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ARVO Annual Meeting Abstract June 2022

KPI-287 Demonstrates Superior Efficacy Over Axitinib in a VEGF-induced Retinal Leakage Model

Winston Ong; Peter Baciu; Elizabeth Enlow

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):299 – F0102.

Articles August 2020

Functional Analysis of Rare Genetic Variants in Complement Factor I ( CFI ) using a Serum-Based Assay in Advanced Age-related Macular Degeneration

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Anuja Java; Peter Baciu; Rafael Widjajahakim; Yun Ju Sung; Jae Yang; David Kavanagh; John Atkinson; Johanna Seddon
TAGS: age-related macular degeneration, complement factor i, cultural formulation interview, fibrinogen, genetics, inactivated c3b
Trans. Vis. Sci. Tech.. 2020; 9(9):37. https://doi.org/10.1167/tvst.9.9.37

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2020

Functional Analysis of Genetic Variants in Complement Factor I in Advanced Age-related Macular Degeneration using a Serum-based Assay

Anuja Java; Peter Baciu; David Kavanagh; John Atkinson; Johanna M Seddon

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3651.

ARVO Annual Meeting Abstract July 2018

Efficient in vivo editing of CEP290 IVS26 by EDIT-101 as a novel therapeutic for treatment of Leber Congenital Amaurosis 10

Michael Stefanidakis; Morgan Maeder; George Bounoutas; Clifford Yudkoff; Hoson Chao; Scott Haskett; Delena Nguyen; Steven J Samuelsson; Georgia Giannoukos; Dawn Ciulla; Eugenio Marco; Christopher Wilson; Peter Baciu; Pam Stetkiewicz; Charlie Albright; Haiyan Jiang

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):385.

ARVO Annual Meeting Abstract July 2018

Functional Analysis of the Complement Inhibitor Factor I in Sera of Patients with Advanced Age-Related Macular Degeneration

Peter Baciu; Jae Yang; David Kavanagh; John Atkinson; Johanna Seddon

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):790.

ARVO Annual Meeting Abstract July 2018

Effect of Tec Kinases Inhibitor on Complement-mediated Release of Basic Fibroblast Growth Factor from Human RPE Cells

Ping Yang; Grace M Tewkesbury; Kristen L Buehne; Jae Yang; Peter Baciu; Glenn J Jaffe

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2461.

ARVO Annual Meeting Abstract June 2017

Qualification of a Multiplex Panel to Analyze Complement Proteins in Human Ocular Tissues

Peter Baciu; Maria Burton; Jae Yang; Justine J Cunningham

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2301.

ARVO Annual Meeting Abstract June 2017

Complement Membrane Attack Complex Release Basic Fibroblast Growth Factor from Human RPE Cells

Ping Yang; Muhammad Abu-Rmaileh; Peter Baciu; Glenn J Jaffe

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5233.

Retinal Cell Biology June 2017

Complement-Mediated Regulation of Apolipoprotein E in Cultured Human RPE Cells

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Ping Yang; Nikolai P. Skiba; Grace M. Tewkesbury; Victoria M. Treboschi; Peter Baciu; Glenn J. Jaffe
TAGS: apolipoprotein e, complement system proteins, retinal pigment cell, proteins, complement membrane attack complex
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):3073-3085. https://doi.org/10.1167/iovs.16-20083

Includes: Supplemental Content

ARVO Annual Meeting Abstract September 2016

Combined Complement Deregulation and Oxidative Stress in SOD1/CD59a null Mice Develop AMD-like Phenotypes

Peter Baciu; Jia-Ying Yang; Iona Raymond; Ping Yang; Victoria Treboschi; Glenn J Jaffe

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5008.

ARVO Annual Meeting Abstract September 2016

The Association of Apolipoprotein E and Membrane Attack Complex in Human RPE Cell

Ping Yang; Victoria Treboschi; Peter Baciu; Glenn J Jaffe

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):6531.

ARVO Annual Meeting Abstract June 2015

Complement-mediated Apolipoprotein E Accumulation in Cultured Human RPE Cell

Ping Yang; Nikolai P Skiba; Grace M Tewkesbury; Peter Baciu; Glenn J Jaffe

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3772.

Retinal Cell Biology May 2014

Retinal Pigment Epithelial Cell Death by the Alternative Complement Cascade: Role of Membrane Regulatory Proteins, Calcium, PKC, and Oxidative Stress

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Ping Yang; Peter Baciu; Brittany C. Parker Kerrigan; Menna Etheridge; Eric Sung; Brett A. Toimil; Jacob E. Berchuck; Glenn J. Jaffe
TAGS: calcium, complement system proteins, retinal pigment cell, oxidative stress, oxidants, regulatory protein, tissue membrane, antibodies
Invest. Ophthalmol. Vis. Sci.. 2014; 55(5):3012-3021. https://doi.org/10.1167/iovs.13-13554

Includes: Supplemental Content

ARVO Annual Meeting Abstract April 2014

The Role of Nrf-2 in Alternative Pathway (AP) Complement and Hydroquinone (HQ)-mediated Heme Oxygenase-1 (HO-1) Expression in Human RPE (hRPE) Cells

Michelle Bao; Zhe Ma; Ping Yang; Peter Baciu; Glenn J Jaffe

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3435.

