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Articles June 2020

Assessment of AAV Dual Vector Safety in the Abca4 −/− Mouse Model of Stargardt Disease

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Michelle E. McClements; Alun R. Barnard; Peter Charbel Issa; Robert E. MacLaren
TAGS: cohort studies, disease vectors, eye, injections, mice, safety, spatial vectors, stargardt's disease, electroretinography, toxic effect
Trans. Vis. Sci. Tech.. 2020; 9(7):20. doi: https://doi.org/10.1167/tvst.9.7.20

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2020

Assessing Residual Photoreceptor Morphology in Choroideremia

Adam M Dubis; Jasleen Kaur Jolly; Lyndon daCruz; Mariya Moosajee; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):819. doi:

Retina August 2019

A Specific Macula-Predominant Retinal Phenotype Is Associated With the CDHR1 Variant c.783G>A, a Silent Mutation Leading to In-Frame Exon Skipping

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Peter Charbel Issa; Martin Gliem; Imran H. Yusuf; Johannes Birtel; Philipp L. Müller; Elisabeth Mangold; Susan M. Downes; Robert E. MacLaren; Christian Betz; Hanno J. Bolz
TAGS: exons, macula densa, macula lutea, mutation, phenotype, retinal diseases, silent mutations, homozygote
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3388-3397. doi: https://doi.org/10.1167/iovs.18-26415

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

Fundus autofluorescence abnormalities and microglia/macrophage activation in the Rpgr -deficient mouse.

Federica Staurenghi; Cristina Martinez-Fernandez dela Camara; Alun R Barnard; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):433. doi:

ARVO Annual Meeting Abstract July 2019

Face perception - can it be improved in age-related macular degeneration and Stargardt disease?

Iain R Wilson; Stephen Lloyd Hicks; Susan M. Downes; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1061. doi:

ARVO Annual Meeting Abstract July 2019

Changes on multimodal imaging after treatment with photodynamic therapy or high-density subthreshold micropulse laser in chronic central serous chorioretinopathy

Thomas Jurian van Rijssen; Leo C Hahn; Elon Van Dijk; Paula Scholz; Myrte Breukink; Eric H Souied; Robert E MacLaren; Giuseppe Querques; Sascha Fauser; Susan M. Downes; Carel C B Hoyng; Camiel Boon

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1155. doi:

ARVO Annual Meeting Abstract July 2019

Preliminary results in 18 patients undergoing retinal gene therapy for X-linked retinitis pigmentosa with codon-optimized AAV8-RPGR

Robert E MacLaren; Janet L Davis; Ninel Gregori; Jasmina Cehajic-Kapetanovic; Byron L Lam; Andrew Lotery; Cristina Martinez-Fernandez dela Camara; Anika Nanda; Anna Paola Salvetti; Paulo Stanga; Kanmin Xue

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1329. doi:

ARVO Annual Meeting Abstract July 2019

Assessment of AAV dual vector safety in the Abca4 KO mouse model

Michelle E McClements; Alun R Barnard; Peter Charbel Issa; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1708. doi:

ARVO Annual Meeting Abstract July 2019

Assessment of low luminance visual acuity as a functional measurement in two distinct types of inherited retinal degeneration.

Laura Wood; Jasleen K Jolly; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1817. doi:

ARVO Annual Meeting Abstract July 2019

Validation of Electronic Visual Acuity Measurement Against Standardised ETDRS Charts In Retinal Disease

Jasleen Kaur Jolly; Kristin Juenemann; Heather Boagey; Joanna Moschandreas; Marie Nadsady; Holly Bridge; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1819. doi:

ARVO Annual Meeting Abstract July 2019

Effect of reduced visual acuity on microperimetry performance in patients with inherited retinal degenerations

Alexandra Davies; Anika Nanda; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1820. doi:

ARVO Annual Meeting Abstract July 2019

Correlation of distinct fundus autofluorescence features with disruption of the overlying ellipsoid zone in choroideremia

Marta Stevanovic; Jasmina Cehajic Kapetanovic; Jasleen Kaur Jolly; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1856. doi:

