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Retina October 2024

Multi-Characteristic Opsin Therapy to Functionalize Retina, Attenuate Retinal Degeneration, and Restore Vision in Mouse Models of Retinitis Pigmentosa

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Subrata Batabyal; Sanghoon Kim; Michael Carlson; Darryl Narcisse; Kissaou Tchedre; Adnan Dibas; Najam A. Sharif; Samarendra Mohanty
TAGS: intravitreal injections, mice, retina, retinal degeneration, vision, injections, tissue degeneration
Trans. Vis. Sci. Tech.. 2024; 13(10):25. https://doi.org/10.1167/tvst.13.10.25

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

OCT-Guided Spatially Targeted Laser Microirradiation Platform for Inducing Geographic Atrophy in Non-Human Primates

Michael Carlson; Sanghoon Kim; Michael Aldape; Subrata Batabyal; Samarendra Mohanty

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):756.

ARVO Annual Meeting Abstract June 2024

Laser Delivery of PEDF Gene into Retina Led to Neuroprotection and Anti-angiogenesis in mice

Sanghoon kim; Subrata Batabyal; Michael Carlson; Adnan Dibas; Samarendra Mohanty

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1249.

ARVO Annual Meeting Abstract June 2024

Multi-characteristic opsin gene therapy attenuates retinal degeneration and restore vision in mouse models of retinitis pigmentosa

Subrata Batabyal; Sanghoon Kim; Michael Carlson; Darryl Narcisse; Kissaou Tchedre; Adnan Dibas; Najam (Naj) Sharif; Samarendra Mohanty

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5356.

ARVO Annual Meeting Abstract June 2024

In vivo efficacy of a novel multi-characteristic opsin (MCO-010) in a mouse model of Leber congenital amaurosis

Najam (Naj) Sharif; Subrata Batabyal; Adnan Dibas; Michael Carlson; Sanghoon Kim; Samarendra Mohanty

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6096.

ARVO Annual Meeting Abstract June 2024

Characterization of a broadband ambient light activatable multi-characteristic opsin supporting its superior performance in restoring vision

Samarendra Mohanty; Pratyajit Mohapatra; Amir Singh; Subrata Batabyal; Michael Carlson; Sanghoon Kim; Najam (Naj) Sharif

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6078.

ARVO Annual Meeting Abstract June 2023

Sonogenetic Vision Restoration for Inherited Retinal Disorders

Subrata Batabyal; Gengxi Lu; Adnan Dibas; Michael Carlson; Sanghoon Kim; Houssam Al Saad; Darryl Narcisse; Mark S. Humayun; Qifa Zhou; Samarendra Mohanty

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):783.

ARVO Annual Meeting Abstract June 2023

Non-viral Targeted Laser Delivery of Multi-Characteristic Opsin Genes for Treatment of Geographic Atrophy

Samarendra Mohanty; Sanghoon Kim; Subrata Batabyal; Michael Carlson; Houssam Al Saad; Benjamin Ferguson; Adnan Dibas

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3861.

ARVO Annual Meeting Abstract June 2023

Engineered Mechanosensitive Channel as Outflow Actuator for Gene Agnostic Gene Therapy of Glaucoma

Adnan Dibas; Subrata Batabyal; Houssam Al Saad; Darryl Narcisse; Sanghoon Kim; Michael Carlson; Samarendra Mohanty

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3790.

ARVO Annual Meeting Abstract June 2023

Wearable goggle ERG system with multiple stimulation wavelengths for Point-of-care diagnosis of ocular health

Michael Carlson; Sanghoon kim; Michael Aldape; Subrata Batabyal; Samarendra Mohanty

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3332.

ARVO Annual Meeting Abstract June 2022

AAV-carried MCO Optogenetic Therapy for the Treatment of Inherited Retinal Disorders

Subrata Batabyal; Adnan Dibas; Houssam Al-Saad; Sanghoon Kim; Michael Carlson; Samarendra Mohanty

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):74 – A0047.

ARVO Annual Meeting Abstract June 2022

Double-masked, Randomized, sham-controlled, Multicenter Phase 2b study of Multi-Characteristic Opsin enabled vision restoration in patients with advanced retinitis pigmentosa: Design and Development of novel endpoints

Samarendra Mohanty; Subrata Batabyal; Sanghoon Kim; Michael Carlson; Ananta Ayyagari; Judy Rittimann; Kissaou Tchedre; Sai H Chavala

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1722 – F0040.

