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Glaucoma October 2024

IOP Reduction in Nonhuman Primates by Microneedle Injection of Drug-Free Hydrogel to Expand the Suprachoroidal Space

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Yooree G. Chung; Shan Fan; Vikas Gulati; Hoi-Lam Li; Haiyan Gong; Carol B. Toris; Mark R. Prausnitz; C. Ross Ethier
TAGS: hydrogel, injections, intraocular pressure, eye, hypertension
Trans. Vis. Sci. Tech.. 2024; 13(10):14. https://doi.org/10.1167/tvst.13.10.14

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

Hydrogel Expansion of the Suprachoroidal Space Lowers IOP by Increasing Unconventional Outflow

Yooree Grace Chung; Mark R Prausnitz; C Ross Ethier

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3501.

Retina March 2023

Suprachoroidal Delivery in Rats and Guinea Pigs Using a High-Precision Microneedle Injector

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Amir Hejri; Isabella I. Bowland; John M. Nickerson; Mark R. Prausnitz
TAGS: caviidae, eye, injections, rats, rodentia, sclera, precision, body tissue, needles
Trans. Vis. Sci. Tech.. 2023; 12(3):31. https://doi.org/10.1167/tvst.12.3.31

Includes: Multimedia, Supplemental Content

Articles May 2022

Evaluation of Spatially Targeted Scleral Stiffening on Neuroprotection in a Rat Model of Glaucoma

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Brandon G. Gerberich; Bailey G. Hannon; Dillon M. Brown; A. Thomas Read; Matthew D. Ritch; Elisa Schrader Echeverri; Lauren Nichols; Cahil Potnis; Sreesh Sridhar; Maya G. Toothman; Stephen A. Schwaner; Erin J. Winger; Hannah Huang; Gabby S. Gershon; Andrew J. Feola; Machelle T. Pardue; Mark R. Prausnitz; C. Ross Ethier
TAGS: eye, glaucoma, sclera, microspheres, intraocular pressure, neuroprotection, hypertension, electroretinography, axon
Trans. Vis. Sci. Tech.. 2022; 11(5):7. https://doi.org/10.1167/tvst.11.5.7

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2021

Reliable suprachoroidal delivery in rodents using a high-precision microneedle injector

Amir Hejri; Isabella I. Bowland; John M Nickerson; Mark R. Prausnitz

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1195.

ARVO Annual Meeting Abstract June 2020

Using retinal function to define ischemic exclusion criteria for animal models of glaucoma

Bailey Hannon; Andrew Feola; Brandon Gerberich; Mark R. Prausnitz; C Ross Ethier; Machelle Pardue

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):271.

Retina April 2018

Targeted Drug Delivery in the Suprachoroidal Space by Swollen Hydrogel Pushing

PDF

Jae Hwan Jung; Patcharin Desit; Mark R. Prausnitz
TAGS: eye, hydrogel, injections, oryctolagus cuniculus
Invest. Ophthalmol. Vis. Sci.. 2018; 59(5):2069-2079. https://doi.org/10.1167/iovs.17-23758

Includes: Supplemental Content

Physiology and Pharmacology January 2017

Clearance Kinetics and Clearance Routes of Molecules From the Suprachoroidal Space After Microneedle Injection

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Bryce Chiang; Ke Wang; C. Ross Ethier; Mark R. Prausnitz
TAGS: drug clearance, fluorescein, injections, molecule, kinetics, eye, sclera
Invest. Ophthalmol. Vis. Sci.. 2017; 58(1):545-554. https://doi.org/10.1167/iovs.16-20679

Includes: Supplemental Content

Physiology and Pharmacology January 2017

Thickness and Closure Kinetics of the Suprachoroidal Space Following Microneedle Injection of Liquid Formulations

PDF

Bryce Chiang; Nitin Venugopal; Hans E. Grossniklaus; Jae Hwan Jung; Henry F. Edelhauser; Mark R. Prausnitz
TAGS: injections, liquids, volume, kinetics
Invest. Ophthalmol. Vis. Sci.. 2017; 58(1):555-564. https://doi.org/10.1167/iovs.16-20377

Includes: Supplemental Content

ARVO Annual Meeting Abstract September 2016

Distribution and Clearance of Particles and Molecules after Microneedle Injection into the Suprachoroidal Space

Bryce Chiang; Mark R Prausnitz

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):761.

ARVO Annual Meeting Abstract September 2016

Electric field-mediated targeting of drug delivery in the suprachoroidal space

Jae Hwan Jung; Bryce Chiang; Mark R Prausnitz

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4030.

ARVO Annual Meeting Abstract June 2015

Pharmacokinetics and Clearance of Molecules after Microneedle Injection into the Suprachoroidal Space

Bryce Chiang; Mark R Prausnitz

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5727.

