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ARVO Annual Meeting Abstract June 2022

Ex vivo analysis of mast cell degranulation in human donor choroids

Imran Ahmed Bhutto; Tomohiro Niizawa; Alexandra Pado; Erin McDonnell; Gerard A Lutty; Malia Michelle Edwards

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3029 – F0400. doi:

Articles December 2021

Topical Ketotifen Fumarate Inhibits Choroidal Mast Cell Degranulation and Loss of Retinal Pigment Epithelial Cells in Rat Model for Geographic Atrophy

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Tomohiro Nizawa; Imran A. Bhutto; Anupama Tiwari; Rhonda R. Grebe; Jesse Alt; Rana Rais; Malia M. Edwards; Gerard A. Lutty
TAGS: atrophy, choroid, electroretinography, eyedrops, gel, hydrogel, ketotifen, mast cell degranulation, mast-cell sarcoma, minimally conscious state
Trans. Vis. Sci. Tech.. 2021; 10(14):37. doi: https://doi.org/10.1167/tvst.10.14.37

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2021

Topical Ketotifen fumarate inhibits mast cell degranulation and loss of retinal pigment epithelial cells in rat model for geographic atrophy

Tomohiro Niizawa; Imran Ahmed Bhutto; Anupama Tiwari; Rhonda R. Grebe; Jesse Alt; Rana Rais; Malia Michelle Edwards; Gerard A Lutty

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):252. doi:

Retinal Cell Biology July 2020

Retinal Glial and Choroidal Vascular Pathology in Donors Clinically Diagnosed With Stargardt Disease

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Malia M. Edwards; Vera L. Bonilha; Imran A. Bhutto; Brent A. Bell; D. Scott McLeod; Joe G. Hollyfield; Gerard A. Lutty
TAGS: donors, retina, stargardt's disease, chief complaint, atrophy, diagnostic imaging, pathology, tissue membrane, eye, neuroglia
Invest. Ophthalmol. Vis. Sci.. 2020; 61(8):27. doi: https://doi.org/10.1167/iovs.61.8.27

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2020

Visualization of choroidal vasculature in pigmented mouse eyes

Imran Ahmed Bhutto; Anupama Tiwari; Benjamin R Thomson; Malia Michelle Edwards; Gerard A Lutty

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2235. doi:

ARVO Annual Meeting Abstract June 2020

Increased expression of epithelial-to-mesenchymal transition markers in geographic atrophy

Anupama Tiwari; Imran Ahmed Bhutto; Malia Michelle Edwards; Rhonda Grebe; Gerard A Lutty

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2273. doi:

ARVO Annual Meeting Abstract July 2019

Tryptase release after degranulation of Mast Cells in a Model for Geographic Atrophy

Rajkumar Baldeosingh; Shuntaro Ogura; Siva Pramodh Kambhampati; Malia Michelle Edwards; Gerard A Lutty

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1231. doi:

ARVO Annual Meeting Abstract July 2019

Müller cell remodeling and phagocytosis in Choroidoremia

Malia Michelle Edwards; Rhonda Grebe; Rajkumar Baldeosingh; Gerard A Lutty

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4388. doi:

Special Issue September 2018

An Acute Injury Model for the Phenotypic Characteristics of Geographic Atrophy

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Imran A. Bhutto; Shuntaro Ogura; Rajkumar Baldeosingh; D. Scott McLeod; Gerard A. Lutty; Malia M. Edwards
TAGS: atrophy, injections, phenotype, wounds and injuries, eye, chief complaint, photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2018; 59(4):AMD143-AMD151. doi: https://doi.org/10.1167/iovs.18-24245

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

Interleukin 33 stimulates Müller cell migration and proliferation.

Malia Michelle Edwards; Rajkumar Baldeosingh; Manasee Gedam; Gerard A Lutty

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1481. doi:

ARVO Annual Meeting Abstract July 2018

Tumor Necrosis Factor alpha stimulates Müller cell migration and proliferation.

