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Retina March 2025

Genome-Wide Association Study to Identify Genetic Variants Associated With Diabetic Maculopathy

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Rajya L. Gurung; Charvi Nangia; Tengda Cai; Liesel M. FitzGerald; Bennet J. McComish; Ebony Liu; Georgia Kaidonis; Bronwyn Ridge; Alex W. Hewitt; Brendan Vote; Nitin Verma; Jamie E. Craig; Colin N. A. Palmer; Kathryn P. Burdon; Weihua Meng
TAGS: cohort studies, diabetes mellitus, genetics, genome-wide association study, macular disorders, meta-analysis, single nucleotide polymorphism, genotype determination, diabetes mellitus, type 2
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):55. https://doi.org/10.1167/iovs.66.3.55

Includes: Supplemental Content

Cornea & External Disease March 2025

Regional Biomechanical Weakening in Keratoconus Corneas Detected by In Vivo High-Frequency Ultrasound Elastography

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Sunny Kwok; Xueliang Pan; Manqi Pan; Zihao Chen; Madison Ammon; Andrew Hendershot; Jun Liu
TAGS: cornea, keratoconus, ultrasound elastography, ultrasonography, eye
Trans. Vis. Sci. Tech.. 2025; 14(3):22. https://doi.org/10.1167/tvst.14.3.22

Biochemistry and Molecular Biology March 2025

LncRNA ENST00000581911 Regulates Extraocular Muscle Remodeling by Interacting With KHSRP in Thyroid Eye Disease

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Mingsu Shi; Rongmei Zhou; Weiai Shen; Yu Liang; Yihan Zhang; Lingyun Liu; Runyi Shao; Yanxi Fang; Chen Zhao; Lianqun Wu
TAGS: bodily secretions, genes, graves' ophthalmopathy, muscle of orbit, polymerase chain reaction, rna, sequence analysis, rna, sincalide, cell proliferation, enzyme-linked immunosorbent assay
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):46. https://doi.org/10.1167/iovs.66.3.46

Includes: Supplemental Content

Cornea March 2025

Evodiamine Promotes Autophagy and Alleviates Oxidative Stress in Dry Eye Disease Through the p53/mTOR Pathway

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Boda Li; Junpeng Liu; Di Zhang; Yiran Chu; Zeying Chen; Jiaruei Tsao; Taige Chen; Jiaxuan Jiang; Kai Hu
TAGS: autophagy, dry eye syndromes, mice, mtor serine-threonine kinases, oxidative stress, western blotting, cornea
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):44. https://doi.org/10.1167/iovs.66.3.44

Includes: Supplemental Content

Clinical and Epidemiologic Research March 2025

Orbital Clinicopathological Differences in Thyroid Eye Disease: An Analysis of Cytokines With Histopathological and Clinical Correlation

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Yue Li; Jiaqi Tang; Gaojing Jing; Yueyue Li; Rui Ma; Xin Kang; Liyuan Rong; Wenlu Liu; Lan Yao; Xiaohui Lv; Aijun Deng; Wei Wu; Xinji Yang
TAGS: connective tissue, cytokine, histopathology tests, graves' ophthalmopathy
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):33. https://doi.org/10.1167/iovs.66.3.33

Includes: Supplemental Content

Retina March 2025

The Combination of Retinal Neurovascular Unit Changes With Carotid Artery Stenosis Enhances the Prediction of Ischemic Stroke

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Zhifan Chen; Shuoxin Liao; Guangzhong Chen; Changmao Li; Chunling Liu; Junbin Liu; Guangyu Wu; Zheng Lyu; Mengya Liu; Xiyu Wu; Guixian Ma; Qianli Meng
TAGS: carotid stenosis, ischemic stroke
Trans. Vis. Sci. Tech.. 2025; 14(3):14. https://doi.org/10.1167/tvst.14.3.14

Includes: Supplemental Content

Cornea March 2025

A Novel Model for Cornea Power Shift in Eyes Wearing Orthokeratology Lenses With Different Back Optic Zone Diameters for Myopia Control

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Ting Wang; Xiaoqin Chen; Mengdi Li; Hua Bi; Xiaoyan Yang; Muhan Sun; Yue Liu; Lihua Li; Bin Zhang
TAGS: cornea, eye, lens (device), lens, crystalline, myopia, orthokeratology contact lenses, optics
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):29. https://doi.org/10.1167/iovs.66.3.29

Includes: Supplemental Content

Public Health March 2025

Visual Deficits in Type 2 Diabetes Mellitus Without Retinopathy: From Retinal Structure to Higher-Level Visual Functions

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Sha Luo; Lin Xia; Yue Wang; Yong Tang; Jiong Dong; Rong Liu; Lixia Feng
TAGS: diabetes mellitus, diabetes mellitus, type 2, retina, retinal diseases, vision, vision disorders
Trans. Vis. Sci. Tech.. 2025; 14(3):10. https://doi.org/10.1167/tvst.14.3.10

