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Retina September 2022

Hyperreflective Membrane at the Vitreoretinal Interface in Diabetic Macular Edema: A Finding in Ultra-High-Resolution Optical Coherence Tomography

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Iori Wada; Shintaro Nakao; Mitsuru Arima; Keijiro Ishikawa; Muneo Yamaguchi; Yoshihiro Kaizu; Haruka Sekiryu; Kenichiro Mori; Kohei Kiyohara; Atsunobu Takeda; Tatsuro Ishibashi; SriniVas R. Sadda; Koh-Hei Sonoda
TAGS: diabetic macular edema, optical coherence tomography, tissue membrane, spectral domain-optical coherence tomography, vitrectomy, eye
Trans. Vis. Sci. Tech.. 2022; 11(9):21. doi: https://doi.org/10.1167/tvst.11.9.21

Includes: Supplemental Content

Retina October 2021

Retinal VEGF-A Overexpression Is Not Sufficient to Induce Lymphangiogenesis Regardless of VEGF-C Upregulation and Lyve1 + Macrophage Infiltration

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Iori Wada; Shintaro Nakao; Muneo Yamaguchi; Yoshihiro Kaizu; Mitsuru Arima; Shinichiro Sawa; Koh-Hei Sonoda
TAGS: diabetic retinopathy, lymphangiogenesis, lymphatic vessels, macrophages, mice, protein overexpression, retina, vascular endothelial growth factor a, vascular endothelial growth factor c, up-regulation (physiology)
Invest. Ophthalmol. Vis. Sci.. 2021; 62(13):17. doi: https://doi.org/10.1167/iovs.62.13.17

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

Local Proliferation of CD206+ CX3CR1+ Macrophages at the Vitreoretinal Interface in Diabetic Retinopathy

Shintaro Nakao; Muneo Yamaguchi; Iori Wada; Yoshihiro Kaizu; Mitsuru Arima; Keijiro Ishikawa; Takahito Nakama; Wataru Shiraishi; Ryo Yamasaki; Junichi Kira; Tatsuro Ishibashi; Koh-hei Sonoda

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2682. doi:

ARVO Annual Meeting Abstract July 2019

ROCK inhibitor Ripasudil reverses phenotype from EMT to MET in subretinal fibrosis

Iori Wada; Shintaro Nakao; Keijiro Ishikawa; Muneo Yamaguchi; Mitsuru Arima; Yoshihiro Kaizu; Tatsuro Ishibashi; Koh-hei Sonoda

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4913. doi:

ARVO Annual Meeting Abstract July 2019

Proximal but not distal retinal ischemia is associated with microaneurysms in diabetic retinopathy

Yoshihiro Kaizu; Shintaro Nakao; Mitsuru Arima; Iori Wada; Muneo Yamaguchi; Keijiro Ishikawa; Koh-hei Sonoda

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5343. doi:

ARVO Annual Meeting Abstract July 2018

Impact of the ROCK inhibitor ripasudil on distribution of claudin-5 in vascular endothelial cells in diabetic retinopathy

Mitsuru Arima; Shintaro Nakao; Feng Hao; Muneo Yamaguchi; Kensuke Shibata; Yoshihiro Kaizu; Iori Wada; Shigeo Yoshida; Koh-hei Sonoda

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5356. doi:

ARVO Annual Meeting Abstract July 2018

The ROCK inhibitor ripasudil suppresses angio-fibrotic switch in subretinal fibrovascular proliferation

Iori Wada; Shintaro Nakao; Keijiro Ishikawa; Muneo Yamaguchi; Yoshihiro Kaizu; Shigeo Yoshida; Koh-hei Sonoda

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):65. doi:

Retina October 2017

Optical Coherence Tomography Angiography Reveals Spatial Bias of Macular Capillary Dropout in Diabetic Retinopathy

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Yoshihiro Kaizu; Shintaro Nakao; Shigeo Yoshida; Takehito Hayami; Mitsuru Arima; Muneo Yamaguchi; Iori Wada; Toshio Hisatomi; Yasuhiro Ikeda; Tatsuro Ishibashi; Koh-Hei Sonoda
TAGS: blood capillaries, angiogram, diabetic retinopathy, diabetes mellitus, optical coherence tomography, eye, fluid flow
Invest. Ophthalmol. Vis. Sci.. 2017; 58(11):4889-4897. doi: https://doi.org/10.1167/iovs.17-22306

