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Articles February 2021

Low Luminance Visual Acuity and Low Luminance Deficit in Choroideremia and RPGR -Associated Retinitis Pigmentosa

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Laura J. Wood; Jasleen K. Jolly; Amandeep S. Josan; Thomas M. W. Buckley; Robert E. MacLaren
TAGS: choroideremia, luminance, retinitis pigmentosa, visual acuity
Trans. Vis. Sci. Tech.. 2021; 10(2):28. doi: https://doi.org/10.1167/tvst.10.2.28

Articles June 2020

Assessment of AAV Dual Vector Safety in the Abca4 −/− Mouse Model of Stargardt Disease

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Michelle E. McClements; Alun R. Barnard; Peter Charbel Issa; Robert E. MacLaren
TAGS: cohort studies, disease vectors, eye, injections, mice, safety, spatial vectors, stargardt's disease, electroretinography, toxic effect
Trans. Vis. Sci. Tech.. 2020; 9(7):20. doi: https://doi.org/10.1167/tvst.9.7.20

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2020

Assessing Residual Photoreceptor Morphology in Choroideremia

Adam M Dubis; Jasleen Kaur Jolly; Lyndon daCruz; Mariya Moosajee; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):819. doi:

Retina August 2019

A Specific Macula-Predominant Retinal Phenotype Is Associated With the CDHR1 Variant c.783G>A, a Silent Mutation Leading to In-Frame Exon Skipping

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Peter Charbel Issa; Martin Gliem; Imran H. Yusuf; Johannes Birtel; Philipp L. Müller; Elisabeth Mangold; Susan M. Downes; Robert E. MacLaren; Christian Betz; Hanno J. Bolz
TAGS: exons, macula densa, macula lutea, mutation, phenotype, retinal diseases, silent mutations, homozygote
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3388-3397. doi: https://doi.org/10.1167/iovs.18-26415

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

First in human clinical trial of robot-assisted subretinal drug delivery under local anaesthesia

Jasmina Cehajic Kapetanovic; Kanmin Xue; Thomas Edwards; Thijs CM Meenink; Maarten J Beelen; Gerrit JL Naus; Marc D de Smet; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2898. doi:

ARVO Annual Meeting Abstract July 2019

Vector shedding and immunology measures in a choroideremia gene therapy trial

Alun R Barnard; Anna Rudenko; Maria In�s Patr�cio; Laurel Clare Chandler; Kanmin Xue; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2919. doi:

ARVO Annual Meeting Abstract July 2019

Genotype-Phenotype Analysis of Three Novel NR2E3 Mutations

Saoud A Al-khuzaei; Stephanie Halford; Penny Clouston; Robert E MacLaren; Susan M. Downes

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2933. doi:

ARVO Annual Meeting Abstract July 2019

Preliminary results in 18 patients undergoing retinal gene therapy for X-linked retinitis pigmentosa with codon-optimized AAV8-RPGR

Robert E MacLaren; Janet L Davis; Ninel Gregori; Jasmina Cehajic-Kapetanovic; Byron L Lam; Andrew Lotery; Cristina Martinez-Fernandez dela Camara; Anika Nanda; Anna Paola Salvetti; Paulo Stanga; Kanmin Xue

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1329. doi:

ARVO Annual Meeting Abstract July 2019

Assessment of AAV dual vector safety in the Abca4 KO mouse model

Michelle E McClements; Alun R Barnard; Peter Charbel Issa; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1708. doi:

ARVO Annual Meeting Abstract July 2019

Guide RNA orientation influences Cas9 expression in a single vector approach to CRISPR editing in a model system

Lewis Fry; Caroline Peddle; Alun R Barnard; Michelle E McClements; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4937. doi:

ARVO Annual Meeting Abstract July 2019

Effect of single guide nucleotide mismatch in CRISPR/Cas9-mediated disruption of the human rhodopsin gene in vitro .