Rajkumar Baldeosingh; Manasee Gedam; Gerard A Lutty; Malia Michelle Edwards

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1483. doi:

ARVO Annual Meeting Abstract July 2018

Choriocapillaris dropout in early age-related macular degeneration

Gerard A Lutty; Imran A. Bhutto; Malia Michelle Edwards; D. Scott McLeod

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2435. doi:

ARVO Annual Meeting Abstract July 2018

A Model for Mast Cell Involvement in Geographic Atrophy

Imran Ahmed Bhutto; Rajkumar Baldeosingh; Shuntaro Ogura; Siva Pramodh Kambhampati; Manasee Gedam; Scott McLeod; Malia Michelle Edwards; Julian Esteve-Rudd; Donald Bierer; William Schubert; Gerard A Lutty

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3470. doi:

ARVO Annual Meeting Abstract July 2018

In vitro and ex vivo models for evaluating drugs that quiesce mast cells, models for mast cell degranulation in geographic atrophy choroid

Shuntaro Ogura; Rajkumar Baldeosingh; Manasee Gedam; Malia Michelle Edwards; Gerard A Lutty

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3471. doi:

Retinal Cell Biology November 2017

Mast Cell-Derived Tryptase in Geographic Atrophy

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D. Scott McLeod; Imran Bhutto; Malia M. Edwards; Manasee Gedam; Rajkumar Baldeosingh; Gerard A. Lutty
TAGS: atrophy, tryptase, eye, minimally conscious state
Invest. Ophthalmol. Vis. Sci.. 2017; 58(13):5887-5896. doi: https://doi.org/10.1167/iovs.17-22989

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2017

Analysis of choriocapillaris ultrastructure in macular regions of eyes obtained from patients with neovascular AMD, geographic atrophy, and pure one and ten chromosomal abnormalities

Rhonda Grebe; Irum Mughal; William Bryden; Jing Tian; Malia Michelle Edwards; Scott McLeod; Gregory S Hageman; Gerard A Lutty

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2260. doi:

ARVO Annual Meeting Abstract June 2017

A Possible Role for Mast Cell-Derived Tryptase in the Pathogenesis of Geographic Atrophy

Scott McLeod; Imran Ahmed Bhutto; Malia Michelle Edwards; Manasee Gedam; Raj Baldeosingh; Gerard A Lutty

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2267. doi:

ARVO Annual Meeting Abstract June 2017

Vitreal cytokines stimulate glial membrane formation

Manasee Gedam; Imran Ahmed Bhutto; Gerard A Lutty; Malia Michelle Edwards

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5390. doi:

ARVO Annual Meeting Abstract June 2017

A Rat Model of RPE Atrophy Resembling Human Geographic Atrophy

Imran Ahmed Bhutto; Siva Pramodh Kambhampati; D Scott McLeod; Malia Edwards; Gerard A Lutty

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2289. doi:

Retinal Cell Biology March 2017

Subretinal Glial Membranes in Eyes With Geographic Atrophy

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Malia M. Edwards; D. Scott McLeod; Imran A. Bhutto; Rhonda Grebe; Maeve Duffy; Gerard A. Lutty
TAGS: atrophic condition of skin, atrophy, embryonic lethal mutation, eye, neuroglia, retina, tissue membrane, vimentin, glial fibrillary acidic protein
Invest. Ophthalmol. Vis. Sci.. 2017; 58(3):1352-1367. doi: https://doi.org/10.1167/iovs.16-21229

Includes: Supplemental Content

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Ex vivo analysis of mast cell degranulation in human donor choroids

Topical Ketotifen Fumarate Inhibits Choroidal Mast Cell Degranulation and Loss of Retinal Pigment Epithelial Cells in Rat Model for Geographic Atrophy

Topical Ketotifen fumarate inhibits mast cell degranulation and loss of retinal pigment epithelial cells in rat model for geographic atrophy

Retinal Glial and Choroidal Vascular Pathology in Donors Clinically Diagnosed With Stargardt Disease

Visualization of choroidal vasculature in pigmented mouse eyes

Increased expression of epithelial-to-mesenchymal transition markers in geographic atrophy

Tryptase release after degranulation of Mast Cells in a Model for Geographic Atrophy

Müller cell remodeling and phagocytosis in Choroidoremia

An Acute Injury Model for the Phenotypic Characteristics of Geographic Atrophy

Interleukin 33 stimulates Müller cell migration and proliferation.

Tumor Necrosis Factor alpha stimulates Müller cell migration and proliferation.

Choriocapillaris dropout in early age-related macular degeneration

A Model for Mast Cell Involvement in Geographic Atrophy

In vitro and ex vivo models for evaluating drugs that quiesce mast cells, models for mast cell degranulation in geographic atrophy choroid

Mast Cell-Derived Tryptase in Geographic Atrophy

Analysis of choriocapillaris ultrastructure in macular regions of eyes obtained from patients with neovascular AMD, geographic atrophy, and pure one and ten chromosomal abnormalities

A Possible Role for Mast Cell-Derived Tryptase in the Pathogenesis of Geographic Atrophy

Vitreal cytokines stimulate glial membrane formation

A Rat Model of RPE Atrophy Resembling Human Geographic Atrophy

Subretinal Glial Membranes in Eyes With Geographic Atrophy

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