Articles September 2017

Imaging of Retinal Vascular Layers: Adaptive Optics Scanning Laser Ophthalmoscopy Versus Optical Coherence Tomography Angiography

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Yoshihiro Kaizu; Shintaro Nakao; Iori Wada; Muneo Yamaguchi; Kohta Fujiwara; Shigeo Yoshida; Toshio Hisatomi; Yasuhiro Ikeda; Takehito Hayami; Tatsuro Ishibashi; Koh-hei Sonoda
TAGS: angiogram, diagnostic imaging, optical coherence tomography, optics, scanning laser ophthalmoscopy
Trans. Vis. Sci. Tech.. 2017; 6(5):2. doi: https://doi.org/10.1167/tvst.6.5.2

ARVO Annual Meeting Abstract June 2017

Evaluation of hyperreflective foci in diabetic macular edema by ultra-high resolution en face optical coherence tomography

Shintaro Nakao; Yoshihiro Kaizu; Iori Wada; Muneo Yamaguchi; Shigeo Yoshida; Shin Tanaka; Masaharu Mizuochi; Tatsuro Ishibashi; Koh-hei Sonoda

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1298. doi:

ARVO Annual Meeting Abstract June 2017

Prediction of long-term visual outcome in patients with macular edema due to branch retinal vein occlusion based on short-term response to anti-VEGF therapy.

Yuki Kubo; Shigeo Yoshida; Yoshito Koyanagi; Muneo Yamaguchi; Yoshiyuki Kobayashi; Takahito Nakama; Shintaro Nakao; Yasuhiro Ikeda; Tatsuro Ishibashi; Koh-hei Sonoda

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1531. doi:

ARVO Annual Meeting Abstract June 2017

Spatial pattern of retinal capillary dropout in diabetic retinopathy: evaluation using OCT angiography

Yoshihiro Kaizu; Shintaro Nakao; Takehito Hayami; Muneo Yamaguchi; Iori Wada; Kohta Fujiwara; Shigeo Yoshida; Tatsuro Ishibashi; Koh-hei Sonoda

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1661. doi:

ARVO Annual Meeting Abstract June 2017

ROCK inhibitor Ripasudil (K-115) suppresses subretinal fibrosis in laser-induced CNV model

Iori Wada; Shintaro Nakao; Muneo Yamaguchi; Keijiro Ishikawa; Shigeo Yoshida; Yoshihiro Kaizu; Tomoyuki Isobe; Yoshio Kaneko; Tatsuro Ishibashi; Koh-hei Sonoda

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):259. doi:

ARVO Annual Meeting Abstract June 2017

Topical ROCK inhibitor Ripasudil (K-115) attenuates M1-like macrophages in the mouse model of oxygen-induced retinopathy

Muneo Yamaguchi; Shintaro Nakao; Iori Wada; Yoshihiro Kaizu; Shigeo Yoshida; Tomoyuki Isobe; Yoshio Kaneko; Tatsuro Ishibashi; Koh-hei Sonoda

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):261. doi:

ARVO Annual Meeting Abstract September 2016

Comparison of AO-SLO and OCT angiography in imaging of the hierarchical structure of retinal vessels

Yoshihiro Kaizu; Shintaro Nakao; Muneo Yamaguchi; miho araki; Yoshiyuki Kobayashi; Takahito Nakama; Shigeo Yoshida; Yuji Oshima; Tatsuro Ishibashi; Koh-Hei Sonoda

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):66. doi:

ARVO Annual Meeting Abstract September 2016

Therapeutic potential of topical ROCK inhibitor Ripasudil (K-115) in choroidal neovascularization

Muneo Yamaguchi; Shintaro Nakao; Yoshihiro Kaizu; Yoshiyuki Kobayashi; Takahito Nakama; Shigeo Yoshida; Yuji Oshima; Tatsuro Ishibashi; Koh-hei Sonoda; Yoshio Kaneko; Tomoyuki Isobe

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):1109. doi:

ARVO Annual Meeting Abstract September 2016

Intravitreal ranibizumab for diabetic macular edema in vitrectomized versus nonvitrectomized eyes

Yoshito Koyanagi; Shigeo Yoshida; Yoshiyuki Kobayashi; Yuki Kubo; Muneo Yamaguchi; Takahito Nakama; Shintaro Nakao; Yuji Oshima; Tatsuro Ishibashi; Koh-hei Sonoda

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2074. doi:

