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ARVO Annual Meeting Abstract June 2024

Long term maintenance of cone structure and function in Rhodopsin knockout pig retina

Maureen A McCall; Archana Jalligampala; Kristin Whitworth; Kevin Wells

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3926.

ARVO Annual Meeting Abstract June 2024

Multiple glycinergic subunits mediate inhibitory inputs to mouse ON-OFF Direction Selective Ganglion Cells

Chase B Hellmer; Ian Pyle; Chi Zhang; Maureen A McCall

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5365.

ARVO Annual Meeting Abstract June 2024

The Rho1-2 meganuclease targeted to the human P23H human rhodopsin allele in a transgenic pig model of Autosomal Dominant Retinitis Pigmentosa (adRP) generates wide variety of inactivating mutations.

Jacob Michael Young; Archana Jalligampala; Maureen A McCall; Ronald G Gregg

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6073.

ARVO Annual Meeting Abstract June 2023

Comparison of Visual Acuity with Decline of Retinal Structure and Function in a Murine Model of P23H Retinitis Pigmentosa – Is There a Role of Plasticity?

Cecilia Attaway; Maureen A McCall; Aaron W McGee

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):5246.

ARVO Annual Meeting Abstract June 2023

Mobility task shows rescue of scotopic vision in a swine model for autosomal dominant Retinitis Pigmentosa after treatment with the meganuclease Rho 1-2

Kautuk Kamboj; Jack E. Feist; Francesca Barone; Gita Jaikumar; Archana Jalligampala; Wei Wang; Jeff Smith; Dave Morris; Jantz Derek; Victor Bartsevich; Kristi Viles; Maureen A McCall

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):5240.

ARVO Annual Meeting Abstract June 2023

Rod and cone structure and function decline in a humanized mouse model of P23H Rhodopsin Autosomal Dominant Retinitis Pigmentosa (adRP)

Mattia Di Paolo; Olivia N Jacobs; Kiersten Elyse Frye; Smith Jeff; Dave Morris; Jantz Derek; Victor Bartsevich; Dale Cowley; Kristi Viles; Maureen A McCall

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):5210.

ARVO Annual Meeting Abstract June 2023

A ribozyme-mediated RNA replacement gene therapy shows efficacy in a pig model of Autosomal Dominant Retinitis Pigmentosa (adRP).

Archana Jalligampala; Kautuk Kamboj; Jennifer M. Noel; Elyse Frye; Joseph Prestigiacomo; Olivia Noelle Jacobs; Stephen Nash; Wei Wang; Ji-Hyun Kim; Seong-Wook Lee; Maureen A McCall

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):803.

ARVO Annual Meeting Abstract June 2023

Semantic segmentation of OCT retinal layers in pigs using a trained U-Net network

David Alston; Archana Jalligampala; Joseph Prestigiacomo; Maureen A McCall

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1116.

ARVO Annual Meeting Abstract June 2023

OFF transient alpha retinal ganglion cells exhibit physiological but not morphological deficits in the DBA/2J mouse model of glaucoma

Chase B Hellmer; Kennedi Morgan; Caitlin White; Maureen A McCall

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3805.

ARVO Annual Meeting Abstract June 2022

The generation and characterization of a large animal model of USH3 disease

Astra Dinculescu; Maureen A McCall; Ronald G Gregg; Archana Jalligampala; Jennifer M. Noel; Rebecca Whiting; Kevin Donnelly; Kristin Whitworth; Randall S Prather; Kevin D Wells; Bethany Redel; J. Hugh McDowell

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1926 – A0072.

ARVO Annual Meeting Abstract June 2022

Characterization of a Humanized Mouse Model of P23H Rhodopsin Autosomal Dominant Retinitis Pigmentosa (adRP)

Maureen A McCall; Olivia N Jacobs; Nazarul Hasan; Jeff Smith; Derek Jantz; Victor Bartsevich; Dale Cowley; Kristi Viles

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2607 – F0490.

ARVO Annual Meeting Abstract June 2022

Stereopure oligonucleotide treatment results in durable rescue of disease phenotype in a P23H hRHO pig model of human autosomal dominant retinitis pigmentosa (adRP)

Jennifer M. Noel; Archana Jalligampala; Olivia N Jacobs; Joseph Prestigiacomo; Hailin Yang; Qianli Pan; Fangjun Liu; Yuan Yin; Richard Looby; Chandra Vargeese; Michael Byrne; Maureen A McCall

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4289.

ARVO Annual Meeting Abstract June 2022

Multiple glycinergic subunits mediate inhibitory inputs to mouse ON-OFF Direction Selective Ganglion Cells

Chase B Hellmer; Ian Pyle; Caitlin White; Chi Zhang; Maureen A McCall

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4571 – F0433.

ARVO Annual Meeting Abstract June 2022

Successful late-stage disease treatment of P23H human RHO (hRHO) using ARCUS nuclease gene editing in a pig model of Autosomal Dominant Retinitis Pigmentosa (adRP)

Archana Jalligampala; Jennifer M. Noel; Olivia Noelle Jacobs; Alec Lynn Bradley; Wei Wang; Maha Haleem Jabbar; Nazarul Hasan; Joseph Prestigiacomo; Jeff Smith; Victor Bartsevich; Kristi Viles; Derek Jantz; Maureen Ann McCall

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1107.