ARVO Annual Meeting Abstract July 2019

First in human clinical trial of robot-assisted subretinal drug delivery under local anaesthesia

Jasmina Cehajic Kapetanovic; Kanmin Xue; Thomas Edwards; Thijs CM Meenink; Maarten J Beelen; Gerrit JL Naus; Marc D de Smet; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2898. doi:

ARVO Annual Meeting Abstract July 2019

Vector shedding and immunology measures in a choroideremia gene therapy trial

Alun R Barnard; Anna Rudenko; Maria In�s Patr�cio; Laurel Clare Chandler; Kanmin Xue; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2919. doi:

ARVO Annual Meeting Abstract July 2019

Genotype-Phenotype Analysis of Three Novel NR2E3 Mutations

Saoud A Al-khuzaei; Stephanie Halford; Penny Clouston; Robert E MacLaren; Susan M. Downes

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2933. doi:

ARVO Annual Meeting Abstract July 2019

Photoreceptor-specific AAV gene replacement enhanced by the adjunctive use of hydroxychloroquine in vivo

Laurel Clare Chandler; Michelle E McClements; Alun R Barnard; Maria In�s Patr�cio; Robert E MacLaren; Kanmin Xue

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3391. doi:

ARVO Annual Meeting Abstract July 2019

Identification of a new Kozak consensus in genes expressed in photoreceptors.

Anum Butt; Michelle E McClements; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3399. doi:

ARVO Annual Meeting Abstract July 2019

In vitro expression model for AAV2.VMD2.BEST1 gene therapy vectors

Cristina Martinez-Fernandez dela Camara; Richard Truran; Gregory Robinson; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3416. doi:

ARVO Annual Meeting Abstract July 2019

Non-identical monozygotic twins with RPGR-associated Retinitis Pigmentosa

Anika Nanda; Penny Clouston; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4499. doi:

ARVO Annual Meeting Abstract July 2019

Enhanced autofluorescence ring findings in RPGR-associated retinitis pigmentosa

Won Kyung Song; Anika Nanda; Jasmina Cehajic-Kapetanovic; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4524. doi:

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Assessment of AAV Dual Vector Safety in the Abca4 −/− Mouse Model of Stargardt Disease

Assessing Residual Photoreceptor Morphology in Choroideremia

A Specific Macula-Predominant Retinal Phenotype Is Associated With the CDHR1 Variant c.783G>A, a Silent Mutation Leading to In-Frame Exon Skipping

Fundus autofluorescence abnormalities and microglia/macrophage activation in the Rpgr -deficient mouse.

Face perception - can it be improved in age-related macular degeneration and Stargardt disease?

Changes on multimodal imaging after treatment with photodynamic therapy or high-density subthreshold micropulse laser in chronic central serous chorioretinopathy

Preliminary results in 18 patients undergoing retinal gene therapy for X-linked retinitis pigmentosa with codon-optimized AAV8-RPGR

Assessment of AAV dual vector safety in the Abca4 KO mouse model

Assessment of low luminance visual acuity as a functional measurement in two distinct types of inherited retinal degeneration.

Validation of Electronic Visual Acuity Measurement Against Standardised ETDRS Charts In Retinal Disease

Effect of reduced visual acuity on microperimetry performance in patients with inherited retinal degenerations

Correlation of distinct fundus autofluorescence features with disruption of the overlying ellipsoid zone in choroideremia

First in human clinical trial of robot-assisted subretinal drug delivery under local anaesthesia

Vector shedding and immunology measures in a choroideremia gene therapy trial

Genotype-Phenotype Analysis of Three Novel NR2E3 Mutations

Photoreceptor-specific AAV gene replacement enhanced by the adjunctive use of hydroxychloroquine in vivo

Identification of a new Kozak consensus in genes expressed in photoreceptors.

In vitro expression model for AAV2.VMD2.BEST1 gene therapy vectors

Non-identical monozygotic twins with RPGR-associated Retinitis Pigmentosa

Enhanced autofluorescence ring findings in RPGR-associated retinitis pigmentosa

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