Cornea November 2014

Intrastromal Delivery of Bevacizumab Using Microneedles to Treat Corneal Neovascularization

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Yoo C. Kim; Hans E. Grossniklaus; Henry F. Edelhauser; Mark R. Prausnitz
TAGS: bevacizumab, corneal neovascularization
Invest. Ophthalmol. Vis. Sci.. 2014; 55(11):7376-7386. https://doi.org/10.1167/iovs.14-15257

Physiology and Pharmacology November 2014

Targeted Delivery of Antiglaucoma Drugs to the Supraciliary Space Using Microneedles

PDF

Yoo C. Kim; Henry F. Edelhauser; Mark R. Prausnitz
TAGS: antiglaucoma agents, brimonidine, eye, intraocular pressure, oryctolagus cuniculus, pharmacodynamics, safety, ciliary body
Invest. Ophthalmol. Vis. Sci.. 2014; 55(11):7387-7397. https://doi.org/10.1167/iovs.14-14651

ARVO Annual Meeting Abstract April 2014

The long posterior ciliary arteries block circumferential flow in the suprachoroidal space of the rabbit eye

Bryce Chiang; Yoo Chun Kim; Mark R Prausnitz

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):484.

ARVO Annual Meeting Abstract April 2014

Targeted delivery of anti-glaucoma drugs to the supraciliary space using microneedles

Yoo Chun Kim; Mark R Prausnitz; Henry F Edelhauser

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):5257.

Physiology and Pharmacology July 2012

Targeted Administration into the Suprachoroidal Space Using a Microneedle for Drug Delivery to the Posterior Segment of the Eye

PDF

Samirkumar R. Patel; Damian E. Berezovsky; Bernard E. McCarey; Vladimir Zarnitsyn; Henry F. Edelhauser; Mark R. Prausnitz
TAGS: drug delivery systems, drug delivery, targeted, eye, oryctolagus cuniculus, fluorescence, body tissue
Invest. Ophthalmol. Vis. Sci.. 2012; 53(8):4433-4441. https://doi.org/10.1167/iovs.12-9872

Includes: Multimedia, Supplemental Content

ARVO Annual Meeting Abstract March 2012

Fluid Infusion Into the Corneal Stroma Using a Microneedle

Samirkumar R. Patel; Eric Powers; Mark R. Prausnitz; Henry F. Edelhauser

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):482.

ARVO Annual Meeting Abstract March 2012

Pharmacokinetics and Biodistribution of Bevacizumab Following Suprachoroidal Injection into the Rabbit Eye Using a Microneedle

Saffar Mansoor; Samikrumar R. Patel; Cetin Tas; Rashmi Pacha-Ravi; Uday B. Kompella; Henry F. Edelhauser; Mark R. Prausnitz

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):498.

ARVO Annual Meeting Abstract March 2012

Intracorneal Delivery Of Bevacizumab Using Microneedles To Treat Injury-induced Neovascularization

Yoo C. Kim; Henry F. Edelhauser; Mark R. Prausnitz

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):507.

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IOP Reduction in Nonhuman Primates by Microneedle Injection of Drug-Free Hydrogel to Expand the Suprachoroidal Space

Hydrogel Expansion of the Suprachoroidal Space Lowers IOP by Increasing Unconventional Outflow

Suprachoroidal Delivery in Rats and Guinea Pigs Using a High-Precision Microneedle Injector

Evaluation of Spatially Targeted Scleral Stiffening on Neuroprotection in a Rat Model of Glaucoma

Reliable suprachoroidal delivery in rodents using a high-precision microneedle injector

Using retinal function to define ischemic exclusion criteria for animal models of glaucoma

Targeted Drug Delivery in the Suprachoroidal Space by Swollen Hydrogel Pushing

Clearance Kinetics and Clearance Routes of Molecules From the Suprachoroidal Space After Microneedle Injection

Thickness and Closure Kinetics of the Suprachoroidal Space Following Microneedle Injection of Liquid Formulations

Distribution and Clearance of Particles and Molecules after Microneedle Injection into the Suprachoroidal Space

Electric field-mediated targeting of drug delivery in the suprachoroidal space

Pharmacokinetics and Clearance of Molecules after Microneedle Injection into the Suprachoroidal Space

Intrastromal Delivery of Bevacizumab Using Microneedles to Treat Corneal Neovascularization

Targeted Delivery of Antiglaucoma Drugs to the Supraciliary Space Using Microneedles

The long posterior ciliary arteries block circumferential flow in the suprachoroidal space of the rabbit eye

Targeted delivery of anti-glaucoma drugs to the supraciliary space using microneedles

Targeted Administration into the Suprachoroidal Space Using a Microneedle for Drug Delivery to the Posterior Segment of the Eye

Fluid Infusion Into the Corneal Stroma Using a Microneedle

Pharmacokinetics and Biodistribution of Bevacizumab Following Suprachoroidal Injection into the Rabbit Eye Using a Microneedle

Intracorneal Delivery Of Bevacizumab Using Microneedles To Treat Injury-induced Neovascularization

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