Caroline Peddle; Michelle E McClements; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4945. doi:

ARVO Annual Meeting Abstract July 2019

Natural History of the Progression of RPGR-Associated X-Linked Retinitis Pigmentosa (XOLARIS) Study: Cross-Sectional Analysis of Baseline Characteristics

Moreno Menghini; David G Birch; Camiel Boon; Jacque L Duncan; M Dominik Fischer; Frank G Holz; Carel C B Hoyng; Kamron N Khan; Isabelle Anne Meunier; Mark E Pennesi; Eeva-Marja Kaarina Sankila; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5168. doi:

ARVO Annual Meeting Abstract July 2019

Mirtron gene therapy for the treatment of rhodopsin-related dominant retinitis pigmentosa

Harry Otway Orlans; Michelle E McClements; Alun R Barnard; Cristina Martinez-Fernandez dela Camara; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5195. doi:

ARVO Annual Meeting Abstract July 2019

Non-identical monozygotic twins with RPGR-associated Retinitis Pigmentosa

Anika Nanda; Penny Clouston; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4499. doi:

ARVO Annual Meeting Abstract July 2019

Enhanced autofluorescence ring findings in RPGR-associated retinitis pigmentosa

Won Kyung Song; Anika Nanda; Jasmina Cehajic-Kapetanovic; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4524. doi:

ARVO Annual Meeting Abstract July 2019

Fundus autofluorescence abnormalities and microglia/macrophage activation in the Rpgr -deficient mouse.

Federica Staurenghi; Cristina Martinez-Fernandez dela Camara; Alun R Barnard; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):433. doi:

ARVO Annual Meeting Abstract July 2019

A semi-automated phenotypic RPE in vitro scratch assay for screening of small molecule compounds able to influence RPE wound healing

Tina storm; Ross Campbell; Iain R Wilson; Arantxa Bolinches-Amoros; Angela J. Russel; Stephen G. Davies; Alun R Barnard; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6394. doi:

ARVO Annual Meeting Abstract July 2019

Retinitis pigmentosa caused by variants in SNRNP200

Imran H Yusuf; Johannes Birtel; Morag Shanks; Penny Clouston; Susan M. Downes; Peter Charbel Issa; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4519. doi:

ARVO Annual Meeting Abstract July 2019

Cost-effectiveness of Choroideremia Gene Therapy

Celine-Lea Halioua-Haubold; Jasleen Kaur Jolly; David A Brindley; Rafael Pinedo-Villanueva; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5461. doi:

ARVO Annual Meeting Abstract July 2019

Assessment of low luminance visual acuity as a functional measurement in two distinct types of inherited retinal degeneration.

Laura Wood; Jasleen K Jolly; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1817. doi:

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Low Luminance Visual Acuity and Low Luminance Deficit in Choroideremia and RPGR -Associated Retinitis Pigmentosa

Assessment of AAV Dual Vector Safety in the Abca4 −/− Mouse Model of Stargardt Disease

Assessing Residual Photoreceptor Morphology in Choroideremia

A Specific Macula-Predominant Retinal Phenotype Is Associated With the CDHR1 Variant c.783G>A, a Silent Mutation Leading to In-Frame Exon Skipping

First in human clinical trial of robot-assisted subretinal drug delivery under local anaesthesia

Vector shedding and immunology measures in a choroideremia gene therapy trial

Genotype-Phenotype Analysis of Three Novel NR2E3 Mutations

Preliminary results in 18 patients undergoing retinal gene therapy for X-linked retinitis pigmentosa with codon-optimized AAV8-RPGR

Assessment of AAV dual vector safety in the Abca4 KO mouse model

Guide RNA orientation influences Cas9 expression in a single vector approach to CRISPR editing in a model system

Effect of single guide nucleotide mismatch in CRISPR/Cas9-mediated disruption of the human rhodopsin gene in vitro .

Natural History of the Progression of RPGR-Associated X-Linked Retinitis Pigmentosa (XOLARIS) Study: Cross-Sectional Analysis of Baseline Characteristics

Mirtron gene therapy for the treatment of rhodopsin-related dominant retinitis pigmentosa

Non-identical monozygotic twins with RPGR-associated Retinitis Pigmentosa

Enhanced autofluorescence ring findings in RPGR-associated retinitis pigmentosa

Fundus autofluorescence abnormalities and microglia/macrophage activation in the Rpgr -deficient mouse.

A semi-automated phenotypic RPE in vitro scratch assay for screening of small molecule compounds able to influence RPE wound healing

Retinitis pigmentosa caused by variants in SNRNP200

Cost-effectiveness of Choroideremia Gene Therapy

Assessment of low luminance visual acuity as a functional measurement in two distinct types of inherited retinal degeneration.

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