):3567-3575. https://doi.org/10.1167/iovs.16-19276

Immunology and Microbiology December 2015

Primed Mycobacterial Uveitis (PMU): Histologic and Cytokine Characterization of a Model of Uveitis in Rats

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Kathryn L. Pepple; Lauren Rotkis; Jennifer Van Grol; Leslie Wilson; Angela Sandt; Deborah L. Lam; Eric Carlson; Russell N. Van Gelder
TAGS: cytokine, rats, uveitis, inflammation
Invest. Ophthalmol. Vis. Sci.. 2015; 56(13):8438-8448. https://doi.org/10.1167/iovs.15-17523

Immunology and Microbiology December 2015

Comparative Proteomic Analysis of Two Uveitis Models in Lewis Rats

PDF

Kathryn L. Pepple; Lauren Rotkis; Leslie Wilson; Angela Sandt; Russell N. Van Gelder
TAGS: inflammation, proteins, rats, uveitis, mass or substance concentration per volume, vitreous body
Invest. Ophthalmol. Vis. Sci.. 2015; 56(13):8449-8456. https://doi.org/10.1167/iovs.15-17524

Includes: Supplemental Content

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Chronic post-infectious uveitis in the PMU mouse model is associated with a Th17 adaptive immune response

Intraocular Innate Lymphoid Cell (ILC) Populations in Three Murine Models of Uveitis

Systemic Administration of Acazicolcept, a Dual CD28 and Inducible T cell Costimulator Inhibitor, Ameliorates Experimental Autoimmune Uveitis

Systemic Administration of Acazicolcept (ALPN-101), a Dual ICOS/CD28 Antagonist, Suppresses Ocular Inflammation in Rat Experimental Autoimmune Uveitis

Developing a deep learning classifier for uveitis scoring on mouse OCT images

Peptidyl Arginine Deiminase 4 (PAD4) inhibition does not prevent neutrophil extracellular traps (NETs) formation or significantly decrease ocular inflammation in two mouse models of uveitis

Intravitreal Injection of ALPN-101, a Dual ICOS/CD28 Antagonist, Suppresses Ocular Inflammation in Rat Experimental Autoimmune Uveitis

Uveitis Therapy With Shark Variable Novel Antigen Receptor Domains Targeting Tumor Necrosis Factor Alpha or Inducible T-Cell Costimulatory Ligand

Inflammatory cell type-specific bioluminescence for quantitative scoring of uveitis in vivo

Fully automated quantification of retinal cones and anterior chamber cells using deep learning

Systemic antigen exposure increases intraocular inflammation in primed mycobacterial uveitis (PMU)

Comparison of Aqueous and Vitreous Lymphocyte Populations From Two Rat Models of Experimental Uveitis

In Vivo Bioluminescence Imaging for Longitudinal Monitoring of Inflammation in Animal Models of Uveitis

Comparison of Spectral Domain and Swept Source Optical Coherence Tomography in a Rat Model of Anterior Uveitis

A pilot feasibility study for using in vivo bioluminescence imaging for longitudinal monitoring of inflammation in a rodent model of uveitis

Quantitative Assessment of Anterior Segment Inflammation in a Rat Model of Uveitis Using Spectral-Domain Optical Coherence Tomography

Primed Mycobacterial Uveitis (PMU): Histologic and Cytokine Characterization of a Model of Uveitis in Rats

Comparative Proteomic Analysis of Two Uveitis Models in Lewis Rats

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