ARVO Annual Meeting Abstract June 2022

Establishing a novel preclinical laser-induced model for regenerative therapies of the outer retina

Silvia Aparicio Domingo; Kang Li; Sanghoon Kim; Michael Carlson; Riya Koley; Hoang Nguyen; Andres Lisker; Miguel Flores-Bellver; Conan Chen; Marc Mathias; Samarendra Mohanty; Valeria Canto Soler

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3028 – F0399.

ARVO Annual Meeting Abstract June 2022

OCT-guided variable-spot ERG enabled spatially resolved measurements to assess retinal function in a selected and integrated region

Sanghoon Kim; Michael Carlson; Silvia Aparicio-Domingo; Kang Li; Subrata Batabyal; Valeria Canto Soler; Samarendra Mohanty

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3535.

ARVO Annual Meeting Abstract June 2021

OCT guided micro-focal ERG system with multiple stimulation wavelengths for characterization of ocular health

Michael Carlson; Sang Hoon Kim; Silvia Aparicio-Domingo; Kang Li; Ben Puig; Subrata Batabyal; Valeria Canto Soler; Samarendra Mohanty

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1347.

ARVO Annual Meeting Abstract June 2021

An OCT guided laser microirradiation system for development of animal model of retinal degeneration

Samarendra Mohanty; Sang hoon Kim; Michael Carlson; Subrata Batabyal; Weldon Wright

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2725.

ARVO Annual Meeting Abstract June 2021

Optical coherence tomography guided laser gene delivery in degenerated retina

Biraj Mahato; Sang hoon Kim; Houssam Al-Saad; Subrata Batabyal; Michael Carlson; Samarendra Mohanty

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3300.

ARVO Annual Meeting Abstract June 2020

Safe non-viral light-based spatially targeted delivery of therapeutic opsin-encoding genes into specific cell types

Subrata Batabyal; Sanghoon Kim; Michael Carlson; Darryl Narcisse; Kissaou Tchedre; Adnan Dibas; Melissa Galicia; Weldon Wright; Samarendra Mohanty

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4502.

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Multi-Characteristic Opsin Therapy to Functionalize Retina, Attenuate Retinal Degeneration, and Restore Vision in Mouse Models of Retinitis Pigmentosa

OCT-Guided Spatially Targeted Laser Microirradiation Platform for Inducing Geographic Atrophy in Non-Human Primates

Laser Delivery of PEDF Gene into Retina Led to Neuroprotection and Anti-angiogenesis in mice

Multi-characteristic opsin gene therapy attenuates retinal degeneration and restore vision in mouse models of retinitis pigmentosa

In vivo efficacy of a novel multi-characteristic opsin (MCO-010) in a mouse model of Leber congenital amaurosis

Characterization of a broadband ambient light activatable multi-characteristic opsin supporting its superior performance in restoring vision

Sonogenetic Vision Restoration for Inherited Retinal Disorders

Non-viral Targeted Laser Delivery of Multi-Characteristic Opsin Genes for Treatment of Geographic Atrophy

Engineered Mechanosensitive Channel as Outflow Actuator for Gene Agnostic Gene Therapy of Glaucoma

Wearable goggle ERG system with multiple stimulation wavelengths for Point-of-care diagnosis of ocular health

AAV-carried MCO Optogenetic Therapy for the Treatment of Inherited Retinal Disorders

Double-masked, Randomized, sham-controlled, Multicenter Phase 2b study of Multi-Characteristic Opsin enabled vision restoration in patients with advanced retinitis pigmentosa: Design and Development of novel endpoints

Establishing a novel preclinical laser-induced model for regenerative therapies of the outer retina

OCT-guided variable-spot ERG enabled spatially resolved measurements to assess retinal function in a selected and integrated region

OCT guided micro-focal ERG system with multiple stimulation wavelengths for characterization of ocular health

An OCT guided laser microirradiation system for development of animal model of retinal degeneration

Optical coherence tomography guided laser gene delivery in degenerated retina

Safe non-viral light-based spatially targeted delivery of therapeutic opsin-encoding genes into specific cell types

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