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Articles May 2022

Characterizing Visual Fields in RPGR Related Retinitis Pigmentosa Using Octopus Static-Automated Perimetry

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Thomas M. W. Buckley; Amandeep Singh Josan; Laura J. Taylor; Jasleen K. Jolly; Jasmina Cehajic-Kapetanovic; Robert E. MacLaren
TAGS: octopus, perimetry, retinitis pigmentosa, visual fields
Trans. Vis. Sci. Tech.. 2022; 11(5):15. doi: https://doi.org/10.1167/tvst.11.5.15

Articles April 2022

Tropism of AAV Vectors in Photoreceptor-Like Cells of Human iPSC-Derived Retinal Organoids

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Michelle E. McClements; Hannah Steward; William Atkin; Emily Archer Goode; Carolina Gándara; Valeria Chichagova; Robert E. MacLaren
TAGS: organoids, spatial vectors, photoreceptors
Trans. Vis. Sci. Tech.. 2022; 11(4):3. doi: https://doi.org/10.1167/tvst.11.4.3

Includes: Supplemental Content

Articles July 2021

Expression of Rab Prenylation Pathway Genes and Relation to Disease Progression in Choroideremia

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Lewis E. Fry; Maria I. Patrício; Jasleen K. Jolly; Kanmin Xue; Robert E. MacLaren
TAGS: choroideremia, disease progression, genes, tissue degeneration, proteins
Trans. Vis. Sci. Tech.. 2021; 10(8):12. doi: https://doi.org/10.1167/tvst.10.8.12

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2021

NIGHT study: natural progression of choroideremia

Byron L Lam; Robert E MacLaren; M. Dominik Fischer; Frank G Holz; Mark E Pennesi; David G Birch; Eeva-Marja Sankila; Isabelleanne Meunier; Kimberly E Stepien; Juliana M.F. Sallum; Cindy Lu; Jiajun Liu; Dan Yoon

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):34. doi:

ARVO Annual Meeting Abstract June 2021

Widespread Thinning of Human Primary Visual Cortex Following Focal Loss of Photoreceptors

Jasleen Kaur Jolly; Bradley Caron; Aislin A Sheldon; Daniel Bullock; Susan M Downes; Franco Pestilli; Robert E MacLaren; Holly Bridge

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3138. doi:

ARVO Annual Meeting Abstract June 2021

Visual function improvements with BIIB112 (NSR-RPGR) in X-linked retinitis pigmentosa: XIRIUS (dose-expansion) and XOLARIS (natural disease progression) studies

Robert E MacLaren; Byron L Lam; Andrew J Lotery; Paulo Eduardo Stanga; Assad Jalil; Mark E Pennesi; David G Birch; Christine Kay; Jiajun Liu; Eileen Liao; Lenore von Krusenstiern

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1479. doi:

ARVO Annual Meeting Abstract June 2021

Genotype-phenotype correlation of novel variants in ABCA4

Saoud Al-khuzaei; Charlotte Foster; Suzanne Broadgate; Mital shah; Morag Shanks; Robert E MacLaren; Peter Charbel Issa; Penny Clouston; Stephanie Halford; Susan M Downes

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1545. doi:

ARVO Annual Meeting Abstract June 2021

Usability of AdaptDx for Dark Adaptation Testing in Choroideremia

Hend M Ahmed; Jasleen K Jolly; Lyndon Da Cruz; Adam M Dubis; Robert E. MacLaren

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2294. doi:

ARVO Annual Meeting Abstract June 2021

Five-year results after AAV2-REP1 gene therapy for choroideremia

Yi Zhai; Manlong Xu; Ioannis S Dimopoulos; Robert E. MacLaren; Rizwan Somani; Matthew TS Tennant; Ian M MacDonald

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3318. doi:

Methods June 2021

Microperimetry Hill of Vision and Volumetric Measures of Retinal Sensitivity

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Amandeep Singh Josan; Thomas M. W. Buckley; Laura J. Wood; Jasleen K. Jolly; Jasmina Cehajic-Kapetanovic; Robert E. MacLaren
TAGS: vision, volume, scotoma
Trans. Vis. Sci. Tech.. 2021; 10(7):12. doi: https://doi.org/10.1167/tvst.10.7.12

Includes: Supplemental Content

Articles February 2021

Low Luminance Visual Acuity and Low Luminance Deficit in Choroideremia and RPGR -Associated Retinitis Pigmentosa

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Laura J. Wood; Jasleen K. Jolly; Amandeep S. Josan; Thomas M. W. Buckley; Robert E. MacLaren
TAGS: choroideremia, luminance, retinitis pigmentosa, visual acuity
Trans. Vis. Sci. Tech.. 2021; 10(2):28. doi: https://doi.org/10.1167/tvst.10.2.28

Articles June 2020

Assessment of AAV Dual Vector Safety in the Abca4 −/− Mouse Model of Stargardt Disease

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Michelle E. McClements; Alun R. Barnard; Peter Charbel Issa; Robert E. MacLaren
TAGS: cohort studies, disease vectors, eye, injections, mice, safety, spatial vectors, stargardt's disease, electroretinography, toxic effect
Trans. Vis. Sci. Tech.. 2020; 9(7):20. doi: https://doi.org/10.1167/tvst.9.7.20