ARVO Annual Meeting Abstract April 2014

Proteomics Analysis of Protein Expression in Human RPE Cells Exposed to Oxidant and Complement Attack through Alternative Pathway

Ping Yang; Nikolai P Skiba; Michelle Bao; Angel Long; Peter Baciu; Glenn J Jaffe

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3437.

ARVO Annual Meeting Abstract June 2013

Hydroquinone Sensitizes Human RPE Cells to Basal Complement Attack by the Alternative Pathway

Ping Yang; Peter Baciu; Glenn Jaffe

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):1185.

Retina April 2013

All- trans -Retinal Sensitizes Human RPE Cells to Alternative Complement Pathway–Induced Cell Death

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Jacob E. Berchuck; Ping Yang; Brett A. Toimil; Zhe Ma; Peter Baciu; Glenn J. Jaffe
TAGS: antibodies, cell death, complement pathway, alternative, retinal pigment cell, disease susceptibility, complement system proteins, resveratrol, antigens, cd59, cd46 antigen
Invest. Ophthalmol. Vis. Sci.. 2013; 54(4):2669-2677. https://doi.org/10.1167/iovs.12-11020

ARVO Annual Meeting Abstract March 2012

The Effect of Combined Oxidant Exposure and AP Complement Attack on Oxidant Production and Gene Expression in Human RPE Cells

Brett A. Toimil; Ping Yang; Jacob E. Berchuck; Peter Baciu; Glenn J. Jaffe

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):3195.

ARVO Annual Meeting Abstract March 2012

Human RPE Cell Injury Mediated by Oxidative Stress and Alternative Complement Cascade

Ping Yang; Brett A. Toimil; Jacob E. Berchuck; Peter Baciu; Glenn J. Jaffe

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):1648.

ARVO Annual Meeting Abstract March 2012

All-trans-Retinal Sensitizes Human RPE Cells to Alternative Complement Pathway-Induced Cell Death

Jacob E. Berchuck; Ping Yang; Brett A. Toimil; Peter Baciu; Glenn J. Jaffe

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):1649.

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KPI-287 Demonstrates Superior Efficacy Over Axitinib in a VEGF-induced Retinal Leakage Model

Functional Analysis of Rare Genetic Variants in Complement Factor I ( CFI ) using a Serum-Based Assay in Advanced Age-related Macular Degeneration

Functional Analysis of Genetic Variants in Complement Factor I in Advanced Age-related Macular Degeneration using a Serum-based Assay

Efficient in vivo editing of CEP290 IVS26 by EDIT-101 as a novel therapeutic for treatment of Leber Congenital Amaurosis 10

Functional Analysis of the Complement Inhibitor Factor I in Sera of Patients with Advanced Age-Related Macular Degeneration

Effect of Tec Kinases Inhibitor on Complement-mediated Release of Basic Fibroblast Growth Factor from Human RPE Cells

Qualification of a Multiplex Panel to Analyze Complement Proteins in Human Ocular Tissues

Complement Membrane Attack Complex Release Basic Fibroblast Growth Factor from Human RPE Cells

Complement-Mediated Regulation of Apolipoprotein E in Cultured Human RPE Cells

Combined Complement Deregulation and Oxidative Stress in SOD1/CD59a null Mice Develop AMD-like Phenotypes

The Association of Apolipoprotein E and Membrane Attack Complex in Human RPE Cell

Complement-mediated Apolipoprotein E Accumulation in Cultured Human RPE Cell

Retinal Pigment Epithelial Cell Death by the Alternative Complement Cascade: Role of Membrane Regulatory Proteins, Calcium, PKC, and Oxidative Stress

The Role of Nrf-2 in Alternative Pathway (AP) Complement and Hydroquinone (HQ)-mediated Heme Oxygenase-1 (HO-1) Expression in Human RPE (hRPE) Cells

Proteomics Analysis of Protein Expression in Human RPE Cells Exposed to Oxidant and Complement Attack through Alternative Pathway

Hydroquinone Sensitizes Human RPE Cells to Basal Complement Attack by the Alternative Pathway

All- trans -Retinal Sensitizes Human RPE Cells to Alternative Complement Pathway–Induced Cell Death

The Effect of Combined Oxidant Exposure and AP Complement Attack on Oxidant Production and Gene Expression in Human RPE Cells

Human RPE Cell Injury Mediated by Oxidative Stress and Alternative Complement Cascade

All-trans-Retinal Sensitizes Human RPE Cells to Alternative Complement Pathway-Induced Cell Death

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