Includes: Supplemental Content

Genetics March 2025

Corneal Biomechanics Are Associated With FBN1 Mutations in Patients With Marfan Syndrome and Ectopia Lentis

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Qiu-Yi Huo; Rui-Zheng Zhang; Wan-Nan Jia; Ya-Lei Wang; Xin Shen; Xin-Yao Chen; Tian-Hui Chen; Yan Liu; Ling-Hao Song; Xinyue Wang; Yong Lv; Ze-Xu Chen; Yong-Xiang Jiang
TAGS: biomechanics, cornea, ectopia lentis, fibrillin-1, marfan syndrome, mutation, genotype
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):23. https://doi.org/10.1167/iovs.66.3.23

Includes: Supplemental Content

Retina March 2025

Characteristics of Retina, Choroid, and Retrobulbar Blood Flow in Myopes With Posterior Staphyloma Using Ultra-Widefield OCTA and CDI

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Fang Liu; Yunzhe Wang; Lingling Niu; Jing Zhao; Kang Xue; Xingtao Zhou
TAGS: choroid, retina, staphyloma, vascular flow, diagnostic imaging
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):21. https://doi.org/10.1167/iovs.66.3.21

Cornea March 2025

Isolated Mitochondrial Transplantation as a Novel Treatment for Corneal Chemical Burns

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Dan Jiang; Jinjie Yu; Xiaoqing Wu; Xintong Yu; Pinyan Jin; Huikang Zheng; Huiru Liu; Wei Xu; Qizhou Lian; Wei Chen
TAGS: mitochondria, cornea, transplantation, mice, chemical burns
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):14. https://doi.org/10.1167/iovs.66.3.14

Includes: Multimedia, Supplemental Content

Immunology and Microbiology March 2025

STING Deficiency Promotes Th17-Like Tfh to Aggravate the Experimental Autoimmune Uveitis

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Zhuang Li; Xiuxing Liu; Zuoyi Li; Zhiqiang Xiao; Guanyu Chen; Yangyang Li; Jun Huang; Yunwei Hu; Haixiang Huang; Wenjie Zhu; Yuxun Shi; Minzhen Wang; Yanyan Xie; Wenru Su; Xiaoqing Chen; Dan Liang
TAGS: autoimmunity, flow cytometry, interleukin-17, mice, rna, small cytoplasmic, t follicular helper cells, uveitis, genes, t-lymphocytes, phenotype
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):8. https://doi.org/10.1167/iovs.66.3.8

Includes: Supplemental Content

Retina March 2025

Fibronectin Mediates Endothelial-to-Mesenchymal Transition in Retina Angiogenesis

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Dan Liu; Zhishang Meng; Chen Jin; Fang Chen; Li Pu; Ze Wu; Qi Zeng; Jing Luo; Wenyi Wu
TAGS: angiogenesis, fibronectins, retina, genes, endothelium, vascular endothelial growth factor a, epithelial to mesenchymal transition, rna, small interfering, rna-seq
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):10. https://doi.org/10.1167/iovs.66.3.10

Includes: Supplemental Content

Refractive Intervention March 2025

Evaluation of the Long-Term Corneal Biomechanics Following SMILE With Different Residual Stromal Bed Thickness in Rabbits

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Hongwei Qin; Xin Yang; Rui He; Yaowen Song; Junchao Wei; Xiaona Liu; Chenyan Wang; Ce Wu; Jie Hou; Zhipeng Gao; Lingfeng Chen; Xiaona Li; Weiyi Chen
TAGS: cornea, oryctolagus cuniculus, biomechanics, stress, surgical procedures, operative
Trans. Vis. Sci. Tech.. 2025; 14(3):3. https://doi.org/10.1167/tvst.14.3.3

Includes: Supplemental Content

Immunology and Microbiology March 2025

Ocular Surface Involvements in the Development of Sjögren's Syndrome–Associated Dry Eye in the IL14α Transgenic Mouse

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Minjie Zhang; Yichen Liang; Han Wu; Rongrong Zong; Xiaobo Zhang; Hui He; Peter Sol Reinach; Zuguo Liu; Long Shen; Wei Li
TAGS: dry eye syndromes, mice, ocular surfaces, sjogren's syndrome, conjunctiva, mice, transgenic
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):2. https://doi.org/10.1167/iovs.66.3.2

Includes: Supplemental Content

Cornea & External Disease February 2025

Validation of the Ocular Pain Assessment Survey Instrument With Rasch Analysis

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Debbie Marie Ng; Xiu Wang; Chang Liu; MingYi Yu; Isabelle Xin Yu Lee; Jipson Hon Fai Wong; Regina Kay Ting Wong; Diana Xin Hui Chan; Yu-Chi Liu; Louis Hak Tien Tong
TAGS: ocular pain, pain, rasch model, reliability, surveys
Trans. Vis. Sci. Tech.. 2025; 14(2):20. https://doi.org/10.1167/tvst.14.2.20