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2020

Assessing Residual Photoreceptor Morphology in Choroideremia

Adam M Dubis; Jasleen Kaur Jolly; Lyndon daCruz; Mariya Moosajee; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):819. doi:

Retina August 2019

A Specific Macula-Predominant Retinal Phenotype Is Associated With the CDHR1 Variant c.783G>A, a Silent Mutation Leading to In-Frame Exon Skipping

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Peter Charbel Issa; Martin Gliem; Imran H. Yusuf; Johannes Birtel; Philipp L. Müller; Elisabeth Mangold; Susan M. Downes; Robert E. MacLaren; Christian Betz; Hanno J. Bolz
TAGS: exons, macula densa, macula lutea, mutation, phenotype, retinal diseases, silent mutations, homozygote
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3388-3397. doi: https://doi.org/10.1167/iovs.18-26415

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

A semi-automated phenotypic RPE in vitro scratch assay for screening of small molecule compounds able to influence RPE wound healing

Tina storm; Ross Campbell; Iain R Wilson; Arantxa Bolinches-Amoros; Angela J. Russel; Stephen G. Davies; Alun R Barnard; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6394. doi:

ARVO Annual Meeting Abstract July 2019

Fundus autofluorescence abnormalities and microglia/macrophage activation in the Rpgr -deficient mouse.

Federica Staurenghi; Cristina Martinez-Fernandez dela Camara; Alun R Barnard; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):433. doi:

ARVO Annual Meeting Abstract July 2019

Face perception - can it be improved in age-related macular degeneration and Stargardt disease?

Iain R Wilson; Stephen Lloyd Hicks; Susan M. Downes; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1061. doi:

ARVO Annual Meeting Abstract July 2019

Changes on multimodal imaging after treatment with photodynamic therapy or high-density subthreshold micropulse laser in chronic central serous chorioretinopathy

Thomas Jurian van Rijssen; Leo C Hahn; Elon Van Dijk; Paula Scholz; Myrte Breukink; Eric H Souied; Robert E MacLaren; Giuseppe Querques; Sascha Fauser; Susan M. Downes; Carel C B Hoyng; Camiel Boon

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1155. doi:

ARVO Annual Meeting Abstract July 2019

Preliminary results in 18 patients undergoing retinal gene therapy for X-linked retinitis pigmentosa with codon-optimized AAV8-RPGR

Robert E MacLaren; Janet L Davis; Ninel Gregori; Jasmina Cehajic-Kapetanovic; Byron L Lam; Andrew Lotery; Cristina Martinez-Fernandez dela Camara; Anika Nanda; Anna Paola Salvetti; Paulo Stanga; Kanmin Xue

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1329. doi:

ARVO Annual Meeting Abstract July 2019

Assessment of AAV dual vector safety in the Abca4 KO mouse model

Michelle E McClements; Alun R Barnard; Peter Charbel Issa; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1708. doi:

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Characterizing Visual Fields in RPGR Related Retinitis Pigmentosa Using Octopus Static-Automated Perimetry

Tropism of AAV Vectors in Photoreceptor-Like Cells of Human iPSC-Derived Retinal Organoids

Expression of Rab Prenylation Pathway Genes and Relation to Disease Progression in Choroideremia

NIGHT study: natural progression of choroideremia

Widespread Thinning of Human Primary Visual Cortex Following Focal Loss of Photoreceptors

Visual function improvements with BIIB112 (NSR-RPGR) in X-linked retinitis pigmentosa: XIRIUS (dose-expansion) and XOLARIS (natural disease progression) studies

Genotype-phenotype correlation of novel variants in ABCA4

Usability of AdaptDx for Dark Adaptation Testing in Choroideremia

Five-year results after AAV2-REP1 gene therapy for choroideremia

Microperimetry Hill of Vision and Volumetric Measures of Retinal Sensitivity

Low Luminance Visual Acuity and Low Luminance Deficit in Choroideremia and RPGR -Associated Retinitis Pigmentosa

Assessment of AAV Dual Vector Safety in the Abca4 −/− Mouse Model of Stargardt Disease

Assessing Residual Photoreceptor Morphology in Choroideremia

A Specific Macula-Predominant Retinal Phenotype Is Associated With the CDHR1 Variant c.783G>A, a Silent Mutation Leading to In-Frame Exon Skipping

A semi-automated phenotypic RPE in vitro scratch assay for screening of small molecule compounds able to influence RPE wound healing

Fundus autofluorescence abnormalities and microglia/macrophage activation in the Rpgr -deficient mouse.

Face perception - can it be improved in age-related macular degeneration and Stargardt disease?

Changes on multimodal imaging after treatment with photodynamic therapy or high-density subthreshold micropulse laser in chronic central serous chorioretinopathy

Preliminary results in 18 patients undergoing retinal gene therapy for X-linked retinitis pigmentosa with codon-optimized AAV8-RPGR

Assessment of AAV dual vector safety in the Abca4 KO mouse model

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