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ARVO Annual Meeting Abstract June 2022

Evaluations of localized topical tissue-targeted AAV5-Id3 gene delivery to treat

Suneel Gupta; Nishant Rajiv Sinha; Lynn M Martin; Landon Keele; Nathan P. Hesemann; Prashant Sinha; Elizabeth A Giuliano; Ratnakar Tripathi; Rajiv R Mohan

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):117 – A0215. doi:

ARVO Annual Meeting Abstract June 2022

Evaluation of delayed/chronic corneal toxicity and clinical manifestations for 4-month after mustard gas exposure to rabbit eyes in vivo

Ratnakar Tripathi; Nishant Rajiv Sinha; Praveen Kumar Balne; Alexandria Hofmann; Sydney L. Green; Laila A Suleaiman; Prashant Sinha; Nathan P Hesemann; Shyam S Chaurasia; Rajiv R Mohan

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):115 – A0213. doi:

ARVO Annual Meeting Abstract June 2022

mTORC regulation of autophagy in the corneal stroma following chemical injury

Nishant Rajiv Sinha; Ratnakar Tripathi; Praveen Kumar Balne; Sydney L. Green; Riley M. Laub; Rajiv R Mohan

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):113 – A0211. doi:

ARVO Annual Meeting Abstract June 2022

H 2 S induces dose-dependent changes in inflammatory and apoptotic responses in human corneal stromal fibroblasts in vitro

Praveen Kumar Balne; Nishant Rajiv Sinha; Ratnakar Tripathi; Andrew Houmes; Laila A. Suleiman; Prashant Sinha; Rajiv R Mohan

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):112 – A0210. doi:

ARVO Annual Meeting Abstract June 2022

Epigenetic mechanism to induce dedifferentiation of corneal myofibroblast to fibroblast

Rajiv R Mohan; Praveen Kumar Balne; Nishant Rajiv Sinha; Alexandria Hofmann; Nicholas Hauser; Ratnakar Tripathi; Prashant Sinha; Suneel Gupta; Kempuraj Duraisamy

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2640. doi:

ARVO Annual Meeting Abstract June 2022

Mustard Gas Exposure causes Retinal Muller Cell Gliosis via Caspase 1-dependent NLRP3 Pyroptosis

Binapani Mahaling; Rajiv R Mohan; Shyam S Chaurasia

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4146 – F0383. doi:

Special Issue August 2021

Long-Term Safety and Tolerability of BMP7 and HGF Gene Overexpression in Rabbit Cornea

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Suneel Gupta; Nishant R. Sinha; Lynn M. Martin; Landon M. Keele; Prashant R. Sinha; Jason T. Rodier; James R. Landreneau; Nathan P. Hesemann; Rajiv R. Mohan
TAGS: cornea, genes, oryctolagus cuniculus, safety, eye, spatial vectors, gene therapy, disease vectors, protein overexpression, body tissue
Trans. Vis. Sci. Tech.. 2021; 10(10):6. doi: https://doi.org/10.1167/tvst.10.10.6

Special Issue August 2021

Six-Month In Vivo Safety Profiling of Topical Ocular AAV5–Decorin Gene Transfer

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Rajiv R. Mohan; Praveen K. Balne; Maryam S. Muayad; Ratnakar Tripathi; Nishant R. Sinha; Suneel Gupta; Jella A. An; Prashant R. Sinha; Nathan P. Hesemann
TAGS: cornea, eye, gene therapy, gene transfer techniques, oryctolagus cuniculus, safety, spatial vectors, genes, disease vectors
Trans. Vis. Sci. Tech.. 2021; 10(10):5. doi: https://doi.org/10.1167/tvst.10.10.5

ARVO Annual Meeting Abstract June 2021

Microbiological spectrum and risk of transmission of infection from donor tissues of enucleated eyes harvested from septicaemic patients

Bhavana Sharma; Deepak Soni; Aditi Dubey; Samendra Karkhur; Deepayan Sarkar; Akhilesh Kumar; Suraj Kubrey; Vidhya Verma; Rajiv R Mohan

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):712. doi:

ARVO Annual Meeting Abstract June 2021

Cellular and molecular changes in human corneal fibroblasts following hydrogen sulfide exposure in vitro

Praveen Kumar Balne; Nishant Rajiv Sinha; Alexandria Caroline Hofmann; Ratnakar Tripathi; Suneel Gupta; Prashant R. Sinha; Rajiv R Mohan

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):944. doi:

ARVO Annual Meeting Abstract June 2021

Mechanism associated with acrolein’s toxicity to the cornea in vitro

Suneel Gupta; Nishant Rajiv Sinha; Praveen Balne; Ratnakar Tripathi; Nathan Hesemann; Prashant R. Sinha; Rajiv R Mohan

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):942. doi:

ARVO Annual Meeting Abstract June 2021

Effects of mustard gas exposure to the corneal basement membrane and epithelial-stromal attachment to human cornea ex vivo

Ratnakar Tripathi; Nishant Rajiv Sinha; Praveen Balne; Suneel Gupta; Nathan Hesemann; Jason T Rodier; Prashant R. Sinha; Shyam S Chaurasia; Rajiv R Mohan

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):939. doi:

ARVO Annual Meeting Abstract June 2021

Collagen Expression in mini Ossabaw pigs Cornea with Type II Diabetes

Nishant Rajiv Sinha; Alexandria Caroline Hofmann; Praveen Balne; Rajiv R Mohan; Shyam S Chaurasia

