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Meeting Abstract (39)
Journal Articles (3)

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Investigative Ophthalmology & Visual Science (40)
Translational Vision Science & Technology (2)

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ARVO Annual Meeting Abstract (39)
Articles (2)
Retina (1)

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Eye Anatomy and Disorders (3)
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electroretinography (2)
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achromatopsia (1)
cohort studies (1)
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ARVO Annual Meeting Abstract June 2024

Validating human-derived organoids as a suitable model for testing optogenetic therapies

Hoda Shamsnajafabadi; Michelle E McClements; Robert E MacLaren; Jasmina Cehajic-Kapetanovic

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1549.

ARVO Annual Meeting Abstract June 2024

Ligand mediated degradation of a prime editor in vivo

Lauren Major; Michelle E McClements; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2221.

ARVO Annual Meeting Abstract June 2024

Testing mirtron vector efficacy in wild-type retinal organoids

Sylvia Franklin; Federica Staurenghi; Michelle E McClements; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5348.

ARVO Annual Meeting Abstract June 2024

Evaluation of mirtron silencing and rhodopsin restoration in a human rhodopsin P23H knock-in mouse model

Qingyun Zheng; Maria Kaukonen; Imran H Yusuf; Federica Staurenghi; Michelle E McClements; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5344.

ARVO Annual Meeting Abstract June 2024

Comparison of Cas13 RNA base editing and SaKKH DNA base editing targeting the Abca4 start codon

Elena Piotter; Michelle E McClements; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6068.

ARVO Annual Meeting Abstract June 2024

Comparing and optimising the editing efficiency of three RNA editor families targeting a pathogenic CRB1 nonsense variant

Julia-Sophia Bellingrath; Dorothea Stark; Michelle E McClements; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6066.

ARVO Annual Meeting Abstract June 2024

Structure-guided chemical modifications to SaCas9 gRNA enhances CRISPR-Cas knockdown efficacy

Ruofan Connie Han; Elisabeth Sweet; Michelle E McClements; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6055.

ARVO Annual Meeting Abstract June 2023

Testing cone targeting with AAV5 and the GRK1 promoter in mice for future CRISPR-based applications

Ellen Rhodes; Ahmed Salman; Michelle E McClements; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):758.

ARVO Annual Meeting Abstract June 2023

CRISPR approach for allele-specific targeting of SNPs associated with Age-related Macular Degeneration in ARPE19 cells

Ahmed Salman; Wonkyung Song; Sarah Young; Michelle E McClements; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):756.

ARVO Annual Meeting Abstract June 2023

Assessment of new mirtron designs for the treatment of autosomal dominant retinitis pigmentosa caused by rhodopsin mutations

Federica Staurenghi; Michelle E McClements; Maria Kaukonen; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):4483.

ARVO Annual Meeting Abstract June 2022

The role of immune checkpoint ligands in retinal immune homeostasis and inflammation

Joel Quinn; Ahmed Salman; Michelle E. McClements; Robert E MacLaren; Calliope Dendrou; Kanmin Xue

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2226 – A0522.

ARVO Annual Meeting Abstract June 2022

Impaired glutamylation of ORF15 presents a unique phenotype in RPGR-related retinal dystrophy

Jasmina Cehajic Kapetanovic; Cristina Martinez-Fernandez de la Camara; Johannes Birtel; Salwah Rehman; Michelle E. McClements; Peter Charbel Issa; Andrew J Lotery; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):137 – A0317.

ARVO Annual Meeting Abstract June 2022

Development of CRISPR-Cas9 repressors for targeted epigenome editing

Ariel Kantor; Ahmed Salman; Michelle E. McClements; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):84 – A0057.

ARVO Annual Meeting Abstract June 2022

Validation of a rod photoreceptor-specific promoter for CRISPR gene therapy

Michelle E McClements; Caroline F Peddle; Federica Staurenghi; Ahmed Salman; William Atkin; Hannah Steward; Emily Archer Goode; Carolina Gandara; Valeria Chichagova; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):83 – A0056.

ARVO Annual Meeting Abstract June 2022

Report of a rare mild phenotype of retinitis pigmentosa in a family with distal USH2A mutations predicted to result in truncated protein

Monica L Hu; Salwah Rehman; Lewis E Fry; Michelle E McClements; Robert E MacLaren; Kanmin Xue

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):133 – A0313.

ARVO Annual Meeting Abstract June 2022

A novel mouse model of Usher Syndrome Type II designed for testing of base editing therapeutics

Lauren Major; Lewis Fry; Robert E MacLaren; Michelle E. McClements; Ahmed Salman; Andrew King; Jun Yang; Lucy McDermott

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1946 – F0364.

ARVO Annual Meeting Abstract June 2022

Development of a functional assay for the assessment of two common CRB1 mutations

Julia-Sophia Bellingrath; Michelle E. McClements; M. Dominik Fischer; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1766 – F0315.

ARVO Annual Meeting Abstract June 2022

RPGR ORF15 glutamylation impaired by mutations in its C-terminal basic domain

Cristina Martinez-Fernandez dela Camara; Jasmina Cehajic Kapetanovic; Michelle E. McClements; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2595 – F0478.

ARVO Annual Meeting Abstract June 2022

Allele-specific targeting of AMD-related SNPs in ARPE19 cells using a CRISPR Cas9 dual plasmid targeting approach

Ellen Rhodes; Ahmed Salman; Wonkyung Song; Michelle E. McClements; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3168 – F0442.

ARVO Annual Meeting Abstract June 2022

Retinal expression profile of SpCas9 and EGFP in the CRISPR-Cas9 knockin mouse, NOD.129(Cg)-Gt(ROSA)26Sor tm1.1(CAG-cas9*,-EGFP)Fezh /J

Ruofan Connie Han; Michelle E. McClements; Peter Charbel Issa; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3166 – F0440.

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