Includes: Supplemental Content

Immunology and Microbiology February 2025

kexB Gene Correlates With Aspergillus flavus Keratitis Severity: A Whole-Genome Analysis

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Jiamin Liu; Min Kang; Yuan Wei; Zijun Zhang; Jinding Pang; Qiankun Chen; Xizhan Xu; Zhenyu Wei; Yang Zhang; Kexin Chen; Zhiqun Wang; Xinxin Lu; Qingfeng Liang
TAGS: genes, genome, keratitis, virulence, aspergillus flavus, cornea, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):42. https://doi.org/10.1167/iovs.66.2.42

Includes: Supplemental Content

Public Health February 2025

The Relationship Between Serum Biochemical Variables and Corneal Biomechanics Measured by Corvis ST Among Healthy Young Adults

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Dan-Lin Li; Min-Xin Liu; Ya-Jie Zheng; Yu Qin; Rong Ma; Gang Liang; Chen-Wei Pan
TAGS: biomechanics, cornea, young adult
Trans. Vis. Sci. Tech.. 2025; 14(2):19. https://doi.org/10.1167/tvst.14.2.19

Retina February 2025

Targeting Runx1 in Pathological Retinal Angiogenesis: A Potential Therapeutic Approach

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Xiaoyan Ding; Xiaodi Zhou; Xinyu Liu; Yanting Lai; Wenjia Yan; Yizhe Cheng; Aohan Hou; Limei Chen; Limei Sun
TAGS: angiogenesis, hypoxia, mice, neovascularization, pathologic, 1-phosphatidylinositol 3-kinase, proto-oncogene proteins c-akt
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):40. https://doi.org/10.1167/iovs.66.2.40

Includes: Supplemental Content

Refractive Intervention February 2025

Refractive Development and Choroidal Vascularity in the Form-Deprivation Pigmented Rabbit Model

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Zhihao Jiang; Wenjia Yan; Haili Fang; Chang Liu; Zhaotian Zhang; Zhiquan Li; Yantao Wei; Yao Ni
TAGS: choroid, dopamine, eye, myopia, oryctolagus cuniculus, refraction
Trans. Vis. Sci. Tech.. 2025; 14(2):18. https://doi.org/10.1167/tvst.14.2.18

Includes: Supplemental Content

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Genome-Wide Association Study to Identify Genetic Variants Associated With Diabetic Maculopathy

Regional Biomechanical Weakening in Keratoconus Corneas Detected by In Vivo High-Frequency Ultrasound Elastography

LncRNA ENST00000581911 Regulates Extraocular Muscle Remodeling by Interacting With KHSRP in Thyroid Eye Disease

Evodiamine Promotes Autophagy and Alleviates Oxidative Stress in Dry Eye Disease Through the p53/mTOR Pathway

Orbital Clinicopathological Differences in Thyroid Eye Disease: An Analysis of Cytokines With Histopathological and Clinical Correlation

The Combination of Retinal Neurovascular Unit Changes With Carotid Artery Stenosis Enhances the Prediction of Ischemic Stroke

A Novel Model for Cornea Power Shift in Eyes Wearing Orthokeratology Lenses With Different Back Optic Zone Diameters for Myopia Control

Visual Deficits in Type 2 Diabetes Mellitus Without Retinopathy: From Retinal Structure to Higher-Level Visual Functions

Corneal Biomechanics Are Associated With FBN1 Mutations in Patients With Marfan Syndrome and Ectopia Lentis

Characteristics of Retina, Choroid, and Retrobulbar Blood Flow in Myopes With Posterior Staphyloma Using Ultra-Widefield OCTA and CDI

Isolated Mitochondrial Transplantation as a Novel Treatment for Corneal Chemical Burns

STING Deficiency Promotes Th17-Like Tfh to Aggravate the Experimental Autoimmune Uveitis

Fibronectin Mediates Endothelial-to-Mesenchymal Transition in Retina Angiogenesis

Evaluation of the Long-Term Corneal Biomechanics Following SMILE With Different Residual Stromal Bed Thickness in Rabbits

Ocular Surface Involvements in the Development of Sjögren's Syndrome–Associated Dry Eye in the IL14α Transgenic Mouse

Validation of the Ocular Pain Assessment Survey Instrument With Rasch Analysis

kexB Gene Correlates With Aspergillus flavus Keratitis Severity: A Whole-Genome Analysis

The Relationship Between Serum Biochemical Variables and Corneal Biomechanics Measured by Corvis ST Among Healthy Young Adults

Targeting Runx1 in Pathological Retinal Angiogenesis: A Potential Therapeutic Approach

Refractive Development and Choroidal Vascularity in the Form-Deprivation Pigmented Rabbit Model

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