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):937. doi:

ARVO Annual Meeting Abstract June 2021

Long-term tolerability profiling of BMP7+HGF overexpression on rabbit cornea in vivo

Rajiv R Mohan; Suneel Gupta; Nishant Rajiv Sinha; Lynn Martin; Nathan Hesemann; Sabeeh Kamil; Prashant R. Sinha; Praveen Balne; Ratnakar Tripathi; Shyam S Chaurasia

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):928. doi:

Perspective November 2020

The Need for Improved Therapeutic Approaches to Protect the Cornea Against Chemotoxic Injuries

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Patrick M. McNutt; Rajiv R. Mohan

Trans. Vis. Sci. Tech.. 2020; 9(12):2. doi: https://doi.org/10.1167/tvst.9.12.2

Articles November 2020

A Novel Topical Ophthalmic Formulation to Mitigate Acute Mustard Gas Keratopathy In Vivo: A Pilot Study

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Ratnakar Tripathi; Praveen K. Balne; Nishant R. Sinha; Lynn M. Martin; Sabeeh Kamil; James R. Landreneau; Suneel Gupta; Jason T. Rodier; Prashant R. Sinha; Nathan P. Hesemann; Alexandria C. Hofmann; Michael K. Fink; Shyam S. Chaurasia; Rajiv R. Mohan

Trans. Vis. Sci. Tech.. 2020; 9(12):6. doi: https://doi.org/10.1167/tvst.9.12.6

ARVO Annual Meeting Abstract June 2020

Investigation of effects of decorin on stromal fibrillogenesis in adult un-injured and injured healing cornea using decorin knockout and wild type mice

Sabeeh Kamil; Suneel Gupta; Lynn M. Martin; Ratnakar Tripathi; Nathan Hesemann; Praveen Kumar Balne; Prashant R. Sinha; Nishant Rajiv Sinha; Alexandria Hofmann; Sydney Green; Frederick W Fraunfelder; Rajiv R Mohan

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2604. doi:

ARVO Annual Meeting Abstract June 2020

SIRT1: A novel target to regulate corneal myofibroblast formation

Ratnakar Tripathi; Lynn M. Martin; Sabeeh Kamil; Nishant Rajiv Sinha; Alexandria Hofmann; Sydney Green; Praveen Balne; Suneel Gupta; Prashant R. Sinha; Nathan Hesemann; Frederick W Fraunfelder; Shyam S Chaurasia; Rajiv R Mohan

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2605. doi:

ARVO Annual Meeting Abstract June 2020

Remarkable inhibition of corneal scarring by Id3 gene therapy in a preclinical rabbit in vivo model

Suneel Gupta; Prashant R. Sinha; Sabeeh Kamil; Nishant Rajiv Sinha; Ratnakar Tripathi; Praveen Kumar Balne; Shyam S Chaurasia; Nathan Hesemann; Rajiv R. Mohan

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2609. doi:

ARVO Annual Meeting Abstract June 2020

Role of Smad3 in healing cornea using knockout (Smad3 -/- ) mice

Sydney Green; Suneel Gupta; Prashant R. Sinha; Nishant Rajiv Sinha; Praveen Balne; Nathan Hesemann; Shyam S Chaurasia; Rajiv R Mohan

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2610. doi:

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Evaluations of localized topical tissue-targeted AAV5-Id3 gene delivery to treat

Evaluation of delayed/chronic corneal toxicity and clinical manifestations for 4-month after mustard gas exposure to rabbit eyes in vivo

mTORC regulation of autophagy in the corneal stroma following chemical injury

H 2 S induces dose-dependent changes in inflammatory and apoptotic responses in human corneal stromal fibroblasts in vitro

Epigenetic mechanism to induce dedifferentiation of corneal myofibroblast to fibroblast

Mustard Gas Exposure causes Retinal Muller Cell Gliosis via Caspase 1-dependent NLRP3 Pyroptosis

Long-Term Safety and Tolerability of BMP7 and HGF Gene Overexpression in Rabbit Cornea

Six-Month In Vivo Safety Profiling of Topical Ocular AAV5–Decorin Gene Transfer

Microbiological spectrum and risk of transmission of infection from donor tissues of enucleated eyes harvested from septicaemic patients

Cellular and molecular changes in human corneal fibroblasts following hydrogen sulfide exposure in vitro

Mechanism associated with acrolein’s toxicity to the cornea in vitro

Effects of mustard gas exposure to the corneal basement membrane and epithelial-stromal attachment to human cornea ex vivo

Collagen Expression in mini Ossabaw pigs Cornea with Type II Diabetes

Long-term tolerability profiling of BMP7+HGF overexpression on rabbit cornea in vivo

The Need for Improved Therapeutic Approaches to Protect the Cornea Against Chemotoxic Injuries

A Novel Topical Ophthalmic Formulation to Mitigate Acute Mustard Gas Keratopathy In Vivo: A Pilot Study

Investigation of effects of decorin on stromal fibrillogenesis in adult un-injured and injured healing cornea using decorin knockout and wild type mice

SIRT1: A novel target to regulate corneal myofibroblast formation

Remarkable inhibition of corneal scarring by Id3 gene therapy in a preclinical rabbit in vivo model

Role of Smad3 in healing cornea using knockout (Smad3 -/- ) mice

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