ARVO Annual Meeting Abstract June 2021

Allele-selective reduction of P23H-mutant rhodopsin with stereopure oligonucleotides rescues phenotype associated with retinitis pigmentosa in preclinical models

Michael Byrne; Vinod Vathipadickal; Lankai Guo; Yuan Yin; Hailin Yang; Richard Looby; Lauren Norwood; James W Fransen; archana jalligampala; Jennifer Noel; Chandra Vargeese; Maureen A McCall

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):185.

ARVO Annual Meeting Abstract June 2021

Rho 1-2 meganuclease, an allele-specific gene-editing therapy, rejuvenates rod photoreceptor structure and function in a pig model of autosomal dominant Retinitis Pigmentosa (adRP).

archana jalligampala; Jennifer Noel; James W Fransen; Wei Wang; Maha Jabbar; Nazarul Hasan; Gobinda Pangeni; Bhubanananda Sahu; Whitney Lewis; Jeff Smith; Victor Bartsevich; Kristi Viles; Derek Jantz; Maureen A McCall

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1478.

ARVO Annual Meeting Abstract June 2021

SPVN06, a Novel Mutation-Independent AAV-based Gene Therapy, Protects Cone Degeneration in a Pig Model of Retinitis Pigmentosa

Jennifer Noel; archana jalligampala; Myriam Marussig; Pierre-Axel VINOT; Melanie MARIE; Melanie Butler; Florence LORGET; Stephane Boissel; Thierry D Leveillard; Jose Alain Sahel; Maureen A McCall

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1189.

ARVO Annual Meeting Abstract June 2020

Stereopure oligonucleotides achieve allele-selective reduction of P23H mutant rhodopsin

Vinod Vathipadiekal; Lankai Guo; Yuan Yin; Qiong Shen; Hailin Yang; Richard Looby; Lauren Norwood; James Fransen; archana jalligampala; Jennifer Noel; Chandra Vargeese; Maureen A McCall; Michael Byrne

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1912.

ARVO Annual Meeting Abstract June 2020

Allele-specific Homing Endonuclease (HE) Gene Editing Induces Rod Function in a P23H Transgenic Swine Model of Retinitis Pigmentosa

James W Fransen; archana jalligampala; Jennifer Noel; Wei Wang; Jeff Smith; Victor Bartsevich; Kristi Viles; Maureen A McCall

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1915.

ARVO Annual Meeting Abstract June 2020

An Allele-Independent Gene Therapy Strategy Induces Rod Function in a Transgenic Swine Model of Autosomal Dominant Retinitis Pigmentosa

archana jalligampala; James Fransen; Jennifer Noel; Gobinda Pangeni; Maha Haleem Jabbar; William W Hauswirth; Alfred S Lewin; Maureen A McCall

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4484.

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Long term maintenance of cone structure and function in Rhodopsin knockout pig retina

Multiple glycinergic subunits mediate inhibitory inputs to mouse ON-OFF Direction Selective Ganglion Cells

The Rho1-2 meganuclease targeted to the human P23H human rhodopsin allele in a transgenic pig model of Autosomal Dominant Retinitis Pigmentosa (adRP) generates wide variety of inactivating mutations.

Comparison of Visual Acuity with Decline of Retinal Structure and Function in a Murine Model of P23H Retinitis Pigmentosa – Is There a Role of Plasticity?

Mobility task shows rescue of scotopic vision in a swine model for autosomal dominant Retinitis Pigmentosa after treatment with the meganuclease Rho 1-2

Rod and cone structure and function decline in a humanized mouse model of P23H Rhodopsin Autosomal Dominant Retinitis Pigmentosa (adRP)

A ribozyme-mediated RNA replacement gene therapy shows efficacy in a pig model of Autosomal Dominant Retinitis Pigmentosa (adRP).

Semantic segmentation of OCT retinal layers in pigs using a trained U-Net network

OFF transient alpha retinal ganglion cells exhibit physiological but not morphological deficits in the DBA/2J mouse model of glaucoma

The generation and characterization of a large animal model of USH3 disease

Characterization of a Humanized Mouse Model of P23H Rhodopsin Autosomal Dominant Retinitis Pigmentosa (adRP)

Stereopure oligonucleotide treatment results in durable rescue of disease phenotype in a P23H hRHO pig model of human autosomal dominant retinitis pigmentosa (adRP)

Multiple glycinergic subunits mediate inhibitory inputs to mouse ON-OFF Direction Selective Ganglion Cells

Successful late-stage disease treatment of P23H human RHO (hRHO) using ARCUS nuclease gene editing in a pig model of Autosomal Dominant Retinitis Pigmentosa (adRP)

Allele-selective reduction of P23H-mutant rhodopsin with stereopure oligonucleotides rescues phenotype associated with retinitis pigmentosa in preclinical models

Rho 1-2 meganuclease, an allele-specific gene-editing therapy, rejuvenates rod photoreceptor structure and function in a pig model of autosomal dominant Retinitis Pigmentosa (adRP).

SPVN06, a Novel Mutation-Independent AAV-based Gene Therapy, Protects Cone Degeneration in a Pig Model of Retinitis Pigmentosa

Stereopure oligonucleotides achieve allele-selective reduction of P23H mutant rhodopsin

Allele-specific Homing Endonuclease (HE) Gene Editing Induces Rod Function in a P23H Transgenic Swine Model of Retinitis Pigmentosa

An Allele-Independent Gene Therapy Strategy Induces Rod Function in a Transgenic Swine Model of Autosomal Dominant Retinitis Pigmentosa

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