Retina April 2016

Vascular Normalization by ROCK Inhibitor: Therapeutic Potential of Ripasudil (K-115) Eye Drop in Retinal Angiogenesis and Hypoxia

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Muneo Yamaguchi; Shintaro Nakao; Ryoichi Arita; Yoshihiro Kaizu; Mitsuru Arima; Yedi Zhou; Takeshi Kita; Shigeo Yoshida; Kazuhiro Kimura; Tomoyuki Isobe; Yoshio Kaneko; Koh-hei Sonoda; Tatsuro Ishibashi
TAGS: eyedrops, hypoxia, retina, mice, angiogenesis, vascular endothelial growth factor a
Invest. Ophthalmol. Vis. Sci.. 2016; 57(4):2264-2276. doi: https://doi.org/10.1167/iovs.15-17411

Includes: Supplemental Content

Retina July 2015

M2 Macrophages Enhance Pathological Neovascularization in the Mouse Model of Oxygen-Induced Retinopathy

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Yedi Zhou; Shigeo Yoshida; Shintaro Nakao; Takeru Yoshimura; Yoshiyuki Kobayashi; Takahito Nakama; Yuki Kubo; Kohta Miyawaki; Muneo Yamaguchi; Keijiro Ishikawa; Yuji Oshima; Koichi Akashi; Tatsuro Ishibashi
TAGS: macrophages, mice, neovascularization, pathologic, retina, oxygen, retinal diseases
Invest. Ophthalmol. Vis. Sci.. 2015; 56(8):4767-4777. doi: https://doi.org/10.1167/iovs.14-16012

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2015

The role of M2 macrophages in promoting ischemia-induced retinal neovascularization in mice

Yedi Zhou; Shigeo Yoshida; Shintaro Nakao; Takeru Yoshimura; Yoshiyuki Kobayashi; Takahito Nakama; Muneo Yamaguchi; Keijiro Ishikawa; Yuji Oshima; Tatsuro Ishibashi

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):422. doi:

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Hyperreflective Membrane at the Vitreoretinal Interface in Diabetic Macular Edema: A Finding in Ultra-High-Resolution Optical Coherence Tomography

Retinal VEGF-A Overexpression Is Not Sufficient to Induce Lymphangiogenesis Regardless of VEGF-C Upregulation and Lyve1 + Macrophage Infiltration

Local Proliferation of CD206+ CX3CR1+ Macrophages at the Vitreoretinal Interface in Diabetic Retinopathy

ROCK inhibitor Ripasudil reverses phenotype from EMT to MET in subretinal fibrosis

Proximal but not distal retinal ischemia is associated with microaneurysms in diabetic retinopathy

Impact of the ROCK inhibitor ripasudil on distribution of claudin-5 in vascular endothelial cells in diabetic retinopathy

The ROCK inhibitor ripasudil suppresses angio-fibrotic switch in subretinal fibrovascular proliferation

Optical Coherence Tomography Angiography Reveals Spatial Bias of Macular Capillary Dropout in Diabetic Retinopathy

Imaging of Retinal Vascular Layers: Adaptive Optics Scanning Laser Ophthalmoscopy Versus Optical Coherence Tomography Angiography

Evaluation of hyperreflective foci in diabetic macular edema by ultra-high resolution en face optical coherence tomography

Prediction of long-term visual outcome in patients with macular edema due to branch retinal vein occlusion based on short-term response to anti-VEGF therapy.

Spatial pattern of retinal capillary dropout in diabetic retinopathy: evaluation using OCT angiography

ROCK inhibitor Ripasudil (K-115) suppresses subretinal fibrosis in laser-induced CNV model

Topical ROCK inhibitor Ripasudil (K-115) attenuates M1-like macrophages in the mouse model of oxygen-induced retinopathy

Comparison of AO-SLO and OCT angiography in imaging of the hierarchical structure of retinal vessels

Therapeutic potential of topical ROCK inhibitor Ripasudil (K-115) in choroidal neovascularization

Intravitreal ranibizumab for diabetic macular edema in vitrectomized versus nonvitrectomized eyes

Vascular Normalization by ROCK Inhibitor: Therapeutic Potential of Ripasudil (K-115) Eye Drop in Retinal Angiogenesis and Hypoxia

M2 Macrophages Enhance Pathological Neovascularization in the Mouse Model of Oxygen-Induced Retinopathy

The role of M2 macrophages in promoting ischemia-induced retinal neovascularization in mice

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